WO2002046465A3 - Method for identification of genes involved in specific diseases - Google Patents

Method for identification of genes involved in specific diseases Download PDF

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Publication number
WO2002046465A3
WO2002046465A3 PCT/GB2001/005458 GB0105458W WO0246465A3 WO 2002046465 A3 WO2002046465 A3 WO 2002046465A3 GB 0105458 W GB0105458 W GB 0105458W WO 0246465 A3 WO0246465 A3 WO 0246465A3
Authority
WO
WIPO (PCT)
Prior art keywords
identification
implicated
gene
disease
experimental conditions
Prior art date
Application number
PCT/GB2001/005458
Other languages
French (fr)
Other versions
WO2002046465A2 (en
Inventor
Jonathan White
Christopher Robert Mundy
Neil Raymond Ward
David Krige
Susan Mary Kingsman
Robert Alan Harris
William Nigel Rayner
Original Assignee
Oxford Biomedica Ltd
Jonathan White
Christopher Robert Mundy
Neil Raymond Ward
David Krige
Susan Mary Kingsman
Robert Alan Harris
William Nigel Rayner
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Priority claimed from GB0030076A external-priority patent/GB0030076D0/en
Priority claimed from GB0103156A external-priority patent/GB0103156D0/en
Priority claimed from GB0125666A external-priority patent/GB0125666D0/en
Application filed by Oxford Biomedica Ltd, Jonathan White, Christopher Robert Mundy, Neil Raymond Ward, David Krige, Susan Mary Kingsman, Robert Alan Harris, William Nigel Rayner filed Critical Oxford Biomedica Ltd
Priority to AU2002220920A priority Critical patent/AU2002220920A1/en
Priority to US10/170,385 priority patent/US20030203372A1/en
Publication of WO2002046465A2 publication Critical patent/WO2002046465A2/en
Publication of WO2002046465A3 publication Critical patent/WO2002046465A3/en

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Classifications

    • C—CHEMISTRY; METALLURGY
    • C12—BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
    • C12Q—MEASURING OR TESTING PROCESSES INVOLVING ENZYMES, NUCLEIC ACIDS OR MICROORGANISMS; COMPOSITIONS OR TEST PAPERS THEREFOR; PROCESSES OF PREPARING SUCH COMPOSITIONS; CONDITION-RESPONSIVE CONTROL IN MICROBIOLOGICAL OR ENZYMOLOGICAL PROCESSES
    • C12Q1/00—Measuring or testing processes involving enzymes, nucleic acids or microorganisms; Compositions therefor; Processes of preparing such compositions
    • C12Q1/68—Measuring or testing processes involving enzymes, nucleic acids or microorganisms; Compositions therefor; Processes of preparing such compositions involving nucleic acids
    • C12Q1/6876—Nucleic acid products used in the analysis of nucleic acids, e.g. primers or probes
    • C12Q1/6883—Nucleic acid products used in the analysis of nucleic acids, e.g. primers or probes for diseases caused by alterations of genetic material
    • C—CHEMISTRY; METALLURGY
    • C12—BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
    • C12Q—MEASURING OR TESTING PROCESSES INVOLVING ENZYMES, NUCLEIC ACIDS OR MICROORGANISMS; COMPOSITIONS OR TEST PAPERS THEREFOR; PROCESSES OF PREPARING SUCH COMPOSITIONS; CONDITION-RESPONSIVE CONTROL IN MICROBIOLOGICAL OR ENZYMOLOGICAL PROCESSES
    • C12Q2600/00—Oligonucleotides characterized by their use
    • C12Q2600/158—Expression markers

Landscapes

  • Chemical & Material Sciences (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • Health & Medical Sciences (AREA)
  • Proteomics, Peptides & Aminoacids (AREA)
  • Organic Chemistry (AREA)
  • Genetics & Genomics (AREA)
  • Zoology (AREA)
  • Analytical Chemistry (AREA)
  • Wood Science & Technology (AREA)
  • Engineering & Computer Science (AREA)
  • Microbiology (AREA)
  • Biochemistry (AREA)
  • Biotechnology (AREA)
  • Molecular Biology (AREA)
  • Biophysics (AREA)
  • Physics & Mathematics (AREA)
  • Pathology (AREA)
  • Immunology (AREA)
  • Bioinformatics & Cheminformatics (AREA)
  • General Engineering & Computer Science (AREA)
  • General Health & Medical Sciences (AREA)
  • Measuring Or Testing Involving Enzymes Or Micro-Organisms (AREA)
  • Micro-Organisms Or Cultivation Processes Thereof (AREA)
  • Peptides Or Proteins (AREA)
  • Medicines That Contain Protein Lipid Enzymes And Other Medicines (AREA)

Abstract

This invention relates to novel methods for the identification of genes and gene products that are implicated in certain disease states. According to the invention, there is provided a method for the identification of a gene that is implicated in a specific disease or physiological condition, said method comprising the steps of comparing: i) the transcriptome or proteome of a first specialised cell type that is implicated in the disease or condition under first and second experimental conditions; with ii) the transcriptome or proteome of a second specialised cell type under said first and said second experimental conditions; and identifying as a gene implicated in the disease or physiological condition, a gene that is differentially regulated in the two specialised cell types under the first and second experimental conditions. The invention also relates to novel genes and gene products identified using these methods.
PCT/GB2001/005458 2000-12-08 2001-12-10 Method for identification of genes involved in specific diseases WO2002046465A2 (en)

Priority Applications (2)

Application Number Priority Date Filing Date Title
AU2002220920A AU2002220920A1 (en) 2000-12-08 2001-12-10 Method for identification of genes involved in specific diseases
US10/170,385 US20030203372A1 (en) 2000-12-08 2002-06-12 Analysis method

Applications Claiming Priority (6)

Application Number Priority Date Filing Date Title
GB0030076.4 2000-12-08
GB0030076A GB0030076D0 (en) 2000-12-08 2000-12-08 Analysis method
GB0103156A GB0103156D0 (en) 2001-02-08 2001-02-08 Analysis method
GB0103156.6 2001-02-08
GB0125666.8 2001-10-25
GB0125666A GB0125666D0 (en) 2001-10-25 2001-10-25 Analysis method

Related Child Applications (1)

Application Number Title Priority Date Filing Date
US10/170,385 Continuation-In-Part US20030203372A1 (en) 2000-12-08 2002-06-12 Analysis method

Publications (2)

Publication Number Publication Date
WO2002046465A2 WO2002046465A2 (en) 2002-06-13
WO2002046465A3 true WO2002046465A3 (en) 2003-11-06

Family

ID=27255999

Family Applications (1)

Application Number Title Priority Date Filing Date
PCT/GB2001/005458 WO2002046465A2 (en) 2000-12-08 2001-12-10 Method for identification of genes involved in specific diseases

Country Status (2)

Country Link
AU (1) AU2002220920A1 (en)
WO (1) WO2002046465A2 (en)

Cited By (2)

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US9182405B2 (en) 2006-04-04 2015-11-10 Singulex, Inc. Highly sensitive system and method for analysis of troponin
US9494598B2 (en) 2006-04-04 2016-11-15 Singulex, Inc. Highly sensitive system and method for analysis of troponin

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JPWO2003044197A1 (en) * 2001-11-21 2005-03-24 独立行政法人科学技術振興機構 Huntington's disease gene transcription factor
WO2003074674A2 (en) 2002-03-01 2003-09-12 Exelixis, Inc. MSRAs AS MODIFIERS OF THE p53 PATHWAY AND METHODS OF USE
AU2003255337A1 (en) * 2002-07-31 2004-02-23 Kylix B.V. Use of genes identified to be involved in tumor development for the development of anti-cancer drugs
JP4820092B2 (en) * 2002-10-18 2011-11-24 サイレンス・セラピューティクス・アーゲー Novel factors for metastasis and their use
AU2003291136A1 (en) * 2002-11-21 2004-06-18 The General Hospital Corporation Redd1, a transcriptional target of p63 and p53, and methods of use therefor
US20060147926A1 (en) 2002-11-25 2006-07-06 Emmert-Buck Michael R Method and apparatus for performing multiple simultaneous manipulations of biomolecules in a two-dimensional array
US20060110393A1 (en) * 2002-12-26 2006-05-25 Eiji Sunahara Novel proteins and use thereof
EP1636588A2 (en) * 2003-06-12 2006-03-22 University of Manitoba Methods for detecting cancer and monitoring cancer progression
SE0302122D0 (en) * 2003-07-22 2003-07-22 Astrazeneca Ab Genetic marker
EP1709152A4 (en) * 2003-12-15 2007-11-07 Univ California Molecular signature of the pten tumor suppressor
JPWO2005061704A1 (en) * 2003-12-24 2007-07-12 武田薬品工業株式会社 Cancer preventive / therapeutic agent
WO2005111239A2 (en) * 2004-04-30 2005-11-24 Decode Genetics Ehf. Haplotypes in the human thioredoxin interacting protein homologue (arrdc3) gene associated with obesity
JPWO2005118631A1 (en) 2004-06-03 2008-05-29 武田薬品工業株式会社 Novel protein complex and its use
US20080274456A1 (en) * 2004-06-09 2008-11-06 Bruce Yankner Methods and Compositions for Modifying Gene Regulation and Dna Damage in Ageing
AU2005277508B2 (en) 2004-08-16 2011-04-14 Quark Pharmaceuticals, Inc Therapeutic uses of inhibitors of RTP801
US7825099B2 (en) 2006-01-20 2010-11-02 Quark Pharmaceuticals, Inc. Treatment or prevention of oto-pathologies by inhibition of pro-apoptotic genes
NL2000439C2 (en) 2006-01-20 2009-03-16 Quark Biotech Therapeutic applications of inhibitors of RTP801.
US7723052B2 (en) 2006-05-11 2010-05-25 Quark Pharmaceuticals, Inc. Screening systems utilizing RTP801
EP2026843A4 (en) 2006-06-09 2011-06-22 Quark Pharmaceuticals Inc Therapeutic uses of inhibitors of rtp801l
US8158356B2 (en) 2006-10-16 2012-04-17 Agrigenomics, Inc. Screening for the genetic defect causing tibial hemimelia in bovines
WO2008106102A2 (en) 2007-02-26 2008-09-04 Quark Pharmaceuticals, Inc. Inhibitors of rtp801 and their use in disease treatment
EP2125775A4 (en) 2007-03-01 2011-07-13 Cedars Sinai Medical Center Antioxidant polymers containing [1,2]-dithiolane moieties and uses thereof
US8614311B2 (en) 2007-12-12 2013-12-24 Quark Pharmaceuticals, Inc. RTP801L siRNA compounds and methods of use thereof
US9028874B2 (en) 2008-01-03 2015-05-12 Cedars-Sinai Medical Center Antioxidant nanosphere comprising [1,2]-dithiolane moieties
US8603531B2 (en) 2008-06-02 2013-12-10 Cedars-Sinai Medical Center Nanometer-sized prodrugs of NSAIDs
JP5564512B2 (en) 2008-11-24 2014-07-30 セダーズ−シナイ メディカル センター Antioxidant camptothecin derivatives and their antioxidant and anti-neoplastic nanospheres
AU2010259022B2 (en) 2009-06-08 2016-05-12 Singulex, Inc. Highly sensitive biomarker panels
US8431346B2 (en) 2009-12-18 2013-04-30 Agrigenomics, Inc. Screening for arthrogryposis multiplex in bovines
GB2493540A (en) * 2011-08-10 2013-02-13 Follicum Ab Agents for stimulating hair growth in mammals
CA2760873C (en) 2011-12-02 2020-04-21 Sabine Mai Diagnostic methods for hematological disorders
EP3294886A4 (en) 2015-05-11 2019-02-20 Mimetics, LLC Methods for identifying targets for antimicrobial and antiproliferative compounds and compositions therefrom

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Cited By (2)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
US9182405B2 (en) 2006-04-04 2015-11-10 Singulex, Inc. Highly sensitive system and method for analysis of troponin
US9494598B2 (en) 2006-04-04 2016-11-15 Singulex, Inc. Highly sensitive system and method for analysis of troponin

Also Published As

Publication number Publication date
AU2002220920A1 (en) 2002-06-18
WO2002046465A2 (en) 2002-06-13

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