WO2002043718A3 - Chemotherapeutic agents for the treatment of angiogenic diseases - Google Patents

Chemotherapeutic agents for the treatment of angiogenic diseases Download PDF

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Publication number
WO2002043718A3
WO2002043718A3 PCT/GB2001/005328 GB0105328W WO0243718A3 WO 2002043718 A3 WO2002043718 A3 WO 2002043718A3 GB 0105328 W GB0105328 W GB 0105328W WO 0243718 A3 WO0243718 A3 WO 0243718A3
Authority
WO
WIPO (PCT)
Prior art keywords
treatment
chemotherapeutic agents
angiogenic diseases
group
alkyl
Prior art date
Application number
PCT/GB2001/005328
Other languages
French (fr)
Other versions
WO2002043718A2 (en
Inventor
Quesada Ana Rodriguez
Torres Miguel Angel Medina
Chapuli Ramon Munoz
Puentes Jose Luis Fernandez
Original Assignee
Univ Malaga
Ruffles Graham Keith
Quesada Ana Rodriguez
Torres Miguel Angel Medina
Chapuli Ramon Munoz
Puentes Jose Luis Fernandez
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Application filed by Univ Malaga, Ruffles Graham Keith, Quesada Ana Rodriguez, Torres Miguel Angel Medina, Chapuli Ramon Munoz, Puentes Jose Luis Fernandez filed Critical Univ Malaga
Priority to AU2002218414A priority Critical patent/AU2002218414A1/en
Publication of WO2002043718A2 publication Critical patent/WO2002043718A2/en
Publication of WO2002043718A3 publication Critical patent/WO2002043718A3/en

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Classifications

    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K31/00—Medicinal preparations containing organic active ingredients
    • A61K31/045—Hydroxy compounds, e.g. alcohols; Salts thereof, e.g. alcoholates
    • A61K31/05—Phenols
    • A61K31/055—Phenols the aromatic ring being substituted by halogen
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P35/00—Antineoplastic agents

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  • Health & Medical Sciences (AREA)
  • Veterinary Medicine (AREA)
  • Chemical & Material Sciences (AREA)
  • Medicinal Chemistry (AREA)
  • Pharmacology & Pharmacy (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • Animal Behavior & Ethology (AREA)
  • General Health & Medical Sciences (AREA)
  • Public Health (AREA)
  • Epidemiology (AREA)
  • Chemical Kinetics & Catalysis (AREA)
  • General Chemical & Material Sciences (AREA)
  • Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
  • Organic Chemistry (AREA)
  • Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
  • Acyclic And Carbocyclic Compounds In Medicinal Compositions (AREA)

Abstract

Compounds of formula (I), wherein R?1, R2 and R3¿ are independently selected from the group consisting of hydrogen, C¿1-6? alkyl and C1-6 acyl; R?4¿ is selected from the group consisting of CN, COOR5 and CONR6R7 (wherein R?5, R6 and R7¿ are independently selected from the group consisting of hydrogen and C¿1-6? alkyl); and X?1 and X2¿ are halogen atoms are useful as chemotherapeutic agents in the treatment of angiogenic diseases.
PCT/GB2001/005328 2000-12-01 2001-12-03 Chemotherapeutic agents for the treatment of angiogenic diseases WO2002043718A2 (en)

Priority Applications (1)

Application Number Priority Date Filing Date Title
AU2002218414A AU2002218414A1 (en) 2000-12-01 2001-12-03 Chemotherapeutic agents for the treatment of angiogenic diseases

Applications Claiming Priority (2)

Application Number Priority Date Filing Date Title
GB0029383.7 2000-12-01
GBGB0029383.7A GB0029383D0 (en) 2000-12-01 2000-12-01 Therapeutic compounds

Publications (2)

Publication Number Publication Date
WO2002043718A2 WO2002043718A2 (en) 2002-06-06
WO2002043718A3 true WO2002043718A3 (en) 2002-11-21

Family

ID=9904297

Family Applications (1)

Application Number Title Priority Date Filing Date
PCT/GB2001/005328 WO2002043718A2 (en) 2000-12-01 2001-12-03 Chemotherapeutic agents for the treatment of angiogenic diseases

Country Status (3)

Country Link
AU (1) AU2002218414A1 (en)
GB (1) GB0029383D0 (en)
WO (1) WO2002043718A2 (en)

Citations (1)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
DE3737108A1 (en) * 1987-11-02 1989-05-11 Werner E G Prof Dr Mueller Use of aeroplysinine and aeroplysinine derivatives for antitumour, cytostatic, antibacterial and antiviral therapy

Patent Citations (1)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
DE3737108A1 (en) * 1987-11-02 1989-05-11 Werner E G Prof Dr Mueller Use of aeroplysinine and aeroplysinine derivatives for antitumour, cytostatic, antibacterial and antiviral therapy

Non-Patent Citations (5)

* Cited by examiner, † Cited by third party
Title
HINTERDING, KLAUS ET AL: "Synthesis and biological evaluation of aeroplysinin analogs: a new class of receptor tyrosine kinase inhibitors", BIOORGANIC & MEDICINAL CHEMISTRY (1998), 6(8), 1153-1162, XP001086402 *
KOULMAN, ALBERT ET AL: "Cytotoxicity and Mode of Action of Aeroplysinin-1 and a Related Dienone from the Sponge Aplysina aerophoba", J. NAT. PROD. (1996), 59(6), 591-594, XP008005004 *
KREUTER M H ET AL: "CYTOSTATIC ACTIVITY OF AEROPLYSININ 1 AGAINST LYMPHOMA AND EPITHELIOMA CELLS", ZEITSCHRIFT FUER NATURFORSCHUNG SECTION C BIOSCIENCES, vol. 44, no. 7-8, 1989, pages 680 - 688, XP008004978, ISSN: 0341-0382 *
KREUTER, MATTHIAS H. ET AL: "Inhibition of intrinsic protein tyrosine kinase activity of EGF-receptor kinase complex from human breast cancer cells by the marine sponge metabolite (+)-aeroplysinin-1", COMP. BIOCHEM. PHYSIOL., B: COMP. BIOCHEM. (1990), 97B(1), 151-8, XP008004987 *
TEEYAPANT, R. ET AL: "Antibiotic and cytotoxic activity of brominated compounds from the marine sponge Verongia aerophoba", Z. NATURFORSCH., C: BIOSCI. (1993), 48(11-12), 939-45, XP008004979 *

Also Published As

Publication number Publication date
WO2002043718A2 (en) 2002-06-06
AU2002218414A1 (en) 2002-06-11
GB0029383D0 (en) 2001-01-17

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