WO2002030558A3 - A linker and a method of chemical synthesis - Google Patents

A linker and a method of chemical synthesis Download PDF

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Publication number
WO2002030558A3
WO2002030558A3 PCT/GB2001/004513 GB0104513W WO0230558A3 WO 2002030558 A3 WO2002030558 A3 WO 2002030558A3 GB 0104513 W GB0104513 W GB 0104513W WO 0230558 A3 WO0230558 A3 WO 0230558A3
Authority
WO
WIPO (PCT)
Prior art keywords
linker
chemical synthesis
linkers
allow easy
allow
Prior art date
Application number
PCT/GB2001/004513
Other languages
French (fr)
Other versions
WO2002030558A2 (en
Inventor
George William Weaver
Adrian Smith
Derek Adeymi Palmer
Martin Thomas French
Original Assignee
Kalibrant Ltd
George William Weaver
Adrian Smith
Derek Adeymi Palmer
Martin Thomas French
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Application filed by Kalibrant Ltd, George William Weaver, Adrian Smith, Derek Adeymi Palmer, Martin Thomas French filed Critical Kalibrant Ltd
Priority to AU2001292140A priority Critical patent/AU2001292140A1/en
Publication of WO2002030558A2 publication Critical patent/WO2002030558A2/en
Publication of WO2002030558A3 publication Critical patent/WO2002030558A3/en

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    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D401/00—Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, at least one ring being a six-membered ring with only one nitrogen atom
    • C07D401/14—Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, at least one ring being a six-membered ring with only one nitrogen atom containing three or more hetero rings
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D213/00—Heterocyclic compounds containing six-membered rings, not condensed with other rings, with one nitrogen atom as the only ring hetero atom and three or more double bonds between ring members or between ring members and non-ring members
    • C07D213/02—Heterocyclic compounds containing six-membered rings, not condensed with other rings, with one nitrogen atom as the only ring hetero atom and three or more double bonds between ring members or between ring members and non-ring members having three double bonds between ring members or between ring members and non-ring members
    • C07D213/04—Heterocyclic compounds containing six-membered rings, not condensed with other rings, with one nitrogen atom as the only ring hetero atom and three or more double bonds between ring members or between ring members and non-ring members having three double bonds between ring members or between ring members and non-ring members having no bond between the ring nitrogen atom and a non-ring member or having only hydrogen or carbon atoms directly attached to the ring nitrogen atom
    • C07D213/24—Heterocyclic compounds containing six-membered rings, not condensed with other rings, with one nitrogen atom as the only ring hetero atom and three or more double bonds between ring members or between ring members and non-ring members having three double bonds between ring members or between ring members and non-ring members having no bond between the ring nitrogen atom and a non-ring member or having only hydrogen or carbon atoms directly attached to the ring nitrogen atom with substituted hydrocarbon radicals attached to ring carbon atoms
    • C07D213/54—Radicals substituted by carbon atoms having three bonds to hetero atoms with at the most one bond to halogen, e.g. ester or nitrile radicals
    • C07D213/56—Amides
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D213/00—Heterocyclic compounds containing six-membered rings, not condensed with other rings, with one nitrogen atom as the only ring hetero atom and three or more double bonds between ring members or between ring members and non-ring members
    • C07D213/02—Heterocyclic compounds containing six-membered rings, not condensed with other rings, with one nitrogen atom as the only ring hetero atom and three or more double bonds between ring members or between ring members and non-ring members having three double bonds between ring members or between ring members and non-ring members
    • C07D213/04—Heterocyclic compounds containing six-membered rings, not condensed with other rings, with one nitrogen atom as the only ring hetero atom and three or more double bonds between ring members or between ring members and non-ring members having three double bonds between ring members or between ring members and non-ring members having no bond between the ring nitrogen atom and a non-ring member or having only hydrogen or carbon atoms directly attached to the ring nitrogen atom
    • C07D213/60—Heterocyclic compounds containing six-membered rings, not condensed with other rings, with one nitrogen atom as the only ring hetero atom and three or more double bonds between ring members or between ring members and non-ring members having three double bonds between ring members or between ring members and non-ring members having no bond between the ring nitrogen atom and a non-ring member or having only hydrogen or carbon atoms directly attached to the ring nitrogen atom with hetero atoms or with carbon atoms having three bonds to hetero atoms with at the most one bond to halogen, e.g. ester or nitrile radicals, directly attached to ring carbon atoms
    • C07D213/61—Halogen atoms or nitro radicals
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D213/00—Heterocyclic compounds containing six-membered rings, not condensed with other rings, with one nitrogen atom as the only ring hetero atom and three or more double bonds between ring members or between ring members and non-ring members
    • C07D213/02—Heterocyclic compounds containing six-membered rings, not condensed with other rings, with one nitrogen atom as the only ring hetero atom and three or more double bonds between ring members or between ring members and non-ring members having three double bonds between ring members or between ring members and non-ring members
    • C07D213/04—Heterocyclic compounds containing six-membered rings, not condensed with other rings, with one nitrogen atom as the only ring hetero atom and three or more double bonds between ring members or between ring members and non-ring members having three double bonds between ring members or between ring members and non-ring members having no bond between the ring nitrogen atom and a non-ring member or having only hydrogen or carbon atoms directly attached to the ring nitrogen atom
    • C07D213/60—Heterocyclic compounds containing six-membered rings, not condensed with other rings, with one nitrogen atom as the only ring hetero atom and three or more double bonds between ring members or between ring members and non-ring members having three double bonds between ring members or between ring members and non-ring members having no bond between the ring nitrogen atom and a non-ring member or having only hydrogen or carbon atoms directly attached to the ring nitrogen atom with hetero atoms or with carbon atoms having three bonds to hetero atoms with at the most one bond to halogen, e.g. ester or nitrile radicals, directly attached to ring carbon atoms
    • C07D213/72—Nitrogen atoms
    • C07D213/74—Amino or imino radicals substituted by hydrocarbon or substituted hydrocarbon radicals
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D213/00—Heterocyclic compounds containing six-membered rings, not condensed with other rings, with one nitrogen atom as the only ring hetero atom and three or more double bonds between ring members or between ring members and non-ring members
    • C07D213/02—Heterocyclic compounds containing six-membered rings, not condensed with other rings, with one nitrogen atom as the only ring hetero atom and three or more double bonds between ring members or between ring members and non-ring members having three double bonds between ring members or between ring members and non-ring members
    • C07D213/04—Heterocyclic compounds containing six-membered rings, not condensed with other rings, with one nitrogen atom as the only ring hetero atom and three or more double bonds between ring members or between ring members and non-ring members having three double bonds between ring members or between ring members and non-ring members having no bond between the ring nitrogen atom and a non-ring member or having only hydrogen or carbon atoms directly attached to the ring nitrogen atom
    • C07D213/60—Heterocyclic compounds containing six-membered rings, not condensed with other rings, with one nitrogen atom as the only ring hetero atom and three or more double bonds between ring members or between ring members and non-ring members having three double bonds between ring members or between ring members and non-ring members having no bond between the ring nitrogen atom and a non-ring member or having only hydrogen or carbon atoms directly attached to the ring nitrogen atom with hetero atoms or with carbon atoms having three bonds to hetero atoms with at the most one bond to halogen, e.g. ester or nitrile radicals, directly attached to ring carbon atoms
    • C07D213/72—Nitrogen atoms
    • C07D213/76—Nitrogen atoms to which a second hetero atom is attached
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D213/00—Heterocyclic compounds containing six-membered rings, not condensed with other rings, with one nitrogen atom as the only ring hetero atom and three or more double bonds between ring members or between ring members and non-ring members
    • C07D213/02—Heterocyclic compounds containing six-membered rings, not condensed with other rings, with one nitrogen atom as the only ring hetero atom and three or more double bonds between ring members or between ring members and non-ring members having three double bonds between ring members or between ring members and non-ring members
    • C07D213/04—Heterocyclic compounds containing six-membered rings, not condensed with other rings, with one nitrogen atom as the only ring hetero atom and three or more double bonds between ring members or between ring members and non-ring members having three double bonds between ring members or between ring members and non-ring members having no bond between the ring nitrogen atom and a non-ring member or having only hydrogen or carbon atoms directly attached to the ring nitrogen atom
    • C07D213/60—Heterocyclic compounds containing six-membered rings, not condensed with other rings, with one nitrogen atom as the only ring hetero atom and three or more double bonds between ring members or between ring members and non-ring members having three double bonds between ring members or between ring members and non-ring members having no bond between the ring nitrogen atom and a non-ring member or having only hydrogen or carbon atoms directly attached to the ring nitrogen atom with hetero atoms or with carbon atoms having three bonds to hetero atoms with at the most one bond to halogen, e.g. ester or nitrile radicals, directly attached to ring carbon atoms
    • C07D213/72—Nitrogen atoms
    • C07D213/76—Nitrogen atoms to which a second hetero atom is attached
    • C07D213/77—Hydrazine radicals

Abstract

The present invention provides dockable linkers (10) for solid phase synthesis. These linkers (10) would allow reactions to be conducted in homogeneous solution but still allow easy isolation and purification of reaction products at each step of a synthetic route. The process would also allow easy analysis of all intermediates generated.
PCT/GB2001/004513 2000-10-11 2001-10-10 A linker and a method of chemical synthesis WO2002030558A2 (en)

Priority Applications (1)

Application Number Priority Date Filing Date Title
AU2001292140A AU2001292140A1 (en) 2000-10-11 2001-10-10 A linker and a method of chemical synthesis

Applications Claiming Priority (2)

Application Number Priority Date Filing Date Title
GB0024941.7 2000-10-11
GB0024941A GB2367818A (en) 2000-10-11 2000-10-11 A linker and a method of chemical synthesis

Publications (2)

Publication Number Publication Date
WO2002030558A2 WO2002030558A2 (en) 2002-04-18
WO2002030558A3 true WO2002030558A3 (en) 2002-09-06

Family

ID=9901098

Family Applications (1)

Application Number Title Priority Date Filing Date
PCT/GB2001/004513 WO2002030558A2 (en) 2000-10-11 2001-10-10 A linker and a method of chemical synthesis

Country Status (3)

Country Link
AU (1) AU2001292140A1 (en)
GB (1) GB2367818A (en)
WO (1) WO2002030558A2 (en)

Families Citing this family (4)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
US20050106602A1 (en) * 2003-11-17 2005-05-19 Hashem Akhavan-Tafti Simplified methods for isolating nucleic acids from cellular materials
US20050106589A1 (en) * 2003-11-17 2005-05-19 Hashem Akhavan-Tafti Compositions and methods for releasing nucleic acids from solid phase binding materials
EP1741486A1 (en) * 2005-07-07 2007-01-10 Total Petrochemicals Research Feluy Catalyst systems based on macrocyclic ligands
CN111171071B (en) * 2020-01-17 2024-01-23 武汉大学 N, O-type multi-tooth functional monomer, preparation method thereof and application thereof in ion imprinting material

Citations (13)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
WO1994003593A1 (en) * 1992-08-04 1994-02-17 The State Of Oregon Acting By And Through The State Board Of Higher Education On Behalf Of The University Of Oregon Amplifier molecules for enhancement of diagnosis and therapy
WO1996018592A1 (en) * 1994-12-10 1996-06-20 Smithkline Beecham Plc Resin-bound phosphonium salts and their use in organic synthesis
WO1997042230A1 (en) * 1996-05-03 1997-11-13 Warner-Lambert Company Rapid purification by polymer supported quench
WO1998006739A1 (en) * 1996-08-16 1998-02-19 Clontech Laboratories, Inc. Method for purification of recombinant proteins
WO1999041216A1 (en) * 1998-02-17 1999-08-19 Chembridge Corporation Supports for solid state chemical reactions and method of use thereof
US6008321A (en) * 1998-03-16 1999-12-28 Pharmacopeia, Inc. Universal linker for combinatorial synthesis
US6017768A (en) * 1994-05-06 2000-01-25 Pharmacopeia, Inc. Combinatorial dihydrobenzopyran library
US6043353A (en) * 1995-12-22 2000-03-28 University Technologies International, Inc. Reusable solid support for oligonucleotide synthesis, process for production thereof and process for use thereof
WO2000020357A2 (en) * 1998-10-05 2000-04-13 Glaxo Group Limited Chemical constructs
US6100329A (en) * 1998-03-12 2000-08-08 Virginia Tech Intellectual Properties, Inc. Reversible, mechanically interlocked polymeric networks which self-assemble
US6111123A (en) * 1998-04-20 2000-08-29 The Regents Of The University Of Michigan Salicylaldimine-crown ether ditopic receptor molecules
US6130096A (en) * 1995-06-06 2000-10-10 British Nuclear Fuels Plc Chemical complexes
WO2001036430A1 (en) * 1999-11-15 2001-05-25 Therasense, Inc. Transition metal complexes with bidentate ligand having an imidazole ring

Patent Citations (13)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
WO1994003593A1 (en) * 1992-08-04 1994-02-17 The State Of Oregon Acting By And Through The State Board Of Higher Education On Behalf Of The University Of Oregon Amplifier molecules for enhancement of diagnosis and therapy
US6017768A (en) * 1994-05-06 2000-01-25 Pharmacopeia, Inc. Combinatorial dihydrobenzopyran library
WO1996018592A1 (en) * 1994-12-10 1996-06-20 Smithkline Beecham Plc Resin-bound phosphonium salts and their use in organic synthesis
US6130096A (en) * 1995-06-06 2000-10-10 British Nuclear Fuels Plc Chemical complexes
US6043353A (en) * 1995-12-22 2000-03-28 University Technologies International, Inc. Reusable solid support for oligonucleotide synthesis, process for production thereof and process for use thereof
WO1997042230A1 (en) * 1996-05-03 1997-11-13 Warner-Lambert Company Rapid purification by polymer supported quench
WO1998006739A1 (en) * 1996-08-16 1998-02-19 Clontech Laboratories, Inc. Method for purification of recombinant proteins
WO1999041216A1 (en) * 1998-02-17 1999-08-19 Chembridge Corporation Supports for solid state chemical reactions and method of use thereof
US6100329A (en) * 1998-03-12 2000-08-08 Virginia Tech Intellectual Properties, Inc. Reversible, mechanically interlocked polymeric networks which self-assemble
US6008321A (en) * 1998-03-16 1999-12-28 Pharmacopeia, Inc. Universal linker for combinatorial synthesis
US6111123A (en) * 1998-04-20 2000-08-29 The Regents Of The University Of Michigan Salicylaldimine-crown ether ditopic receptor molecules
WO2000020357A2 (en) * 1998-10-05 2000-04-13 Glaxo Group Limited Chemical constructs
WO2001036430A1 (en) * 1999-11-15 2001-05-25 Therasense, Inc. Transition metal complexes with bidentate ligand having an imidazole ring

Non-Patent Citations (3)

* Cited by examiner, † Cited by third party
Title
J. REBEK, JR.: "Molecular recognition and biophysical organic chemistry", ACC. CHEM. RES., vol. 23, no. 12, 1990, pages 399 - 404, XP002201957 *
S.C. ZIMMERMAN AND B.F. DUERR: "Controlled molecular aggregation. 1. Cyclic trimerization via hydrogen bonding", J. ORG. CHEM., vol. 57, 1992, pages 2215 - 2217, XP002201956 *
ZAFAR A ET AL: "Linked bis-isophthalic acid derivatives as building blocks in the design of self-assembling structures", TETRAHEDRON LETTERS, ELSEVIER SCIENCE PUBLISHERS, AMSTERDAM, NL, vol. 37, no. 14, 1 April 1996 (1996-04-01), pages 2327 - 2330, XP004029933, ISSN: 0040-4039 *

Also Published As

Publication number Publication date
AU2001292140A1 (en) 2002-04-22
GB2367818A (en) 2002-04-17
GB0024941D0 (en) 2000-11-29
WO2002030558A2 (en) 2002-04-18

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