WO2002041871A3 - Composition comprising an imexon or derivatives thereof and lipids - Google Patents

Composition comprising an imexon or derivatives thereof and lipids Download PDF

Info

Publication number
WO2002041871A3
WO2002041871A3 PCT/US2001/043292 US0143292W WO0241871A3 WO 2002041871 A3 WO2002041871 A3 WO 2002041871A3 US 0143292 W US0143292 W US 0143292W WO 0241871 A3 WO0241871 A3 WO 0241871A3
Authority
WO
WIPO (PCT)
Prior art keywords
imexon
lipids
derivatives
composition
derivative
Prior art date
Application number
PCT/US2001/043292
Other languages
French (fr)
Other versions
WO2002041871A2 (en
WO2002041871A9 (en
Inventor
Gabriel Lopez-Berestein
William A Remers
Evan M Hersh
Original Assignee
Univ Texas
Univ Arizona
Gabriel Lopez-Berestein
William A Remers
Evan M Hersh
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Application filed by Univ Texas, Univ Arizona, Gabriel Lopez-Berestein, William A Remers, Evan M Hersh filed Critical Univ Texas
Priority to AU2002216672A priority Critical patent/AU2002216672A1/en
Priority to CA002431947A priority patent/CA2431947A1/en
Publication of WO2002041871A2 publication Critical patent/WO2002041871A2/en
Publication of WO2002041871A3 publication Critical patent/WO2002041871A3/en
Publication of WO2002041871A9 publication Critical patent/WO2002041871A9/en

Links

Classifications

    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K45/00—Medicinal preparations containing active ingredients not provided for in groups A61K31/00 - A61K41/00
    • A61K45/06—Mixtures of active ingredients without chemical characterisation, e.g. antiphlogistics and cardiaca
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K31/00—Medicinal preparations containing organic active ingredients
    • A61K31/33—Heterocyclic compounds
    • A61K31/395—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins
    • A61K31/396—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins having three-membered rings, e.g. aziridine
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K9/00—Medicinal preparations characterised by special physical form
    • A61K9/10—Dispersions; Emulsions
    • A61K9/107—Emulsions ; Emulsion preconcentrates; Micelles
    • A61K9/1075—Microemulsions or submicron emulsions; Preconcentrates or solids thereof; Micelles, e.g. made of phospholipids or block copolymers
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K9/00—Medicinal preparations characterised by special physical form
    • A61K9/10—Dispersions; Emulsions
    • A61K9/127—Liposomes
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P37/00—Drugs for immunological or allergic disorders
    • A61P37/02—Immunomodulators

Landscapes

  • Health & Medical Sciences (AREA)
  • Chemical & Material Sciences (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • Medicinal Chemistry (AREA)
  • Pharmacology & Pharmacy (AREA)
  • Animal Behavior & Ethology (AREA)
  • General Health & Medical Sciences (AREA)
  • Public Health (AREA)
  • Veterinary Medicine (AREA)
  • Epidemiology (AREA)
  • Dispersion Chemistry (AREA)
  • Immunology (AREA)
  • Biophysics (AREA)
  • Molecular Biology (AREA)
  • Engineering & Computer Science (AREA)
  • Bioinformatics & Cheminformatics (AREA)
  • Chemical Kinetics & Catalysis (AREA)
  • General Chemical & Material Sciences (AREA)
  • Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
  • Organic Chemistry (AREA)
  • Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
  • Medicines That Contain Protein Lipid Enzymes And Other Medicines (AREA)
  • Acyclic And Carbocyclic Compounds In Medicinal Compositions (AREA)

Abstract

Disclosed are novel compositions comprising a lipid and imexon or a derivative thereof. Also disclosed are liposomal compositions comprising imexon or derivative thereof. Methods for administrating pharmaceutically acceptable compositions comprising a lipid and imexon or a derivative thereof for the treatment of diseases, such as cancer, are also disclosed herein.
PCT/US2001/043292 2000-11-21 2001-11-20 Composition comprising an imexon or derivatives thereof and lipids WO2002041871A2 (en)

Priority Applications (2)

Application Number Priority Date Filing Date Title
AU2002216672A AU2002216672A1 (en) 2000-11-21 2001-11-20 Composition comprising an imexon or derivatives thereof and lipids
CA002431947A CA2431947A1 (en) 2000-11-21 2001-11-20 Composition comprising an imexon or derivatives thereof and lipids

Applications Claiming Priority (2)

Application Number Priority Date Filing Date Title
US72104000A 2000-11-21 2000-11-21
US09/721.040 2000-11-21

Publications (3)

Publication Number Publication Date
WO2002041871A2 WO2002041871A2 (en) 2002-05-30
WO2002041871A3 true WO2002041871A3 (en) 2003-04-17
WO2002041871A9 WO2002041871A9 (en) 2003-05-30

Family

ID=24896274

Family Applications (1)

Application Number Title Priority Date Filing Date
PCT/US2001/043292 WO2002041871A2 (en) 2000-11-21 2001-11-20 Composition comprising an imexon or derivatives thereof and lipids

Country Status (3)

Country Link
AU (1) AU2002216672A1 (en)
CA (1) CA2431947A1 (en)
WO (1) WO2002041871A2 (en)

Families Citing this family (1)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
CN1889943A (en) * 2003-12-08 2007-01-03 美国亚利桑那大学董事会 Synergistic anti-cancer compounds

Citations (5)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
US4083987A (en) * 1975-07-08 1978-04-11 Boehringer Mannheim Gmbh 4-Imino-1,3-diazabicyclo-(3.1.0)-hexan-2-one as a cancerostat and immuno-stimulant
US4321194A (en) * 1978-08-03 1982-03-23 Boehringer Mannheim Gmbh N-Substituted aziridine-2-carboxylic acid derivatives for immuno stimulation
US4397848A (en) * 1979-02-21 1983-08-09 Boehringer Mannheim Gmbh N-Substituted aziridine-2-carboxylic acid immunostimulant derivatives
DE3844655A1 (en) * 1988-07-28 1990-05-17 Boehringer Mannheim Gmbh Use of imexon as immunosuppressant
WO1999000120A1 (en) * 1997-06-27 1999-01-07 Arizona Board Of Regents, University Of Arizona Novel cyanoaziridines for treating cancer

Patent Citations (5)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
US4083987A (en) * 1975-07-08 1978-04-11 Boehringer Mannheim Gmbh 4-Imino-1,3-diazabicyclo-(3.1.0)-hexan-2-one as a cancerostat and immuno-stimulant
US4321194A (en) * 1978-08-03 1982-03-23 Boehringer Mannheim Gmbh N-Substituted aziridine-2-carboxylic acid derivatives for immuno stimulation
US4397848A (en) * 1979-02-21 1983-08-09 Boehringer Mannheim Gmbh N-Substituted aziridine-2-carboxylic acid immunostimulant derivatives
DE3844655A1 (en) * 1988-07-28 1990-05-17 Boehringer Mannheim Gmbh Use of imexon as immunosuppressant
WO1999000120A1 (en) * 1997-06-27 1999-01-07 Arizona Board Of Regents, University Of Arizona Novel cyanoaziridines for treating cancer

Non-Patent Citations (3)

* Cited by examiner, † Cited by third party
Title
DORR, R.T.: "Preclinical pharmacokinetics and antitumor activity of imexon", INVESTIGATIONAL NEW DRUGS, vol. 13, no. 2, 1995, pages 113 - 116, XP001080564 *
HERSH, E.M.: "Suppression of Human Lymphoma Developement in the Severe Combined Immune-deficient Mouse by Imexon Therapy", JOURNAL OF IMMUNOTHERAPY, vol. 13, no. 2, 1993, pages 77 - 83, XP001080540 *
IYENGAR, B.S.: "Novel Antitumor 2-Cyanoaziridine-1-carboxamides", JOURNAL OF MEDICINAL CHEMISTRY, vol. 42, 1999, pages 510 - 514, XP002201160 *

Also Published As

Publication number Publication date
CA2431947A1 (en) 2002-05-30
WO2002041871A2 (en) 2002-05-30
AU2002216672A1 (en) 2002-06-03
WO2002041871A9 (en) 2003-05-30

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