WO2002031132A3 - 8843, a human dual specificity phosphatase family member and uses therefor - Google Patents

8843, a human dual specificity phosphatase family member and uses therefor Download PDF

Info

Publication number
WO2002031132A3
WO2002031132A3 PCT/US2001/031661 US0131661W WO0231132A3 WO 2002031132 A3 WO2002031132 A3 WO 2002031132A3 US 0131661 W US0131661 W US 0131661W WO 0231132 A3 WO0231132 A3 WO 0231132A3
Authority
WO
WIPO (PCT)
Prior art keywords
dual specificity
specificity phosphatase
family member
uses therefor
phosphatase family
Prior art date
Application number
PCT/US2001/031661
Other languages
French (fr)
Other versions
WO2002031132A2 (en
Inventor
Nadine Weich
Original Assignee
Millennium Pharm Inc
Nadine Weich
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Application filed by Millennium Pharm Inc, Nadine Weich filed Critical Millennium Pharm Inc
Priority to AU2002211597A priority Critical patent/AU2002211597A1/en
Priority to EP01979662A priority patent/EP1402010A2/en
Publication of WO2002031132A2 publication Critical patent/WO2002031132A2/en
Publication of WO2002031132A3 publication Critical patent/WO2002031132A3/en

Links

Classifications

    • C—CHEMISTRY; METALLURGY
    • C12—BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
    • C12N—MICROORGANISMS OR ENZYMES; COMPOSITIONS THEREOF; PROPAGATING, PRESERVING, OR MAINTAINING MICROORGANISMS; MUTATION OR GENETIC ENGINEERING; CULTURE MEDIA
    • C12N9/00—Enzymes; Proenzymes; Compositions thereof; Processes for preparing, activating, inhibiting, separating or purifying enzymes
    • C12N9/14—Hydrolases (3)
    • C12N9/16—Hydrolases (3) acting on ester bonds (3.1)
    • A—HUMAN NECESSITIES
    • A01—AGRICULTURE; FORESTRY; ANIMAL HUSBANDRY; HUNTING; TRAPPING; FISHING
    • A01K—ANIMAL HUSBANDRY; CARE OF BIRDS, FISHES, INSECTS; FISHING; REARING OR BREEDING ANIMALS, NOT OTHERWISE PROVIDED FOR; NEW BREEDS OF ANIMALS
    • A01K2217/00—Genetically modified animals
    • A01K2217/07—Animals genetically altered by homologous recombination
    • A01K2217/075—Animals genetically altered by homologous recombination inducing loss of function, i.e. knock out
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07K—PEPTIDES
    • C07K2319/00—Fusion polypeptide

Abstract

The invention provides isolated nucleic acids molecules, designated 8843 nucleic acid molecules, which encode novel dual specificity phosphatase members. The invention also provides methods of modulating the differentiation and proliferation of erythroid progenitors, and CD34 positive cells. The invention further provides methods of treating, preventing and diagnosing eythroid-associated disorders such as anemias, leukemias, and erythrocytosis.
PCT/US2001/031661 2000-10-11 2001-10-10 8843, a human dual specificity phosphatase family member and uses therefor WO2002031132A2 (en)

Priority Applications (2)

Application Number Priority Date Filing Date Title
AU2002211597A AU2002211597A1 (en) 2000-10-11 2001-10-10 8843, a human dual specificity phosphatase family member and uses therefor
EP01979662A EP1402010A2 (en) 2000-10-11 2001-10-10 8843, a human dual specificity phosphatase family member and uses therefor

Applications Claiming Priority (2)

Application Number Priority Date Filing Date Title
US68667300A 2000-10-11 2000-10-11
US09/686,673 2000-10-11

Publications (2)

Publication Number Publication Date
WO2002031132A2 WO2002031132A2 (en) 2002-04-18
WO2002031132A3 true WO2002031132A3 (en) 2003-03-13

Family

ID=24757266

Family Applications (1)

Application Number Title Priority Date Filing Date
PCT/US2001/031661 WO2002031132A2 (en) 2000-10-11 2001-10-10 8843, a human dual specificity phosphatase family member and uses therefor

Country Status (3)

Country Link
EP (1) EP1402010A2 (en)
AU (1) AU2002211597A1 (en)
WO (1) WO2002031132A2 (en)

Citations (4)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
WO1999015658A2 (en) * 1997-09-23 1999-04-01 Incyte Pharmaceuticals, Inc. Human regulatory molecules
WO2000018890A2 (en) * 1998-09-30 2000-04-06 Millennium Pharmaceuticals, Inc. Protein phosphatase molecules and uses therefor
WO2001055301A2 (en) * 2000-01-31 2001-08-02 Human Genome Sciences, Inc. Nucleic acids, proteins, and antibodies
WO2001092491A2 (en) * 2000-05-30 2001-12-06 Sugen, Inc. Mammalian protein phosphatases identified by in-silico analysis

Patent Citations (5)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
WO1999015658A2 (en) * 1997-09-23 1999-04-01 Incyte Pharmaceuticals, Inc. Human regulatory molecules
WO2000018890A2 (en) * 1998-09-30 2000-04-06 Millennium Pharmaceuticals, Inc. Protein phosphatase molecules and uses therefor
WO2001055301A2 (en) * 2000-01-31 2001-08-02 Human Genome Sciences, Inc. Nucleic acids, proteins, and antibodies
WO2001055163A1 (en) * 2000-01-31 2001-08-02 Human Genome Sciences, Inc. Nucleic acids, proteins, and antibodies
WO2001092491A2 (en) * 2000-05-30 2001-12-06 Sugen, Inc. Mammalian protein phosphatases identified by in-silico analysis

Non-Patent Citations (5)

* Cited by examiner, † Cited by third party
Title
DATABASE GSP [online] 17 December 2001 (2001-12-17), ROSEN CA ET AL: "Novel human enzyme polypeptide #606", XP002222369, retrieved from EBI Database accession no. AAU23520 *
DATABASE GSP [online] 4 December 2001 (2001-12-04), ROSEN CA ET AL: "Novel human neoplastic disease associated polypeptide #141", XP002222370, retrieved from EBI Database accession no. AAU21708 *
DATABASE GSP [online] 4 December 2001 (2001-12-04), ROSEN CA ET AL: "Novel human neoplastic disease associated polypeptide #258.", XP002222371, retrieved from EBI Database accession no. AAU21825 *
FAUMAN E B ET AL: "Structure and function of the protein tyrosine phosphatases", TIBS TRENDS IN BIOCHEMICAL SCIENCES, ELSEVIER PUBLICATION, CAMBRIDGE, EN, vol. 21, no. 11, 1 November 1996 (1996-11-01), pages 413 - 417, XP004071016, ISSN: 0968-0004 *
MARTELL K J ET AL: "THE VH1-LIKE DUAL-SPECIFICITY PROTEIN TYROSINE PHOSPHATASES", MOLECULAR AND CELLS, KOREAN SOCIETY FOR MOLECULAR SOCIETY, KR, vol. 8, no. 1, 28 February 1998 (1998-02-28), pages 2 - 11, XP001057593 *

Also Published As

Publication number Publication date
WO2002031132A2 (en) 2002-04-18
EP1402010A2 (en) 2004-03-31
AU2002211597A1 (en) 2002-04-22

Similar Documents

Publication Publication Date Title
WO2001070977A3 (en) Fibroblast growth factor receptor-like molecules and uses thereof
WO1999054459A8 (en) Nucleic acid molecules with novel chemical compositions capable of modulating gene expression
WO2003012057A3 (en) Antisense modulation of serum amyloid a4 expression
WO1999036550A3 (en) Human protease molecules
WO1999038972A3 (en) Human genes and gene expression products ii
WO2000028090A3 (en) Diagnostic assay for cancer
WO1999053061A3 (en) Tumor associated nucleic acids and uses therefor
WO2001061007A3 (en) Fibroblast growth factor-23 molecules and uses thereof
WO2001068854A3 (en) Fibroblast growth factor-like molecules and uses thereof
CA2284142A1 (en) Compositions containing lysophosphotidic acids which inhibit apoptosis and uses thereof
WO2001042474A3 (en) Interferon-like molecules and uses thereof
WO1999002704A3 (en) Dual specifically phosphatase and methods of use
WO2001016334A3 (en) Human hydrolytic enzymes
WO2002062818A3 (en) Antisense modulation of casein kinase 2-alpha expression
WO2002097046A3 (en) B7 related protein-2 molecules and uses thereof
WO2001032888A3 (en) Human transferase molecules
WO2002031132A3 (en) 8843, a human dual specificity phosphatase family member and uses therefor
WO1998049317A3 (en) Diagnosis and treatment of phosphatase- 0r kinase-related disorders
WO2003055980A3 (en) Il-17 like molecules and uses thereof
WO1999041373A3 (en) Human transport-associated molecules
WO2003070965A3 (en) The eaat2 promoter and uses thereof
WO2002055725A3 (en) Novel nucleic acids, methods and transformed cells for the modulation of gibberellin production
WO1999049037A3 (en) Protein phosphatase-related molecules
WO2000018916A3 (en) Human genes and gene expression products
WO2001044269A3 (en) Brain protein markers

Legal Events

Date Code Title Description
AK Designated states

Kind code of ref document: A2

Designated state(s): AE AG AL AM AT AU AZ BA BB BG BR BY BZ CA CH CN CO CR CU CZ DE DK DM DZ EC EE ES FI GB GD GE GH GM HR HU ID IL IN IS JP KE KG KP KR KZ LC LK LR LS LT LU LV MA MD MG MK MN MW MX MZ NO NZ PL PT RO RU SD SE SG SI SK SL TJ TM TR TT TZ UA UG US UZ VN YU ZA ZW

AL Designated countries for regional patents

Kind code of ref document: A2

Designated state(s): GH GM KE LS MW MZ SD SL SZ TZ UG ZW AM AZ BY KG KZ MD RU TJ TM AT BE CH CY DE DK ES FI FR GB GR IE IT LU MC NL PT SE TR BF BJ CF CG CI CM GA GN GQ GW ML MR NE SN TD TG

DFPE Request for preliminary examination filed prior to expiration of 19th month from priority date (pct application filed before 20040101)
121 Ep: the epo has been informed by wipo that ep was designated in this application
REG Reference to national code

Ref country code: DE

Ref legal event code: 8642

WWE Wipo information: entry into national phase

Ref document number: 2001979662

Country of ref document: EP

WWP Wipo information: published in national office

Ref document number: 2001979662

Country of ref document: EP

NENP Non-entry into the national phase

Ref country code: JP