WO2002036747A3 - Peripheral nerve type sodium channels - Google Patents

Peripheral nerve type sodium channels Download PDF

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Publication number
WO2002036747A3
WO2002036747A3 PCT/EP2001/012463 EP0112463W WO0236747A3 WO 2002036747 A3 WO2002036747 A3 WO 2002036747A3 EP 0112463 W EP0112463 W EP 0112463W WO 0236747 A3 WO0236747 A3 WO 0236747A3
Authority
WO
WIPO (PCT)
Prior art keywords
modulators
antagonists
agonists
peripheral nerve
sodium channels
Prior art date
Application number
PCT/EP2001/012463
Other languages
French (fr)
Other versions
WO2002036747A2 (en
Inventor
Edward Leon Barsoumian
Masaki Iizuka
Seiichiro Nishimura
Isamu Akiba
Tetsuo Seki
Original Assignee
Boehringer Ingelheim Int
Edward Leon Barsoumian
Masaki Iizuka
Seiichiro Nishimura
Isamu Akiba
Tetsuo Seki
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Application filed by Boehringer Ingelheim Int, Edward Leon Barsoumian, Masaki Iizuka, Seiichiro Nishimura, Isamu Akiba, Tetsuo Seki filed Critical Boehringer Ingelheim Int
Priority to AU2002215976A priority Critical patent/AU2002215976A1/en
Publication of WO2002036747A2 publication Critical patent/WO2002036747A2/en
Publication of WO2002036747A3 publication Critical patent/WO2002036747A3/en

Links

Classifications

    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07K—PEPTIDES
    • C07K14/00—Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof
    • C07K14/435—Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof from animals; from humans
    • C07K14/705—Receptors; Cell surface antigens; Cell surface determinants

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  • Health & Medical Sciences (AREA)
  • Chemical & Material Sciences (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • Organic Chemistry (AREA)
  • Biochemistry (AREA)
  • Genetics & Genomics (AREA)
  • Gastroenterology & Hepatology (AREA)
  • Toxicology (AREA)
  • Immunology (AREA)
  • Biophysics (AREA)
  • General Health & Medical Sciences (AREA)
  • Zoology (AREA)
  • Medicinal Chemistry (AREA)
  • Molecular Biology (AREA)
  • Proteomics, Peptides & Aminoacids (AREA)
  • Cell Biology (AREA)
  • Micro-Organisms Or Cultivation Processes Thereof (AREA)
  • Medicines That Contain Protein Lipid Enzymes And Other Medicines (AREA)

Abstract

The present invention provides cell lines expressing one or more recombinant peripheral nerve (PN) sodium channels, preferably a human PN sodium channel. The invention also provides methods for preparing said cell lines. The invention furthermore pertains to the use of said cell lines for the identification of PN sodium channel agonists, antagonists or modulators and methods for the identification of said agonists, antagonists or modulators. The invention also provides pharmaceutical compositions comprising said agonists, antagonists or modulators. The invention furthermore is concerned with the use of agonists, antagonists or modulators in the manufacture of a medicament for the treatment of chronic pain disorders.
PCT/EP2001/012463 2000-11-06 2001-10-27 Peripheral nerve type sodium channels WO2002036747A2 (en)

Priority Applications (1)

Application Number Priority Date Filing Date Title
AU2002215976A AU2002215976A1 (en) 2000-11-06 2001-10-27 Peripheral nerve type sodium channels

Applications Claiming Priority (2)

Application Number Priority Date Filing Date Title
DE10054878.4 2000-11-06
DE2000154878 DE10054878A1 (en) 2000-11-06 2000-11-06 Peripheral nerve type sodium channels

Publications (2)

Publication Number Publication Date
WO2002036747A2 WO2002036747A2 (en) 2002-05-10
WO2002036747A3 true WO2002036747A3 (en) 2002-11-07

Family

ID=7662252

Family Applications (1)

Application Number Title Priority Date Filing Date
PCT/EP2001/012463 WO2002036747A2 (en) 2000-11-06 2001-10-27 Peripheral nerve type sodium channels

Country Status (3)

Country Link
AU (1) AU2002215976A1 (en)
DE (1) DE10054878A1 (en)
WO (1) WO2002036747A2 (en)

Families Citing this family (2)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
GB2400103A (en) * 2003-04-02 2004-10-06 Ionix Pharmaceuticals Ltd Cell lines expressing VGSC, Nav1.8
US8183221B2 (en) 2007-09-05 2012-05-22 Medtronic, Inc. Suppression of SCN9A gene expression and/or function for the treatment of pain

Citations (2)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
WO1996014077A1 (en) * 1994-11-02 1996-05-17 Trophix Pharmaceuticals, Inc. Peripheral nervous system specific sodium channels, dna encoding therefor, crystallization, x-ray diffraction, computer molecular modeling, rational drug design, drug screening, and methods of making and using thereof
WO1999047670A1 (en) * 1998-03-18 1999-09-23 Glaxo Group Limited Mammalian sodium channel proteins

Patent Citations (2)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
WO1996014077A1 (en) * 1994-11-02 1996-05-17 Trophix Pharmaceuticals, Inc. Peripheral nervous system specific sodium channels, dna encoding therefor, crystallization, x-ray diffraction, computer molecular modeling, rational drug design, drug screening, and methods of making and using thereof
WO1999047670A1 (en) * 1998-03-18 1999-09-23 Glaxo Group Limited Mammalian sodium channel proteins

Non-Patent Citations (5)

* Cited by examiner, † Cited by third party
Title
DATABASE EMBL 18 May 1999 (1999-05-18), "Homo sapiens tetrodotoxin-resistant voltage-gated sodium channel", XP002198532, Database accession no. AF117907 *
DATABASE EMBL 31 May 1995 (1995-05-31), "H. sapiens mRNA for voltage-activated sodium channel", XP002198531, Database accession no. X82835 *
KLUGBAUER N ET AL: "STRUCTURE AND FUNCTIONAL EXPRESSION OF A NEW MEMBER OF THE TETRODOTOXIN-SENSITIVE VOLTAGE-ACTIVATED SODIUM CHANNEL FAMILY FROMHUMAN NEUROENDOCRINE CELLS", EMBO JOURNAL, OXFORD UNIVERSITY PRESS, SURREY, GB, vol. 14, no. 6, X82835, 15 March 1995 (1995-03-15), pages 1084 - 1090, XP002069908, ISSN: 0261-4189 *
MAO JIANREN ET AL: "Systemic lidocaine for neuropathic pain relief.", PAIN, vol. 87, no. 1, July 2000 (2000-07-01), pages 7 - 17, XP002199480, ISSN: 0304-3959 *
RABERT DOUGLAS K ET AL.: "A tetrodotoxin-resistant voltage-gated sodium channel from human dorsal root ganglia, hPN3/SCN10A", PAIN, vol. 78, no. 2, November 1998 (1998-11-01), pages 107 - 114, XP002198530 *

Also Published As

Publication number Publication date
WO2002036747A2 (en) 2002-05-10
AU2002215976A1 (en) 2002-05-15
DE10054878A1 (en) 2002-05-08

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