WO2002040656A3 - 47476, 67210, 49875, 46842, 33201, 83378, 84233, 64708, 85041, and 84234, novel human guanine nucleotide dissociation stimulator, glycosyltransferase, dead type helicase, centaurin, dehydrogenase/reductase, and metal transporter family members and uses thereof - Google Patents

47476, 67210, 49875, 46842, 33201, 83378, 84233, 64708, 85041, and 84234, novel human guanine nucleotide dissociation stimulator, glycosyltransferase, dead type helicase, centaurin, dehydrogenase/reductase, and metal transporter family members and uses thereof Download PDF

Info

Publication number
WO2002040656A3
WO2002040656A3 PCT/US2001/045291 US0145291W WO0240656A3 WO 2002040656 A3 WO2002040656 A3 WO 2002040656A3 US 0145291 W US0145291 W US 0145291W WO 0240656 A3 WO0240656 A3 WO 0240656A3
Authority
WO
WIPO (PCT)
Prior art keywords
centaurin
glycosyltransferase
reductase
dehydrogenase
family members
Prior art date
Application number
PCT/US2001/045291
Other languages
French (fr)
Other versions
WO2002040656A2 (en
Inventor
Rachel E Meyers
Rory A J Curtis
Maria Alexandra Glucksmann
Original Assignee
Millennium Pharm Inc
Rachel E Meyers
Rory A J Curtis
Maria Alexandra Glucksmann
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Application filed by Millennium Pharm Inc, Rachel E Meyers, Rory A J Curtis, Maria Alexandra Glucksmann filed Critical Millennium Pharm Inc
Priority to AU2002239421A priority Critical patent/AU2002239421A1/en
Publication of WO2002040656A2 publication Critical patent/WO2002040656A2/en
Priority to US10/176,306 priority patent/US20030130485A1/en
Publication of WO2002040656A3 publication Critical patent/WO2002040656A3/en
Priority to US10/968,812 priority patent/US20050214893A1/en

Links

Classifications

    • C—CHEMISTRY; METALLURGY
    • C12—BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
    • C12N—MICROORGANISMS OR ENZYMES; COMPOSITIONS THEREOF; PROPAGATING, PRESERVING, OR MAINTAINING MICROORGANISMS; MUTATION OR GENETIC ENGINEERING; CULTURE MEDIA
    • C12N9/00—Enzymes; Proenzymes; Compositions thereof; Processes for preparing, activating, inhibiting, separating or purifying enzymes
    • C12N9/0004—Oxidoreductases (1.)
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07K—PEPTIDES
    • C07K14/00—Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof
    • C07K14/435—Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof from animals; from humans
    • C07K14/46—Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof from animals; from humans from vertebrates
    • C07K14/47—Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof from animals; from humans from vertebrates from mammals
    • C07K14/4701—Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof from animals; from humans from vertebrates from mammals not used
    • C07K14/4702—Regulators; Modulating activity
    • C—CHEMISTRY; METALLURGY
    • C12—BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
    • C12N—MICROORGANISMS OR ENZYMES; COMPOSITIONS THEREOF; PROPAGATING, PRESERVING, OR MAINTAINING MICROORGANISMS; MUTATION OR GENETIC ENGINEERING; CULTURE MEDIA
    • C12N9/00—Enzymes; Proenzymes; Compositions thereof; Processes for preparing, activating, inhibiting, separating or purifying enzymes
    • C12N9/10—Transferases (2.)
    • C12N9/1048—Glycosyltransferases (2.4)
    • C—CHEMISTRY; METALLURGY
    • C12—BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
    • C12N—MICROORGANISMS OR ENZYMES; COMPOSITIONS THEREOF; PROPAGATING, PRESERVING, OR MAINTAINING MICROORGANISMS; MUTATION OR GENETIC ENGINEERING; CULTURE MEDIA
    • C12N9/00—Enzymes; Proenzymes; Compositions thereof; Processes for preparing, activating, inhibiting, separating or purifying enzymes
    • C12N9/90—Isomerases (5.)
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K38/00—Medicinal preparations containing peptides

Landscapes

  • Health & Medical Sciences (AREA)
  • Chemical & Material Sciences (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • Organic Chemistry (AREA)
  • Zoology (AREA)
  • Genetics & Genomics (AREA)
  • Bioinformatics & Cheminformatics (AREA)
  • Engineering & Computer Science (AREA)
  • Wood Science & Technology (AREA)
  • General Health & Medical Sciences (AREA)
  • Medicinal Chemistry (AREA)
  • Biochemistry (AREA)
  • Molecular Biology (AREA)
  • Biotechnology (AREA)
  • General Engineering & Computer Science (AREA)
  • Biomedical Technology (AREA)
  • Microbiology (AREA)
  • Toxicology (AREA)
  • Gastroenterology & Hepatology (AREA)
  • Biophysics (AREA)
  • Proteomics, Peptides & Aminoacids (AREA)
  • Micro-Organisms Or Cultivation Processes Thereof (AREA)
  • Preparation Of Compounds By Using Micro-Organisms (AREA)
  • Peptides Or Proteins (AREA)

Abstract

The invention provides isolated nucleic acids molecules, designated 47476, 67210, 49875, 46842, 33201, 83378, 84233, 64708, 85041, and 84234 nucleic acid molecules, which encode novel Guanine Nucleotide Dissociation Stimulator, Glycosyltransferase, DEAD type helicase, Centaurin, Dehydrogenase/Reductase, and Metal Transporter family members. The invention also provides antisense nucleic acid molecules, recombinant expression vectors containing 47476, 67210, 49875, 46842, 33201, 83378, 84233, 64708, 85041, or 84234 nucleic acid molecules, host cells nt which the expression vectors have been introduced, and nonhuman transgenic animals in which a 474476, 67210, 49875, 46842, 33201, 83378, 84233, 64708, 85041, or 84234 gene has been introduced or disrupted. The invention still further provides isolated 47476, 67210, 49875, 46842, 33201, 83378, 84233, 64708, 85041, or 84234 proteins, fusion proteins, antigenic peptides and anti-47476, 67210, 49875, 46842, 33201, 83378, 84233, 64708, 85041, or 84234 antibodies. Diagnostic methods utilizing compositions of the invention are also provided.
PCT/US2001/045291 2000-11-14 2001-11-14 47476, 67210, 49875, 46842, 33201, 83378, 84233, 64708, 85041, and 84234, novel human guanine nucleotide dissociation stimulator, glycosyltransferase, dead type helicase, centaurin, dehydrogenase/reductase, and metal transporter family members and uses thereof WO2002040656A2 (en)

Priority Applications (3)

Application Number Priority Date Filing Date Title
AU2002239421A AU2002239421A1 (en) 2000-11-14 2001-11-14 47476, 67210, 49875, 46842, 33201, 83378, 84233, 64708, 85041, and 84234, novel human guanine nucleotide dissociation stimulator, glycosyltransferase, dead type helicase, centaurin, dehydrogenase/reductase, and metal transporter family members and uses thereof
US10/176,306 US20030130485A1 (en) 2000-11-14 2002-06-20 Novel human genes and methods of use thereof
US10/968,812 US20050214893A1 (en) 2000-11-14 2004-10-19 Novel human genes and methods of use thereof

Applications Claiming Priority (12)

Application Number Priority Date Filing Date Title
US24836200P 2000-11-14 2000-11-14
US24836500P 2000-11-14 2000-11-14
US24833100P 2000-11-14 2000-11-14
US60/248,331 2000-11-14
US60/248,362 2000-11-14
US60/248,365 2000-11-14
US25007700P 2000-11-30 2000-11-30
US25017600P 2000-11-30 2000-11-30
US25032700P 2000-11-30 2000-11-30
US60/250,077 2000-11-30
US60/250,327 2000-11-30
US60/250,176 2000-11-30

Related Child Applications (1)

Application Number Title Priority Date Filing Date
US10/176,306 Continuation-In-Part US20030130485A1 (en) 2000-11-14 2002-06-20 Novel human genes and methods of use thereof

Publications (2)

Publication Number Publication Date
WO2002040656A2 WO2002040656A2 (en) 2002-05-23
WO2002040656A3 true WO2002040656A3 (en) 2004-02-26

Family

ID=27559353

Family Applications (1)

Application Number Title Priority Date Filing Date
PCT/US2001/045291 WO2002040656A2 (en) 2000-11-14 2001-11-14 47476, 67210, 49875, 46842, 33201, 83378, 84233, 64708, 85041, and 84234, novel human guanine nucleotide dissociation stimulator, glycosyltransferase, dead type helicase, centaurin, dehydrogenase/reductase, and metal transporter family members and uses thereof

Country Status (2)

Country Link
AU (1) AU2002239421A1 (en)
WO (1) WO2002040656A2 (en)

Families Citing this family (2)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
JP2004267015A (en) * 2003-03-05 2004-09-30 National Institute Of Advanced Industrial & Technology Nucleic acid and method for testing canceration using the same nucleic acid
US20060003410A1 (en) * 2004-06-10 2006-01-05 Lee-Ming Chuang Prostaglandin reductase

Non-Patent Citations (6)

* Cited by examiner, † Cited by third party
Title
CLYDE-SMITH JODI ET AL: "Characterization of RasGRP2, a plasma membrane-targeted, dual specificity Ras/Rap exchange factor.", JOURNAL OF BIOLOGICAL CHEMISTRY, vol. 275, no. 41, 13 October 2000 (2000-10-13), pages 32260 - 32267, XP002216973, ISSN: 0021-9258 *
EBINU J O ET AL: "RASGRP, A RAS GUANYL NUCLEOTIDE-RELEASING PROTEIN WITH CALCIUM- ANDDIACYLGLYCEROL-BINDING MOTIFS", SCIENCE, AMERICAN ASSOCIATION FOR THE ADVANCEMENT OF SCIENCE,, US, vol. 280, 15 May 1998 (1998-05-15), pages 1082 - 1086, XP000882708, ISSN: 0036-8075 *
LI L ET AL: "Cloning of Ras guanine nucleotide releasing protein 4, and evaluation of its expression in rat mast cells and thei bone marrow progenitors", MOLECULAR IMMUNOLOGY, - September 2002 (2002-09-01), pages 1283 - 1288, XP002216977 *
LORENZO PATRICIA S ET AL: "Phorbol esters modulate the Ras exchange factor RasGRP3.", CANCER RESEARCH, vol. 61, no. 3, 1 February 2001 (2001-02-01), pages 943 - 949, XP002216974, ISSN: 0008-5472 *
REUTHERS G W ET AL: "RasGRP4 is a novel Ras activator isolated from acute myeloid leukemia", JOURNAL OF BIOLOGICAL CHEMISTRY, vol. 277, no. 34, - 23 August 2002 (2002-08-23), pages 30508 - 30514, XP002216976 *
YANG YI ET AL: "RasGRP4, a new mast cell-restricted Ras guanine nucleotide-releasing protein with calcium- and diacylglycerol-binding motifs. Identification of defective variants of this signaling protein in asthma, mastocytosis, and mast cell leukemia patients and demonstration of the importance of RasGRP4 in mast", JOURNAL OF BIOLOGICAL CHEMISTRY, vol. 277, no. 28, 12 July 2002 (2002-07-12), pages 25756 - 25774, XP002216975, ISSN: 0021-9258 *

Also Published As

Publication number Publication date
WO2002040656A2 (en) 2002-05-23
AU2002239421A1 (en) 2002-05-27

Similar Documents

Publication Publication Date Title
WO2001072976A3 (en) 32142, 21481, 25964, 21686, novel human dehydrogenase molecules and uses therefor
WO2001096392A8 (en) 22109, a novel human thioredoxin family member and uses thereof
WO2002033061A3 (en) 32229, a human acyl-coa dehydrogenase family member and uses thereof
WO2002006302A3 (en) 16816 and 16839, novel human phospholipase c molecules and uses therefor
WO2003033660A3 (en) 9136, a human aldehyde dehydrogenase family member and uses therefor
WO2002008258A3 (en) 65494, a human g-protein-coupled receptor family member and uses thereof
WO2002006330A3 (en) 13237,18480,2245 or 16228 human protein kinase molecules and uses therefor
WO2002026803A3 (en) 22108 and 47916, novel human thioredoxin family members and uses thereof
WO2002016589A3 (en) Human abc transporter family member and uses thereof
WO2002040656A3 (en) 47476, 67210, 49875, 46842, 33201, 83378, 84233, 64708, 85041, and 84234, novel human guanine nucleotide dissociation stimulator, glycosyltransferase, dead type helicase, centaurin, dehydrogenase/reductase, and metal transporter family members and uses thereof
WO2001083719A3 (en) 25692, a novel human o-methyltransferase family member and uses thereof
WO2001064904A3 (en) 25324, 50287, 28899, 47007, and 42967 transferase family members and uses therefor
WO2002006485A3 (en) 47885, a novel human ubiquitin-activating enzyme and uses therefor
WO2002020801A3 (en) 26199, 33530, 33949, 47148, 50226, and 58764, human transferase family members and uses therefor
WO2002000863A3 (en) 32140, a novel human aldehyde dehydrogenase and uses therefor
WO2001090145A3 (en) 57805, a human cadherin family member and uses thereof
WO2002002761A3 (en) 57658, a human uridine kinase and uses thereof
WO2002057457A3 (en) Human proteins 55562 and 21617, and methods of use thereof
WO2002010401A3 (en) 18431 and 32374, human protein kinase family members and uses therefor
WO2002029037A3 (en) 57800, a novel human cadherin and uses therefor
WO2002038773A3 (en) A human phospholipase c and uses thereof
WO2002029040A3 (en) 25219, a novel human aminotransferase and uses therefor
WO2002008400A3 (en) 25233, a human aminotransferase and uses therefor
WO2001075119A3 (en) 21509 and 33770, novel human dehydrogenase family members and uses thereof
WO2002016603A3 (en) 23228, a novel human tetraspanin family member and uses thereof

Legal Events

Date Code Title Description
AK Designated states

Kind code of ref document: A2

Designated state(s): AE AG AL AM AT AU AZ BA BB BG BR BY BZ CA CH CN CO CR CU CZ DE DK DM DZ EC EE ES FI GB GD GE GH GM HR HU ID IL IN IS JP KE KG KP KR KZ LC LK LR LS LT LU LV MA MD MG MK MN MW MX MZ NO NZ PL PT RO RU SD SE SG SI SK SL TJ TM TR TT TZ UA UG US UZ VN YU ZA ZW

AL Designated countries for regional patents

Kind code of ref document: A2

Designated state(s): GH GM KE LS MW MZ SD SL SZ TZ UG ZW AM AZ BY KG KZ MD RU TJ TM AT BE CH CY DE DK ES FI FR GB GR IE IT LU MC NL PT SE TR BF BJ CF CG CI CM GA GN GQ GW ML MR NE SN TD TG

121 Ep: the epo has been informed by wipo that ep was designated in this application
DFPE Request for preliminary examination filed prior to expiration of 19th month from priority date (pct application filed before 20040101)
REG Reference to national code

Ref country code: DE

Ref legal event code: 8642

122 Ep: pct application non-entry in european phase
NENP Non-entry into the national phase

Ref country code: JP

WWW Wipo information: withdrawn in national office

Ref document number: JP

DPE2 Request for preliminary examination filed before expiration of 19th month from priority date (pct application filed from 20040101)