WO2002038743A3 - Deaminase catalyzing the removal of the cyclopropyl moiety from abacavir-mp - Google Patents

Deaminase catalyzing the removal of the cyclopropyl moiety from abacavir-mp Download PDF

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Publication number
WO2002038743A3
WO2002038743A3 PCT/US2001/048008 US0148008W WO0238743A3 WO 2002038743 A3 WO2002038743 A3 WO 2002038743A3 US 0148008 W US0148008 W US 0148008W WO 0238743 A3 WO0238743 A3 WO 0238743A3
Authority
WO
WIPO (PCT)
Prior art keywords
abacavir
removal
cyclopropyl moiety
deaminase
catalyzing
Prior art date
Application number
PCT/US2001/048008
Other languages
French (fr)
Other versions
WO2002038743A2 (en
Inventor
Robert Kevin Blackburn
William Alfred Burkhart
Steve A Haneline
Wayne Howard Miller
Mary Benbow Moyer
David John Porter
Steven A Short
Original Assignee
Glaxo Group Ltd
Robert Kevin Blackburn
William Alfred Burkhart
Steve A Haneline
Wayne Howard Miller
Mary Benbow Moyer
David John Porter
Steven A Short
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Application filed by Glaxo Group Ltd, Robert Kevin Blackburn, William Alfred Burkhart, Steve A Haneline, Wayne Howard Miller, Mary Benbow Moyer, David John Porter, Steven A Short filed Critical Glaxo Group Ltd
Priority to AU2002229011A priority Critical patent/AU2002229011A1/en
Publication of WO2002038743A2 publication Critical patent/WO2002038743A2/en
Publication of WO2002038743A3 publication Critical patent/WO2002038743A3/en

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Classifications

    • C—CHEMISTRY; METALLURGY
    • C12—BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
    • C12N—MICROORGANISMS OR ENZYMES; COMPOSITIONS THEREOF; PROPAGATING, PRESERVING, OR MAINTAINING MICROORGANISMS; MUTATION OR GENETIC ENGINEERING; CULTURE MEDIA
    • C12N9/00—Enzymes; Proenzymes; Compositions thereof; Processes for preparing, activating, inhibiting, separating or purifying enzymes
    • C12N9/14—Hydrolases (3)
    • C12N9/78—Hydrolases (3) acting on carbon to nitrogen bonds other than peptide bonds (3.5)
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K38/00—Medicinal preparations containing peptides

Abstract

A novel deaminase enzyme capable of catalyzing conversion of the monophosphorylated form of a purine nucleoside analogue, and methods of using such enzyme.
PCT/US2001/048008 2000-11-09 2001-11-02 Deaminase catalyzing the removal of the cyclopropyl moiety from abacavir-mp WO2002038743A2 (en)

Priority Applications (1)

Application Number Priority Date Filing Date Title
AU2002229011A AU2002229011A1 (en) 2000-11-09 2001-11-02 Deaminase catalyzing the removal of the cyclopropyl moiety from abacavir-mp

Applications Claiming Priority (2)

Application Number Priority Date Filing Date Title
US24797600P 2000-11-09 2000-11-09
US60/247,976 2000-11-09

Publications (2)

Publication Number Publication Date
WO2002038743A2 WO2002038743A2 (en) 2002-05-16
WO2002038743A3 true WO2002038743A3 (en) 2003-01-09

Family

ID=22937126

Family Applications (1)

Application Number Title Priority Date Filing Date
PCT/US2001/048008 WO2002038743A2 (en) 2000-11-09 2001-11-02 Deaminase catalyzing the removal of the cyclopropyl moiety from abacavir-mp

Country Status (2)

Country Link
AU (1) AU2002229011A1 (en)
WO (1) WO2002038743A2 (en)

Families Citing this family (4)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
AU2001284902A1 (en) * 2000-08-15 2002-02-25 Zymogenetics Inc. Human adenosine deaminase
WO2002016586A2 (en) 2000-08-21 2002-02-28 Bristol-Myers Squibb Company Adenosine deaminase homolog
AU2001297575A1 (en) * 2000-11-08 2002-10-08 Millennium Pharmaceuticals, Inc. 38650, 28472, 5495, 65507, 81588 and 14354 methods and compositions of human proteins and uses thereof
EP3640344B1 (en) * 2018-10-03 2024-03-13 ARKRAY, Inc. Direct electron transfer-type oxidoreductase-modified molecular recognition element

Citations (4)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
WO2001057182A2 (en) * 2000-01-31 2001-08-09 Human Genome Sciences, Inc. Nucleic acids, proteins, and antibodies
WO2001057190A2 (en) * 2000-02-03 2001-08-09 Hyseq, Inc. Novel nucleic acids and polypeptides
WO2002014483A2 (en) * 2000-08-15 2002-02-21 Zymogenetics Inc Human adenosine deaminase
WO2002016586A2 (en) * 2000-08-21 2002-02-28 Bristol-Myers Squibb Company Adenosine deaminase homolog

Patent Citations (4)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
WO2001057182A2 (en) * 2000-01-31 2001-08-09 Human Genome Sciences, Inc. Nucleic acids, proteins, and antibodies
WO2001057190A2 (en) * 2000-02-03 2001-08-09 Hyseq, Inc. Novel nucleic acids and polypeptides
WO2002014483A2 (en) * 2000-08-15 2002-02-21 Zymogenetics Inc Human adenosine deaminase
WO2002016586A2 (en) * 2000-08-21 2002-02-28 Bristol-Myers Squibb Company Adenosine deaminase homolog

Non-Patent Citations (13)

* Cited by examiner, † Cited by third party
Title
CENTELLES J J ET AL: "PURIFICATION AND PARTIAL CHARACTERIZATION OF BRAIN ADENOSINE DEAMINASE INHIBITION BY PURINE COMPOUNDS AND BY DRUGS", JOURNAL OF NEUROSCIENCE RESEARCH, vol. 19, no. 2, 1988, pages 258 - 267, XP001105393, ISSN: 0360-4012 *
COMPTON MINDY L ET AL: "9-(2-phosphonylmethoxyethyl)-N6-cyclopropyl-2,6-diaminopurine (cpr-PMEDAP) as a prodrug of 9-(2-phosphonylmethoxyethyl)guanine (PMEG).", BIOCHEMICAL PHARMACOLOGY, vol. 58, no. 4, 15 August 1999 (1999-08-15), pages 709 - 714, XP002211846, ISSN: 0006-2952 *
DALUGE S M ET AL: "1592U89, A NOVEL CARBOCYCLIC NUCLEOSIDE ANALOG WITH POTENT, SELECTIVE ANTI-HUMAN IMMUNODEFICIENCY VIRUS ACTIVITY", ANTIMICROBIAL AGENTS AND CHEMOTHERAPY, AMERICAN SOCIETY FOR MICROBIOLOGY, WASHINGTON, DC, US, vol. 41, no. 5, May 1997 (1997-05-01), pages 1082 - 1093, XP000990462, ISSN: 0066-4804 *
DATABASE EMBL [online] 17 August 2000 (2000-08-17), XP002211849, retrieved from EBI Database accession no. BE569580 *
DATABASE EMBL [online] 2 July 2000 (2000-07-02), XP002211848, retrieved from EBI Database accession no. BE157237 *
DATABASE EMBL [online] 6 September 1996 (1996-09-06), XP002211847, retrieved from EBI Database accession no. HSA44789 *
DATABASE EPOP [online] 22 March 2002 (2002-03-22), XP002211854, retrieved from EBI Database accession no. AX392793 *
DATABASE GSP [online] 18 June 2002 (2002-06-18), XP002211853, retrieved from EBI Database accession no. ABB77090 *
DATABASE GSP [online] 6 November 2001 (2001-11-06), XP002211851, retrieved from EBI Database accession no. AAM79306 *
DATABASE GSP [online] 7 November 2001 (2001-11-07), XP002211852, retrieved from EBI Database accession no. AAM90763 *
DATABASE SWALL [online] 1 June 2001 (2001-06-01), XP002211850, retrieved from EBI Database accession no. Q9D4Q6 *
FALETTO M B ET AL: "UNIQUE INTRACELLULAR ACTIVATION OF THE POTENT ANTI-HUMAN IMMUNODEFICIENCY VIRUS AGENT 1592U89", ANTIMICROBIAL AGENTS AND CHEMOTHERAPY, AMERICAN SOCIETY FOR MICROBIOLOGY, WASHINGTON, DC, US, vol. 41, no. 5, 1997, pages 1099 - 1107, XP000886350, ISSN: 0066-4804 *
HATSE S ET AL: "N6-cyclopropyl-PMEDAP: a novel derivative of 9-(2-phosphonylmethoxyethyl)-2,6-diaminopurine (PMEDAP) with distinct metabolic, antiproliferative, and differentiation-inducing properties.", BIOCHEMICAL PHARMACOLOGY. ENGLAND 15 JUL 1999, vol. 58, no. 2, 15 July 1999 (1999-07-15), pages 311 - 323, XP002213675, ISSN: 0006-2952 *

Also Published As

Publication number Publication date
WO2002038743A2 (en) 2002-05-16
AU2002229011A1 (en) 2002-05-21

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