WO2002044130A1 - Substituted carboxylic acid derivatives - Google Patents

Substituted carboxylic acid derivatives Download PDF

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Publication number
WO2002044130A1
WO2002044130A1 PCT/JP2001/010353 JP0110353W WO0244130A1 WO 2002044130 A1 WO2002044130 A1 WO 2002044130A1 JP 0110353 W JP0110353 W JP 0110353W WO 0244130 A1 WO0244130 A1 WO 0244130A1
Authority
WO
WIPO (PCT)
Prior art keywords
carboxylic acid
acid derivatives
substituted carboxylic
same
drugs
Prior art date
Application number
PCT/JP2001/010353
Other languages
French (fr)
Japanese (ja)
Inventor
Hiroyuki Miyachi
Masahiro Nomura
Yukie Takahashi
Takahiro Tanase
Kouji Murakami
Original Assignee
Kyorin Pharmaceutical Co., Ltd.
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Application filed by Kyorin Pharmaceutical Co., Ltd. filed Critical Kyorin Pharmaceutical Co., Ltd.
Priority to AU2002222550A priority Critical patent/AU2002222550A1/en
Priority to JP2002546500A priority patent/JPWO2002044130A1/en
Publication of WO2002044130A1 publication Critical patent/WO2002044130A1/en

Links

Classifications

    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K31/00—Medicinal preparations containing organic active ingredients
    • A61K31/185—Acids; Anhydrides, halides or salts thereof, e.g. sulfur acids, imidic, hydrazonic or hydroximic acids
    • A61K31/19—Carboxylic acids, e.g. valproic acid
    • A61K31/192—Carboxylic acids, e.g. valproic acid having aromatic groups, e.g. sulindac, 2-aryl-propionic acids, ethacrynic acid 
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P3/00—Drugs for disorders of the metabolism
    • A61P3/04—Anorexiants; Antiobesity agents
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P3/00—Drugs for disorders of the metabolism
    • A61P3/06—Antihyperlipidemics
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P3/00—Drugs for disorders of the metabolism
    • A61P3/08—Drugs for disorders of the metabolism for glucose homeostasis
    • A61P3/10—Drugs for disorders of the metabolism for glucose homeostasis for hyperglycaemia, e.g. antidiabetics
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P43/00—Drugs for specific purposes, not provided for in groups A61P1/00-A61P41/00
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P9/00—Drugs for disorders of the cardiovascular system
    • A61P9/10—Drugs for disorders of the cardiovascular system for treating ischaemic or atherosclerotic diseases, e.g. antianginal drugs, coronary vasodilators, drugs for myocardial infarction, retinopathy, cerebrovascula insufficiency, renal arteriosclerosis
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07C—ACYCLIC OR CARBOCYCLIC COMPOUNDS
    • C07C235/00—Carboxylic acid amides, the carbon skeleton of the acid part being further substituted by oxygen atoms
    • C07C235/70—Carboxylic acid amides, the carbon skeleton of the acid part being further substituted by oxygen atoms having carbon atoms of carboxamide groups and doubly-bound oxygen atoms bound to the same carbon skeleton
    • C07C235/84—Carboxylic acid amides, the carbon skeleton of the acid part being further substituted by oxygen atoms having carbon atoms of carboxamide groups and doubly-bound oxygen atoms bound to the same carbon skeleton with the carbon atom of at least one of the carboxamide groups bound to a carbon atom of a six-membered aromatic ring

Abstract

Novel substituted carboxylic acid derivatives which bind to human peroxisome proliferator-activated receptor α (PPARα) as a ligand thereof and activate the same, thereby being efficacious as remedies for metabolic diseases such as lipid-lowering drugs (particularly in the liver), drugs preventing the progress of arteriosclerosis, anti-obesity drugs and remedies for diabetes; and a process for producing the same. Namely, substituted carboxylic acid derivatives represented by the following general formula (1), esters thereof and pharmaceutically acceptable salts and hydrates of the same; and a process for producing these compounds: (1) wherein R1 represents hydrogen, halogeno, hydroxy, 2-phenylethyl, 2-phenylethoxy, hydroxyphenoxy or benzyloxyphenoxy; and R2 represents lower (C¿1-4?) alkyl.
PCT/JP2001/010353 2000-11-29 2001-11-28 Substituted carboxylic acid derivatives WO2002044130A1 (en)

Priority Applications (2)

Application Number Priority Date Filing Date Title
AU2002222550A AU2002222550A1 (en) 2000-11-29 2001-11-28 Substituted carboxylic acid derivatives
JP2002546500A JPWO2002044130A1 (en) 2000-11-29 2001-11-28 Substituted carboxylic acid derivatives

Applications Claiming Priority (2)

Application Number Priority Date Filing Date Title
JP2000-363677 2000-11-29
JP2000363677 2000-11-29

Publications (1)

Publication Number Publication Date
WO2002044130A1 true WO2002044130A1 (en) 2002-06-06

Family

ID=18834748

Family Applications (1)

Application Number Title Priority Date Filing Date
PCT/JP2001/010353 WO2002044130A1 (en) 2000-11-29 2001-11-28 Substituted carboxylic acid derivatives

Country Status (3)

Country Link
JP (1) JPWO2002044130A1 (en)
AU (1) AU2002222550A1 (en)
WO (1) WO2002044130A1 (en)

Cited By (9)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
WO2003051821A1 (en) * 2001-12-19 2003-06-26 Astrazeneca Ab Substituted phenylpropionic acid derivatives as agonists to human peroxisome proliferator-activated receptor alpha (ppar)
WO2005009942A1 (en) * 2003-07-28 2005-02-03 Kyorin Pharmaceutical Co., Ltd. Optically active substituted phenylpropionic acid derivative
FR2875805A1 (en) * 2004-09-27 2006-03-31 Genfit S A SUBSTITUTED N- (BENZYL) PHENYLACETAMIDE DERIVATIVE COMPOUNDS, PREPARATION AND USES
JP2006512334A (en) * 2002-12-10 2006-04-13 ノバルティス アクチエンゲゼルシャフト Combination of DPP-IV inhibitor and PPAR-alpha compound
WO2006105304A2 (en) * 2005-03-31 2006-10-05 Janssen Pharmaceutica N.V. Phenyl and pyridyl lta4h modulators
JP2007001912A (en) * 2005-06-22 2007-01-11 Univ Of Tokyo Substituted phenylpropionic acid derivative
US7462644B2 (en) 2002-12-21 2008-12-09 Astrazeneca Ab Therapeutic agents
US7488844B2 (en) 2001-12-19 2009-02-10 Astrazeneca Ab Therapeutic agents
US7902367B2 (en) 2004-08-11 2011-03-08 Kyorin Pharmaceutical Co., Ltd. Cyclic amino benzoic acid derivative

Citations (3)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
JP2000256194A (en) * 1999-01-06 2000-09-19 Mitsui Chemicals Inc Intranuclear receptor agonist and agent for enhancing its effect
WO2000075103A1 (en) * 1999-06-09 2000-12-14 Kyorin Pharmaceutical Co., Ltd. SUBSTITUTED PHENYLPROPIONIC ACID DERIVATIVES AS AGONISTS TO HUMAN PEROXISOME PROLIFERATOR-ACTIVATED RECEPTOR (PPAR) $g(a)
WO2001025181A1 (en) * 1999-10-01 2001-04-12 Eisai Co., Ltd. Carboxylic acid derivatives and drugs containing the same

Patent Citations (3)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
JP2000256194A (en) * 1999-01-06 2000-09-19 Mitsui Chemicals Inc Intranuclear receptor agonist and agent for enhancing its effect
WO2000075103A1 (en) * 1999-06-09 2000-12-14 Kyorin Pharmaceutical Co., Ltd. SUBSTITUTED PHENYLPROPIONIC ACID DERIVATIVES AS AGONISTS TO HUMAN PEROXISOME PROLIFERATOR-ACTIVATED RECEPTOR (PPAR) $g(a)
WO2001025181A1 (en) * 1999-10-01 2001-04-12 Eisai Co., Ltd. Carboxylic acid derivatives and drugs containing the same

Cited By (15)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
US7256307B2 (en) 2001-12-19 2007-08-14 Astrazeneca Ab Substituted phenypropionic acid derivatives as agonists to human peroxisome proliferator-activated receptor α(PPAR)
WO2003051822A1 (en) * 2001-12-19 2003-06-26 Astrazeneca Ab Substituted phenylpropionic acid derivatives as agonists to human peroxisome proliferator-activated receptor alpha (ppar)
US7514471B2 (en) 2001-12-19 2009-04-07 Astrazeneca Ab Substituted phenylpropionic acid derivatives as agonists to human peroxisome proliferator-activated receptor α (PPAR)
WO2003051821A1 (en) * 2001-12-19 2003-06-26 Astrazeneca Ab Substituted phenylpropionic acid derivatives as agonists to human peroxisome proliferator-activated receptor alpha (ppar)
US7488844B2 (en) 2001-12-19 2009-02-10 Astrazeneca Ab Therapeutic agents
JP2006512334A (en) * 2002-12-10 2006-04-13 ノバルティス アクチエンゲゼルシャフト Combination of DPP-IV inhibitor and PPAR-alpha compound
US7462644B2 (en) 2002-12-21 2008-12-09 Astrazeneca Ab Therapeutic agents
WO2005009942A1 (en) * 2003-07-28 2005-02-03 Kyorin Pharmaceutical Co., Ltd. Optically active substituted phenylpropionic acid derivative
US7902367B2 (en) 2004-08-11 2011-03-08 Kyorin Pharmaceutical Co., Ltd. Cyclic amino benzoic acid derivative
WO2006035157A3 (en) * 2004-09-27 2006-06-29 Genfit Substituted n-(benzyl)phenylacetamide derivative compounds, preparation method thereof and uses of same as ppar ligands in the treatment of lipid and/or glucidic disorders
WO2006035157A2 (en) * 2004-09-27 2006-04-06 Genfit Substituted n-(benzyl)phenylacetamide derivative compounds, preparation method thereof and uses of same as ppar ligands in the treatment of lipid and/or glucidic disorders
FR2875805A1 (en) * 2004-09-27 2006-03-31 Genfit S A SUBSTITUTED N- (BENZYL) PHENYLACETAMIDE DERIVATIVE COMPOUNDS, PREPARATION AND USES
WO2006105304A3 (en) * 2005-03-31 2007-04-05 Janssen Pharmaceutica Nv Phenyl and pyridyl lta4h modulators
WO2006105304A2 (en) * 2005-03-31 2006-10-05 Janssen Pharmaceutica N.V. Phenyl and pyridyl lta4h modulators
JP2007001912A (en) * 2005-06-22 2007-01-11 Univ Of Tokyo Substituted phenylpropionic acid derivative

Also Published As

Publication number Publication date
JPWO2002044130A1 (en) 2004-04-02
AU2002222550A1 (en) 2002-06-11

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