WO2002041828A3 - Houttuyninum compositions and methods for inhibiting the activity of erbb-2 based thereon - Google Patents

Houttuyninum compositions and methods for inhibiting the activity of erbb-2 based thereon Download PDF

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Publication number
WO2002041828A3
WO2002041828A3 PCT/US2001/043123 US0143123W WO0241828A3 WO 2002041828 A3 WO2002041828 A3 WO 2002041828A3 US 0143123 W US0143123 W US 0143123W WO 0241828 A3 WO0241828 A3 WO 0241828A3
Authority
WO
WIPO (PCT)
Prior art keywords
activity
erbb
houttuyninum
compositions
inhibiting
Prior art date
Application number
PCT/US2001/043123
Other languages
French (fr)
Other versions
WO2002041828A2 (en
Inventor
Dajun Yang
Xiao F Zhu
Jingson Wang
Yixing Zeng
Original Assignee
Dajun Yang
Xiao F Zhu
Jingson Wang
Yixing Zeng
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Application filed by Dajun Yang, Xiao F Zhu, Jingson Wang, Yixing Zeng filed Critical Dajun Yang
Priority to AU2002239258A priority Critical patent/AU2002239258A1/en
Publication of WO2002041828A2 publication Critical patent/WO2002041828A2/en
Publication of WO2002041828A3 publication Critical patent/WO2002041828A3/en

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Classifications

    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K36/00—Medicinal preparations of undetermined constitution containing material from algae, lichens, fungi or plants, or derivatives thereof, e.g. traditional herbal medicines
    • A61K36/18—Magnoliophyta (angiosperms)
    • A61K36/185—Magnoliopsida (dicotyledons)

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  • Health & Medical Sciences (AREA)
  • Natural Medicines & Medicinal Plants (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • Chemical & Material Sciences (AREA)
  • Engineering & Computer Science (AREA)
  • Alternative & Traditional Medicine (AREA)
  • Biotechnology (AREA)
  • Botany (AREA)
  • Medical Informatics (AREA)
  • Medicinal Chemistry (AREA)
  • Microbiology (AREA)
  • Mycology (AREA)
  • Pharmacology & Pharmacy (AREA)
  • Epidemiology (AREA)
  • Animal Behavior & Ethology (AREA)
  • General Health & Medical Sciences (AREA)
  • Public Health (AREA)
  • Veterinary Medicine (AREA)
  • Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
  • Medicines Containing Plant Substances (AREA)

Abstract

The present invention relates to methods and compositions for inhibiting the activity of erbB-2. The described methods and compositions are particularly useful for inhibiting cellular proliferative disorders, such as cancer, characterized by over-activity and/or inappropriate activity of erbB-2. More particularly, method for the treatment of a cellular proliferative disorder characterized by over-activity or inappropriate activity of erbB-2 is provided including the step of administering to a patient in need of such treatment a therapeutically effective amount of soluble extract of houttuynum, or a compound selected from the group consisting of houttuyninum, Houttuymia cordata, neo-houttuyninum (decanoyl acetaldehyde), analogs thereof, pharmaceutically acceptable salts thereof, and/or prodrugs thereof.
PCT/US2001/043123 2000-11-17 2001-11-19 Houttuyninum compositions and methods for inhibiting the activity of erbb-2 based thereon WO2002041828A2 (en)

Priority Applications (1)

Application Number Priority Date Filing Date Title
AU2002239258A AU2002239258A1 (en) 2000-11-17 2001-11-19 Houttuyninum compositions and methods for inhibiting the activity of erbb-2 based thereon

Applications Claiming Priority (2)

Application Number Priority Date Filing Date Title
US24927200P 2000-11-17 2000-11-17
US60/249,272 2000-11-17

Publications (2)

Publication Number Publication Date
WO2002041828A2 WO2002041828A2 (en) 2002-05-30
WO2002041828A3 true WO2002041828A3 (en) 2002-08-01

Family

ID=22942748

Family Applications (1)

Application Number Title Priority Date Filing Date
PCT/US2001/043123 WO2002041828A2 (en) 2000-11-17 2001-11-19 Houttuyninum compositions and methods for inhibiting the activity of erbb-2 based thereon

Country Status (2)

Country Link
AU (1) AU2002239258A1 (en)
WO (1) WO2002041828A2 (en)

Families Citing this family (11)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
CA2417500C (en) 2000-07-28 2008-11-18 Georgetown University Medical Center Erbb-2 selective small molecule kinase inhibitors
US7432304B2 (en) 2001-05-30 2008-10-07 The Regents Of The University Of Michigan Small molecule antagonists of Bcl-2 family proteins
WO2003038060A2 (en) 2001-11-01 2003-05-08 The Regents Of The University Of Michigan Small molecule inhibitors targeted at bcl-2
GB0225282D0 (en) * 2002-10-31 2002-12-11 Astrazeneca Ab assay
SG151299A1 (en) 2004-03-25 2009-04-30 Univ Michigan Gossypol co-crystals and the use thereof
CN102153492B (en) * 2010-01-29 2016-01-13 刘力 Medicine of anti-infectious disease and its production and use
US20140194528A1 (en) * 2013-01-10 2014-07-10 Hong Kong Baptist University Usage of sodium houttuyfonate on inhibiting idiopathic pulmonary fibrosis and bleomycin induced pulmonary fibrosis
CN103265459B (en) * 2013-06-03 2015-09-09 四川省惠达药业有限公司 A kind of novel sodium houttuyfonate compound, its preparation method and pharmaceutical composition thereof
CN107095870B (en) * 2017-06-13 2019-05-21 佛山科学技术学院 A kind of compound medicament composition and application thereof with anti-lymphadenoma effect
CN112336744B (en) * 2020-12-08 2023-03-07 河南省医药科学研究院 New houttuynin sodium and its application in preparing antineoplastic medicine by combining with cisplatin
CN112791074B (en) * 2021-03-17 2022-10-04 中山大学 Application of houttuynin and/or sodium new houttuynin in preparing NDM-1 inhibitor

Citations (7)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
JPS59152323A (en) * 1983-02-08 1984-08-31 Moriyuki Hiramatsu Fomentation
JPS61249929A (en) * 1985-04-25 1986-11-07 Koichi Sakurai Production of herb drink effective to gastric cancer and gastric ulcer and the like
CN1086723A (en) * 1993-06-09 1994-05-18 吴传福 The manufacture method of compound pulmonary carcinoma tablet
CN1105246A (en) * 1993-08-24 1995-07-19 吴雪姣 Oral liquid
CN1113789A (en) * 1994-05-21 1995-12-27 崔延宏 Anti-cancer compound preparation
CN1114570A (en) * 1994-07-02 1996-01-10 云南滇东北制药总厂 Qingyan Jiedu Koufuye (oral liquor capable of relieving sore-throat and detoxicating) and preparing method thereof
CN1228310A (en) * 1998-03-09 1999-09-15 张富永 Xiaoaisan powder for curing cancer

Patent Citations (7)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
JPS59152323A (en) * 1983-02-08 1984-08-31 Moriyuki Hiramatsu Fomentation
JPS61249929A (en) * 1985-04-25 1986-11-07 Koichi Sakurai Production of herb drink effective to gastric cancer and gastric ulcer and the like
CN1086723A (en) * 1993-06-09 1994-05-18 吴传福 The manufacture method of compound pulmonary carcinoma tablet
CN1105246A (en) * 1993-08-24 1995-07-19 吴雪姣 Oral liquid
CN1113789A (en) * 1994-05-21 1995-12-27 崔延宏 Anti-cancer compound preparation
CN1114570A (en) * 1994-07-02 1996-01-10 云南滇东北制药总厂 Qingyan Jiedu Koufuye (oral liquor capable of relieving sore-throat and detoxicating) and preparing method thereof
CN1228310A (en) * 1998-03-09 1999-09-15 张富永 Xiaoaisan powder for curing cancer

Non-Patent Citations (7)

* Cited by examiner, † Cited by third party
Title
DATABASE DWPI [online] "Method for producing compound pulmonary carcinoma tablet", XP002951257, accession no. WEST *
DATABASE DWPI [online] "Oral Chinese herbal medicine having anti-cancer properties", XP002951256, accession no. WEST *
DATABASE DWPI [online] "Oral liquid for smokers for e.g. relieving sore-throat", XP002951255, accession no. WEST *
DATABASE DWPI [online] "Oral liquid for treating rheumatoid diseases and cancer", XP002951256, accession no. WEST *
DATABASE DWPI [online] "Xiaoaisan powder for curing cancer", XP002951253, accession no. WEST *
DATABASE JPAB [online] "Fomentation", XP002951254, accession no. WEST *
DATABASE JPAB [online] "Production of herb drink effective to gastric cancer and gastric ulcer and the like", XP002951252, accession no. WEST *

Also Published As

Publication number Publication date
AU2002239258A1 (en) 2002-06-03
WO2002041828A2 (en) 2002-05-30

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