WO2002044147A1 - Process for preparing distamycin derivatives - Google Patents
Process for preparing distamycin derivatives Download PDFInfo
- Publication number
- WO2002044147A1 WO2002044147A1 PCT/EP2001/013050 EP0113050W WO0244147A1 WO 2002044147 A1 WO2002044147 A1 WO 2002044147A1 EP 0113050 W EP0113050 W EP 0113050W WO 0244147 A1 WO0244147 A1 WO 0244147A1
- Authority
- WO
- WIPO (PCT)
- Prior art keywords
- formula
- compound
- process according
- derivative
- amino
- Prior art date
Links
- 0 C[n]1c(C(NCCNC(N)=N)=O)cc(NC(C(*)=C)=O)c1 Chemical compound C[n]1c(C(NCCNC(N)=N)=O)cc(NC(C(*)=C)=O)c1 0.000 description 2
Classifications
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D403/00—Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, not provided for by group C07D401/00
- C07D403/02—Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, not provided for by group C07D401/00 containing two hetero rings
- C07D403/12—Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, not provided for by group C07D401/00 containing two hetero rings linked by a chain containing hetero atoms as chain links
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D207/00—Heterocyclic compounds containing five-membered rings not condensed with other rings, with one nitrogen atom as the only ring hetero atom
- C07D207/02—Heterocyclic compounds containing five-membered rings not condensed with other rings, with one nitrogen atom as the only ring hetero atom with only hydrogen or carbon atoms directly attached to the ring nitrogen atom
- C07D207/30—Heterocyclic compounds containing five-membered rings not condensed with other rings, with one nitrogen atom as the only ring hetero atom with only hydrogen or carbon atoms directly attached to the ring nitrogen atom having two double bonds between ring members or between ring members and non-ring members
- C07D207/34—Heterocyclic compounds containing five-membered rings not condensed with other rings, with one nitrogen atom as the only ring hetero atom with only hydrogen or carbon atoms directly attached to the ring nitrogen atom having two double bonds between ring members or between ring members and non-ring members with hetero atoms or with carbon atoms having three bonds to hetero atoms with at the most one bond to halogen, e.g. ester or nitrile radicals, directly attached to ring carbon atoms
- C07D207/42—Nitro radicals
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P35/00—Antineoplastic agents
Definitions
- the present invention relates to a process for preparing distamycin derivatives and, more in particular, it relates to a process for preparing acryloyl-distamycin-guanidino derivatives, known to possess a remarkable antitumor activity.
- the international patent application WO 98/04524 in the name of the Applicant itself discloses distamycin derivatives, having valuable biological properties as antitumor agents, wherein the distamycin formyl group is replaced by an acryloyl moiety and the amidino group is replaced by several nitrogen-containing ending groups, among which is guanidino.
- the said acryloyl-distamycin-guanidines can be advantageously prepared through a chemical process which allows to obtain the desired products in high yields and purity and in a limited number of steps.
- R is a bromine or chlorine atom; or _ pharmaceutically acceptable salt thereof; which process comprises: a) reacting, under basic conditions, 2-amino- ethylguanidine with a compound of formula
- R is a bromine or chlorine atom; so as to obtain the compound of formula (I) and, optionally, converting it into a pharmaceutically acceptable salt thereof .
- the process object of the present invention allows to obtain the compounds of formula (I) under mild operative conditions, in high yields and purity.
- the process of the invention is directed to the preparation of the compound of formula (I) wherein R is a bromine atom, that is the compound formerly indicated as PNU 166196.
- R is a bromine atom
- the possibility for the R group of being bromine or chlorine will depend upon the compound of formula (V) being used in step c) .
- the reaction of step a) is carried out between 2-amino- ethylguanidine, optionally in the form of a pharmaceutically acceptable salt, preferably as 2-amino- ethylguanidine dihydrochloride, and a slight excess, for instance from 1 to 2 equivalents, of the compound of formula (II) .
- the X group represents hydroxy or a suitable leaving group such as, for instance, bromine, chlorine, 2 , 4 , 5-trichlorophenoxy, 2,4- dinitrophenoxy, succinimido-N-oxy or imidazolyl .
- the X group is a bromine or chlorine atom.
- the reaction is performed under basic conditions with from 1 to 4 equivalents of an organic or inorganic base such as, for instance, sodium or potassium hydroxide, carbonate or bicarbonate, or with an organic amine such as triethylamine, ethyldiisopropylamine, piperidine and the like.
- an organic or inorganic base such as, for instance, sodium or potassium hydroxide, carbonate or bicarbonate, or with an organic amine such as triethylamine, ethyldiisopropylamine, piperidine and the like.
- Sodium carbonate or bicarbonate are preferably used.
- the reaction occurs in the presence of a suitable solvent such as, for instance, dioxane, tetrahydrofuran, dimethylsulfoxide, dimethylformamide, water and admixtures thereof.
- step a) is preferably carried out in the presence of dioxane, tetrahydrofuran, water or admixtures thereof.
- the reaction temperature may vary from about 0°C to about 50°C and for a time varying from about 1 to about 24 hours.
- the intermediate nitro-compound of formula (III) may be isolated, either as such or in the form of a pharmaceutically acceptable salt, for instance as hydrochloride salt, or may be further processed, without being isolated, under reductive conditions as per step b) of the process.
- the reduction of the compound of formula (III) , as per step b) of the process, is carried out according to well-known methods for reducing nitro-derivatives to amino- derivatives .
- Typical reductive conditions include the use of conventional reducing agents such as, for instance, sodium hypophosphite, hydrazine, sulfides, polysulfides and the like, or catalytic hydrogenation.
- the compound of formula (III) is hydrogenated under heterogeneous catalytic conditions in the presence of platinum or palladium catalysts, for instance palladium on charcoal (Pd/C) .
- platinum or palladium catalysts for instance palladium on charcoal (Pd/C) .
- a suitable solvent for instance dioxane, tetrahydrofuran, dimethylsulfoxide, dimethylformamide, water and admixtures thereof.
- the intermediate nitro-compound of formula (IV) may be isolated, either as such or in the form of a pharmaceutically acceptable salt, for instance as hydrochloride salt, or may be further processed, without being isolated, in step c) of the process.
- step c) the reduction of the compound of formula (IV) is carried out according to well-known methods for reducing nitro-derivatives to amino-derivatives, as above reported.
- the reaction is carried out under catalytic hydrogenation conditions in the presence of palladium or platinum catalysts, as set forth above.
- the resultant amino-derivative is then reacted, without being isolated, with a compound of formula (V) according to conventional methods for the acylation of amino derivatives .
- the reaction is performed in the presence of a solvent such as, for instance, dioxane, tetrahydrofuran, water, dimethylsulfoxide, dimethylformamide or admixtures thereof, in the presence of a conventional condensing agent and of an inorganic or organic base such as, for instance, sodium or potassium hydroxide, carbonate or bicarbonate, or with an organic amine such as, for instance, triethylamine, ethyldiisopropylamine, piperidine and the like.
- a solvent such as, for instance, dioxane, tetrahydrofuran, water, dimethylsulfoxide, dimethylformamide or admixtures thereof
- a conventional condensing agent and of an inorganic or organic base such as, for instance, sodium or potassium hydroxide, carbonate or bicarbonate, or with an organic amine such as, for instance, triethylamine, ethyldiisopropylamine, piperidine and
- Preferred condensing agents are, for instance, N,N'- dicyclohexylcarbodii ide (DCC) or (N'-(3- dimethylaminopropyl) -N-ethylcarbodiimide) hydrochloride (EDC) •
- the reaction temperature may vary from about -10°C to about 50°C and for a time varying from about 1 to about 24 hours.
- the preparation of the compound of formula (I) wherein R is a bromine atom PNU 166196
- step c) is carried out with a compound of formula (V) wherein R is a bromine atom.
- the whole process can be carried out in the presence of a unique reaction solvent, for instance dioxane, tetrahydrofuran, water or admixtures thereof.
- a unique reaction solvent for instance dioxane, tetrahydrofuran, water or admixtures thereof.
- all the reaction steps from a) to c) can be carried out in one pot without the need of isolating any intermediate .
- each of the reactions defined in steps from a) to c) are performed as follows, by first reacting a compound of formula (II) with 2-amino-ethylguanidine dihydrochloride so as to obtain a compound of formula
- the conversion of the distamycin derivative of formula (I) into a pharmaceutically acceptable salt or, on the other side, the conversion of a salt thereof into the free compound may be carried out according to well known techniques .
- Examples of pharmaceutically acceptable salts of the compounds of formula (I) are the acid addition salts with pharmaceutically acceptable acids such as, for instance, hydrochloric, hydrobromic, sulfuric, nitric, acetic, trifluoroacetic, propionic, succinic, malonic, citric, tartaric, methanesulfonic, p-toluensulfonic acid and the like .
- pharmaceutically acceptable acids such as, for instance, hydrochloric, hydrobromic, sulfuric, nitric, acetic, trifluoroacetic, propionic, succinic, malonic, citric, tartaric, methanesulfonic, p-toluensulfonic acid and the like .
- the compound 2-ethyl-aminoguanidine for instance as dihydrochloride salt, is a known compound which can be prepared according to known methods; see, for instance, Syntethic Communications 20(16), 2559-2564 (1990).
- the compound of formula (II) is known or can be easily prepared according to known methods; for a reference to the preparation of the compound of formula (II) wherein X is hydroxy see, as an example, US 4,942,227.
- the compound of formula (V) in its turn, is a commercially available compound.
- the process of the invention allows to perform a set of subsequent reactions by using a limited number of reactive derivatives.
- the compound of formula (II) in fact, is very conveniently used in two different reactions of the process: first, as a starting material with 2-aminoethylguanidine dihydrochloride, in step a) , and subsequently as a reactive intermediate in step b) .
- the intermediate compound of formula (IV) is novel and, hence, represents a further object of this invention.
- the compounds of formula (I) are useful in therapy as antitumor agents .
- a proper amount of 2 - amino-ethylguanidine dihydrochloride is reacted, in a solvent system preferably comprising dioxane, tetrahydrofuran, water or admixtures thereof and in the presence of a base, for instance an inorganic base such as sodium carbonate or bicarbonate, with a proper amount, preferably a slight excess, of the compound of formula (II) .
- a base for instance an inorganic base such as sodium carbonate or bicarbonate
- reaction is carried out under mild operative conditions and the resultant nitro-derivative of formula (III) is first hydrogenated under heterogeneous catalytic conditions, in the presence of palladium on charcoal, and subsequently reacted with a proper amount, preferably a slight excess, of the compound of formula (II) , under basic conditions .
- the mixture was hydrogenated into a 2 1 hydrogenation reactor at room temperature for 4 hours.
- the catalyst was filtered off, the solvent concentrated under vacuum and the resultant suspension was filtered.
- reaction mixture was stirred for 3 hours at 100 °C, cooled and subsequently concentrated under vacuum.
- reaction mixture was stirred for 1 hour at room temperature, then water (100 ml) was added. A solution 2N of hydrochloric acid was then added up to pH
- Example 7 Preparation of N-methyl-4- [ (N' -methyl-4-nitro-pyrrolyl-2- yl) carbonylamino] pyrrole-2 -carboxylic acid chloride ethylguanidine hydrochloride .
- the suspension was stirred for 2 hours at room temperature.
- the mixture was then hydrogenated into a 2 1 hydrogenation reactor at room temperature for 3 hours and then filtered.
- the mixture was then concentrated under vacuum until a suspension was obtained and the resulting suspension was cooled at room temperature and filtered.
- the resultant solution was treated with acetone (1300 ml) , cooled overnight at 4°C and filtered.
Landscapes
- Organic Chemistry (AREA)
- Chemical & Material Sciences (AREA)
- Health & Medical Sciences (AREA)
- General Health & Medical Sciences (AREA)
- Veterinary Medicine (AREA)
- Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
- General Chemical & Material Sciences (AREA)
- Pharmacology & Pharmacy (AREA)
- Life Sciences & Earth Sciences (AREA)
- Animal Behavior & Ethology (AREA)
- Chemical Kinetics & Catalysis (AREA)
- Public Health (AREA)
- Medicinal Chemistry (AREA)
- Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
- Organic Low-Molecular-Weight Compounds And Preparation Thereof (AREA)
- Saccharide Compounds (AREA)
- Low-Molecular Organic Synthesis Reactions Using Catalysts (AREA)
- Pyrrole Compounds (AREA)
- Preparation Of Compounds By Using Micro-Organisms (AREA)
- Nitrogen And Oxygen Or Sulfur-Condensed Heterocyclic Ring Systems (AREA)
- Cephalosporin Compounds (AREA)
Abstract
Description
Claims
Priority Applications (23)
Application Number | Priority Date | Filing Date | Title |
---|---|---|---|
NZ525230A NZ525230A (en) | 2000-11-28 | 2001-11-07 | Process for preparing distamycin derivatives |
SI200130298T SI1347958T1 (en) | 2000-11-28 | 2001-11-07 | |
JP2002546517A JP4574944B2 (en) | 2000-11-28 | 2001-11-07 | Process for the preparation of distamycin derivatives |
CA002427177A CA2427177C (en) | 2000-11-28 | 2001-11-07 | Process for preparing distamycin derivatives |
EEP200300204A EE05218B1 (en) | 2000-11-28 | 2001-11-07 | Method for the preparation of a distamycin derivative |
DE60108528T DE60108528T2 (en) | 2000-11-28 | 2001-11-07 | PROCESS FOR THE PREPARATION OF DISTAMYCINE DERIVATIVES |
HU0302158A HU229670B1 (en) | 2000-11-28 | 2001-11-07 | Process for preparing distamycin derivatives |
BR0115351-0A BR0115351A (en) | 2000-11-28 | 2001-11-07 | Process for preparing distamycin derivatives |
EP01998537A EP1347958B1 (en) | 2000-11-28 | 2001-11-07 | Process for preparing distamycin derivatives |
IL15538501A IL155385A0 (en) | 2000-11-28 | 2001-11-07 | Process for preparing distamycin derivatives |
KR1020037007081A KR100847234B1 (en) | 2000-11-28 | 2001-11-07 | Process for preparing distamycin derivatives |
DK01998537T DK1347958T3 (en) | 2001-11-07 | 2001-11-07 | Process for the preparation of distamycin derivatives |
AU2069602A AU2069602A (en) | 2000-11-28 | 2001-11-07 | Process for preparing distamycin derivatives |
SK832-2003A SK286610B6 (en) | 2000-11-28 | 2001-11-07 | Process for preparing distamycin derivatives |
EA200300617A EA005399B1 (en) | 2000-11-28 | 2001-11-07 | Method for preparing distamycin derivatives |
US10/415,091 US6906199B2 (en) | 2000-11-28 | 2001-11-07 | Process for preparing distamycin derivatives |
AT01998537T ATE287395T1 (en) | 2000-11-28 | 2001-11-07 | METHOD FOR PRODUCING DISTAMYCIN DERIVATIVES |
MXPA03004679A MXPA03004679A (en) | 2000-11-28 | 2001-11-07 | Process for preparing distamycin derivatives. |
AU2002220696A AU2002220696B2 (en) | 2000-11-28 | 2001-11-07 | Process for preparing distamycin derivatives |
PL362179A PL205821B1 (en) | 2000-11-28 | 2001-11-07 | Process for preparing distamycin derivatives |
IL155385A IL155385A (en) | 2000-11-28 | 2003-04-10 | Process for preparing distamycin derivatives |
NO20032297A NO324601B1 (en) | 2000-11-28 | 2003-05-21 | Process for the preparation of distamycin derivatives and intermediates for use therein. |
HK04103702A HK1060732A1 (en) | 2000-11-28 | 2004-05-25 | Process for preparing distamycin derivatives. |
Applications Claiming Priority (2)
Application Number | Priority Date | Filing Date | Title |
---|---|---|---|
GB0029004.9 | 2000-11-28 | ||
GBGB0029004.9A GB0029004D0 (en) | 2000-11-28 | 2000-11-28 | Process for preparing distamycin derivatives |
Publications (1)
Publication Number | Publication Date |
---|---|
WO2002044147A1 true WO2002044147A1 (en) | 2002-06-06 |
Family
ID=9904031
Family Applications (1)
Application Number | Title | Priority Date | Filing Date |
---|---|---|---|
PCT/EP2001/013050 WO2002044147A1 (en) | 2000-11-28 | 2001-11-07 | Process for preparing distamycin derivatives |
Country Status (31)
Country | Link |
---|---|
US (1) | US6906199B2 (en) |
EP (1) | EP1347958B1 (en) |
JP (1) | JP4574944B2 (en) |
KR (1) | KR100847234B1 (en) |
CN (1) | CN1190418C (en) |
AR (1) | AR035073A1 (en) |
AT (1) | ATE287395T1 (en) |
AU (2) | AU2002220696B2 (en) |
BR (1) | BR0115351A (en) |
CA (1) | CA2427177C (en) |
CZ (1) | CZ303461B6 (en) |
DE (1) | DE60108528T2 (en) |
EA (1) | EA005399B1 (en) |
EE (1) | EE05218B1 (en) |
ES (1) | ES2236365T3 (en) |
GB (1) | GB0029004D0 (en) |
HK (1) | HK1060732A1 (en) |
HU (1) | HU229670B1 (en) |
IL (2) | IL155385A0 (en) |
MX (1) | MXPA03004679A (en) |
MY (1) | MY134563A (en) |
NO (1) | NO324601B1 (en) |
NZ (1) | NZ525230A (en) |
PE (1) | PE20020551A1 (en) |
PL (1) | PL205821B1 (en) |
PT (1) | PT1347958E (en) |
SI (1) | SI1347958T1 (en) |
SK (1) | SK286610B6 (en) |
TW (1) | TWI287002B (en) |
WO (1) | WO2002044147A1 (en) |
ZA (1) | ZA200302771B (en) |
Families Citing this family (4)
Publication number | Priority date | Publication date | Assignee | Title |
---|---|---|---|---|
KR100842363B1 (en) * | 2007-04-05 | 2008-07-02 | 김춘동 | Tube squeezer |
EP2968231B1 (en) * | 2013-03-15 | 2020-07-01 | Boehringer Ingelheim Animal Health USA Inc. | Antimicrobial polyamide compositions and mastitis treatment |
JP2015080906A (en) * | 2013-10-23 | 2015-04-27 | セイコーエプソン株式会社 | Liquid storage container and liquid ejection device |
WO2023149487A1 (en) * | 2022-02-02 | 2023-08-10 | 国立大学法人千葉大学 | Method for producing pyrrole-imidazole polyamide |
Citations (1)
Publication number | Priority date | Publication date | Assignee | Title |
---|---|---|---|---|
WO1998004524A1 (en) * | 1996-07-25 | 1998-02-05 | Pharmacia & Upjohn S.P.A. | Acryloyl substituted distamycin derivatives, process for preparing them, and their use as antitumor and antiviral agents |
Family Cites Families (15)
Publication number | Priority date | Publication date | Assignee | Title |
---|---|---|---|---|
GB8612218D0 (en) | 1986-05-20 | 1986-06-25 | Erba Farmitalia | Site specific alkylating agents |
AU605512B2 (en) | 1986-10-07 | 1991-01-17 | Boehringer Mannheim Italia S.P.A. | Pharmaceutical compositions having antineoplastic activity |
GB8906709D0 (en) | 1989-03-23 | 1989-05-10 | Creighton Andrew M | Acryloyl substituted pyrrole derivatives |
JP2919867B2 (en) | 1989-09-27 | 1999-07-19 | 千寿製薬株式会社 | Antitumor agent |
IT1272234B (en) | 1994-05-02 | 1997-06-16 | Consiglio Nazionale Ricerche | GLUTATIONIC DERIVATIVES OF ANTHRACYCLINES AND PROCEDURE TO OBTAIN THEM. |
GB9416005D0 (en) | 1994-08-08 | 1994-09-28 | Erba Carlo Spa | Peptidic compounds analogous to distamycin a and process for their preparation |
US5880097A (en) | 1996-01-04 | 1999-03-09 | Terrapin Techologies, Inc. | Tethered prodrugs |
GB9610079D0 (en) | 1996-05-14 | 1996-07-17 | Pharmacia Spa | Distamycin deriratives process for preparing them and their use as antitumor and antiviral agents |
KR100469778B1 (en) * | 1996-05-14 | 2005-05-16 | 파머시아 앤 업잔 에스.피.에이. | Distamycin derivatives, process for preparing them, and their use as antitumor and antiviral agents |
GB9623522D0 (en) | 1996-11-11 | 1997-01-08 | Pharmacia & Upjohn Spa | Benzoheterocycle distamycin derivatives process for preparing them and their use as antitumour and antiviral agents |
GB9727524D0 (en) | 1997-12-31 | 1998-02-25 | Pharmacia & Upjohn Spa | Synergistic antitumor composition containing a biologically active ureido compound |
GB9806689D0 (en) | 1998-03-27 | 1998-05-27 | Pharmacia & Upjohn Spa | Acryloyl derivatives analogous to distamycin,process for preparing them,and their use as antitumour and antiviral agents |
GB9806692D0 (en) | 1998-03-27 | 1998-05-27 | Pharmacia & Upjohn Spa | Benzoheterocyclic distamycin derivatives, process for preparing them and their use as antitumour agents |
GB9816653D0 (en) | 1998-07-30 | 1998-09-30 | Pharmacia & Upjohn Spa | Oxidised sulfurated distamycin derivatives process for preparing them and their use as antitumor agents |
GB9816652D0 (en) | 1998-07-30 | 1998-09-30 | Pharmacia & Upjohn Spa | Sulfurated distamycin derivatives process for preparing them and their use as antitumor agents |
-
2000
- 2000-11-28 GB GBGB0029004.9A patent/GB0029004D0/en not_active Ceased
-
2001
- 2001-11-07 KR KR1020037007081A patent/KR100847234B1/en not_active IP Right Cessation
- 2001-11-07 ZA ZA200302771A patent/ZA200302771B/en unknown
- 2001-11-07 CZ CZ20031132A patent/CZ303461B6/en not_active IP Right Cessation
- 2001-11-07 PL PL362179A patent/PL205821B1/en unknown
- 2001-11-07 SK SK832-2003A patent/SK286610B6/en not_active IP Right Cessation
- 2001-11-07 CN CNB018193862A patent/CN1190418C/en not_active Expired - Fee Related
- 2001-11-07 PT PT01998537T patent/PT1347958E/en unknown
- 2001-11-07 IL IL15538501A patent/IL155385A0/en active IP Right Grant
- 2001-11-07 MX MXPA03004679A patent/MXPA03004679A/en active IP Right Grant
- 2001-11-07 NZ NZ525230A patent/NZ525230A/en not_active IP Right Cessation
- 2001-11-07 JP JP2002546517A patent/JP4574944B2/en not_active Expired - Fee Related
- 2001-11-07 HU HU0302158A patent/HU229670B1/en not_active IP Right Cessation
- 2001-11-07 AT AT01998537T patent/ATE287395T1/en active
- 2001-11-07 CA CA002427177A patent/CA2427177C/en not_active Expired - Fee Related
- 2001-11-07 EE EEP200300204A patent/EE05218B1/en not_active IP Right Cessation
- 2001-11-07 BR BR0115351-0A patent/BR0115351A/en active Search and Examination
- 2001-11-07 SI SI200130298T patent/SI1347958T1/xx unknown
- 2001-11-07 US US10/415,091 patent/US6906199B2/en not_active Expired - Fee Related
- 2001-11-07 AU AU2002220696A patent/AU2002220696B2/en not_active Ceased
- 2001-11-07 WO PCT/EP2001/013050 patent/WO2002044147A1/en active IP Right Grant
- 2001-11-07 AU AU2069602A patent/AU2069602A/en active Pending
- 2001-11-07 DE DE60108528T patent/DE60108528T2/en not_active Expired - Lifetime
- 2001-11-07 EA EA200300617A patent/EA005399B1/en not_active IP Right Cessation
- 2001-11-07 EP EP01998537A patent/EP1347958B1/en not_active Expired - Lifetime
- 2001-11-07 ES ES01998537T patent/ES2236365T3/en not_active Expired - Lifetime
- 2001-11-21 TW TW090128821A patent/TWI287002B/en not_active IP Right Cessation
- 2001-11-26 PE PE2001001178A patent/PE20020551A1/en not_active Application Discontinuation
- 2001-11-26 AR ARP010105477A patent/AR035073A1/en not_active Application Discontinuation
- 2001-11-27 MY MYPI20015410A patent/MY134563A/en unknown
-
2003
- 2003-04-10 IL IL155385A patent/IL155385A/en not_active IP Right Cessation
- 2003-05-21 NO NO20032297A patent/NO324601B1/en not_active IP Right Cessation
-
2004
- 2004-05-25 HK HK04103702A patent/HK1060732A1/en not_active IP Right Cessation
Patent Citations (1)
Publication number | Priority date | Publication date | Assignee | Title |
---|---|---|---|---|
WO1998004524A1 (en) * | 1996-07-25 | 1998-02-05 | Pharmacia & Upjohn S.P.A. | Acryloyl substituted distamycin derivatives, process for preparing them, and their use as antitumor and antiviral agents |
Non-Patent Citations (1)
Title |
---|
COZZI P ET AL: "Cytotoxic alpha-bromoacrylic derivatives of distamycin analogues modified at the amidino moiety", BIOORGANIC & MEDICINAL CHEMISTRY LETTERS, OXFORD, GB, vol. 10, no. 11, June 2000 (2000-06-01), pages 1273 - 1276, XP004200573, ISSN: 0960-894X * |
Also Published As
Similar Documents
Publication | Publication Date | Title |
---|---|---|
KR100421073B1 (en) | Preparation of substituted perhydroisoindoles | |
US20050107614A1 (en) | Process for the preparation of repaglinide | |
EP1347958B1 (en) | Process for preparing distamycin derivatives | |
AU2002220696A1 (en) | Process for preparing distamycin derivatives | |
EP1758867B1 (en) | Process for preparing oxcarbazepine | |
WO1992009574A2 (en) | Poly-aminopyrrolecarboxamido derivatives, processes for their preparation and pharmaceutical compositions containing them | |
US6951951B2 (en) | Process for preparing distamycin derivatives | |
KR20000016898A (en) | Process for preparing pyrrolidinyl hydroxamic acid compounds | |
EP2240442B1 (en) | Preparation process useful in synthesis of atorvastatin | |
JP2003509504A (en) | Synthetic method of ritonavir | |
IE912005A1 (en) | "New process for the industrial preparation of 4-chloro 3-sulphamoyl-N-(2,3-dihydro-2-methyl-1H-indol-1- yl)- benzamide from 2,3-dihydro-2-methyl-1H-indole and hydrox ylamine-O-sulphonic acid" | |
EP1641753B1 (en) | Process for the synthesis of distamycin and derivatives thereof using 1-methyl-4-formylamino-2-pyrrolecarbonyl chloride iteratively as an intermediate | |
US20040029810A1 (en) | Process for preparing distamycin derivatives | |
KR20070087764A (en) | A process for preparing losartan |
Legal Events
Date | Code | Title | Description |
---|---|---|---|
AK | Designated states |
Kind code of ref document: A1 Designated state(s): AE AG AL AM AT AU AZ BA BB BG BR BY BZ CA CH CN CO CR CU CZ DE DK DM DZ EC EE ES FI GB GD GE GH GM HR HU ID IL IN IS JP KE KG KP KR KZ LC LK LR LS LT LU LV MA MD MG MK MN MW MX MZ NO NZ PH PL PT RO RU SD SE SG SI SK SL TJ TM TR TT TZ UA UG US UZ VN YU ZA ZW |
|
AL | Designated countries for regional patents |
Kind code of ref document: A1 Designated state(s): GH GM KE LS MW MZ SD SL SZ TZ UG ZW AM AZ BY KG KZ MD RU TJ TM AT BE CH CY DE DK ES FI FR GB GR IE IT LU MC NL PT SE TR BF BJ CF CG CI CM GA GN GQ GW ML MR NE SN TD TG |
|
121 | Ep: the epo has been informed by wipo that ep was designated in this application | ||
WWE | Wipo information: entry into national phase |
Ref document number: 2003/02771 Country of ref document: ZA Ref document number: 200302771 Country of ref document: ZA Ref document number: 525230 Country of ref document: NZ |
|
WWE | Wipo information: entry into national phase |
Ref document number: 155385 Country of ref document: IL Ref document number: 2002220696 Country of ref document: AU |
|
WWE | Wipo information: entry into national phase |
Ref document number: 1-2003-500275 Country of ref document: PH |
|
WWE | Wipo information: entry into national phase |
Ref document number: PV2003-1132 Country of ref document: CZ |
|
WWE | Wipo information: entry into national phase |
Ref document number: 2427177 Country of ref document: CA |
|
WWE | Wipo information: entry into national phase |
Ref document number: 018193862 Country of ref document: CN |
|
WWE | Wipo information: entry into national phase |
Ref document number: PA/a/2003/004679 Country of ref document: MX Ref document number: 1020037007081 Country of ref document: KR Ref document number: 2002546517 Country of ref document: JP |
|
WWE | Wipo information: entry into national phase |
Ref document number: 2001998537 Country of ref document: EP |
|
WWE | Wipo information: entry into national phase |
Ref document number: 996/CHENP/2003 Country of ref document: IN |
|
WWE | Wipo information: entry into national phase |
Ref document number: 03053205 Country of ref document: CO |
|
WWE | Wipo information: entry into national phase |
Ref document number: 8322003 Country of ref document: SK Ref document number: 200300617 Country of ref document: EA |
|
WWP | Wipo information: published in national office |
Ref document number: 1020037007081 Country of ref document: KR |
|
WWP | Wipo information: published in national office |
Ref document number: PV2003-1132 Country of ref document: CZ |
|
WWE | Wipo information: entry into national phase |
Ref document number: 10415091 Country of ref document: US |
|
WWP | Wipo information: published in national office |
Ref document number: 2001998537 Country of ref document: EP |
|
REG | Reference to national code |
Ref country code: DE Ref legal event code: 8642 |
|
WWP | Wipo information: published in national office |
Ref document number: 525230 Country of ref document: NZ |
|
WWG | Wipo information: grant in national office |
Ref document number: 525230 Country of ref document: NZ |
|
WWG | Wipo information: grant in national office |
Ref document number: 2001998537 Country of ref document: EP |
|
WWG | Wipo information: grant in national office |
Ref document number: 12003500275 Country of ref document: PH |