WO2002040991A3 - Calibration standards, methods, and kits for water determination by karl fischer titration - Google Patents

Calibration standards, methods, and kits for water determination by karl fischer titration Download PDF

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Publication number
WO2002040991A3
WO2002040991A3 PCT/US2001/027790 US0127790W WO0240991A3 WO 2002040991 A3 WO2002040991 A3 WO 2002040991A3 US 0127790 W US0127790 W US 0127790W WO 0240991 A3 WO0240991 A3 WO 0240991A3
Authority
WO
WIPO (PCT)
Prior art keywords
karl fischer
kits
reagent
methods
calibration standards
Prior art date
Application number
PCT/US2001/027790
Other languages
French (fr)
Other versions
WO2002040991A2 (en
Inventor
Scott Andrew Miller
Original Assignee
Lilly Co Eli
Scott Andrew Miller
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Application filed by Lilly Co Eli, Scott Andrew Miller filed Critical Lilly Co Eli
Priority to US10/399,117 priority Critical patent/US7122376B2/en
Priority to EP01981313A priority patent/EP1356275A2/en
Priority to JP2002542868A priority patent/JP2004529316A/en
Priority to AU2002212966A priority patent/AU2002212966A1/en
Publication of WO2002040991A2 publication Critical patent/WO2002040991A2/en
Publication of WO2002040991A3 publication Critical patent/WO2002040991A3/en
Priority to US10/793,722 priority patent/US7049146B2/en

Links

Classifications

    • G—PHYSICS
    • G01—MEASURING; TESTING
    • G01N—INVESTIGATING OR ANALYSING MATERIALS BY DETERMINING THEIR CHEMICAL OR PHYSICAL PROPERTIES
    • G01N31/00—Investigating or analysing non-biological materials by the use of the chemical methods specified in the subgroup; Apparatus specially adapted for such methods
    • G01N31/16—Investigating or analysing non-biological materials by the use of the chemical methods specified in the subgroup; Apparatus specially adapted for such methods using titration
    • G01N31/168—Determining water content by using Karl Fischer reagent

Landscapes

  • Health & Medical Sciences (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • Molecular Biology (AREA)
  • Physics & Mathematics (AREA)
  • Chemical & Material Sciences (AREA)
  • Analytical Chemistry (AREA)
  • Biochemistry (AREA)
  • General Health & Medical Sciences (AREA)
  • General Physics & Mathematics (AREA)
  • Immunology (AREA)
  • Pathology (AREA)
  • Investigating Or Analyzing Non-Biological Materials By The Use Of Chemical Means (AREA)

Abstract

The invention relates to a formed tablet calibration standard-reagent for calibrating Karl Fischer reactions for determining water content in a substance, said reagent containing a first component, namely sodium tartrate dihydrate, and a second component, namely magnesium stearate. The invention further relates to a method for determining the water content of a substance using a Karl Fischer analysis. The invention further relates to a formed tablet calibration standard-reagent kit, comprising a sealed package containing said formed tablet calibration standard-reagent.
PCT/US2001/027790 2000-11-14 2001-11-01 Calibration standards, methods, and kits for water determination by karl fischer titration WO2002040991A2 (en)

Priority Applications (5)

Application Number Priority Date Filing Date Title
US10/399,117 US7122376B2 (en) 2001-11-01 2001-11-01 Calibration standards, methods, and kits for water determination
EP01981313A EP1356275A2 (en) 2000-11-14 2001-11-01 Calibration standards, methods, and kits for water determination by karl fischer titration
JP2002542868A JP2004529316A (en) 2000-11-14 2001-11-01 Calibration standards, methods and kits for moisture determination
AU2002212966A AU2002212966A1 (en) 2000-11-14 2001-11-01 Calibration standards, methods, and kits for water determination by karl fischer titration
US10/793,722 US7049146B2 (en) 2000-11-14 2004-03-05 Calibration standards, methods, and kits for water determination

Applications Claiming Priority (2)

Application Number Priority Date Filing Date Title
US24848700P 2000-11-14 2000-11-14
US60/248,487 2000-11-14

Related Child Applications (3)

Application Number Title Priority Date Filing Date
US10/399,117 A-371-Of-International US7122376B2 (en) 2000-11-14 2001-11-01 Calibration standards, methods, and kits for water determination
US10399117 A-371-Of-International 2001-11-01
US10/793,722 Continuation-In-Part US7049146B2 (en) 2000-11-14 2004-03-05 Calibration standards, methods, and kits for water determination

Publications (2)

Publication Number Publication Date
WO2002040991A2 WO2002040991A2 (en) 2002-05-23
WO2002040991A3 true WO2002040991A3 (en) 2003-08-28

Family

ID=22939359

Family Applications (1)

Application Number Title Priority Date Filing Date
PCT/US2001/027790 WO2002040991A2 (en) 2000-11-14 2001-11-01 Calibration standards, methods, and kits for water determination by karl fischer titration

Country Status (4)

Country Link
EP (1) EP1356275A2 (en)
JP (1) JP2004529316A (en)
AU (1) AU2002212966A1 (en)
WO (1) WO2002040991A2 (en)

Families Citing this family (7)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
US7049146B2 (en) 2000-11-14 2006-05-23 Facet Analytical Services And Technology, Llc Calibration standards, methods, and kits for water determination
US7122376B2 (en) 2001-11-01 2006-10-17 Facet Analytical Services And Technology, Llc Calibration standards, methods, and kits for water determination
US7118916B2 (en) * 2002-10-21 2006-10-10 Lifescan, Inc. Method of reducing analysis time of endpoint-type reaction profiles
DE10336571B3 (en) 2003-08-08 2005-01-27 Merck Patent Gmbh Process to prepare water to a standard required for use in association with furnace technology or the Karl-Fischer process
CN100335898C (en) * 2005-03-08 2007-09-05 张家港市国泰华荣化工新材料有限公司 Method for measuring water content in C1-C8 low level primary amine
CN102192971B (en) * 2011-03-18 2013-09-04 辽宁省计量科学研究院 Disintegration time limit testing standard substance and preparation method thereof
CN110850024B (en) * 2018-08-21 2021-11-09 中国计量科学研究院 Water detection calibration system, detection model establishing method and water detection method

Citations (2)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
EP0482465A2 (en) * 1990-10-25 1992-04-29 MERCK PATENT GmbH Waterstandard
US5340541A (en) * 1993-03-05 1994-08-23 Eli Lilly And Company Automated Karl Fischer titration apparatus and method

Patent Citations (2)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
EP0482465A2 (en) * 1990-10-25 1992-04-29 MERCK PATENT GmbH Waterstandard
US5340541A (en) * 1993-03-05 1994-08-23 Eli Lilly And Company Automated Karl Fischer titration apparatus and method

Non-Patent Citations (3)

* Cited by examiner, † Cited by third party
Title
BURGER A ET AL: "Polymorphism and preformulation studies of lifibrol", EUROPEAN JOURNAL OF PHARMACEUTICS AND BIOPHARMACEUTICS, ELSEVIER SCIENCE PUBLISHERS B.V., AMSTERDAM, NL, vol. 49, no. 1, 3 January 2000 (2000-01-03), pages 65 - 72, XP004257136, ISSN: 0939-6411 *
NEUSS J D ET AL: "SODIUM TARTRATE DIHYDRATE AS A PRIMARY STANDARD FOR KARL FISCHER REAGENT", ANALYTICAL CHEMISTRY, AMERICAN CHEMICAL SOCIETY. COLUMBUS, US, vol. 23, 1951, pages 1332 - 1333, XP001042005, ISSN: 0003-2700 *
OHM A: "Interaction of Bay t 3839 coprecipitates with insoluble excipients", EUROPEAN JOURNAL OF PHARMACEUTICS AND BIOPHARMACEUTICS, ELSEVIER SCIENCE PUBLISHERS B.V., AMSTERDAM, NL, vol. 49, no. 2, 1 March 2000 (2000-03-01), pages 183 - 189, XP004257154, ISSN: 0939-6411 *

Also Published As

Publication number Publication date
WO2002040991A2 (en) 2002-05-23
AU2002212966A1 (en) 2002-05-27
EP1356275A2 (en) 2003-10-29
JP2004529316A (en) 2004-09-24

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