WO2002031496A3 - Device for determining skin aging in vitro - Google Patents

Device for determining skin aging in vitro Download PDF

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Publication number
WO2002031496A3
WO2002031496A3 PCT/EP2001/011281 EP0111281W WO0231496A3 WO 2002031496 A3 WO2002031496 A3 WO 2002031496A3 EP 0111281 W EP0111281 W EP 0111281W WO 0231496 A3 WO0231496 A3 WO 0231496A3
Authority
WO
WIPO (PCT)
Prior art keywords
skin
stress
aging
vitro
skin aging
Prior art date
Application number
PCT/EP2001/011281
Other languages
German (de)
French (fr)
Other versions
WO2002031496A2 (en
Inventor
Dirk Petersohn
Guenter Schmitt
Thomas Foerster
Original Assignee
Henkel Kgaa
Dirk Petersohn
Guenter Schmitt
Thomas Foerster
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Application filed by Henkel Kgaa, Dirk Petersohn, Guenter Schmitt, Thomas Foerster filed Critical Henkel Kgaa
Priority to AU2002213982A priority Critical patent/AU2002213982A1/en
Publication of WO2002031496A2 publication Critical patent/WO2002031496A2/en
Publication of WO2002031496A3 publication Critical patent/WO2002031496A3/en

Links

Classifications

    • G—PHYSICS
    • G01—MEASURING; TESTING
    • G01N—INVESTIGATING OR ANALYSING MATERIALS BY DETERMINING THEIR CHEMICAL OR PHYSICAL PROPERTIES
    • G01N33/00—Investigating or analysing materials by specific methods not covered by groups G01N1/00 - G01N31/00
    • G01N33/48—Biological material, e.g. blood, urine; Haemocytometers
    • G01N33/50—Chemical analysis of biological material, e.g. blood, urine; Testing involving biospecific ligand binding methods; Immunological testing
    • G01N33/5005—Chemical analysis of biological material, e.g. blood, urine; Testing involving biospecific ligand binding methods; Immunological testing involving human or animal cells
    • G01N33/5008—Chemical analysis of biological material, e.g. blood, urine; Testing involving biospecific ligand binding methods; Immunological testing involving human or animal cells for testing or evaluating the effect of chemical or biological compounds, e.g. drugs, cosmetics
    • G01N33/5082—Supracellular entities, e.g. tissue, organisms
    • G01N33/5088—Supracellular entities, e.g. tissue, organisms of vertebrates
    • G—PHYSICS
    • G01—MEASURING; TESTING
    • G01N—INVESTIGATING OR ANALYSING MATERIALS BY DETERMINING THEIR CHEMICAL OR PHYSICAL PROPERTIES
    • G01N33/00—Investigating or analysing materials by specific methods not covered by groups G01N1/00 - G01N31/00
    • G01N33/48—Biological material, e.g. blood, urine; Haemocytometers
    • G01N33/50—Chemical analysis of biological material, e.g. blood, urine; Testing involving biospecific ligand binding methods; Immunological testing
    • G01N33/68—Chemical analysis of biological material, e.g. blood, urine; Testing involving biospecific ligand binding methods; Immunological testing involving proteins, peptides or amino acids
    • G01N33/6881—Chemical analysis of biological material, e.g. blood, urine; Testing involving biospecific ligand binding methods; Immunological testing involving proteins, peptides or amino acids from skin

Landscapes

  • Health & Medical Sciences (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • Engineering & Computer Science (AREA)
  • Biomedical Technology (AREA)
  • Immunology (AREA)
  • Molecular Biology (AREA)
  • Chemical & Material Sciences (AREA)
  • Urology & Nephrology (AREA)
  • Hematology (AREA)
  • Cell Biology (AREA)
  • General Health & Medical Sciences (AREA)
  • Medicinal Chemistry (AREA)
  • Microbiology (AREA)
  • Food Science & Technology (AREA)
  • General Physics & Mathematics (AREA)
  • Physics & Mathematics (AREA)
  • Analytical Chemistry (AREA)
  • Pathology (AREA)
  • Biochemistry (AREA)
  • Biotechnology (AREA)
  • Proteomics, Peptides & Aminoacids (AREA)
  • Bioinformatics & Cheminformatics (AREA)
  • Toxicology (AREA)
  • Tropical Medicine & Parasitology (AREA)
  • Cosmetics (AREA)
  • Investigating Or Analysing Biological Materials (AREA)
  • Measuring And Recording Apparatus For Diagnosis (AREA)

Abstract

The invention relates to a method for determining skin stress and/or skin aging in humans or animals in vitro. The invention further relates to test kits for determining skin stress and/or skin aging and to the use of spondin 2, cathepsin L, vimentin fragments or actin gamma 1 as a stress and/or aging marker of the skin. The invention also relates to a method for analyzing the effectiveness of cosmetic or pharmaceutical active substances against skin stress and/or skin aging, and to agents for regulating, especially maintaining, homeostasis of human and animal skin.
PCT/EP2001/011281 2000-10-09 2001-09-29 Device for determining skin aging in vitro WO2002031496A2 (en)

Priority Applications (1)

Application Number Priority Date Filing Date Title
AU2002213982A AU2002213982A1 (en) 2000-10-09 2001-09-29 Device for determining skin aging in vitro

Applications Claiming Priority (2)

Application Number Priority Date Filing Date Title
DE2000150274 DE10050274A1 (en) 2000-10-09 2000-10-09 In vitro assays for skin stress and skin ageing includes determination of spondin 2, cathepsin L, actin gamma 1 and vimentin fragments secreted by skin fibroblasts
DE10050274.1 2000-10-09

Publications (2)

Publication Number Publication Date
WO2002031496A2 WO2002031496A2 (en) 2002-04-18
WO2002031496A3 true WO2002031496A3 (en) 2002-12-12

Family

ID=7659356

Family Applications (1)

Application Number Title Priority Date Filing Date
PCT/EP2001/011281 WO2002031496A2 (en) 2000-10-09 2001-09-29 Device for determining skin aging in vitro

Country Status (3)

Country Link
AU (1) AU2002213982A1 (en)
DE (1) DE10050274A1 (en)
WO (1) WO2002031496A2 (en)

Cited By (1)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
US8148093B2 (en) 2003-08-15 2012-04-03 Diadexus, Inc. Pro108 antibody compositions and methods of use and use of Pro108 to assess cancer risk

Families Citing this family (8)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
DE10100127A1 (en) * 2001-01-03 2002-10-02 Henkel Kgaa Procedure for determining the homeostasis of the skin
DE10100121A1 (en) * 2001-01-03 2002-08-01 Henkel Kgaa Method for determining skin stress or skin aging in vitro
DE10229981A1 (en) * 2002-07-03 2004-02-05 Henkel Kgaa Procedure for the identification of infection-specific regulated genes of the skin
FR2849202A1 (en) * 2002-12-20 2004-06-25 Oreal Evaluating the cosmetic activity of a product comprises contacting the product with a plant material and determining the change in a mechanical, optical or physicochemical parameter
FR2923610B1 (en) * 2007-11-14 2009-11-27 Galderma Res & Dev NON-INVASIVE METHOD OF COLLECTING BIOLOGICAL DATA FOR THE ESTABLISHMENT OF DIAGNOSIS OF SKIN PATHOLOGY.
JP6042904B2 (en) * 2011-11-25 2016-12-14 シャネル パフュームズ ビューテ Novel markers of papillary and reticulated fibroblasts and uses thereof
US9254311B2 (en) 2012-04-02 2016-02-09 Moderna Therapeutics, Inc. Modified polynucleotides for the production of proteins
AU2013243951A1 (en) * 2012-04-02 2014-10-30 Moderna Therapeutics, Inc. Modified polynucleotides for the production of secreted proteins

Citations (2)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
WO1998045442A2 (en) * 1997-04-10 1998-10-15 Zymogenetics, Inc. Secreted f-spondin homologs
WO1998050073A1 (en) * 1997-05-09 1998-11-12 Smithkline Beecham Corporation Integrin ligand, human mindin

Family Cites Families (5)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
PT851028E (en) * 1996-12-24 2007-02-28 Nestle Sa Immortalized human epithelial cell line from cornea
FR2757635B1 (en) * 1996-12-24 1999-02-05 Oreal METHOD FOR EVALUATING UV-A DAMAGE TO THE SKIN
FR2767833B1 (en) * 1997-08-29 2001-03-02 Oreal ISOLATED SKIN POLYPEPTIDE AND ITS USE
US6476193B1 (en) * 1998-10-06 2002-11-05 Curagen Corporation NLK1 protein and NLK1 protein complexes
FR2791259B1 (en) * 1999-03-24 2001-08-17 Roche Posay Lab Pharma USE OF VITAMIN C OR THE LIKE TO INCREASE THE RATE OF DIFFERENTIATION AND / OR PROLIFERATION OF SKIN CELLS

Patent Citations (2)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
WO1998045442A2 (en) * 1997-04-10 1998-10-15 Zymogenetics, Inc. Secreted f-spondin homologs
WO1998050073A1 (en) * 1997-05-09 1998-11-12 Smithkline Beecham Corporation Integrin ligand, human mindin

Non-Patent Citations (9)

* Cited by examiner, † Cited by third party
Title
CLOUGH G: "Experimental models of skin inflammation.", CLINICAL AND EXPERIMENTAL ALLERGY, vol. 29, no. SUPPL. 3, July 1999 (1999-07-01), pages 105 - 108, XP001097102, ISSN: 0954-7894 *
DATABASE EMBL [online] XP002207068, retrieved from EMBL Database accession no. AAW83328 *
DATABASE EMBL [online] XP002207069, retrieved from EMBL Database accession no. AAW70589 *
DJAVAHERI-MERGNY M ET AL: "Early alterations of actin in cultured human keratinocytes and fibroblasts exposed to long-wavelength radiations. Possible involvement in the UVA-induced perturbations of endocytotic processes.", PHOTOCHEMISTRY AND PHOTOBIOLOGY. UNITED STATES JAN 1994, vol. 59, no. 1, January 1994 (1994-01-01), pages 48 - 52, XP002207708, ISSN: 0031-8655 *
KROGSTAD ANNE LENE: "Neurogenic control of blood flow and histamine release in psoriatic skin.", ACTA DERMATO-VENEREOLOGICA SUPPLEMENTUM, no. 203, 1999, pages 7 - 37, XP008006129, ISSN: 0365-8341 *
LEMAIRE R ET AL: "Selective induction of the secretion of cathepsins B and L by cytokines in synovial fibroblast-like cells.", BRITISH JOURNAL OF RHEUMATOLOGY. ENGLAND JUL 1997, vol. 36, no. 7, July 1997 (1997-07-01), pages 735 - 743, XP008005949, ISSN: 0263-7103 *
PRASAD SARADA C ET AL: "Apoptosis-associated proteolysis of vimentin in human prostate epithelial tumor cells", BIOCHEMICAL AND BIOPHYSICAL RESEARCH COMMUNICATIONS, ACADEMIC PRESS INC. ORLANDO, FL, US, vol. 249, no. 2, 19 August 1998 (1998-08-19), pages 332 - 338, XP002150824, ISSN: 0006-291X *
RAFFERTY N S ET AL: "Comparative response to UV irradiation of cytoskeletal elements in rabbit and skate lens epithelial cells.", CURRENT EYE RESEARCH. ENGLAND APR 1997, vol. 16, no. 4, April 1997 (1997-04-01), pages 310 - 319, XP008006194, ISSN: 0271-3683 *
YANAGIDA M ET AL: "Matrix assisted laser desorption/ionization-time of flight-mass spectrometry analysis of proteins detected by anti-phosphotyrosine antibody on two-dimensional-gels of fibrolast cell lysates after tumor necrosis factor-alpha stimulation.", ELECTROPHORESIS. GERMANY MAY 2000, vol. 21, no. 9, May 2000 (2000-05-01), pages 1890 - 1898, XP002206924, ISSN: 0173-0835 *

Cited By (1)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
US8148093B2 (en) 2003-08-15 2012-04-03 Diadexus, Inc. Pro108 antibody compositions and methods of use and use of Pro108 to assess cancer risk

Also Published As

Publication number Publication date
DE10050274A1 (en) 2002-04-18
WO2002031496A2 (en) 2002-04-18
AU2002213982A1 (en) 2002-04-22

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