WO2002026960A3 - Modulation de l'expression genique au moyen de domaines de localisation - Google Patents
Modulation de l'expression genique au moyen de domaines de localisation Download PDFInfo
- Publication number
- WO2002026960A3 WO2002026960A3 PCT/US2001/042377 US0142377W WO0226960A3 WO 2002026960 A3 WO2002026960 A3 WO 2002026960A3 US 0142377 W US0142377 W US 0142377W WO 0226960 A3 WO0226960 A3 WO 0226960A3
- Authority
- WO
- WIPO (PCT)
- Prior art keywords
- gene expression
- modulation
- domains
- localization domains
- localization
- Prior art date
Links
Classifications
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07K—PEPTIDES
- C07K14/00—Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof
- C07K14/435—Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof from animals; from humans
- C07K14/43504—Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof from animals; from humans from invertebrates
- C07K14/43563—Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof from animals; from humans from invertebrates from insects
- C07K14/43577—Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof from animals; from humans from invertebrates from insects from flies
- C07K14/43581—Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof from animals; from humans from invertebrates from insects from flies from Drosophila
-
- C—CHEMISTRY; METALLURGY
- C12—BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
- C12N—MICROORGANISMS OR ENZYMES; COMPOSITIONS THEREOF; PROPAGATING, PRESERVING, OR MAINTAINING MICROORGANISMS; MUTATION OR GENETIC ENGINEERING; CULTURE MEDIA
- C12N15/00—Mutation or genetic engineering; DNA or RNA concerning genetic engineering, vectors, e.g. plasmids, or their isolation, preparation or purification; Use of hosts therefor
- C12N15/09—Recombinant DNA-technology
- C12N15/63—Introduction of foreign genetic material using vectors; Vectors; Use of hosts therefor; Regulation of expression
-
- C—CHEMISTRY; METALLURGY
- C12—BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
- C12N—MICROORGANISMS OR ENZYMES; COMPOSITIONS THEREOF; PROPAGATING, PRESERVING, OR MAINTAINING MICROORGANISMS; MUTATION OR GENETIC ENGINEERING; CULTURE MEDIA
- C12N15/00—Mutation or genetic engineering; DNA or RNA concerning genetic engineering, vectors, e.g. plasmids, or their isolation, preparation or purification; Use of hosts therefor
- C12N15/09—Recombinant DNA-technology
- C12N15/63—Introduction of foreign genetic material using vectors; Vectors; Use of hosts therefor; Regulation of expression
- C12N15/79—Vectors or expression systems specially adapted for eukaryotic hosts
- C12N15/82—Vectors or expression systems specially adapted for eukaryotic hosts for plant cells, e.g. plant artificial chromosomes (PACs)
- C12N15/8216—Methods for controlling, regulating or enhancing expression of transgenes in plant cells
- C12N15/822—Reducing position variability, e.g. by the use of scaffold attachment region/matrix attachment region (SAR/MAR); Use of SAR/MAR to regulate gene expression
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07K—PEPTIDES
- C07K2319/00—Fusion polypeptide
Landscapes
- Health & Medical Sciences (AREA)
- Life Sciences & Earth Sciences (AREA)
- Genetics & Genomics (AREA)
- Chemical & Material Sciences (AREA)
- Organic Chemistry (AREA)
- Engineering & Computer Science (AREA)
- Zoology (AREA)
- Biotechnology (AREA)
- Molecular Biology (AREA)
- Bioinformatics & Cheminformatics (AREA)
- General Engineering & Computer Science (AREA)
- Wood Science & Technology (AREA)
- Biomedical Technology (AREA)
- General Health & Medical Sciences (AREA)
- Insects & Arthropods (AREA)
- Biophysics (AREA)
- Biochemistry (AREA)
- Physics & Mathematics (AREA)
- Microbiology (AREA)
- Plant Pathology (AREA)
- Tropical Medicine & Parasitology (AREA)
- Toxicology (AREA)
- Gastroenterology & Hepatology (AREA)
- Medicinal Chemistry (AREA)
- Proteomics, Peptides & Aminoacids (AREA)
- Cell Biology (AREA)
- Micro-Organisms Or Cultivation Processes Thereof (AREA)
- Peptides Or Proteins (AREA)
- Medicines Containing Material From Animals Or Micro-Organisms (AREA)
Abstract
Priority Applications (1)
Application Number | Priority Date | Filing Date | Title |
---|---|---|---|
AU2002213431A AU2002213431A1 (en) | 2000-09-29 | 2001-09-28 | Modulation of gene expression using localization domains |
Applications Claiming Priority (2)
Application Number | Priority Date | Filing Date | Title |
---|---|---|---|
US23688400P | 2000-09-29 | 2000-09-29 | |
US60/236,884 | 2000-09-29 |
Publications (2)
Publication Number | Publication Date |
---|---|
WO2002026960A2 WO2002026960A2 (fr) | 2002-04-04 |
WO2002026960A3 true WO2002026960A3 (fr) | 2003-04-17 |
Family
ID=22891390
Family Applications (1)
Application Number | Title | Priority Date | Filing Date |
---|---|---|---|
PCT/US2001/042377 WO2002026960A2 (fr) | 2000-09-29 | 2001-09-28 | Modulation de l'expression genique au moyen de domaines de localisation |
Country Status (2)
Country | Link |
---|---|
AU (1) | AU2002213431A1 (fr) |
WO (1) | WO2002026960A2 (fr) |
Families Citing this family (7)
Publication number | Priority date | Publication date | Assignee | Title |
---|---|---|---|---|
US20050136040A1 (en) * | 2001-10-11 | 2005-06-23 | Imperial College Innovations Limited | Control of gene expression using a complex of an oligonucleotide and a regulatory peptide |
CA2508052A1 (fr) * | 2002-12-05 | 2004-06-17 | Imperial College Innovations Limited | Suppression de l'apoptose |
CA2539439C (fr) | 2003-09-19 | 2012-10-23 | Sangamo Biosciences, Inc. | Proteines a doigt de zinc issues du genie genetique pour la regulation de l'expression genique |
NZ576800A (en) | 2006-12-14 | 2013-02-22 | Dow Agrosciences Llc | Optimized non-canonical zinc finger proteins |
WO2023081756A1 (fr) | 2021-11-03 | 2023-05-11 | The J. David Gladstone Institutes, A Testamentary Trust Established Under The Will Of J. David Gladstone | Édition précise du génome à l'aide de rétrons |
WO2023141602A2 (fr) | 2022-01-21 | 2023-07-27 | Renagade Therapeutics Management Inc. | Rétrons modifiés et méthodes d'utilisation |
WO2024044723A1 (fr) | 2022-08-25 | 2024-02-29 | Renagade Therapeutics Management Inc. | Rétrons modifiés et méthodes d'utilisation |
Citations (5)
Publication number | Priority date | Publication date | Assignee | Title |
---|---|---|---|---|
WO1997011972A1 (fr) * | 1995-09-28 | 1997-04-03 | The Trustees Of Columbia University In The City Of New York | Proteine chimere de polypeptide et d'acide nucleique de liaison d'adn et d'adn methyltransferase et ses utilisations |
WO2000041566A1 (fr) * | 1999-01-12 | 2000-07-20 | Sanagamo Biosciences, Inc. | Regulation de l'expression genique endogene dans des cellules au moyen de proteines a doigts de zinc |
WO2000042219A1 (fr) * | 1999-01-12 | 2000-07-20 | Sangamo Biosciences, Inc. | Selection de sites cibles pour proteines a doigts de zinc et methodes de fabrication de proteines a doigts de zinc destinees a se lier avec des sites preselectionnes |
WO2001030843A1 (fr) * | 1999-10-25 | 2001-05-03 | Novartis Ag | Proteines de regulateur de transcription activees par un ligand |
WO2001083793A2 (fr) * | 2000-04-28 | 2001-11-08 | Sangamo Biosciences, Inc. | Modification ciblee de la structure de chromatine |
-
2001
- 2001-09-28 AU AU2002213431A patent/AU2002213431A1/en not_active Abandoned
- 2001-09-28 WO PCT/US2001/042377 patent/WO2002026960A2/fr active Application Filing
Patent Citations (5)
Publication number | Priority date | Publication date | Assignee | Title |
---|---|---|---|---|
WO1997011972A1 (fr) * | 1995-09-28 | 1997-04-03 | The Trustees Of Columbia University In The City Of New York | Proteine chimere de polypeptide et d'acide nucleique de liaison d'adn et d'adn methyltransferase et ses utilisations |
WO2000041566A1 (fr) * | 1999-01-12 | 2000-07-20 | Sanagamo Biosciences, Inc. | Regulation de l'expression genique endogene dans des cellules au moyen de proteines a doigts de zinc |
WO2000042219A1 (fr) * | 1999-01-12 | 2000-07-20 | Sangamo Biosciences, Inc. | Selection de sites cibles pour proteines a doigts de zinc et methodes de fabrication de proteines a doigts de zinc destinees a se lier avec des sites preselectionnes |
WO2001030843A1 (fr) * | 1999-10-25 | 2001-05-03 | Novartis Ag | Proteines de regulateur de transcription activees par un ligand |
WO2001083793A2 (fr) * | 2000-04-28 | 2001-11-08 | Sangamo Biosciences, Inc. | Modification ciblee de la structure de chromatine |
Non-Patent Citations (6)
Title |
---|
BOEKE JOERN ET AL: "The minimal repression domain of MBD2b overlaps with the methyl-CpG-binding domain and binds directly to Sin3A.", JOURNAL OF BIOLOGICAL CHEMISTRY, vol. 275, no. 45, 18 August 2000 (2000-08-18), pages 34963 - 34967, XP002215833, ISSN: 0021-9258 * |
CROSS S H ET AL: "PURIFICATION OF CPG ISLANDS USING A METHYLATED DNA BINDING COLUMN", NATURE GENETICS, NEW YORK, NY, US, vol. 6, no. 3, 1 March 1994 (1994-03-01), pages 236 - 244, XP000578157, ISSN: 1061-4036 * |
KALUDOV NIKOLA K ET AL: "MeCP2 driven transcriptional repression in vitro: Selectivity for methylated DNA, action at a distance and contacts with the basal transcription machinery.", NUCLEIC ACIDS RESEARCH, vol. 28, no. 9, 1 May 2000 (2000-05-01), pages 1921 - 1928, XP002215832, ISSN: 0305-1048 * |
NAN XINSHENG ET AL: "MeCP2 is a transcriptional repressor with abundant binding sites in genomic chromatin.", CELL, vol. 88, no. 4, 1997, pages 471 - 481, XP002215831, ISSN: 0092-8674 * |
STEENSEL VAN B ET AL: "Identification of in vivo DNA targets of chromatin proteins using tethered Dam methyltransferase", NATURE BIOTECHNOLOGY, NATURE PUBLISHING, US, vol. 18, no. 4, April 2000 (2000-04-01), pages 424 - 428, XP002187507, ISSN: 1087-0156 * |
WOLFFE A P ET AL: "CO-REPRESSOR COMPLEXES AND REMODELLING CHROMATIN FOR REPRESSION", BIOCHEMICAL SOCIETY TRANSACTIONS, COLCHESTER, ESSEX, GB, vol. 28, no. 4, August 2000 (2000-08-01), pages 379 - 386, XP001052910, ISSN: 0300-5127 * |
Also Published As
Publication number | Publication date |
---|---|
WO2002026960A2 (fr) | 2002-04-04 |
AU2002213431A1 (en) | 2002-04-08 |
Similar Documents
Publication | Publication Date | Title |
---|---|---|
WO2005044976A3 (fr) | Composes oligomeres utilises pour la modulation de genes | |
AU6322900A (en) | Method for generating resistance against cgmmv in plants, genetic constructs for use in said method, and cgmmv-resistant plants obtained via said method | |
WO2002036743A3 (fr) | Modulation antisens de l'expression de calreticuline | |
WO2002044376A8 (fr) | Modulation de l'expression genetique au moyen de proteines de liaison avec isolants | |
WO2000053724A3 (fr) | Compositions et procedes convenant a la modification de la transcription de genes | |
WO2001075087A8 (fr) | Variantes de lasubtilisine | |
AU9125198A (en) | Compositions, kits, and methods for effecting adenine nucleotide modulation of dna mismatch recognition proteins | |
EP1248794A4 (fr) | Modulation antisens de l'expression de la proteine smad7 | |
WO2001002019A3 (fr) | Maitrise de l'expression genique | |
WO2003010284A3 (fr) | Modulation antisens de l'expression de la proteine reactive c | |
HK1045326A1 (zh) | 微生物的β-葡萄糖甘酸酶基因,基因產品及其用法 | |
WO2003022222A3 (fr) | Modulation anti-sens de l'expression d'une proteine kinase r | |
EP1135402A4 (fr) | Modulation antisens de l'expression d'egr-1 | |
EP1430072A4 (fr) | Modulation antisens de l'expression de la proteine de transfert de l'ester de cholesteryle | |
WO2004024940A3 (fr) | Modulation d'un gene mediee par arn | |
WO2002026960A3 (fr) | Modulation de l'expression genique au moyen de domaines de localisation | |
AU2001264935A1 (en) | Method for introducing and expressing genes in animal cells, and bacterial blebsfor use in same | |
AU2001238212A1 (en) | Modified fluorescent proteins | |
AU2002228805A1 (en) | Antisense modulation of damage-specific dna binding protein 2, p48 expression | |
AU2003234198A1 (en) | Novel genes, compositions, and methods for modulating the unfolded protein response | |
WO2001049721A3 (fr) | Nouveaux genes bacteriens et proteines qui sont essentielles pour la viabilite cellulaire et leurs utilisations | |
WO2002062954A3 (fr) | Modulation antisens de l'expression de la caseine kinase 2-beta | |
WO2001083513A3 (fr) | Modulation antisens de l'inhibiteur de l'expression de la fixation 1 a l'adn | |
WO2001031051A3 (fr) | Modulation par antisens de l'expression de la proteine kinase c-theta | |
EP1144690A4 (fr) | Modulation antisens de l'expression d'un inhibiteur cellulaire d'apoptose-2 |
Legal Events
Date | Code | Title | Description |
---|---|---|---|
AK | Designated states |
Kind code of ref document: A2 Designated state(s): AL AM AT AU AZ BA BB BG BR BY CA CH CN CU CZ DE DK EE ES FI GB GD GE GH GM HR HU ID IL IN IS JP KE KG KP KR KZ LC LK LR LS LT LU LV MD MG MK MN MW MX NO NZ PL PT RO RU SD SE SG SI SK SL TJ TM TR TT UA UG UZ VN YU ZW |
|
AL | Designated countries for regional patents |
Kind code of ref document: A2 Designated state(s): GH GM KE LS MW MZ SD SL SZ TZ UG ZW AM AZ BY KG KZ MD RU TJ TM AT BE CH CY DE DK ES FI FR GB GR IE IT LU MC NL PT SE TR BF BJ CF CG CI CM GA GN GQ GW ML MR NE SN TD TG |
|
121 | Ep: the epo has been informed by wipo that ep was designated in this application | ||
REG | Reference to national code |
Ref country code: DE Ref legal event code: 8642 |
|
122 | Ep: pct application non-entry in european phase | ||
NENP | Non-entry into the national phase |
Ref country code: JP |