WO2002044351A2 - Regulation de la coa ligase humaine d'acides gras - Google Patents

Regulation de la coa ligase humaine d'acides gras Download PDF

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Publication number
WO2002044351A2
WO2002044351A2 PCT/EP2001/013795 EP0113795W WO0244351A2 WO 2002044351 A2 WO2002044351 A2 WO 2002044351A2 EP 0113795 W EP0113795 W EP 0113795W WO 0244351 A2 WO0244351 A2 WO 0244351A2
Authority
WO
WIPO (PCT)
Prior art keywords
fatty acid
coa ligase
polypeptide
acid coa
polynucleotide
Prior art date
Application number
PCT/EP2001/013795
Other languages
English (en)
Other versions
WO2002044351A3 (fr
Inventor
Alex Smolyar
Original Assignee
Bayer Aktiengesellschaft
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Application filed by Bayer Aktiengesellschaft filed Critical Bayer Aktiengesellschaft
Priority to AU2002227949A priority Critical patent/AU2002227949A1/en
Publication of WO2002044351A2 publication Critical patent/WO2002044351A2/fr
Publication of WO2002044351A3 publication Critical patent/WO2002044351A3/fr

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Classifications

    • C—CHEMISTRY; METALLURGY
    • C12—BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
    • C12N—MICROORGANISMS OR ENZYMES; COMPOSITIONS THEREOF; PROPAGATING, PRESERVING, OR MAINTAINING MICROORGANISMS; MUTATION OR GENETIC ENGINEERING; CULTURE MEDIA
    • C12N9/00—Enzymes; Proenzymes; Compositions thereof; Processes for preparing, activating, inhibiting, separating or purifying enzymes
    • C12N9/93—Ligases (6)
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K38/00—Medicinal preparations containing peptides

Abstract

L'invention concerne des réactifs qui régulent la CoA ligase humaine d'acides gras et des réactifs qui se lient à des produits géniques de la CoA ligase humaine d'acides gras, ces réactifs pouvant jouer un rôle dans la prévention, l'amélioration ou la correction de maladies ou de dysfonctionnements tels que, de façon non exhaustive, des troubles du SNC, des troubles cardiovasculaires et le cancer.
PCT/EP2001/013795 2000-12-01 2001-11-27 Regulation de la coa ligase humaine d'acides gras WO2002044351A2 (fr)

Priority Applications (1)

Application Number Priority Date Filing Date Title
AU2002227949A AU2002227949A1 (en) 2000-12-01 2001-11-27 Regulation of human fatty acid coa ligase

Applications Claiming Priority (2)

Application Number Priority Date Filing Date Title
US25012300P 2000-12-01 2000-12-01
US60/250,123 2000-12-01

Publications (2)

Publication Number Publication Date
WO2002044351A2 true WO2002044351A2 (fr) 2002-06-06
WO2002044351A3 WO2002044351A3 (fr) 2002-11-21

Family

ID=22946378

Family Applications (1)

Application Number Title Priority Date Filing Date
PCT/EP2001/013795 WO2002044351A2 (fr) 2000-12-01 2001-11-27 Regulation de la coa ligase humaine d'acides gras

Country Status (2)

Country Link
AU (1) AU2002227949A1 (fr)
WO (1) WO2002044351A2 (fr)

Cited By (1)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
EP1456400A2 (fr) * 2001-12-19 2004-09-15 Exelixis, Inc. Modulation de la signalisation des recepteurs de l'insuline par ciblage de genes de facl (acyl-coa synthetase))

Non-Patent Citations (8)

* Cited by examiner, † Cited by third party
Title
DATABASE [Online] EBI; 27 November 1998 (1998-11-27) "Mus musculus SA protein mRNA" retrieved from EMBL Database accession no. AF068246 XP002213137 *
DATABASE [Online] EBI; 4 June 1999 (1999-06-04) "Bos taurus mitochondrial mRNA for xenobiotic/medium chain fatty acid:CoA ligase from XL-III" retrieved from EMBL Database accession no. AJ132751 XP002213138 *
FUJINO TAKAHIRO ET AL: "Molecular identification and characterization of two medium-chain acyl-CoA synthetases, MACS1 and the Sa gene product." JOURNAL OF BIOLOGICAL CHEMISTRY, vol. 276, no. 38, 21 September 2001 (2001-09-21), pages 35961-35966, XP001094129 ISSN: 0021-9258 *
IWAI NAOHARU ET AL: "Association between SAH, an acyl-CoA synthetase gene, and hypertriglyceridemia, obesity, and hypertension." CIRCULATION, vol. 105, no. 1, pages 41-47, XP001105333 January 1-8, 2002 ISSN: 0009-7322 *
IWAI NAOHARU ET AL: "Human SA gene locus as a candidate locus for essential hypertension." HYPERTENSION (DALLAS), vol. 23, no. 3, March 1994 (1994-03), pages 375-380, XP001097389 ISSN: 0194-911X -& DATABASE [Online] EBI; 15 April 1994 (1994-04-15) "Human SA mRNA for SA gene product, acetyl-CoA synthetase homologue" retrieved from EMBL Database accession no. D16350 XP002213135 *
KNIGHTS K M ET AL: "Xenobiotic-CoA ligases: Kinetic and molecular characterization." CURRENT DRUG METABOLISM, vol. 1, no. 1, July 2000 (2000-07), pages 49-66, XP001105301 July, 2000 ISSN: 1389-2002 *
LOFTUS BRENDAN J ET AL: "Genome duplications and other features in 12 Mb of DNA sequence from human chromosome 16p and 16q." GENOMICS, vol. 60, no. 3, 15 September 1999 (1999-09-15), pages 295-308, XP002177511 ISSN: 0888-7543 -& DATABASE [Online] EBI; 1 August 1998 (1998-08-01) "SA gene" retrieved from EMBL Database accession no. O60363 XP002213134 *
NABIKA TORU ET AL: "Evaluation of the SA Locus in Human Hypertension." HYPERTENSION (DALLAS), vol. 25, no. 1, 1995, pages 6-13, XP001104818 ISSN: 0194-911X -& DATABASE [Online] EBI; 2 February 1995 (1995-02-02) "H. sapiens SA mRNA" retrieved from EMBL Database accession no. X80062 XP002213136 *

Cited By (2)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
EP1456400A2 (fr) * 2001-12-19 2004-09-15 Exelixis, Inc. Modulation de la signalisation des recepteurs de l'insuline par ciblage de genes de facl (acyl-coa synthetase))
EP1456400A4 (fr) * 2001-12-19 2005-09-14 Exelixis Inc Modulation de la signalisation des recepteurs de l'insuline par ciblage de genes de facl (acyl-coa synthetase))

Also Published As

Publication number Publication date
AU2002227949A1 (en) 2002-06-11
WO2002044351A3 (fr) 2002-11-21

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