WO2002046163A3 - Derives de quinoleine et leur utilisation - Google Patents

Derives de quinoleine et leur utilisation Download PDF

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Publication number
WO2002046163A3
WO2002046163A3 PCT/DE2001/004452 DE0104452W WO0246163A3 WO 2002046163 A3 WO2002046163 A3 WO 2002046163A3 DE 0104452 W DE0104452 W DE 0104452W WO 0246163 A3 WO0246163 A3 WO 0246163A3
Authority
WO
WIPO (PCT)
Prior art keywords
quinoline derivatives
epileptics
sodium channel
relates
dependent disorders
Prior art date
Application number
PCT/DE2001/004452
Other languages
German (de)
English (en)
Other versions
WO2002046163A2 (fr
Inventor
Michael Wackernagel
Original Assignee
Michael Wackernagel
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Application filed by Michael Wackernagel filed Critical Michael Wackernagel
Priority to AU2002216939A priority Critical patent/AU2002216939A1/en
Priority to DE10195304T priority patent/DE10195304D2/de
Publication of WO2002046163A2 publication Critical patent/WO2002046163A2/fr
Publication of WO2002046163A3 publication Critical patent/WO2002046163A3/fr

Links

Classifications

    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D215/00—Heterocyclic compounds containing quinoline or hydrogenated quinoline ring systems
    • C07D215/02—Heterocyclic compounds containing quinoline or hydrogenated quinoline ring systems having no bond between the ring nitrogen atom and a non-ring member or having only hydrogen atoms or carbon atoms directly attached to the ring nitrogen atom
    • C07D215/16—Heterocyclic compounds containing quinoline or hydrogenated quinoline ring systems having no bond between the ring nitrogen atom and a non-ring member or having only hydrogen atoms or carbon atoms directly attached to the ring nitrogen atom with hetero atoms or with carbon atoms having three bonds to hetero atoms with at the most one bond to halogen, e.g. ester or nitrile radicals, directly attached to ring carbon atoms
    • C07D215/20—Oxygen atoms
    • C07D215/22—Oxygen atoms attached in position 2 or 4
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P25/00—Drugs for disorders of the nervous system
    • A61P25/08—Antiepileptics; Anticonvulsants

Landscapes

  • Chemical & Material Sciences (AREA)
  • Organic Chemistry (AREA)
  • Health & Medical Sciences (AREA)
  • Medicinal Chemistry (AREA)
  • Pain & Pain Management (AREA)
  • Neurology (AREA)
  • Neurosurgery (AREA)
  • Bioinformatics & Cheminformatics (AREA)
  • Chemical Kinetics & Catalysis (AREA)
  • General Chemical & Material Sciences (AREA)
  • Engineering & Computer Science (AREA)
  • Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
  • Biomedical Technology (AREA)
  • Pharmacology & Pharmacy (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • Animal Behavior & Ethology (AREA)
  • General Health & Medical Sciences (AREA)
  • Public Health (AREA)
  • Veterinary Medicine (AREA)
  • Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)

Abstract

L'invention concerne de nouveaux dérivés de quinoléine destinés au traitement prophylactique et thérapeutique de maladies dues au canal sodium, notamment l'épilepsie. La présente invention porte également sur des préparations pharmaceutiques comprenant ces dérivés de quinoléine et sur des méthodes de traitement de maladies dues au canal sodium, notamment l'épilepsie. Par rapport à des composés reflétant l'état actuel de la technique, lesdits dérivés de quinoléine allient une haute efficacité à une très faible toxicité.
PCT/DE2001/004452 2000-12-04 2001-11-27 Derives de quinoleine et leur utilisation WO2002046163A2 (fr)

Priority Applications (2)

Application Number Priority Date Filing Date Title
AU2002216939A AU2002216939A1 (en) 2000-12-04 2001-11-27 Quinoline derivatives and their use as anti-epileptics
DE10195304T DE10195304D2 (de) 2000-12-04 2001-11-27 Chinolin-Derivative und ihre Verwendung

Applications Claiming Priority (2)

Application Number Priority Date Filing Date Title
DE10060145.6 2000-12-04
DE10060145A DE10060145C1 (de) 2000-12-04 2000-12-04 Chinolin-Derivate, ihre Verwendung und diese enthaltende pharmazeutische Zusammensetzung

Publications (2)

Publication Number Publication Date
WO2002046163A2 WO2002046163A2 (fr) 2002-06-13
WO2002046163A3 true WO2002046163A3 (fr) 2003-02-13

Family

ID=7665688

Family Applications (1)

Application Number Title Priority Date Filing Date
PCT/DE2001/004452 WO2002046163A2 (fr) 2000-12-04 2001-11-27 Derives de quinoleine et leur utilisation

Country Status (3)

Country Link
AU (1) AU2002216939A1 (fr)
DE (2) DE10060145C1 (fr)
WO (1) WO2002046163A2 (fr)

Families Citing this family (3)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
EP1908752A4 (fr) * 2005-06-07 2009-09-02 Dainippon Sumitomo Pharma Co Nouveau dérivé de 2-quinolone
WO2008113006A1 (fr) * 2007-03-14 2008-09-18 Xenon Pharmaceuticals Inc. Procédés d'utilisation de composés à base de quinolinone dans le traitement des maladies ou des affections associées aux canaux sodiques
WO2023036995A1 (fr) * 2021-09-13 2023-03-16 Centre National De La Recherche Scientifique Alcynylcarbinols à cytotoxicité élevée

Citations (3)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
EP0326331A2 (fr) * 1988-01-29 1989-08-02 DowElanco Quinoléines et cinnolines substituées
WO1994024116A1 (fr) * 1993-04-09 1994-10-27 Syntex Pharmaceuticals Limited Derives heterocycliques utilises dans le traitement de l'ischemie et d'autres pathologies associees
WO1997014681A1 (fr) * 1995-10-16 1997-04-24 Fujisawa Pharmaceutical Co., Ltd. Composes heterocycliques tels que des h+-atpases

Patent Citations (3)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
EP0326331A2 (fr) * 1988-01-29 1989-08-02 DowElanco Quinoléines et cinnolines substituées
WO1994024116A1 (fr) * 1993-04-09 1994-10-27 Syntex Pharmaceuticals Limited Derives heterocycliques utilises dans le traitement de l'ischemie et d'autres pathologies associees
WO1997014681A1 (fr) * 1995-10-16 1997-04-24 Fujisawa Pharmaceutical Co., Ltd. Composes heterocycliques tels que des h+-atpases

Non-Patent Citations (7)

* Cited by examiner, † Cited by third party
Title
CHEMICAL ABSTRACTS, vol. 122, no. 2, 9 January 1995, Columbus, Ohio, US; abstract no. 10811s, BHAGAWAT, LALITA P. ET AL.: "Synthesis and solid state polymerization of novel diacetylenes" XP002203884 *
DATABASE CAPLUS [online] CHEMICAL ABSTRACTS SERVICE, COLUMBUS, OHIO, US; XP002203885, Database accession no. 122:10811 *
JOHANNES REISCH ET AL.: "Acetylenchemie. 18. Mitt.: Molekülvariationen am Rutaceenalkaloid Dictamnin via Pd/Cu katalysierte Alkin-Kupplung", JOURNAL OF HETEROCYCLIC CHEMISTRY., vol. 28, no. 1, - 1991, HETEROCORPORATION. PROVO., US, pages 167 - 171, XP002203883, ISSN: 0022-152X *
JOHANNES REISCH ET AL.: "Dictamnin und Derivate durch Pd/Cu-katalysierte Alkin-Kupplung", LIEBIGS ANNALEN DER CHEMIE., vol. 1, - 1988, VERLAG CHEMIE GMBH. WEINHEIM., DE, pages 69 - 73, XP002203882, ISSN: 0170-2041 *
POLYM. SCI., vol. 1, - 1994, pages 82 - 87 *
TAKAO SAKAMOTO ET AL.: "A facile synthesis of ethynyl-substituted six-membered N-heteroaromatic compounds", SYNTHESIS., vol. 4, - 1983, GEORG THIEME VERLAG. STUTTGART., DE, pages 312 - 314, XP002203881, ISSN: 0039-7881 *
YAMANAKA H ET AL: "STUDIES OF QUINOLINE AND ISOQUINOLINE DERIVATIVES. II. COUPLING REACTION OF HALOQUINOLINES AND HALOISQUINOLINES WITH MONOSUBSTITUTED ACETYLENES IN THE PRESENCE OF PALLADIUM COMPLEX", CHEMICAL AND PHARMACEUTICAL BULLETIN, PHARMACEUTICAL SOCIETY OF JAPAN. TOKYO, JP, vol. 27, no. 1, 1979, pages 270 - 273, XP000952500, ISSN: 0009-2363 *

Also Published As

Publication number Publication date
DE10060145C1 (de) 2002-06-13
WO2002046163A2 (fr) 2002-06-13
AU2002216939A1 (en) 2002-06-18
DE10195304D2 (de) 2003-10-23

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