WO2002052934A2 - Composiciones pesticidas y anti-parasitarias - Google Patents
Composiciones pesticidas y anti-parasitarias Download PDFInfo
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- WO2002052934A2 WO2002052934A2 PCT/CU2001/000014 CU0100014W WO02052934A2 WO 2002052934 A2 WO2002052934 A2 WO 2002052934A2 CU 0100014 W CU0100014 W CU 0100014W WO 02052934 A2 WO02052934 A2 WO 02052934A2
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- composition according
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- chitinolytic
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- parasitic
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- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P31/00—Antiinfectives, i.e. antibiotics, antiseptics, chemotherapeutics
- A61P31/04—Antibacterial agents
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- A—HUMAN NECESSITIES
- A01—AGRICULTURE; FORESTRY; ANIMAL HUSBANDRY; HUNTING; TRAPPING; FISHING
- A01N—PRESERVATION OF BODIES OF HUMANS OR ANIMALS OR PLANTS OR PARTS THEREOF; BIOCIDES, e.g. AS DISINFECTANTS, AS PESTICIDES OR AS HERBICIDES; PEST REPELLANTS OR ATTRACTANTS; PLANT GROWTH REGULATORS
- A01N63/00—Biocides, pest repellants or attractants, or plant growth regulators containing microorganisms, viruses, microbial fungi, animals or substances produced by, or obtained from, microorganisms, viruses, microbial fungi or animals, e.g. enzymes or fermentates
- A01N63/50—Isolated enzymes; Isolated proteins
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- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P31/00—Antiinfectives, i.e. antibiotics, antiseptics, chemotherapeutics
- A61P31/10—Antimycotics
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- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P33/00—Antiparasitic agents
Definitions
- This invention encompasses some synergistic compositions, of the pesticide and antiparasitic type, which are useful for the control of phytonematodes and parasitic zoonematodes, for the control of diseases (fungal and bacterial) and for the control of parasitic trematodes ⁇ Hepatic fasciola).
- Nematodes are the cause of the greatest damage to agriculture in tropical, subtropical and temperate regions around the world (Nickle
- Synergistic nematocidal compositions publishes a method that includes concurrent administration to eliminate the damage caused by nematodes to plants, site, soil or seeds that need treatment , of (a) a metabolite of the fungus Myrothecium verrucaria and (b) a chemical pesticide, as well as the synergistic nematicidal compositions useful in this case (Warrior P., Heiman DF and Rehberger Linda A. 1996.
- Another approach is to combine spores of Pasteuria penetrans, a bacterial parasite of nematodes, with organophosphorus nematicides (Nordmeyer D. 1987. Synergistic nematocidal compositions of Pasteuria penetrans spores and an organophosphorus nematocide. 1987. CIBA-GEIGY AG Patent AU 06057386A1. 01 / 29/1987).
- Chitinolytic fungi and bacteria which share the nematode habitat, can maintain a certain biological balance and somehow limit the proliferation of nematodes.
- Two strains of chitinolytic bacteria have been claimed (Toda T. and Matsuda H. 1993. Antibacterial, anti-nematode and / or plant-cell activating composition, and chitinolytic microorganisms for producing the same. Toda Biosystem Laboratory, Japan. Patent US5208159, 05 / 04/1993), as antibacterial, antinematode, and / or plant-cell activating composition.
- chitinolytic effect on nematodes There are some examples of the chitinolytic effect on nematodes. Some of the most representative are the strains of new bacteria described that are created by the introduction of DNA that codes for chitinase production, an enzyme that can degrade chitin present in fungi and nematodes (Suslow T. and Jones DG 1994. Novel chitinase-producing bacteria and plants. DNA Plant Technology Corporation, US04940840, 07/10/1990). The strains are useful in chitinase production in order to inhibit plant pathogens. Novel pathogen-resistant plants are also described, which are the result of the introduction of DNA encoding chitinase production.
- Nematodes Biological control ⁇ n rice fields- role of hydrogen sulfide. Science 148: 524-26) and Hollis (Hollis, JP, and R. Rodr ⁇ guez-Kábana. 1966. Rapid kill of nematodes in flooded soil. Phytopathology 56, pp 1015-19) observed correspondence between the bacterium Desulfovibrio desulfuricans, sulphide production of hydrogen and the nematodes that parasitize plants, whose population declined in Louisiana's rice plantations. Sulfides are inhibitors of the electron transport chain of the aerobic organism's breathing process, as are other metabolites produced by some soil bacteria (Rodr ⁇ guez-Kábana, R. 1991. Biological control of plant parasitic nematodes. NEMATROPICA, 21 (1), pp 111-
- PAECIL TM also known as BIOACT or Nemachek, is a biological nematicide that contains a patented strain of the Paecilomyces lilacinus fungus in a dry and stable spore concentrate for soil and seed treatments. This species of fungus is commonly found in all soils of the world.
- the patented strain that was used as the active ingredient of PAECIL TM has a special effectiveness against the nematodes that parasitize plants.
- the Australian National Registration Authority is currently evaluating the product as a pesticide (Holland, R. PAECIL TM 1998. http://www.ticorp.com.au/article1.htm).
- Hepatic fasciola which was the first known parasitic trematode, parasitic to man, living in the bile ducts (Saleha A. 1991. Liver fluke disease (fasciolosis) epidemiology, economic impact and public health significance. Southeast Asian J. Trop. Med. Public health 22 supp 1dic. P 361-4). It causes digestive disorders that consist of gastric asepsis, disorders in motility of the colon, pain at the level of the liver and gallbladder, liver cramps and fevers. It can present aberrant locations such as in the lung, hepatic vein, eyes, brain and other tissues. Helminths that parasitize animals are significant pests in relation to sheep and cattle. The resistance to antielmintics is wide, particularly in populations of parasitic nematodes of small ruminants.
- the fungus Duddingtonia flagrans a predator that forms nets, produces immobile spores of broad walls, clamidopores, that can survive the passage through the gastrointestinal tract of cattle, horses, sheep and pigs (Larsen M. 1999. Biological control of helminths. int J Parasite !. Jan; 29 (1): 139-46, and Larsen, M. 2000. Prospects for controlling animal parasitic nematodes by predacious micro fungi. Parasitology, 120, S120-S121).
- Dictyocaulus viviparus a parasite that reaches sexual maturity and is located in the adult state in the lungs of cattle, especially in young animals.
- the disease that occurs is called vermin bronchitis or bovine dictyocaulosis and the infestation is caused by ingesting the infesting larvae, present in the pastures.
- the treatment of this parasitosis is carried out with the use of anthelmintics (Borgsteede FHM, from Leeuw WA & Burg WPJ 1988.
- Borgsteede FHM anthelmintics
- Agrobacterium radiobacter which controls Agrobacterium tumefaciens
- Bio-Fungus Trichoderma spp that controls the following fungi Phytophthora, Rhizoctonia solani, Pythium spp., Fusarium, Verticillium), Aspire (Candida oleophila 1-182 that controls Botrytis spp. and Penicillium spp), etc.
- the invention relates to a composition, which contains at least one qutinolytic agent or a chitinolytic activity inducing agent, and sulfur or a sulphide producing agent obtained from microorganisms or chemical compounds, in which the chitinolytic agent or an inducing agent the chitinolytic activity, and the sulfide or a sulphide producing agent obtained from microorganisms or chemical compounds, are applied concurrently to a substantially lower range than when using any of the components separately to achieve effective control over helminths and causative agents of bacterial and fungal diseases.
- the invention also relates to the use of such compositions and / or the concurrent administration of the aforementioned compounds from different sources, such as biological and chemical products for the effective control of a wide range of plant parasitic nematodes (Meloidogyne spp, Angina spp, Ditylenchus spp, Pratylenchus spp, Heterodera spp, Aphelenchus spp, Radopholus spp, Xiphinema spp, Rotylenchulus spp), of nematodes and trematodes parasites of animals (Haemonchus spp, Trichostrongylus spp., Dictyocaulus fascia, Dictyocaulus spp.
- the chitinolytic agent or the chitinolytic activity inducing agent and the sulfide or the sulphide producing agent may be mixed in any appropriate form, such as a solution, suspension, emulsion, powder or granular mixture, and is applied to the plant or soil as a fertilizer, pre-packed soil, seed cover device, a powder, a granulate, a nebulizer, a suspension, a liquid, or any of the forms indicated, in an encapsulated form, for the control of parasitic helminths, and fungal and bacterial diseases.
- the optimal ranges of application of the chitinolytic agent or the agent that induces chitinolytic activity and sulfur or a sulphide producing agent in the case of a particular nematode, trematode, bacterium or fungus, and in the case of specific conditions, are determined through experimental studies of ranges, carried out in vitro, in the greenhouse or in field conditions.
- composition comprising a microorganism, between 10 7 CFU and 10 12 CFU per gram of composition, which produces chitinolytic agents and sulfur concurrently, is appropriate for the control of helminths, bacteria and fungi.
- compositions comprise the combinations of the following agents in the aforementioned proportions: 1. Chitinase and Na 2 S. 2. Chitinase and FeS.
- compositions are effective against a wide range of plant parasitic nematodes, including (not limiting) Meloidogyne species, such as M. incognita; Angina species, such as A. tritici; Ditylencus species, such as D. dipsaci; Pratylenchus species, such as P. coffee; Heterodera species, such as H. glycines; species of
- Aphelenchus such as A. avenae
- Radopholus species such as R. similis
- Xiphinema species such as X. index
- Rotylenchulus species such as R. reniformis
- nematodes that parasitize animals such as: Haemonchus spp., Trichostrongylus spp., Ostertagia spp., Nematodirus spp., Cooperia spp., Ascaris spp., Bunostomum spp., Oesophagostomum spp.,
- Chabertia spp. Trichuris spp., Strongylus spp., Trichonema spp., Dictyocaulus spp., Capillaria spp., Heterakis spp., Toxocara spp., Ascaridia spp., Oxyuris spp., Ancylostoma spp., Uncinaria spp., Toxascaris spp. . and Parascaris spp; and trematodes that parasitize animals such as hepatic fasciola; and pathogenic bacteria such as Erwinia chrysanthemi, Burkholderia glumae,
- Pestalotia palmarum, Alternar ⁇ a tabacina, Sarocladium orizae, and pathogenic fungi such as Pestalotia palmarum, Alternar ⁇ a tabacina, Sarocladium orizae.
- pathogenic fungi such as Pestalotia palmarum, Alternar ⁇ a tabacina, Sarocladium orizae.
- Example 1 In vitro evaluation of the nematicidal effect of hydrogen sulphide from chemical sources and a chitinolytic enzyme.
- Haemonchus sp and Trichostrongylus colubriformis nematode were collected from the abomasum of a sheep (ram) and a bovine (beef) respectively. The females of the adult nematodes were washed in physiological solution and treated with "Hibitane" (Acetate
- Chlorhexidine at 0.5% for 1 minute, this process was developed at a temperature of 37 ° C.
- the collections of the nematode D. viviparus were made from lungs infested with a bovine (cattle), previously slaughtered. The procedure was the same as for Haemonchus sp. and T. colubriformis, except that in the case of females they were allowed to perform the laying for a period of 2 to 3 hours.
- the total volume of water containing the masses of eggs and the larvae was filtered through a sieve of a 60 ⁇ m mesh. From this moment all the manipulation was carried out under aseptic conditions within a vertical laminar flow and using 24-hole tissue culture plates. The eggs detached from the masses that failed to hatch, were retained on the mesh of a 30 ⁇ m sieve, and the larvae are collected on a last sieve of a 5 ⁇ m mesh, which was introduced into a solution of Hibitane at 0 , 5% for 3 minutes and then 3 washes were performed with LB medium diluted 10 times in sterile distilled water.
- Hydrogen sulfide was obtained by reaction with hydrochloric acid of two sulphide salts (Na 2 S and FeS) and from the anaerobic fermentation of the bacterium Desulfovibrio desulfuricans subs. ATCC desulfuricans 27774 (isolated from the rumen of an sheep).
- the chitinolytic enzyme used was SIGMA C1650 chitinase obtained from the Serratia marcescens bacteria.
- the eggs and larvae of the nematodes under study were subjected to the following treatments for 24 hours:
- Control Treatment without applying chitinase and circulating air through the valve.
- Chitinase treatment chitinase at a rate of 0.2 units per replicate.
- Sulfide treatment hydrogen sulfide from Na 2 S with a flow of
- Sulfide treatment hydrogen sulfide from FeS with a flow of 0.2 to 0.3 mg / minute.
- Sulfide treatment hydrogen sulfide from Desulfovibrio desulfuricans with a flow of 0.2 to 0.3 mg / minute.
- the effectiveness (E) is the result of subtracting 1 the value of the relative frequency (Fr) of hatching or live larvae, as the case may be.
- Fr is the ratio between the number of hatched larvae or live larvae of each treatment (Ntto) and the number of hatched larvae or live larvae of treatment 1 (Nc):
- Example 2 Greenhouse evaluation of the nematicidal effect of a chitinolytic activity inducing agent (chitin) and a hydrogen sulfide producing microorganism (Desulfovibrio desulfuricans subps. ATCC 29577 desulfuricans isolated from soil).
- chitin chitinolytic activity inducing agent
- hydrogen sulfide producing microorganism Desulfovibrio desulfuricans subps. ATCC 29577 desulfuricans isolated from soil.
- a brown soil of neutral pH was selected, dried and passed through a 0.5 cm mesh to remove undesirable particles; sterilized in a vertical autoclave for 1 hour 120 ° C and 1 atmosphere (Sambrook J., Fritsch EF and Maniatis T. 1989. Molecular Cloning: A Laboratory Manual 2 ⁇ d .Ed Cold Spring Harbor Laboratory, Cold Spring Harbor, NY,.. USES); allowed to dry room temperature for 3 or 4 days, to subsequently carry out the mixtures provided in the treatments with river sand, earthworm and chitin humus (ICN catalog number 101334).
- Control Treatment 70% soil, 25% river sand and 5% humus.
- Chitin treatment 70% soil, 25% river sand, 4% humus and 1% chitin.
- Microorganism Treatment 70% soil, 25% river sand, 5% humus and D. desulfuricans, applied at a concentration of 10 10 CFU / pot.
- the pots were placed in greenhouses and remained at rest for three days after the treatments were carried out and the nematodes inoculated. At this stage, daily watering was maintained to maintain good humidity conditions in them.
- Fr is the ratio between the number of live specimens of each treatment (Ntto) and the number of live specimens of treatment 1 (Nc):
- the expected effectiveness (EE) must be equal to the sum of the individual effects (El) that are given by the effectiveness attributed to the action of chitin (Eq) as an inducer of the chitinolytic activity of microorganisms present in the soil mixture with humus, and the effectiveness attributed to the action of hydrogen sulfide (Esd) from the bacteria D. desulfuricans ; minus the intersection effect (ei) between both treatments (Sigarroa, A. 1985. Biometrics and experimental design. 1st part. Minister of Education Sup. Ed People and Education. Chapter 3. page 69-107).
- Example 3 Demonstration of the chitinolytic activity and sulphide production of the Corynebacterium paurometabolum C-924 and Tsukamurella paurometabola DSM 20162 bacteria.
- Determination of sulphide production In gas collection tubes of 100 mL, samples of the gas stream from the fermentation in 5 L bioreactors, of the C-924 and DSM 20162 strains were taken. The total culture time was 24 h. Beginning to detect the formation of hydrogen sulfide after 16 h.
- Carrier gas Nitrogen 1.5 ml / min.
- the bacterial cultures of the strains under study were grown in LB medium at a temperature of 28 ° C and 100 rpm stirring for 24 hours, after this time they were centrifuged at 3500 rpm and the supernatants filtered through two 0.2 ⁇ m membranes .
- the filtrate product was subjected to activity tests on plates prepared from a colloidal chitin suspension (0.5%), agarose was also added up to 0.8% or to achieve gelation of the medium and ensure a porosity that allowed the best diffusion of proteins.
- 5mm diameter wells were made in which 100 ⁇ l of the filtered supernatant of each bacterial strain was added. Three replicates were placed for each plate and incubated at 28 ° C and in the dark.
- the +++ sign refers to the highest hydrolysis halo observed, the ++ sign refers to an intermediate hydrolysis halo, and the + sign refers to the smallest hydrolysis halo observed.
- Both strains C. paurometabolum and T. paurometabola. Showed chitin hydrolysis halo as well as the positive control used (S. marcescen), while the E. coli strain (negative control) did not produce hydrolysis halo
- Example 4 In vitro evaluation of the effect of sulfides and chitinases, produced by the bacteria Corynebacterium paurometabolum C-924 and Tsukamurella paurometabola DSM 20162, on the parasite Fasciola hepatic (trematode).
- Eggs of the Fasciola hepatic parasite were used. Egg collections were made directly from the bile of an infested liver of a bovine (bovine), previously slaughtered. The biliary content was resuspended in a 3-fold volume of sterile distilled water and allowed to stand for 2 to 3 hours at 28 ° C, with the aim that the eggs precipitate. Subsequently, the greatest possible volume of the supernatant liquid was carefully extracted. The precipitate was filtered through a 71 ⁇ m mesh screen, the eggs being retained within it. From this moment all the manipulation was carried out under aseptic conditions within a vertical laminar flow and using 24-hole tissue culture plates. The sieve, containing the F. hepatic eggs, was placed in a 0.5% Hibitane solution for 3 minutes and then 3 washes were performed with LB medium diluted 10 times in sterile distilled water.
- Control Treatment 1 ml of diluted LB medium was added 10 times to each valve, without applying chitinase and circulating air through it.
- Fr is the ratio between the number of eggs hatched from each treatment (Ntto) and the number of eggs hatched from treatment 1 (Nc):
- the expected effectiveness must be equal to the sum of the individual effects (El) that are given by the effectiveness attributed to the action of chitinase (Eq) and the effectiveness attributed to the action of sulfide hydrogen (Esn, Esf and Esd) minus the intersection effect (ei) (Sigarroa, 1985).
- Example 5 In vitro evaluation of the effect of a bacterial strain (Corynebacterium paurometabolum C-924) producing hydrogen sulphide and with chitinolytic activity, on different bacteria and fungi.
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Priority Applications (12)
Application Number | Priority Date | Filing Date | Title |
---|---|---|---|
CA2431669A CA2431669C (en) | 2001-01-03 | 2001-12-17 | Pesticidal and antiparasitic compositions comprising chitinase or chitin and sulfide |
IL15670001A IL156700A0 (en) | 2001-01-03 | 2001-12-17 | Pesticidal and antiparasitic compositions |
US10/250,561 US20040071663A1 (en) | 2001-01-03 | 2001-12-17 | Pesticidal and antiparasitic compositions |
EP01272600A EP1356733B1 (en) | 2001-01-03 | 2001-12-17 | Pesticidal and antiparasitic compositions |
MXPA03006040A MXPA03006040A (es) | 2001-01-03 | 2001-12-17 | Composiciones pesticidas y antiparasitarias. |
BRPI0116711-1A BR0116711B1 (pt) | 2001-01-03 | 2001-12-17 | Composição pesticida ou antiparasitária |
DE60112973T DE60112973T2 (de) | 2001-01-03 | 2001-12-17 | Pestizide und antiparasitische zusammensetzungen |
AU2002216898A AU2002216898B2 (en) | 2001-01-03 | 2001-12-17 | Pesticidal and antiparasitic compositions |
AT01272600T ATE302552T1 (de) | 2001-01-03 | 2001-12-17 | Pestizide und antiparasitische zusammensetzungen |
JP2002553900A JP2004522727A (ja) | 2001-01-03 | 2001-12-17 | 殺虫用及び駆虫用の組成物 |
IL156700A IL156700A (en) | 2001-01-03 | 2003-06-29 | Ingredients for pest control and parasites |
US12/857,194 US8268306B2 (en) | 2001-01-03 | 2010-08-16 | Pesticidal and antiparasitic compositions |
Applications Claiming Priority (2)
Application Number | Priority Date | Filing Date | Title |
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CU20010004A CU23176A1 (es) | 2001-01-03 | 2001-01-03 | Composiciones pesticidas y antiparasitarias |
CU20010004 | 2001-01-03 |
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US10/250,561 A-371-Of-International US20040071663A1 (en) | 2001-01-03 | 2001-12-17 | Pesticidal and antiparasitic compositions |
US10250561 A-371-Of-International | 2001-12-17 | ||
US12/857,194 Division US8268306B2 (en) | 2001-01-03 | 2010-08-16 | Pesticidal and antiparasitic compositions |
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WO2002052934A2 true WO2002052934A2 (es) | 2002-07-11 |
WO2002052934A3 WO2002052934A3 (es) | 2002-09-19 |
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PCT/CU2001/000014 WO2002052934A2 (es) | 2001-01-03 | 2001-12-17 | Composiciones pesticidas y anti-parasitarias |
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US (2) | US20040071663A1 (es) |
EP (1) | EP1356733B1 (es) |
JP (2) | JP2004522727A (es) |
CN (1) | CN1241480C (es) |
AT (1) | ATE302552T1 (es) |
AU (1) | AU2002216898B2 (es) |
BR (1) | BR0116711B1 (es) |
CA (1) | CA2431669C (es) |
CU (1) | CU23176A1 (es) |
DE (1) | DE60112973T2 (es) |
DK (1) | DK1356733T3 (es) |
EC (1) | ECSP034675A (es) |
ES (1) | ES2247009T3 (es) |
IL (2) | IL156700A0 (es) |
MX (1) | MXPA03006040A (es) |
PA (1) | PA8536401A1 (es) |
PE (1) | PE20020778A1 (es) |
RU (1) | RU2249957C1 (es) |
UY (1) | UY27112A1 (es) |
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CU23590A1 (es) * | 2007-04-30 | 2010-10-30 | Ct Ingenieria Genetica Biotech | Composición biofertilizante |
US9526251B2 (en) | 2010-02-25 | 2016-12-27 | Marrone Bio Innovations, Inc. | Use of Burkholderia formulations, compositions and compounds to modulate crop yield and/or corn rootworm infestation |
AR080234A1 (es) * | 2010-02-25 | 2012-03-21 | Marrone Bio Innovations Inc | Cepa bacteriana aislada del genero burkholderia y metabolitos pesticidas del mismo |
US8822193B2 (en) | 2010-02-25 | 2014-09-02 | Marrone Bio Innovations, Inc. | Isolated bacterial strain of the genus Burkholderia and pesticidal metabolites therefrom |
TW201225844A (en) * | 2010-10-25 | 2012-07-01 | Marrone Bio Innovations Inc | Chromobacterium bioactive compositions and metabolites |
AU2012301466B2 (en) * | 2011-08-27 | 2015-07-23 | Marrone Bio Innovations, Inc. | Isolated bacterial strain of the genus Burkholderia and pesticidal metabolites therefrom-formulations and uses |
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US20150305348A1 (en) * | 2012-12-03 | 2015-10-29 | Bayer Cropscience Ag | Composition comprising biological control agents |
CL2013000307A1 (es) | 2013-01-30 | 2014-04-04 | Bio Insumos Nativa Ltda | Composicion bionematicida que comprende al menos dos cepas de bacillus o los productos de fermentacion de las mismas, y un vehiculo agronomicamente aceptable; formulacion que comprende la composicion; cepa de bacilo nematicida |
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GB201502611D0 (en) * | 2015-02-17 | 2015-04-01 | Hydrolice As | Method of treatment and/or prevention of a sea lice infestation on fish, and compositions for that use |
EP3195727A1 (en) * | 2016-01-22 | 2017-07-26 | Forschungsinstitut Fur Biologischen Landbau (FiBL) | Duddingtonia flagrans strain and feed additive formulation for biological pest control |
MX2020002634A (es) * | 2017-09-08 | 2020-07-13 | Marrone Bio Innovations Inc | Nuevo compuesto herbicida. |
RU2694182C1 (ru) * | 2018-09-17 | 2019-07-09 | Федеральное государственное бюджетное образовательное учреждение высшего образования "Горский государственный аграрный университет" | Способ биологической борьбы с болезнями и вредителями городских зеленых насаждений |
CU24557B1 (es) * | 2018-09-27 | 2021-12-08 | Ct Ingenieria Genetica Biotecnologia | Composición sólida de uso agrícola que comprende cepa bacteriana de brevibacterium celere |
CN111088291B (zh) * | 2018-10-24 | 2022-05-06 | 吉林大学 | 一种食线虫真菌分离株次级代谢产物及粗提物和医用用途 |
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ZA963440B (en) | 1995-05-05 | 1997-02-24 | Abbott Lab | Synergistic nematocidal compositions. |
-
2001
- 2001-01-03 CU CU20010004A patent/CU23176A1/es unknown
- 2001-12-17 CA CA2431669A patent/CA2431669C/en not_active Expired - Lifetime
- 2001-12-17 US US10/250,561 patent/US20040071663A1/en not_active Abandoned
- 2001-12-17 EP EP01272600A patent/EP1356733B1/en not_active Expired - Lifetime
- 2001-12-17 AU AU2002216898A patent/AU2002216898B2/en not_active Ceased
- 2001-12-17 CN CNB018217265A patent/CN1241480C/zh not_active Expired - Lifetime
- 2001-12-17 BR BRPI0116711-1A patent/BR0116711B1/pt not_active IP Right Cessation
- 2001-12-17 AT AT01272600T patent/ATE302552T1/de active
- 2001-12-17 RU RU2003124061/13A patent/RU2249957C1/ru not_active IP Right Cessation
- 2001-12-17 JP JP2002553900A patent/JP2004522727A/ja active Pending
- 2001-12-17 MX MXPA03006040A patent/MXPA03006040A/es active IP Right Grant
- 2001-12-17 ES ES01272600T patent/ES2247009T3/es not_active Expired - Lifetime
- 2001-12-17 IL IL15670001A patent/IL156700A0/xx active IP Right Grant
- 2001-12-17 DE DE60112973T patent/DE60112973T2/de not_active Expired - Lifetime
- 2001-12-17 DK DK01272600T patent/DK1356733T3/da active
- 2001-12-17 WO PCT/CU2001/000014 patent/WO2002052934A2/es active IP Right Grant
- 2001-12-18 PE PE2001001263A patent/PE20020778A1/es active IP Right Grant
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2002
- 2002-01-03 UY UY27112A patent/UY27112A1/es not_active IP Right Cessation
- 2002-01-03 PA PA20028536401A patent/PA8536401A1/es unknown
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2003
- 2003-06-26 EC EC2003004675A patent/ECSP034675A/es unknown
- 2003-06-29 IL IL156700A patent/IL156700A/en not_active IP Right Cessation
- 2003-07-01 ZA ZA200305121A patent/ZA200305121B/xx unknown
-
2007
- 2007-06-27 JP JP2007168329A patent/JP2007326861A/ja not_active Abandoned
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2010
- 2010-08-16 US US12/857,194 patent/US8268306B2/en not_active Expired - Fee Related
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EP0401560A1 (en) * | 1989-05-16 | 1990-12-12 | Toda Biosystem Laboratory | Antibacterial, anti-nematode and/or plant-cell activating composition, and chitinolytic microorganisms for producing the same |
WO1994013784A1 (en) * | 1992-12-15 | 1994-06-23 | Cornell Research Foundation, Inc. | Antifungal synergistic combination of enzyme fungicide and non-enzymatic fungicide and use thereof |
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Also Published As
Publication number | Publication date |
---|---|
JP2007326861A (ja) | 2007-12-20 |
JP2004522727A (ja) | 2004-07-29 |
EP1356733B1 (en) | 2005-08-24 |
PA8536401A1 (es) | 2003-06-30 |
AU2002216898B2 (en) | 2006-09-07 |
RU2249957C1 (ru) | 2005-04-20 |
WO2002052934A3 (es) | 2002-09-19 |
RU2003124061A (ru) | 2005-01-27 |
EP1356733A2 (en) | 2003-10-29 |
IL156700A0 (en) | 2004-01-04 |
DK1356733T3 (da) | 2005-11-14 |
ATE302552T1 (de) | 2005-09-15 |
UY27112A1 (es) | 2002-03-22 |
CA2431669C (en) | 2012-02-07 |
CU23176A1 (es) | 2006-09-22 |
IL156700A (en) | 2007-07-24 |
CN1484494A (zh) | 2004-03-24 |
MXPA03006040A (es) | 2003-09-10 |
CA2431669A1 (en) | 2002-07-11 |
DE60112973T2 (de) | 2006-05-18 |
BR0116711B1 (pt) | 2014-10-07 |
PE20020778A1 (es) | 2002-10-16 |
BR0116711A (pt) | 2003-12-23 |
US8268306B2 (en) | 2012-09-18 |
ES2247009T3 (es) | 2006-03-01 |
ECSP034675A (es) | 2003-10-28 |
DE60112973D1 (de) | 2005-09-29 |
US20110064718A1 (en) | 2011-03-17 |
ZA200305121B (en) | 2004-07-19 |
CN1241480C (zh) | 2006-02-15 |
US20040071663A1 (en) | 2004-04-15 |
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