WO2002026324A3 - Tocol-based compositions containing amiodarone - Google Patents

Tocol-based compositions containing amiodarone Download PDF

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Publication number
WO2002026324A3
WO2002026324A3 PCT/US2001/030320 US0130320W WO0226324A3 WO 2002026324 A3 WO2002026324 A3 WO 2002026324A3 US 0130320 W US0130320 W US 0130320W WO 0226324 A3 WO0226324 A3 WO 0226324A3
Authority
WO
WIPO (PCT)
Prior art keywords
tocol
compositions containing
based compositions
containing amiodarone
amiodarone
Prior art date
Application number
PCT/US2001/030320
Other languages
French (fr)
Other versions
WO2002026324A2 (en
Inventor
Karel J Lambert
Dean R Kessler
Andrew M Nienstedt
Greg A Hartgraves
Panayiotis P Constantinides
Original Assignee
Sonus Pharma Inc
Karel J Lambert
Dean R Kessler
Andrew M Nienstedt
Greg A Hartgraves
Panayiotis P Constantinides
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Application filed by Sonus Pharma Inc, Karel J Lambert, Dean R Kessler, Andrew M Nienstedt, Greg A Hartgraves, Panayiotis P Constantinides filed Critical Sonus Pharma Inc
Priority to AU9482601A priority Critical patent/AU9482601A/en
Publication of WO2002026324A2 publication Critical patent/WO2002026324A2/en
Publication of WO2002026324A3 publication Critical patent/WO2002026324A3/en

Links

Classifications

    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K47/00—Medicinal preparations characterised by the non-active ingredients used, e.g. carriers or inert additives; Targeting or modifying agents chemically bound to the active ingredient
    • A61K47/06—Organic compounds, e.g. natural or synthetic hydrocarbons, polyolefins, mineral oil, petrolatum or ozokerite
    • A61K47/22—Heterocyclic compounds, e.g. ascorbic acid, tocopherol or pyrrolidones
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K31/00—Medicinal preparations containing organic active ingredients
    • A61K31/33—Heterocyclic compounds
    • A61K31/335—Heterocyclic compounds having oxygen as the only ring hetero atom, e.g. fungichromin
    • A61K31/35—Heterocyclic compounds having oxygen as the only ring hetero atom, e.g. fungichromin having six-membered rings with one oxygen as the only ring hetero atom
    • A61K31/352—Heterocyclic compounds having oxygen as the only ring hetero atom, e.g. fungichromin having six-membered rings with one oxygen as the only ring hetero atom condensed with carbocyclic rings, e.g. methantheline 
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K31/00—Medicinal preparations containing organic active ingredients
    • A61K31/33—Heterocyclic compounds
    • A61K31/335—Heterocyclic compounds having oxygen as the only ring hetero atom, e.g. fungichromin
    • A61K31/35—Heterocyclic compounds having oxygen as the only ring hetero atom, e.g. fungichromin having six-membered rings with one oxygen as the only ring hetero atom
    • A61K31/352—Heterocyclic compounds having oxygen as the only ring hetero atom, e.g. fungichromin having six-membered rings with one oxygen as the only ring hetero atom condensed with carbocyclic rings, e.g. methantheline 
    • A61K31/353—3,4-Dihydrobenzopyrans, e.g. chroman, catechin
    • A61K31/355—Tocopherols, e.g. vitamin E
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K9/00—Medicinal preparations characterised by special physical form
    • A61K9/10—Dispersions; Emulsions
    • A61K9/107—Emulsions ; Emulsion preconcentrates; Micelles
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K9/00—Medicinal preparations characterised by special physical form
    • A61K9/10—Dispersions; Emulsions
    • A61K9/107—Emulsions ; Emulsion preconcentrates; Micelles
    • A61K9/1075—Microemulsions or submicron emulsions; Preconcentrates or solids thereof; Micelles, e.g. made of phospholipids or block copolymers
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P9/00—Drugs for disorders of the cardiovascular system
    • A61P9/06—Antiarrhythmics

Landscapes

  • Health & Medical Sciences (AREA)
  • Chemical & Material Sciences (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • Medicinal Chemistry (AREA)
  • Pharmacology & Pharmacy (AREA)
  • Animal Behavior & Ethology (AREA)
  • General Health & Medical Sciences (AREA)
  • Public Health (AREA)
  • Veterinary Medicine (AREA)
  • Epidemiology (AREA)
  • Dispersion Chemistry (AREA)
  • Chemical Kinetics & Catalysis (AREA)
  • General Chemical & Material Sciences (AREA)
  • Engineering & Computer Science (AREA)
  • Bioinformatics & Cheminformatics (AREA)
  • Cardiology (AREA)
  • Heart & Thoracic Surgery (AREA)
  • Molecular Biology (AREA)
  • Biophysics (AREA)
  • Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
  • Organic Chemistry (AREA)
  • Oil, Petroleum & Natural Gas (AREA)
  • Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
  • Medicinal Preparation (AREA)

Abstract

Pharmaceutical compositions comprise amiodarone or one of its prodrugs or analogs and one or more tocols.
PCT/US2001/030320 2000-09-27 2001-09-27 Tocol-based compositions containing amiodarone WO2002026324A2 (en)

Priority Applications (1)

Application Number Priority Date Filing Date Title
AU9482601A AU9482601A (en) 2000-09-27 2001-09-27 Tocol-based compositions containing amiodarone

Applications Claiming Priority (2)

Application Number Priority Date Filing Date Title
US23586500P 2000-09-27 2000-09-27
US60/235,865 2000-09-27

Publications (2)

Publication Number Publication Date
WO2002026324A2 WO2002026324A2 (en) 2002-04-04
WO2002026324A3 true WO2002026324A3 (en) 2002-07-04

Family

ID=22887207

Family Applications (1)

Application Number Title Priority Date Filing Date
PCT/US2001/030320 WO2002026324A2 (en) 2000-09-27 2001-09-27 Tocol-based compositions containing amiodarone

Country Status (2)

Country Link
AU (1) AU9482601A (en)
WO (1) WO2002026324A2 (en)

Families Citing this family (6)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
EP1711163A2 (en) * 2004-02-05 2006-10-18 Baxter International Inc. Dispersions prepared by use of self-stabilizing agents
KR100623013B1 (en) * 2004-09-04 2006-09-19 김영대 Nano-emulsion, the use thereof, and preparing method thereof
EP2335686A1 (en) * 2009-12-21 2011-06-22 LEK Pharmaceuticals d.d. An aqueous intravenous nanosuspension with reduced adverse effects
EP2768486B1 (en) * 2011-10-21 2018-10-03 First Tech International Limited Tocotrienol compositions
CN103054799B (en) * 2012-10-11 2015-04-08 北京泰德制药股份有限公司 Amiodarone hydrochloride injection emulsion and preparation method thereof
EP4161505A4 (en) * 2020-06-04 2024-06-12 Hovid Berhad Composition for normalisation of fatty liver and method for producing the same

Citations (2)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
WO2000050007A1 (en) * 1999-02-26 2000-08-31 Lipocine, Inc. Compositions and methods for improved delivery of hydrophobic therapeutic agents
WO2000059475A1 (en) * 1999-04-06 2000-10-12 Lipocine, Inc. Compositions and methods for improved delivery of ionizable hydrophobic therapeutic agents

Patent Citations (2)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
WO2000050007A1 (en) * 1999-02-26 2000-08-31 Lipocine, Inc. Compositions and methods for improved delivery of hydrophobic therapeutic agents
WO2000059475A1 (en) * 1999-04-06 2000-10-12 Lipocine, Inc. Compositions and methods for improved delivery of ionizable hydrophobic therapeutic agents

Non-Patent Citations (1)

* Cited by examiner, † Cited by third party
Title
HONEGGER, U. E. ET AL.: "VITAMINE E REDUCES ACCUMULATION OF AMIODARONE AND DESETHYLAMIODARONE AND INHIBITS PHOSPHOLIPIDOSIS IN CULTURED HUMAN CELLS", BIOCHEMICAL PHARMACOLOGY, vol. 49, no. 12, 10 February 1995 (1995-02-10), pages 1741 - 1745, XP002196701 *

Also Published As

Publication number Publication date
WO2002026324A2 (en) 2002-04-04
AU9482601A (en) 2002-04-08

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