WO2002042422A3 - Interactions moleculaires dans des cellules hematopoietiques - Google Patents

Interactions moleculaires dans des cellules hematopoietiques Download PDF

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Publication number
WO2002042422A3
WO2002042422A3 PCT/US2001/044138 US0144138W WO0242422A3 WO 2002042422 A3 WO2002042422 A3 WO 2002042422A3 US 0144138 W US0144138 W US 0144138W WO 0242422 A3 WO0242422 A3 WO 0242422A3
Authority
WO
WIPO (PCT)
Prior art keywords
hematopoietic cells
molecular interactions
cells
reagents
methods
Prior art date
Application number
PCT/US2001/044138
Other languages
English (en)
Other versions
WO2002042422A2 (fr
Inventor
Peter Lu
Joshua D Rabinowitz
Johannes Schweizer
Original Assignee
Arbor Vita Corp
Peter Lu
Joshua D Rabinowitz
Johannes Schweizer
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Application filed by Arbor Vita Corp, Peter Lu, Joshua D Rabinowitz, Johannes Schweizer filed Critical Arbor Vita Corp
Priority to EP01987086A priority Critical patent/EP1387692A4/fr
Priority to AU2002239336A priority patent/AU2002239336A1/en
Publication of WO2002042422A2 publication Critical patent/WO2002042422A2/fr
Publication of WO2002042422A3 publication Critical patent/WO2002042422A3/fr

Links

Classifications

    • G—PHYSICS
    • G01—MEASURING; TESTING
    • G01N—INVESTIGATING OR ANALYSING MATERIALS BY DETERMINING THEIR CHEMICAL OR PHYSICAL PROPERTIES
    • G01N33/00—Investigating or analysing materials by specific methods not covered by groups G01N1/00 - G01N31/00
    • G01N33/48—Biological material, e.g. blood, urine; Haemocytometers
    • G01N33/50—Chemical analysis of biological material, e.g. blood, urine; Testing involving biospecific ligand binding methods; Immunological testing
    • G01N33/5005—Chemical analysis of biological material, e.g. blood, urine; Testing involving biospecific ligand binding methods; Immunological testing involving human or animal cells
    • G01N33/5008—Chemical analysis of biological material, e.g. blood, urine; Testing involving biospecific ligand binding methods; Immunological testing involving human or animal cells for testing or evaluating the effect of chemical or biological compounds, e.g. drugs, cosmetics
    • G01N33/5044—Chemical analysis of biological material, e.g. blood, urine; Testing involving biospecific ligand binding methods; Immunological testing involving human or animal cells for testing or evaluating the effect of chemical or biological compounds, e.g. drugs, cosmetics involving specific cell types
    • G01N33/5064—Endothelial cells
    • G—PHYSICS
    • G01—MEASURING; TESTING
    • G01N—INVESTIGATING OR ANALYSING MATERIALS BY DETERMINING THEIR CHEMICAL OR PHYSICAL PROPERTIES
    • G01N33/00—Investigating or analysing materials by specific methods not covered by groups G01N1/00 - G01N31/00
    • G01N33/48—Biological material, e.g. blood, urine; Haemocytometers
    • G01N33/50—Chemical analysis of biological material, e.g. blood, urine; Testing involving biospecific ligand binding methods; Immunological testing
    • G01N33/5005—Chemical analysis of biological material, e.g. blood, urine; Testing involving biospecific ligand binding methods; Immunological testing involving human or animal cells
    • G01N33/5008—Chemical analysis of biological material, e.g. blood, urine; Testing involving biospecific ligand binding methods; Immunological testing involving human or animal cells for testing or evaluating the effect of chemical or biological compounds, e.g. drugs, cosmetics
    • G01N33/5044—Chemical analysis of biological material, e.g. blood, urine; Testing involving biospecific ligand binding methods; Immunological testing involving human or animal cells for testing or evaluating the effect of chemical or biological compounds, e.g. drugs, cosmetics involving specific cell types
    • G01N33/5047—Cells of the immune system
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K38/00—Medicinal preparations containing peptides
    • G—PHYSICS
    • G01—MEASURING; TESTING
    • G01N—INVESTIGATING OR ANALYSING MATERIALS BY DETERMINING THEIR CHEMICAL OR PHYSICAL PROPERTIES
    • G01N2333/00—Assays involving biological materials from specific organisms or of a specific nature
    • G01N2333/435—Assays involving biological materials from specific organisms or of a specific nature from animals; from humans
    • G01N2333/705—Assays involving receptors, cell surface antigens or cell surface determinants

Landscapes

  • Health & Medical Sciences (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • Engineering & Computer Science (AREA)
  • Immunology (AREA)
  • Biomedical Technology (AREA)
  • Hematology (AREA)
  • Cell Biology (AREA)
  • Chemical & Material Sciences (AREA)
  • Urology & Nephrology (AREA)
  • Molecular Biology (AREA)
  • Toxicology (AREA)
  • Physics & Mathematics (AREA)
  • Biotechnology (AREA)
  • Tropical Medicine & Parasitology (AREA)
  • Bioinformatics & Cheminformatics (AREA)
  • Food Science & Technology (AREA)
  • Medicinal Chemistry (AREA)
  • Microbiology (AREA)
  • Analytical Chemistry (AREA)
  • Biochemistry (AREA)
  • General Health & Medical Sciences (AREA)
  • General Physics & Mathematics (AREA)
  • Pathology (AREA)
  • Peptides Or Proteins (AREA)
  • Medicines That Contain Protein Lipid Enzymes And Other Medicines (AREA)
  • Medicines Containing Material From Animals Or Micro-Organisms (AREA)

Abstract

L'invention concerne des réactifs et des procédés servant à inhiber ou à amplifier des interactions entre des protéines dans des cellules hématopoïétiques ou d'autres cellules jouant un rôle dans la transmission d'une réponse immune. Ces réactifs et ces procédés sont utiles pour traiter une variété de maladies et d'états pour lesquels les cellules du système immunitaire jouent un rôle d'intermédiaire.
PCT/US2001/044138 2000-11-10 2001-11-09 Interactions moleculaires dans des cellules hematopoietiques WO2002042422A2 (fr)

Priority Applications (2)

Application Number Priority Date Filing Date Title
EP01987086A EP1387692A4 (fr) 2000-11-11 2001-11-09 Interactions moleculaires dans des cellules hematopoietiques
AU2002239336A AU2002239336A1 (en) 2000-11-10 2001-11-09 Molecular interactions in hematopoietic cells

Applications Claiming Priority (8)

Application Number Priority Date Filing Date Title
US71005900A 2000-11-10 2000-11-10
US09/710,059 2000-11-10
US72206900A 2000-11-24 2000-11-24
US72191500A 2000-11-24 2000-11-24
US09/721,915 2000-11-24
US09/722,069 2000-11-24
US72455300A 2000-11-28 2000-11-28
US09/724,553 2000-11-28

Publications (2)

Publication Number Publication Date
WO2002042422A2 WO2002042422A2 (fr) 2002-05-30
WO2002042422A3 true WO2002042422A3 (fr) 2003-08-14

Family

ID=27505517

Family Applications (1)

Application Number Title Priority Date Filing Date
PCT/US2001/044138 WO2002042422A2 (fr) 2000-11-10 2001-11-09 Interactions moleculaires dans des cellules hematopoietiques

Country Status (3)

Country Link
EP (1) EP1387692A4 (fr)
AU (1) AU2002239336A1 (fr)
WO (1) WO2002042422A2 (fr)

Families Citing this family (19)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
US6942981B1 (en) 1999-05-14 2005-09-13 Arbor Vita Corporation Method of determining interactions with PDZ-domain polypeptides
WO2004109288A1 (fr) * 2003-06-06 2004-12-16 Astrazeneca Ab Methode de diagnostic
WO2005097828A2 (fr) * 2004-04-01 2005-10-20 Board Of Regents, The University Of Texas System Peptides de cav2.2 inhibant la douleur
EP2374469A3 (fr) * 2004-12-21 2012-01-25 MUSC Foundation For Research Development Compositions et procédés pour la promotion de la cicatrisation de plaies et de la régénération de tissus
AU2012202117B2 (en) * 2004-12-21 2014-06-26 Musc Foundation For Research Development Compositions and methods for promoting wound healing and tissue regeneration
US9408381B2 (en) 2004-12-21 2016-08-09 Musc Foundation For Research Development Alpha Connexin c-Terminal (ACT) peptides for use in transplant
US8633160B2 (en) 2005-12-30 2014-01-21 Nono Inc. Small molecule inhibitors of PDZ interactions
WO2012048276A2 (fr) 2010-10-08 2012-04-12 Caridianbct, Inc. Procédés et systèmes configurables pour la culture et la récolte de cellules dans un système de bioréacteur à fibres creuses
SG11201405359YA (en) 2012-03-01 2014-09-26 Firststring Res Inc Topical gels containing alpha connexin c-terminal (act) peptides
WO2015073918A1 (fr) 2013-11-16 2015-05-21 Terumo Bct, Inc. Expansion de cellules dans un bioréacteur
CN106232800B (zh) 2014-03-25 2020-07-03 泰尔茂比司特公司 介质的被动替代
JP6683686B2 (ja) 2014-08-22 2020-04-22 オークランド ユニサービシーズ リミティド チャネル調節剤
CN106715676A (zh) 2014-09-26 2017-05-24 泰尔茂比司特公司 按计划供养
WO2017004592A1 (fr) 2015-07-02 2017-01-05 Terumo Bct, Inc. Croissance cellulaire à l'aide de stimuli mécaniques
WO2017205667A1 (fr) 2016-05-25 2017-11-30 Terumo Bct, Inc. Expansion cellulaire
US11685883B2 (en) 2016-06-07 2023-06-27 Terumo Bct, Inc. Methods and systems for coating a cell growth surface
US11104874B2 (en) 2016-06-07 2021-08-31 Terumo Bct, Inc. Coating a bioreactor
US11624046B2 (en) 2017-03-31 2023-04-11 Terumo Bct, Inc. Cell expansion
CN110612344B (zh) 2017-03-31 2023-09-12 泰尔茂比司特公司 细胞扩增

Family Cites Families (1)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
EP0670040A1 (fr) * 1993-09-22 1995-09-06 Baxter Diagnostics Inc. Immobilisation de proteines chimiquement reticulees sur des supports solides

Non-Patent Citations (5)

* Cited by examiner, † Cited by third party
Title
FAULKNER G. ET AL.: "A new Z-band alternatively spliced PDZ-motif protein", THE JOURNAL OF CELL BIOLOGY, vol. 146, no. 2, 26 July 1999 (1999-07-26), pages 465 - 475, XP002958709 *
See also references of EP1387692A4 *
VALLENIUS T. ET AL.: "CLP-36 PDZ-LIM protein associates with nonmuscle alpha-actinin-1 and alpha-actinin-4", THE JOURNAL OF BIOLOGICAL CHEMISTRY, vol. 275, no. 15, 14 April 2000 (2000-04-14), pages 11100 - 11105, XP002958708 *
WECHSLER A. ET AL.: "Brain spectrin binding to the NMDA receptor is regulated by phosphorylation, calcium and calmodulin", THE EMBO JOURNAL, vol. 17, no. 14, 1998, pages 3931 - 3939, XP002958710 *
XIA H. ET AL.: "Actinin-associated LIM protein: identification of a domain interaction between PDZ and spectrin-like repeat motifs", THE JOURNAL OF CELL BIOLOGY, vol. 139, no. 2, October 1997 (1997-10-01), pages 507 - 515, XP002958711 *

Also Published As

Publication number Publication date
WO2002042422A2 (fr) 2002-05-30
EP1387692A4 (fr) 2004-07-21
EP1387692A2 (fr) 2004-02-11
AU2002239336A1 (en) 2002-06-03

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