WO2002033088A3 - Human carboxypeptidase, scramblase, and protocadherin family members and uses thereof - Google Patents

Human carboxypeptidase, scramblase, and protocadherin family members and uses thereof Download PDF

Info

Publication number
WO2002033088A3
WO2002033088A3 PCT/US2001/046717 US0146717W WO0233088A3 WO 2002033088 A3 WO2002033088 A3 WO 2002033088A3 US 0146717 W US0146717 W US 0146717W WO 0233088 A3 WO0233088 A3 WO 0233088A3
Authority
WO
WIPO (PCT)
Prior art keywords
scramblase
nucleic acid
family members
acid molecules
expression vectors
Prior art date
Application number
PCT/US2001/046717
Other languages
French (fr)
Other versions
WO2002033088A2 (en
Inventor
Rachel A Meyers
Rory A J Curtis
Rosana Kapeller-Libermann
Original Assignee
Millennium Pharm Inc
Rachel A Meyers
Rory A J Curtis
Rosana Kapeller-Libermann
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Application filed by Millennium Pharm Inc, Rachel A Meyers, Rory A J Curtis, Rosana Kapeller-Libermann filed Critical Millennium Pharm Inc
Priority to AU2002227253A priority Critical patent/AU2002227253A1/en
Publication of WO2002033088A2 publication Critical patent/WO2002033088A2/en
Priority to US10/176,306 priority patent/US20030130485A1/en
Publication of WO2002033088A3 publication Critical patent/WO2002033088A3/en
Priority to US10/968,812 priority patent/US20050214893A1/en

Links

Classifications

    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07K—PEPTIDES
    • C07K14/00—Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof
    • C07K14/435—Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof from animals; from humans
    • C07K14/705—Receptors; Cell surface antigens; Cell surface determinants
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07K—PEPTIDES
    • C07K14/00—Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof
    • C07K14/435—Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof from animals; from humans
    • C07K14/46—Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof from animals; from humans from vertebrates
    • C07K14/47—Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof from animals; from humans from vertebrates from mammals
    • C—CHEMISTRY; METALLURGY
    • C12—BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
    • C12N—MICROORGANISMS OR ENZYMES; COMPOSITIONS THEREOF; PROPAGATING, PRESERVING, OR MAINTAINING MICROORGANISMS; MUTATION OR GENETIC ENGINEERING; CULTURE MEDIA
    • C12N9/00—Enzymes; Proenzymes; Compositions thereof; Processes for preparing, activating, inhibiting, separating or purifying enzymes
    • C12N9/14—Hydrolases (3)
    • C12N9/48—Hydrolases (3) acting on peptide bonds (3.4)

Landscapes

  • Health & Medical Sciences (AREA)
  • Chemical & Material Sciences (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • Organic Chemistry (AREA)
  • Zoology (AREA)
  • Genetics & Genomics (AREA)
  • Medicinal Chemistry (AREA)
  • Molecular Biology (AREA)
  • General Health & Medical Sciences (AREA)
  • Biochemistry (AREA)
  • Bioinformatics & Cheminformatics (AREA)
  • Toxicology (AREA)
  • Proteomics, Peptides & Aminoacids (AREA)
  • Biophysics (AREA)
  • Wood Science & Technology (AREA)
  • Gastroenterology & Hepatology (AREA)
  • Engineering & Computer Science (AREA)
  • General Engineering & Computer Science (AREA)
  • Immunology (AREA)
  • Cell Biology (AREA)
  • Biomedical Technology (AREA)
  • Biotechnology (AREA)
  • Microbiology (AREA)
  • Peptides Or Proteins (AREA)
  • Preparation Of Compounds By Using Micro-Organisms (AREA)

Abstract

The invention provides isolated nucleic acids molecules, designated 23566, 33489, and 57779 nucleic acid molecules, which encode novel carboxypeptidase, scramblase, and protocadherin family members, respectively. The invention also provides antisense nucleic acid molecules, recombinant expression vectors containing 23566, 33489, or 57779 nucleic acid molecules, host cells into which the expression vectors have been introduced, and nonhuman transgenic animals in which a 23566, 33489, or 57779 gene has been introduced or disrupted. The invention still further provides isolated 23566, 33489, or 57779 proteins, fusion proteins, antigenic peptides and anti-23566, 33489, or 57779 antibodies. Diagnostic methods utilizing compositions of the invention are also provided.
PCT/US2001/046717 2000-10-20 2001-10-22 Human carboxypeptidase, scramblase, and protocadherin family members and uses thereof WO2002033088A2 (en)

Priority Applications (3)

Application Number Priority Date Filing Date Title
AU2002227253A AU2002227253A1 (en) 2000-10-20 2001-10-22 Human carboxypeptidase, scramblase, and protocadherin family members and uses thereof
US10/176,306 US20030130485A1 (en) 2000-11-14 2002-06-20 Novel human genes and methods of use thereof
US10/968,812 US20050214893A1 (en) 2000-11-14 2004-10-19 Novel human genes and methods of use thereof

Applications Claiming Priority (6)

Application Number Priority Date Filing Date Title
US24198900P 2000-10-20 2000-10-20
US24232400P 2000-10-20 2000-10-20
US60/241,989 2000-10-20
US60/242,324 2000-10-20
US24251800P 2000-10-23 2000-10-23
US60/242,518 2000-10-23

Publications (2)

Publication Number Publication Date
WO2002033088A2 WO2002033088A2 (en) 2002-04-25
WO2002033088A3 true WO2002033088A3 (en) 2003-08-28

Family

ID=27399542

Family Applications (1)

Application Number Title Priority Date Filing Date
PCT/US2001/046717 WO2002033088A2 (en) 2000-10-20 2001-10-22 Human carboxypeptidase, scramblase, and protocadherin family members and uses thereof

Country Status (2)

Country Link
AU (1) AU2002227253A1 (en)
WO (1) WO2002033088A2 (en)

Families Citing this family (1)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
EP1254265A4 (en) * 2000-02-03 2004-06-30 Nuvelo Inc Methods and materials relating to metallocarboxypeptidase-like polypeptides and polynucleotides

Citations (2)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
WO1999006549A2 (en) * 1997-08-01 1999-02-11 Genset 5' ESTs FOR SECRETED PROTEINS EXPRESSED IN TESTIS AND OTHER TISSUES
WO2001057265A1 (en) * 2000-02-03 2001-08-09 Hyseq, Inc. Methods and materials relating to metallocarboxypeptidase-like polypeptides and polynucleotides

Patent Citations (2)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
WO1999006549A2 (en) * 1997-08-01 1999-02-11 Genset 5' ESTs FOR SECRETED PROTEINS EXPRESSED IN TESTIS AND OTHER TISSUES
WO2001057265A1 (en) * 2000-02-03 2001-08-09 Hyseq, Inc. Methods and materials relating to metallocarboxypeptidase-like polypeptides and polynucleotides

Non-Patent Citations (5)

* Cited by examiner, † Cited by third party
Title
BEVERS E M ET AL: "Lipid translocation across the plasma membrane of mammalian cells", BIOCHIMICA ET BIOPHYSICA ACTA, vol. 1439, no. 3, 18 August 1999 (1999-08-18), pages 317 - 330, XP004277203 *
DATABASE EMBL [online] 1 October 2000 (2000-10-01), SATO T ET AL: "Carboxypeptidase R", XP002229284, retrieved from EBI Database accession no. Q9JHH6 *
MATSUMOTO A ET AL: "A NOVEL CARBOXYPEPTIDASE B THAT PROCESSES NATIVE BETA-AMYLOID PRECURSOR PROTEIN IS PRESENT IN HUMAN HIPPOCAMPUS", EUROPEAN JOURNAL OF NEUROSCIENCE, OXFORD UNIVERSITY PRESS, GB, vol. 12, 2000, pages 227 - 238, XP002929025, ISSN: 0953-816X *
ROTH M ET AL: "DETERMINATION OF PANCREATIC CARBOXYPEPTIDASE A IN HUMAN BLOOD SERUM", CLINICA CHIMICA ACTA, AMSTERDAM, NL, vol. 135, 1983, pages 65 - 71, XP001106319, ISSN: 0009-8981 *
SANO K ET AL: "Protocadherins: a large family of cadherin-related molecules in central nervous system", EMBO JOURNAL, OXFORD UNIVERSITY PRESS, SURREY, GB, vol. 12, no. 6, 1993, pages 2249 - 2256, XP002087750, ISSN: 0261-4189 *

Also Published As

Publication number Publication date
WO2002033088A2 (en) 2002-04-25
AU2002227253A1 (en) 2002-04-29

Similar Documents

Publication Publication Date Title
WO2001090323A3 (en) 46638, a putative family member of human lipoxygenase
WO2001090325A3 (en) 50365, a hexokinase family member and uses thereof
WO2002006302A3 (en) 16816 and 16839, novel human phospholipase c molecules and uses therefor
WO2002006330A3 (en) 13237,18480,2245 or 16228 human protein kinase molecules and uses therefor
WO2002016589A3 (en) Human abc transporter family member and uses thereof
WO2002026803A3 (en) 22108 and 47916, novel human thioredoxin family members and uses thereof
WO2001083719A3 (en) 25692, a novel human o-methyltransferase family member and uses thereof
WO2001094563A3 (en) 46980, a novel human neuroligin family member and uses thereof
WO2001066764A3 (en) 16835, a human phospholipase c and uses thereof
WO2001090146A3 (en) 57256 and 58289, human transporters and uses thereof
WO2002020801A3 (en) 26199, 33530, 33949, 47148, 50226, and 58764, human transferase family members and uses therefor
WO2001090145A3 (en) 57805, a human cadherin family member and uses thereof
WO2002018439A3 (en) 52991, a human transporter protein and uses therefor
WO2002033088A3 (en) Human carboxypeptidase, scramblase, and protocadherin family members and uses thereof
WO2002038773A3 (en) A human phospholipase c and uses thereof
WO2002050256A3 (en) 53010, a human carboxylesterase family member and uses thereof
WO2001073051A3 (en) 46743 and 27417, novel human acyltransferase family members and uses therefor
WO2002008400A3 (en) 25233, a human aminotransferase and uses therefor
WO2002029040A3 (en) 25219, a novel human aminotransferase and uses therefor
WO2001079498A3 (en) 16051a and 16051b, novel human pdz family members and uses thereof
WO2002055682A3 (en) 56634, a novel human phosphatidylinositol 4-phosphate 5-kinase family member and uses thereof
WO2002002761A3 (en) 57658, a human uridine kinase and uses thereof
WO2002010401A3 (en) 18431 and 32374, human protein kinase family members and uses therefor
WO2002024911A3 (en) 63760, a novel human transporter and uses thereof
WO2002008397A3 (en) A human atpase and uses therefor

Legal Events

Date Code Title Description
AK Designated states

Kind code of ref document: A2

Designated state(s): AE AG AL AM AT AU AZ BA BB BG BR BY BZ CA CH CN CO CR CU CZ DE DK DM DZ EC EE ES FI GB GD GE GH GM HR HU ID IL IN IS JP KE KG KP KR KZ LC LK LR LS LT LU LV MA MD MG MK MN MW MX MZ NO NZ PH PL PT RO RU SD SE SG SI SK SL TJ TM TR TT TZ UA UG US UZ VN YU ZA ZW

AL Designated countries for regional patents

Kind code of ref document: A2

Designated state(s): GH GM KE LS MW MZ SD SL SZ TZ UG ZW AM AZ BY KG KZ MD RU TJ TM AT BE CH CY DE DK ES FI FR GB GR IE IT LU MC NL PT SE TR BF BJ CF CG CI CM GA GN GQ GW ML MR NE SN TD TG

WWE Wipo information: entry into national phase

Ref document number: 10176306

Country of ref document: US

121 Ep: the epo has been informed by wipo that ep was designated in this application
DFPE Request for preliminary examination filed prior to expiration of 19th month from priority date (pct application filed before 20040101)
REG Reference to national code

Ref country code: DE

Ref legal event code: 8642

122 Ep: pct application non-entry in european phase
NENP Non-entry into the national phase

Ref country code: JP