WO2002046139A3 - Sels de 1,7- et de 1,9-diarylpolymethine - Google Patents

Sels de 1,7- et de 1,9-diarylpolymethine Download PDF

Info

Publication number
WO2002046139A3
WO2002046139A3 PCT/FR2001/003844 FR0103844W WO0246139A3 WO 2002046139 A3 WO2002046139 A3 WO 2002046139A3 FR 0103844 W FR0103844 W FR 0103844W WO 0246139 A3 WO0246139 A3 WO 0246139A3
Authority
WO
WIPO (PCT)
Prior art keywords
group
salts
diarylpentamethine
another
radical
Prior art date
Application number
PCT/FR2001/003844
Other languages
English (en)
Other versions
WO2002046139A2 (fr
Inventor
Yves Madaule
Corinne Payrastre
Albert Izquierdo
Original Assignee
Centre Nat Rech Scient
Univ Toulouse
Yves Madaule
Corinne Payrastre
Albert Izquierdo
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Priority claimed from FR0015928A external-priority patent/FR2817862B1/fr
Priority claimed from FR0109743A external-priority patent/FR2827597B1/fr
Application filed by Centre Nat Rech Scient, Univ Toulouse, Yves Madaule, Corinne Payrastre, Albert Izquierdo filed Critical Centre Nat Rech Scient
Priority to EP01999551A priority Critical patent/EP1339671A2/fr
Priority to US10/433,890 priority patent/US20040054178A1/en
Publication of WO2002046139A2 publication Critical patent/WO2002046139A2/fr
Publication of WO2002046139A3 publication Critical patent/WO2002046139A3/fr

Links

Classifications

    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D295/00—Heterocyclic compounds containing polymethylene-imine rings with at least five ring members, 3-azabicyclo [3.2.2] nonane, piperazine, morpholine or thiomorpholine rings, having only hydrogen atoms directly attached to the ring carbon atoms
    • C07D295/04—Heterocyclic compounds containing polymethylene-imine rings with at least five ring members, 3-azabicyclo [3.2.2] nonane, piperazine, morpholine or thiomorpholine rings, having only hydrogen atoms directly attached to the ring carbon atoms with substituted hydrocarbon radicals attached to ring nitrogen atoms
    • C07D295/08—Heterocyclic compounds containing polymethylene-imine rings with at least five ring members, 3-azabicyclo [3.2.2] nonane, piperazine, morpholine or thiomorpholine rings, having only hydrogen atoms directly attached to the ring carbon atoms with substituted hydrocarbon radicals attached to ring nitrogen atoms substituted by singly bound oxygen or sulfur atoms
    • C07D295/096—Heterocyclic compounds containing polymethylene-imine rings with at least five ring members, 3-azabicyclo [3.2.2] nonane, piperazine, morpholine or thiomorpholine rings, having only hydrogen atoms directly attached to the ring carbon atoms with substituted hydrocarbon radicals attached to ring nitrogen atoms substituted by singly bound oxygen or sulfur atoms with the ring nitrogen atoms and the oxygen or sulfur atoms separated by carbocyclic rings or by carbon chains interrupted by carbocyclic rings
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K49/00—Preparations for testing in vivo
    • A61K49/001—Preparation for luminescence or biological staining
    • A61K49/0013—Luminescence
    • A61K49/0017—Fluorescence in vivo
    • A61K49/0019—Fluorescence in vivo characterised by the fluorescent group, e.g. oligomeric, polymeric or dendritic molecules
    • A61K49/0021—Fluorescence in vivo characterised by the fluorescent group, e.g. oligomeric, polymeric or dendritic molecules the fluorescent group being a small organic molecule
    • A61K49/0032—Methine dyes, e.g. cyanine dyes
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07C—ACYCLIC OR CARBOCYCLIC COMPOUNDS
    • C07C211/00—Compounds containing amino groups bound to a carbon skeleton
    • C07C211/01—Compounds containing amino groups bound to a carbon skeleton having amino groups bound to acyclic carbon atoms
    • C07C211/26—Compounds containing amino groups bound to a carbon skeleton having amino groups bound to acyclic carbon atoms of an unsaturated carbon skeleton containing at least one six-membered aromatic ring
    • C07C211/28—Compounds containing amino groups bound to a carbon skeleton having amino groups bound to acyclic carbon atoms of an unsaturated carbon skeleton containing at least one six-membered aromatic ring having amino groups linked to the six-membered aromatic ring by unsaturated carbon chains
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07C—ACYCLIC OR CARBOCYCLIC COMPOUNDS
    • C07C211/00—Compounds containing amino groups bound to a carbon skeleton
    • C07C211/62—Quaternary ammonium compounds
    • C07C211/63—Quaternary ammonium compounds having quaternised nitrogen atoms bound to acyclic carbon atoms
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07C—ACYCLIC OR CARBOCYCLIC COMPOUNDS
    • C07C217/00—Compounds containing amino and etherified hydroxy groups bound to the same carbon skeleton
    • C07C217/02—Compounds containing amino and etherified hydroxy groups bound to the same carbon skeleton having etherified hydroxy groups and amino groups bound to acyclic carbon atoms of the same carbon skeleton
    • C07C217/48—Compounds containing amino and etherified hydroxy groups bound to the same carbon skeleton having etherified hydroxy groups and amino groups bound to acyclic carbon atoms of the same carbon skeleton the carbon skeleton being unsaturated and containing rings
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07C—ACYCLIC OR CARBOCYCLIC COMPOUNDS
    • C07C217/00—Compounds containing amino and etherified hydroxy groups bound to the same carbon skeleton
    • C07C217/54—Compounds containing amino and etherified hydroxy groups bound to the same carbon skeleton having etherified hydroxy groups bound to carbon atoms of at least one six-membered aromatic ring and amino groups bound to acyclic carbon atoms or to carbon atoms of rings other than six-membered aromatic rings of the same carbon skeleton
    • C07C217/64—Compounds containing amino and etherified hydroxy groups bound to the same carbon skeleton having etherified hydroxy groups bound to carbon atoms of at least one six-membered aromatic ring and amino groups bound to acyclic carbon atoms or to carbon atoms of rings other than six-membered aromatic rings of the same carbon skeleton with amino groups linked to the six-membered aromatic ring, or to the condensed ring system containing that ring, by carbon chains further substituted by singly-bound oxygen atoms
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07C—ACYCLIC OR CARBOCYCLIC COMPOUNDS
    • C07C251/00—Compounds containing nitrogen atoms doubly-bound to a carbon skeleton
    • C07C251/02—Compounds containing nitrogen atoms doubly-bound to a carbon skeleton containing imino groups
    • C07C251/04—Compounds containing nitrogen atoms doubly-bound to a carbon skeleton containing imino groups having carbon atoms of imino groups bound to hydrogen atoms or to acyclic carbon atoms
    • C07C251/10—Compounds containing nitrogen atoms doubly-bound to a carbon skeleton containing imino groups having carbon atoms of imino groups bound to hydrogen atoms or to acyclic carbon atoms to carbon atoms of an unsaturated carbon skeleton
    • C07C251/16—Compounds containing nitrogen atoms doubly-bound to a carbon skeleton containing imino groups having carbon atoms of imino groups bound to hydrogen atoms or to acyclic carbon atoms to carbon atoms of an unsaturated carbon skeleton containing six-membered aromatic rings
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07C—ACYCLIC OR CARBOCYCLIC COMPOUNDS
    • C07C251/00—Compounds containing nitrogen atoms doubly-bound to a carbon skeleton
    • C07C251/02—Compounds containing nitrogen atoms doubly-bound to a carbon skeleton containing imino groups
    • C07C251/24—Compounds containing nitrogen atoms doubly-bound to a carbon skeleton containing imino groups having carbon atoms of imino groups bound to carbon atoms of six-membered aromatic rings
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07C—ACYCLIC OR CARBOCYCLIC COMPOUNDS
    • C07C251/00—Compounds containing nitrogen atoms doubly-bound to a carbon skeleton
    • C07C251/72—Hydrazones
    • C07C251/86—Hydrazones having doubly-bound carbon atoms of hydrazone groups bound to carbon atoms of six-membered aromatic rings
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07C—ACYCLIC OR CARBOCYCLIC COMPOUNDS
    • C07C251/00—Compounds containing nitrogen atoms doubly-bound to a carbon skeleton
    • C07C251/72—Hydrazones
    • C07C251/88—Hydrazones having also the other nitrogen atom doubly-bound to a carbon atom, e.g. azines
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07C—ACYCLIC OR CARBOCYCLIC COMPOUNDS
    • C07C43/00—Ethers; Compounds having groups, groups or groups
    • C07C43/02—Ethers
    • C07C43/03—Ethers having all ether-oxygen atoms bound to acyclic carbon atoms
    • C07C43/14—Unsaturated ethers
    • C07C43/164—Unsaturated ethers containing six-membered aromatic rings
    • C07C43/166—Unsaturated ethers containing six-membered aromatic rings having unsaturation outside the aromatic rings
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07C—ACYCLIC OR CARBOCYCLIC COMPOUNDS
    • C07C43/00—Ethers; Compounds having groups, groups or groups
    • C07C43/02—Ethers
    • C07C43/03—Ethers having all ether-oxygen atoms bound to acyclic carbon atoms
    • C07C43/14—Unsaturated ethers
    • C07C43/17—Unsaturated ethers containing halogen
    • C07C43/174—Unsaturated ethers containing halogen containing six-membered aromatic rings
    • C07C43/176—Unsaturated ethers containing halogen containing six-membered aromatic rings having unsaturation outside the aromatic rings
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07C—ACYCLIC OR CARBOCYCLIC COMPOUNDS
    • C07C43/00—Ethers; Compounds having groups, groups or groups
    • C07C43/02—Ethers
    • C07C43/20—Ethers having an ether-oxygen atom bound to a carbon atom of a six-membered aromatic ring
    • C07C43/215—Ethers having an ether-oxygen atom bound to a carbon atom of a six-membered aromatic ring having unsaturation outside the six-membered aromatic rings
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D295/00—Heterocyclic compounds containing polymethylene-imine rings with at least five ring members, 3-azabicyclo [3.2.2] nonane, piperazine, morpholine or thiomorpholine rings, having only hydrogen atoms directly attached to the ring carbon atoms
    • C07D295/04—Heterocyclic compounds containing polymethylene-imine rings with at least five ring members, 3-azabicyclo [3.2.2] nonane, piperazine, morpholine or thiomorpholine rings, having only hydrogen atoms directly attached to the ring carbon atoms with substituted hydrocarbon radicals attached to ring nitrogen atoms
    • C07D295/12—Heterocyclic compounds containing polymethylene-imine rings with at least five ring members, 3-azabicyclo [3.2.2] nonane, piperazine, morpholine or thiomorpholine rings, having only hydrogen atoms directly attached to the ring carbon atoms with substituted hydrocarbon radicals attached to ring nitrogen atoms substituted by singly or doubly bound nitrogen atoms
    • C07D295/125—Heterocyclic compounds containing polymethylene-imine rings with at least five ring members, 3-azabicyclo [3.2.2] nonane, piperazine, morpholine or thiomorpholine rings, having only hydrogen atoms directly attached to the ring carbon atoms with substituted hydrocarbon radicals attached to ring nitrogen atoms substituted by singly or doubly bound nitrogen atoms with the ring nitrogen atoms and the substituent nitrogen atoms attached to the same carbon chain, which is not interrupted by carbocyclic rings
    • C07D295/13—Heterocyclic compounds containing polymethylene-imine rings with at least five ring members, 3-azabicyclo [3.2.2] nonane, piperazine, morpholine or thiomorpholine rings, having only hydrogen atoms directly attached to the ring carbon atoms with substituted hydrocarbon radicals attached to ring nitrogen atoms substituted by singly or doubly bound nitrogen atoms with the ring nitrogen atoms and the substituent nitrogen atoms attached to the same carbon chain, which is not interrupted by carbocyclic rings to an acyclic saturated chain
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D295/00—Heterocyclic compounds containing polymethylene-imine rings with at least five ring members, 3-azabicyclo [3.2.2] nonane, piperazine, morpholine or thiomorpholine rings, having only hydrogen atoms directly attached to the ring carbon atoms
    • C07D295/04—Heterocyclic compounds containing polymethylene-imine rings with at least five ring members, 3-azabicyclo [3.2.2] nonane, piperazine, morpholine or thiomorpholine rings, having only hydrogen atoms directly attached to the ring carbon atoms with substituted hydrocarbon radicals attached to ring nitrogen atoms
    • C07D295/12—Heterocyclic compounds containing polymethylene-imine rings with at least five ring members, 3-azabicyclo [3.2.2] nonane, piperazine, morpholine or thiomorpholine rings, having only hydrogen atoms directly attached to the ring carbon atoms with substituted hydrocarbon radicals attached to ring nitrogen atoms substituted by singly or doubly bound nitrogen atoms
    • C07D295/135—Heterocyclic compounds containing polymethylene-imine rings with at least five ring members, 3-azabicyclo [3.2.2] nonane, piperazine, morpholine or thiomorpholine rings, having only hydrogen atoms directly attached to the ring carbon atoms with substituted hydrocarbon radicals attached to ring nitrogen atoms substituted by singly or doubly bound nitrogen atoms with the ring nitrogen atoms and the substituent nitrogen atoms separated by carbocyclic rings or by carbon chains interrupted by carbocyclic rings
    • C—CHEMISTRY; METALLURGY
    • C09—DYES; PAINTS; POLISHES; NATURAL RESINS; ADHESIVES; COMPOSITIONS NOT OTHERWISE PROVIDED FOR; APPLICATIONS OF MATERIALS NOT OTHERWISE PROVIDED FOR
    • C09B—ORGANIC DYES OR CLOSELY-RELATED COMPOUNDS FOR PRODUCING DYES, e.g. PIGMENTS; MORDANTS; LAKES
    • C09B23/00—Methine or polymethine dyes, e.g. cyanine dyes
    • C09B23/0066—Methine or polymethine dyes, e.g. cyanine dyes the polymethine chain being part of a carbocyclic ring,(e.g. benzene, naphtalene, cyclohexene, cyclobutenene-quadratic acid)
    • C—CHEMISTRY; METALLURGY
    • C09—DYES; PAINTS; POLISHES; NATURAL RESINS; ADHESIVES; COMPOSITIONS NOT OTHERWISE PROVIDED FOR; APPLICATIONS OF MATERIALS NOT OTHERWISE PROVIDED FOR
    • C09B—ORGANIC DYES OR CLOSELY-RELATED COMPOUNDS FOR PRODUCING DYES, e.g. PIGMENTS; MORDANTS; LAKES
    • C09B23/00—Methine or polymethine dyes, e.g. cyanine dyes
    • C09B23/02—Methine or polymethine dyes, e.g. cyanine dyes the polymethine chain containing an odd number of >CH- or >C[alkyl]- groups
    • C09B23/08—Methine or polymethine dyes, e.g. cyanine dyes the polymethine chain containing an odd number of >CH- or >C[alkyl]- groups more than three >CH- groups, e.g. polycarbocyanines
    • C09B23/086—Methine or polymethine dyes, e.g. cyanine dyes the polymethine chain containing an odd number of >CH- or >C[alkyl]- groups more than three >CH- groups, e.g. polycarbocyanines more than five >CH- groups
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07C—ACYCLIC OR CARBOCYCLIC COMPOUNDS
    • C07C2601/00—Systems containing only non-condensed rings
    • C07C2601/12—Systems containing only non-condensed rings with a six-membered ring
    • C07C2601/16—Systems containing only non-condensed rings with a six-membered ring the ring being unsaturated

Landscapes

  • Chemical & Material Sciences (AREA)
  • Organic Chemistry (AREA)
  • Health & Medical Sciences (AREA)
  • Engineering & Computer Science (AREA)
  • Biomedical Technology (AREA)
  • Epidemiology (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • Animal Behavior & Ethology (AREA)
  • General Health & Medical Sciences (AREA)
  • Public Health (AREA)
  • Veterinary Medicine (AREA)
  • Organic Low-Molecular-Weight Compounds And Preparation Thereof (AREA)

Abstract

L'invention concerne des sels de 1,7-diarylpentaméthine et de 1,9-diarylheptaméthine, notamment des sels de carboxonium heptacarbonés ou nonacarbonés, et des streptocyanines. Les composés répondent à la formule [G-D-G']+ Q- dans laquelle Q est un anion d'un acide fort, et- G et G' représentent indépendamment l'un de l'autre un groupe OEt, amino, hydrazono, hydrazino, phosphaimino, amidino ou guanidino; ou un radical multivalent éventuellement relié à au moins l'une de ses autres extrémités à un autre groupe D; - D représente un groupement cationique 1,7-diarylpentaméthine ou 1,9-diarylheptaméthine dans lequel les groupes aryles portent des substituants représentant indépendamment les uns des autres un hydrogène, un halogène, un radical alkyle ou un radical alkyloxy ayant de 1 à 15 atomes de carbone ou un groupe acétamido CH¿3?C(O)HN-.
PCT/FR2001/003844 2000-12-07 2001-12-05 Sels de 1,7- et de 1,9-diarylpolymethine WO2002046139A2 (fr)

Priority Applications (2)

Application Number Priority Date Filing Date Title
EP01999551A EP1339671A2 (fr) 2000-12-07 2001-12-05 Sels de 1,7- et de 1,9-diarylpolymethine
US10/433,890 US20040054178A1 (en) 2000-12-07 2001-12-05 1,7, and 1,9-diarylpolymethine salts

Applications Claiming Priority (4)

Application Number Priority Date Filing Date Title
FR0015928A FR2817862B1 (fr) 2000-12-07 2000-12-07 Nouveaux sels de 1,7-diarylpentamethine
FR00/15928 2000-12-07
FR01/09743 2001-07-20
FR0109743A FR2827597B1 (fr) 2001-07-20 2001-07-20 Sels de 1,9-diarylheptamethine

Publications (2)

Publication Number Publication Date
WO2002046139A2 WO2002046139A2 (fr) 2002-06-13
WO2002046139A3 true WO2002046139A3 (fr) 2002-08-01

Family

ID=26212766

Family Applications (1)

Application Number Title Priority Date Filing Date
PCT/FR2001/003844 WO2002046139A2 (fr) 2000-12-07 2001-12-05 Sels de 1,7- et de 1,9-diarylpolymethine

Country Status (3)

Country Link
US (1) US20040054178A1 (fr)
EP (1) EP1339671A2 (fr)
WO (1) WO2002046139A2 (fr)

Families Citing this family (1)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
WO2013012886A1 (fr) * 2011-07-18 2013-01-24 Georgia State University Research Foundation, Inc. Carbocyanines pour la stabilisation de l'adn g-quadruplexe et inhibition de la télomérase

Citations (3)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
GB1229319A (fr) * 1967-08-11 1971-04-21
EP0119831A2 (fr) * 1983-03-15 1984-09-26 Minnesota Mining And Manufacturing Company Système coloré blanchissable par la chaleur
WO2000053678A1 (fr) * 1999-03-11 2000-09-14 Dyomics Colorants marqueurs proches de l'infrarouge (nir) compatibles aux lasers

Family Cites Families (2)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
US5661139A (en) * 1995-01-13 1997-08-26 Alteon Inc. Bis-(2-aryl) hydrazones
US6815133B2 (en) * 2002-04-12 2004-11-09 Samsung Electronics Co., Ltd. Sulfonyldiphenylene based charge transport compositions

Patent Citations (3)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
GB1229319A (fr) * 1967-08-11 1971-04-21
EP0119831A2 (fr) * 1983-03-15 1984-09-26 Minnesota Mining And Manufacturing Company Système coloré blanchissable par la chaleur
WO2000053678A1 (fr) * 1999-03-11 2000-09-14 Dyomics Colorants marqueurs proches de l'infrarouge (nir) compatibles aux lasers

Non-Patent Citations (3)

* Cited by examiner, † Cited by third party
Title
CHEMICAL ABSTRACTS, vol. 72, no. 25, 22 June 1970, Columbus, Ohio, US; abstract no. 132188, MAKIN, S. M. ET AL: "Unsaturated ethers. XXXI. Condensation of.beta.-ethoxyacrolein acetal with vinylalkyl ethers and 1-alkoxydienes. New method for synthesizing cyanine compounds" XP002172472 *
PAYRASTRE C ET AL: "A synthetic pathway to macrocyclic and optically active pentamethinium salts", TETRAHEDRON LETTERS, ELSEVIER SCIENCE PUBLISHERS, AMSTERDAM, NL, vol. 35, no. 19, 1994, pages 3059 - 3562, XP002172471, ISSN: 0040-4039 *
ZH. ORG. KHIM. (1970), 6(3), 455-9, 1970 *

Also Published As

Publication number Publication date
WO2002046139A2 (fr) 2002-06-13
US20040054178A1 (en) 2004-03-18
EP1339671A2 (fr) 2003-09-03

Similar Documents

Publication Publication Date Title
DE60124504D1 (de) Stabile emulsionszubereitungen
HUP0204405A2 (en) Water soluble prodrugs of azole compounds
IS6257A (is) Frumuviðloðunartálmar
WO2002000622A3 (fr) Nouveaux derives d'aminoalcool
MY116542A (en) New inhibitors of platelet aggregation.
WO2001017972A3 (fr) Nouveaux herbicides
MXPA04005802A (es) Derivados sustituidos de fenilo.
EP0902007A4 (fr) Derives de chalcone et medicaments les contenant
CA2277947A1 (fr) Derives de pyrrolidine ayant une activite inhibant la phospholipase a2
WO2001072263A3 (fr) Utilisation d'ectoine ou de derives d'ectoine pour proteger la proteine du stress de la peau
MXPA02004440A (es) Derivados de pirrol como inhibidores de la fosfodiesterasa vii.
TW200612931A (en) Substituted biphenyl derivatives
EP1110961A4 (fr) Composes heterocycliques oxygenes
DE69907419D1 (en) Antitumorwirkstoffe
WO2002020017A3 (fr) Utilisation de l'ectoine ou de derives de l'ectoine pour la stabilisation du p53
AP9701010A0 (en) Piperidineacetic acid derivatives useful as fibrinogen.
WO2002046139A3 (fr) Sels de 1,7- et de 1,9-diarylpolymethine
WO1997031016A3 (fr) Nouveaux inhibiteurs des processus lies a la presence de sh2
EP0882721A4 (fr) Acides sialiques 2,7-dideoxy-7-fluoro- 2, 3-didehydro a quadruple substitution
AU9025601A (en) Cephem compounds and esbl-detecting reagents containing the same
WO2003031404A3 (fr) Techniques de production d'isoxazoles et de 2-isoxazolines substituees
TW325463B (en) 4-Aminobenzoylguanidine-derivatives
AU2002356319A1 (en) Dna minor groove binding compounds
NO943961L (no) Sykliske aminderivater
IE832830L (en) Benzofuran derivatives.

Legal Events

Date Code Title Description
AK Designated states

Kind code of ref document: A2

Designated state(s): JP US

AL Designated countries for regional patents

Kind code of ref document: A2

Designated state(s): AT BE CH CY DE DK ES FI FR GB GR IE IT LU MC NL PT SE TR

AK Designated states

Kind code of ref document: A3

Designated state(s): JP US

AL Designated countries for regional patents

Kind code of ref document: A3

Designated state(s): AT BE CH CY DE DK ES FI FR GB GR IE IT LU MC NL PT SE TR

121 Ep: the epo has been informed by wipo that ep was designated in this application
WWE Wipo information: entry into national phase

Ref document number: 2001999551

Country of ref document: EP

WWE Wipo information: entry into national phase

Ref document number: 10433890

Country of ref document: US

WWP Wipo information: published in national office

Ref document number: 2001999551

Country of ref document: EP

NENP Non-entry into the national phase

Ref country code: JP

WWW Wipo information: withdrawn in national office

Country of ref document: JP

WWW Wipo information: withdrawn in national office

Ref document number: 2001999551

Country of ref document: EP