WO2002042423A3 - Modulation antisens de l'expression de src-2 - Google Patents

Modulation antisens de l'expression de src-2 Download PDF

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Publication number
WO2002042423A3
WO2002042423A3 PCT/US2001/044220 US0144220W WO0242423A3 WO 2002042423 A3 WO2002042423 A3 WO 2002042423A3 US 0144220 W US0144220 W US 0144220W WO 0242423 A3 WO0242423 A3 WO 0242423A3
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WO
WIPO (PCT)
Prior art keywords
src
expression
antisense modulation
methods
compounds
Prior art date
Application number
PCT/US2001/044220
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English (en)
Other versions
WO2002042423A2 (fr
Inventor
Burt W O'malley
Frank C Bennett
Lex M Cowsert
Original Assignee
Isis Pharmaceuticals Inc
Baylor College Medicine
Burt W O'malley
Frank C Bennett
Lex M Cowsert
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Application filed by Isis Pharmaceuticals Inc, Baylor College Medicine, Burt W O'malley, Frank C Bennett, Lex M Cowsert filed Critical Isis Pharmaceuticals Inc
Priority to AU2002237678A priority Critical patent/AU2002237678A1/en
Priority to JP2002545129A priority patent/JP2004536558A/ja
Priority to EP01986485A priority patent/EP1343913A2/fr
Publication of WO2002042423A2 publication Critical patent/WO2002042423A2/fr
Publication of WO2002042423A3 publication Critical patent/WO2002042423A3/fr

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    • C—CHEMISTRY; METALLURGY
    • C12—BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
    • C12N—MICROORGANISMS OR ENZYMES; COMPOSITIONS THEREOF; PROPAGATING, PRESERVING, OR MAINTAINING MICROORGANISMS; MUTATION OR GENETIC ENGINEERING; CULTURE MEDIA
    • C12N15/00—Mutation or genetic engineering; DNA or RNA concerning genetic engineering, vectors, e.g. plasmids, or their isolation, preparation or purification; Use of hosts therefor
    • C12N15/09—Recombinant DNA-technology
    • C12N15/11—DNA or RNA fragments; Modified forms thereof; Non-coding nucleic acids having a biological activity
    • C12N15/113—Non-coding nucleic acids modulating the expression of genes, e.g. antisense oligonucleotides; Antisense DNA or RNA; Triplex- forming oligonucleotides; Catalytic nucleic acids, e.g. ribozymes; Nucleic acids used in co-suppression or gene silencing
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P43/00—Drugs for specific purposes, not provided for in groups A61P1/00-A61P41/00
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K38/00—Medicinal preparations containing peptides
    • C—CHEMISTRY; METALLURGY
    • C12—BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
    • C12N—MICROORGANISMS OR ENZYMES; COMPOSITIONS THEREOF; PROPAGATING, PRESERVING, OR MAINTAINING MICROORGANISMS; MUTATION OR GENETIC ENGINEERING; CULTURE MEDIA
    • C12N2310/00—Structure or type of the nucleic acid
    • C12N2310/30—Chemical structure
    • C12N2310/31—Chemical structure of the backbone
    • C12N2310/315—Phosphorothioates
    • C—CHEMISTRY; METALLURGY
    • C12—BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
    • C12N—MICROORGANISMS OR ENZYMES; COMPOSITIONS THEREOF; PROPAGATING, PRESERVING, OR MAINTAINING MICROORGANISMS; MUTATION OR GENETIC ENGINEERING; CULTURE MEDIA
    • C12N2310/00—Structure or type of the nucleic acid
    • C12N2310/30—Chemical structure
    • C12N2310/32—Chemical structure of the sugar
    • C12N2310/321—2'-O-R Modification
    • C—CHEMISTRY; METALLURGY
    • C12—BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
    • C12N—MICROORGANISMS OR ENZYMES; COMPOSITIONS THEREOF; PROPAGATING, PRESERVING, OR MAINTAINING MICROORGANISMS; MUTATION OR GENETIC ENGINEERING; CULTURE MEDIA
    • C12N2310/00—Structure or type of the nucleic acid
    • C12N2310/30—Chemical structure
    • C12N2310/33—Chemical structure of the base
    • C12N2310/334—Modified C
    • C12N2310/3341—5-Methylcytosine
    • C—CHEMISTRY; METALLURGY
    • C12—BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
    • C12N—MICROORGANISMS OR ENZYMES; COMPOSITIONS THEREOF; PROPAGATING, PRESERVING, OR MAINTAINING MICROORGANISMS; MUTATION OR GENETIC ENGINEERING; CULTURE MEDIA
    • C12N2310/00—Structure or type of the nucleic acid
    • C12N2310/30—Chemical structure
    • C12N2310/34—Spatial arrangement of the modifications
    • C12N2310/341—Gapmers, i.e. of the type ===---===
    • C—CHEMISTRY; METALLURGY
    • C12—BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
    • C12N—MICROORGANISMS OR ENZYMES; COMPOSITIONS THEREOF; PROPAGATING, PRESERVING, OR MAINTAINING MICROORGANISMS; MUTATION OR GENETIC ENGINEERING; CULTURE MEDIA
    • C12N2310/00—Structure or type of the nucleic acid
    • C12N2310/30—Chemical structure
    • C12N2310/34—Spatial arrangement of the modifications
    • C12N2310/346—Spatial arrangement of the modifications having a combination of backbone and sugar modifications
    • Y—GENERAL TAGGING OF NEW TECHNOLOGICAL DEVELOPMENTS; GENERAL TAGGING OF CROSS-SECTIONAL TECHNOLOGIES SPANNING OVER SEVERAL SECTIONS OF THE IPC; TECHNICAL SUBJECTS COVERED BY FORMER USPC CROSS-REFERENCE ART COLLECTIONS [XRACs] AND DIGESTS
    • Y02—TECHNOLOGIES OR APPLICATIONS FOR MITIGATION OR ADAPTATION AGAINST CLIMATE CHANGE
    • Y02P—CLIMATE CHANGE MITIGATION TECHNOLOGIES IN THE PRODUCTION OR PROCESSING OF GOODS
    • Y02P20/00—Technologies relating to chemical industry
    • Y02P20/50—Improvements relating to the production of bulk chemicals
    • Y02P20/582—Recycling of unreacted starting or intermediate materials

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  • Health & Medical Sciences (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • Engineering & Computer Science (AREA)
  • Genetics & Genomics (AREA)
  • Organic Chemistry (AREA)
  • Biomedical Technology (AREA)
  • Bioinformatics & Cheminformatics (AREA)
  • Chemical & Material Sciences (AREA)
  • Molecular Biology (AREA)
  • Zoology (AREA)
  • Biotechnology (AREA)
  • General Engineering & Computer Science (AREA)
  • General Health & Medical Sciences (AREA)
  • Wood Science & Technology (AREA)
  • Biophysics (AREA)
  • Medicinal Chemistry (AREA)
  • Biochemistry (AREA)
  • Plant Pathology (AREA)
  • Physics & Mathematics (AREA)
  • Chemical Kinetics & Catalysis (AREA)
  • General Chemical & Material Sciences (AREA)
  • Microbiology (AREA)
  • Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
  • Pharmacology & Pharmacy (AREA)
  • Animal Behavior & Ethology (AREA)
  • Public Health (AREA)
  • Veterinary Medicine (AREA)
  • Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
  • Medicines That Contain Protein Lipid Enzymes And Other Medicines (AREA)

Abstract

Composés antisens, compositions et procédés servant à moduler l'expression de SRC-2. Ces compositions contiennent des composés antisens, en particulier, des oligonucléotides antisens, ciblés vers des acides nucléiques codant SRC-2. Procédés d'utilisation de ces composés afin de moduler l'expression de SRC-2 et de traiter des maladies associées à l'expression de SRC-2.
PCT/US2001/044220 2000-11-27 2001-11-26 Modulation antisens de l'expression de src-2 WO2002042423A2 (fr)

Priority Applications (3)

Application Number Priority Date Filing Date Title
AU2002237678A AU2002237678A1 (en) 2000-11-27 2001-11-26 Antisense modulation of src-2 expression
JP2002545129A JP2004536558A (ja) 2000-11-27 2001-11-26 Ｓｒｃ−２発現のアンチセンスモジュレーション
EP01986485A EP1343913A2 (fr) 2000-11-27 2001-11-26 Modulation antisens de l'expression de src-2

Applications Claiming Priority (2)

Application Number Priority Date Filing Date Title
US72353000A 2000-11-27 2000-11-27
US09/723,530 2000-11-27

Publications (2)

Publication Number Publication Date
WO2002042423A2 WO2002042423A2 (fr) 2002-05-30
WO2002042423A3 true WO2002042423A3 (fr) 2003-01-30

Family

ID=24906651

Family Applications (1)

Application Number Title Priority Date Filing Date
PCT/US2001/044220 WO2002042423A2 (fr) 2000-11-27 2001-11-26 Modulation antisens de l'expression de src-2

Country Status (4)

Country Link
EP (1) EP1343913A2 (fr)
JP (1) JP2004536558A (fr)
AU (1) AU2002237678A1 (fr)
WO (1) WO2002042423A2 (fr)

Citations (1)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
WO1998056806A1 (fr) * 1997-06-12 1998-12-17 The Regents Of The University Of California Proteine de coactivation de facteur de transcription, p/cip

Patent Citations (1)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
WO1998056806A1 (fr) * 1997-06-12 1998-12-17 The Regents Of The University Of California Proteine de coactivation de facteur de transcription, p/cip

Non-Patent Citations (2)

* Cited by examiner, † Cited by third party
Title
GEWIRTZ ET AL.: "Facilitating oligonucleotide delivery: helping antisense deliver on its promise", PROC. NATL. ACAD. SCI. USA, vol. 93, April 1996 (1996-04-01), pages 3161 - 3163, XP002909913 *
VOEGEL ET AL.: "TIF2, a 160 kDa transcriptional mediator for the ligand-dependent activation function AF-2 of nuclear receptors", EMBO J., vol. 15, no. 14, 1996, pages 3667 - 3675, XP002045757 *

Also Published As

Publication number Publication date
AU2002237678A1 (en) 2002-06-03
EP1343913A2 (fr) 2003-09-17
JP2004536558A (ja) 2004-12-09
WO2002042423A2 (fr) 2002-05-30

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