WO2002041898A3 - Antibacterial methods and screens - Google Patents

Antibacterial methods and screens Download PDF

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Publication number
WO2002041898A3
WO2002041898A3 PCT/GB2001/005156 GB0105156W WO0241898A3 WO 2002041898 A3 WO2002041898 A3 WO 2002041898A3 GB 0105156 W GB0105156 W GB 0105156W WO 0241898 A3 WO0241898 A3 WO 0241898A3
Authority
WO
WIPO (PCT)
Prior art keywords
pathway
screens
negative bacteria
gram negative
methods
Prior art date
Application number
PCT/GB2001/005156
Other languages
French (fr)
Other versions
WO2002041898A2 (en
Inventor
Richard William Titball
Timothy Philip Atkins
Karen Elizabeth Isherwood
Jill Frances Ellis
Original Assignee
Secr Defence
Richard William Titball
Timothy Philip Atkins
Karen Elizabeth Isherwood
Jill Frances Ellis
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Application filed by Secr Defence, Richard William Titball, Timothy Philip Atkins, Karen Elizabeth Isherwood, Jill Frances Ellis filed Critical Secr Defence
Priority to AU2002223870A priority Critical patent/AU2002223870A1/en
Publication of WO2002041898A2 publication Critical patent/WO2002041898A2/en
Publication of WO2002041898A3 publication Critical patent/WO2002041898A3/en

Links

Classifications

    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K31/00—Medicinal preparations containing organic active ingredients
    • A61K31/33—Heterocyclic compounds
    • A61K31/395—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins
    • A61K31/495—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins having six-membered rings with two or more nitrogen atoms as the only ring heteroatoms, e.g. piperazine or tetrazines
    • A61K31/505—Pyrimidines; Hydrogenated pyrimidines, e.g. trimethoprim
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K31/00—Medicinal preparations containing organic active ingredients
    • A61K31/16—Amides, e.g. hydroxamic acids
    • A61K31/18—Sulfonamides
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K31/00—Medicinal preparations containing organic active ingredients
    • A61K31/33—Heterocyclic compounds
    • A61K31/395—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins
    • A61K31/41—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins having five-membered rings with two or more ring hetero atoms, at least one of which being nitrogen, e.g. tetrazole
    • A61K31/4164—1,3-Diazoles
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K31/00—Medicinal preparations containing organic active ingredients
    • A61K31/33—Heterocyclic compounds
    • A61K31/395—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins
    • A61K31/495—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins having six-membered rings with two or more nitrogen atoms as the only ring heteroatoms, e.g. piperazine or tetrazines
    • A61K31/505—Pyrimidines; Hydrogenated pyrimidines, e.g. trimethoprim
    • A61K31/519—Pyrimidines; Hydrogenated pyrimidines, e.g. trimethoprim ortho- or peri-condensed with heterocyclic rings
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K31/00—Medicinal preparations containing organic active ingredients
    • A61K31/64—Sulfonylureas, e.g. glibenclamide, tolbutamide, chlorpropamide
    • Y—GENERAL TAGGING OF NEW TECHNOLOGICAL DEVELOPMENTS; GENERAL TAGGING OF CROSS-SECTIONAL TECHNOLOGIES SPANNING OVER SEVERAL SECTIONS OF THE IPC; TECHNICAL SUBJECTS COVERED BY FORMER USPC CROSS-REFERENCE ART COLLECTIONS [XRACs] AND DIGESTS
    • Y02—TECHNOLOGIES OR APPLICATIONS FOR MITIGATION OR ADAPTATION AGAINST CLIMATE CHANGE
    • Y02A—TECHNOLOGIES FOR ADAPTATION TO CLIMATE CHANGE
    • Y02A50/00—TECHNOLOGIES FOR ADAPTATION TO CLIMATE CHANGE in human health protection, e.g. against extreme weather
    • Y02A50/30—Against vector-borne diseases, e.g. mosquito-borne, fly-borne, tick-borne or waterborne diseases whose impact is exacerbated by climate change

Landscapes

  • Health & Medical Sciences (AREA)
  • Chemical & Material Sciences (AREA)
  • Medicinal Chemistry (AREA)
  • Pharmacology & Pharmacy (AREA)
  • Epidemiology (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • Animal Behavior & Ethology (AREA)
  • General Health & Medical Sciences (AREA)
  • Public Health (AREA)
  • Veterinary Medicine (AREA)
  • Micro-Organisms Or Cultivation Processes Thereof (AREA)
  • Medicines That Contain Protein Lipid Enzymes And Other Medicines (AREA)
  • Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
  • Acyclic And Carbocyclic Compounds In Medicinal Compositions (AREA)

Abstract

A method of killing or controling the growth of Gram negative bacteria which comprises interrupting the branched chain amino acid biosynthesis pathway by either (a) applying to the Gram negative bacteria or to the environment thereof a chemical inhibitor of an enzyme active in said pathway or (b) downregulating expression of a gene which encodes an enzyme active in said pathway. The methods can be used in treatment or prophylaxis of bacterial infection.
PCT/GB2001/005156 2000-11-22 2001-11-22 Antibacterial methods and screens WO2002041898A2 (en)

Priority Applications (1)

Application Number Priority Date Filing Date Title
AU2002223870A AU2002223870A1 (en) 2000-11-22 2001-11-22 Antibacterial methods and screens

Applications Claiming Priority (2)

Application Number Priority Date Filing Date Title
GB0028393.7 2000-11-22
GBGB0028393.7A GB0028393D0 (en) 2000-11-22 2000-11-22 Antibacterial methods and screens

Publications (2)

Publication Number Publication Date
WO2002041898A2 WO2002041898A2 (en) 2002-05-30
WO2002041898A3 true WO2002041898A3 (en) 2002-10-17

Family

ID=9903602

Family Applications (1)

Application Number Title Priority Date Filing Date
PCT/GB2001/005156 WO2002041898A2 (en) 2000-11-22 2001-11-22 Antibacterial methods and screens

Country Status (3)

Country Link
AU (1) AU2002223870A1 (en)
GB (1) GB0028393D0 (en)
WO (1) WO2002041898A2 (en)

Families Citing this family (2)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
EP2090662A3 (en) * 2006-04-05 2012-10-31 Metanomics GmbH Process for the production of a fine chemical
WO2012074490A1 (en) * 2010-11-29 2012-06-07 Agency For Science, Technology And Research Control of bacterial growth

Citations (1)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
US5998420A (en) * 1996-04-08 1999-12-07 University Of Medicine & Dentistry Of New Jersey Method for treating Mycobacterium tuberculosis

Patent Citations (1)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
US5998420A (en) * 1996-04-08 1999-12-07 University Of Medicine & Dentistry Of New Jersey Method for treating Mycobacterium tuberculosis

Non-Patent Citations (2)

* Cited by examiner, † Cited by third party
Title
BABCZINSKI P ET AL: "MODE OF ACTION OF HERBICIDAL ALS-INHIBITORS ON ACETOLACTASE SYNTHASE FROM GREEN PLANT CELL CULTURES YEAST, AND ESCHERICHIA COLI", PESTICIDE SCIENCE, ELSEVIER APPLIED SCIENCE PUBLISHER. BARKING, GB, vol. 31, 1991, pages 305 - 323, XP000654157, ISSN: 0031-613X *
LAROSSA, R. ET AL.: "The Sulfonylurea Herbicide Sulfometuron Methyl is a extremely potent and selective Inhibitor of Acetolactate Synthase in Salmonella typhimurium", THE JOURNAL OF BIOLOGICAL CHEMISTRY, vol. 259, no. 14, 25 July 1984 (1984-07-25), pages 8753 - 8757, XP002195562 *

Also Published As

Publication number Publication date
GB0028393D0 (en) 2001-01-03
WO2002041898A2 (en) 2002-05-30
AU2002223870A1 (en) 2002-06-03

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