WO2002026111A2 - Systemes et procedes d'aide a la decision pour evaluer l'etat de sante vasculaire - Google Patents

Systemes et procedes d'aide a la decision pour evaluer l'etat de sante vasculaire Download PDF

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Publication number
WO2002026111A2
WO2002026111A2 PCT/US2001/030536 US0130536W WO0226111A2 WO 2002026111 A2 WO2002026111 A2 WO 2002026111A2 US 0130536 W US0130536 W US 0130536W WO 0226111 A2 WO0226111 A2 WO 0226111A2
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WO
WIPO (PCT)
Prior art keywords
vascular
data
health
analysis
vessel
Prior art date
Application number
PCT/US2001/030536
Other languages
English (en)
Other versions
WO2002026111A3 (fr
Inventor
Kevin Crutchfield
Robert Mozayent
John Davidson
Simon Fitall
Original Assignee
New Health Sciences, Inc.
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Application filed by New Health Sciences, Inc. filed Critical New Health Sciences, Inc.
Priority to AU1531302A priority Critical patent/AU1531302A/xx
Publication of WO2002026111A2 publication Critical patent/WO2002026111A2/fr
Publication of WO2002026111A3 publication Critical patent/WO2002026111A3/fr

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Classifications

    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61B—DIAGNOSIS; SURGERY; IDENTIFICATION
    • A61B5/00—Measuring for diagnostic purposes; Identification of persons
    • A61B5/02—Detecting, measuring or recording pulse, heart rate, blood pressure or blood flow; Combined pulse/heart-rate/blood pressure determination; Evaluating a cardiovascular condition not otherwise provided for, e.g. using combinations of techniques provided for in this group with electrocardiography or electroauscultation; Heart catheters for measuring blood pressure
    • A61B5/02007—Evaluating blood vessel condition, e.g. elasticity, compliance
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61B—DIAGNOSIS; SURGERY; IDENTIFICATION
    • A61B5/00—Measuring for diagnostic purposes; Identification of persons
    • A61B5/41—Detecting, measuring or recording for evaluating the immune or lymphatic systems
    • A61B5/411—Detecting or monitoring allergy or intolerance reactions to an allergenic agent or substance
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61B—DIAGNOSIS; SURGERY; IDENTIFICATION
    • A61B8/00—Diagnosis using ultrasonic, sonic or infrasonic waves
    • A61B8/06—Measuring blood flow
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61B—DIAGNOSIS; SURGERY; IDENTIFICATION
    • A61B8/00—Diagnosis using ultrasonic, sonic or infrasonic waves
    • A61B8/08—Detecting organic movements or changes, e.g. tumours, cysts, swellings
    • A61B8/0808—Detecting organic movements or changes, e.g. tumours, cysts, swellings for diagnosis of the brain
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61B—DIAGNOSIS; SURGERY; IDENTIFICATION
    • A61B8/00—Diagnosis using ultrasonic, sonic or infrasonic waves
    • A61B8/56—Details of data transmission or power supply
    • G—PHYSICS
    • G01—MEASURING; TESTING
    • G01S—RADIO DIRECTION-FINDING; RADIO NAVIGATION; DETERMINING DISTANCE OR VELOCITY BY USE OF RADIO WAVES; LOCATING OR PRESENCE-DETECTING BY USE OF THE REFLECTION OR RERADIATION OF RADIO WAVES; ANALOGOUS ARRANGEMENTS USING OTHER WAVES
    • G01S15/00—Systems using the reflection or reradiation of acoustic waves, e.g. sonar systems
    • G01S15/88—Sonar systems specially adapted for specific applications
    • G01S15/89—Sonar systems specially adapted for specific applications for mapping or imaging
    • G01S15/8906—Short-range imaging systems; Acoustic microscope systems using pulse-echo techniques
    • G01S15/8979—Combined Doppler and pulse-echo imaging systems
    • G—PHYSICS
    • G01—MEASURING; TESTING
    • G01S—RADIO DIRECTION-FINDING; RADIO NAVIGATION; DETERMINING DISTANCE OR VELOCITY BY USE OF RADIO WAVES; LOCATING OR PRESENCE-DETECTING BY USE OF THE REFLECTION OR RERADIATION OF RADIO WAVES; ANALOGOUS ARRANGEMENTS USING OTHER WAVES
    • G01S7/00—Details of systems according to groups G01S13/00, G01S15/00, G01S17/00
    • G01S7/52—Details of systems according to groups G01S13/00, G01S15/00, G01S17/00 of systems according to group G01S15/00
    • G01S7/52017—Details of systems according to groups G01S13/00, G01S15/00, G01S17/00 of systems according to group G01S15/00 particularly adapted to short-range imaging
    • G01S7/52023—Details of receivers
    • G01S7/52036—Details of receivers using analysis of echo signal for target characterisation
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61B—DIAGNOSIS; SURGERY; IDENTIFICATION
    • A61B5/00—Measuring for diagnostic purposes; Identification of persons
    • A61B5/72—Signal processing specially adapted for physiological signals or for diagnostic purposes
    • A61B5/7235—Details of waveform analysis
    • A61B5/7264—Classification of physiological signals or data, e.g. using neural networks, statistical classifiers, expert systems or fuzzy systems
    • G—PHYSICS
    • G01—MEASURING; TESTING
    • G01S—RADIO DIRECTION-FINDING; RADIO NAVIGATION; DETERMINING DISTANCE OR VELOCITY BY USE OF RADIO WAVES; LOCATING OR PRESENCE-DETECTING BY USE OF THE REFLECTION OR RERADIATION OF RADIO WAVES; ANALOGOUS ARRANGEMENTS USING OTHER WAVES
    • G01S15/00—Systems using the reflection or reradiation of acoustic waves, e.g. sonar systems
    • G01S15/88—Sonar systems specially adapted for specific applications
    • G01S15/89—Sonar systems specially adapted for specific applications for mapping or imaging
    • G01S15/8906—Short-range imaging systems; Acoustic microscope systems using pulse-echo techniques
    • G01S15/8909—Short-range imaging systems; Acoustic microscope systems using pulse-echo techniques using a static transducer configuration
    • G01S15/8915—Short-range imaging systems; Acoustic microscope systems using pulse-echo techniques using a static transducer configuration using a transducer array
    • G01S15/8925—Short-range imaging systems; Acoustic microscope systems using pulse-echo techniques using a static transducer configuration using a transducer array the array being a two-dimensional transducer configuration, i.e. matrix or orthogonal linear arrays

Definitions

  • Strokes result from blockage of blood flow in cerebral vessels due to constriction of the vessel resulting from an embolus or stenosis. Strokes may also arise from tearing of the vessel wall due to any number of circumstances. Accordingly, a blockage may result in ischemic stroke depriving neural tissue distal to the blockage of oxygen and glucose. A tearing or rupture of the vessel may result in bleeding into the brain, also known as a hemorrhagic stroke. Intracranial bleeding exerts deleterious effects on surrounding tissue due to increased intracranial pressure and direct exposure of neurons to blood.
  • V Velocity of blood flow
  • vascular data can be transmitted to a central receiving facility, which receives the data, analyzes it, produces a value indicative of the state of vascular health, and then transmit this information to another location, such as the originating data transmitting station, or perhaps directly to the health care provider's office.
  • This system should provide access to sophisticated computing capabilities that would enhance the accuracy of health care providers' diagnostic and prognostic capabilities concerning vascular health.
  • This system should be able to receive high volumes of patient data and rapidly process the data in order to obtain diagnoses and prognoses of disease. Such a system could be used for diagnosis and prognosis of any disease or condition related to vascular health.
  • the screening method for adverse effects of a treatment on a vessel as described above may be applied both before and after administration of the treatment.
  • Va end diastolic velocity
  • Yet other object of the present invention is to provide a non-invasive method to evaluate substances, such as drugs, suspected of have vascular activity in individuals with no apparent vascular problems.
  • a further advantage of the present invention is that it is rapid and inexpensive to perform.
  • One way in which the system of the present invention is trained is one wherein the software quantitates the rationale being used by the expert.
  • the expert and the system come to mirror each other.
  • the expert is very specific, concrete and quantitative regarding the data analysis.
  • the software maintains a detailed bookkeeping of the analytical process.
  • the purpose of the software is to capture the expert's analysis.
  • patient data is utilized by the automated decision support system according to the present invention.
  • This data may include personal data, such as date of birth, ethnic group, sex, physical activity level, and address.
  • the data may further include clinical data such as a visit identification, height, weight, date of visit, age, blood pressure, pulse rate, respiration rate, and so forth.
  • Specific operation of the DSA 1022 sub-module can include initialization by one or more external commands; and use of knowledge bases to store concept patterns and knowledge base algorithms used to infer concepts from leaf-level data provided, with the basis for the inferences being the TCD data and clinical data.
  • the algorithms infer the concepts in several intermediate steps, each represented in the concept graph, such that it is sufficient for one skilled in the art of the problem domain to follow the chain of reasoning.
  • the conditions represented in the concept graph include, but are not limited to, vasodilation, hyperemic vasodilation, pathological vasodilation, non-compliance, and irreversible stenosis.
  • the concept graphs provide a path for following a chain of reasoning backwards from a conclusion.
  • the Knowledge base 2362 maintains the knowledge for TCD analysis.
  • the inventions analytical techniques may be modified by changing these Knowledge base 2362 files.
  • the Patient database 2382 stores data about a patient pertinent to analysis of his TCD data. Each patient is assigned a unique ID by the user of the system. Information contained in the Patient database 2382 includes that shown in Table 4.
  • the central server comprises the computer-based database of vascular information.
  • the central server implements analytic and interpretive algorithms. It will be apparent to those of skill in the art, however, that the communication station and the computation station may be implemented in a single computer. The configuration of an exemplary central server will be described in greater detail below.

Landscapes

  • Health & Medical Sciences (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • Engineering & Computer Science (AREA)
  • Physics & Mathematics (AREA)
  • Animal Behavior & Ethology (AREA)
  • Veterinary Medicine (AREA)
  • Biophysics (AREA)
  • Pathology (AREA)
  • Public Health (AREA)
  • Biomedical Technology (AREA)
  • Heart & Thoracic Surgery (AREA)
  • Medical Informatics (AREA)
  • Molecular Biology (AREA)
  • Surgery (AREA)
  • General Health & Medical Sciences (AREA)
  • Radar, Positioning & Navigation (AREA)
  • Remote Sensing (AREA)
  • Radiology & Medical Imaging (AREA)
  • Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
  • Computer Networks & Wireless Communication (AREA)
  • General Physics & Mathematics (AREA)
  • Vascular Medicine (AREA)
  • Acoustics & Sound (AREA)
  • Immunology (AREA)
  • Neurology (AREA)
  • Physiology (AREA)
  • Cardiology (AREA)
  • Hematology (AREA)
  • Ultra Sonic Daignosis Equipment (AREA)
  • Measuring Pulse, Heart Rate, Blood Pressure Or Blood Flow (AREA)

Abstract

Cette invention se rapporte d'une façon générale à des systèmes et à des procédés pour évaluer la circulation sanguine dans des vaisseaux sanguins, pour évaluer l'état de santé vasculaire, pour effectuer des essais cliniques, pour déterminer les effets secondaires d'interventions thérapeutiques et pour évaluer les effets de facteurs de risque, de thérapies et de substances, y compris des substances thérapeutiques, sur des vaisseaux sanguins, notamment des vaisseaux sanguins du cerveau, toutes ces opérations étant effectuées par mesure de divers paramètres de la circulation sanguine dans un ou plusieurs vaisseaux et par analyse des résultats selon un mode défini. Les paramètres pertinents de la circulation sanguine sont la vitesse d'écoulement moyenne, l'accélération systolique et l'index de pulsatilité. En mesurant et en analysant ces paramètres, on peut évaluer l'état de santé vasculaire d'un vaisseau particulier, de vaisseaux multiples et d'un individu. Ces mesures peuvent également servir à déterminer si une substance produit un effet, soit néfaste soit bénéfique, sur l'état de santé vasculaire. Dans l'un des nombreux modes de réalisation, cette invention propose en outre un système expert de réalisation de ces procédés.
PCT/US2001/030536 2000-09-29 2001-10-01 Systemes et procedes d'aide a la decision pour evaluer l'etat de sante vasculaire WO2002026111A2 (fr)

Priority Applications (1)

Application Number Priority Date Filing Date Title
AU1531302A AU1531302A (en) 2000-09-29 2001-10-01 Decision support systems and methods for assessing vascular health

Applications Claiming Priority (2)

Application Number Priority Date Filing Date Title
US23666300P 2000-09-29 2000-09-29
US60/236,663 2000-09-29

Publications (2)

Publication Number Publication Date
WO2002026111A2 true WO2002026111A2 (fr) 2002-04-04
WO2002026111A3 WO2002026111A3 (fr) 2002-07-04

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AU (1) AU1531302A (fr)
WO (1) WO2002026111A2 (fr)

Cited By (5)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
DE102005022360A1 (de) * 2005-02-21 2006-08-31 Universität Duisburg-Essen Vorrichtung und Verfahren zur Bestimmung von Gewebe des menschlichen oder tierischen Körpers
CN110235206A (zh) * 2017-04-07 2019-09-13 北京悦琦创通科技有限公司 推理机训练方法和装置、升级方法和装置及存储介质
CN111192653A (zh) * 2020-01-20 2020-05-22 张学堂 一种家庭化幽门螺杆菌决策自引系统
CN112955974A (zh) * 2018-10-26 2021-06-11 皇家飞利浦有限公司 处置反应指数的确定
CN113066083A (zh) * 2021-04-25 2021-07-02 青岛海信医疗设备股份有限公司 流体的多普勒参数确定方法和电子设备

Citations (1)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
US4835690A (en) * 1985-11-19 1989-05-30 Picker International, Inc. Integrated expert system for medical imaging scan, set-up, and scheduling

Patent Citations (1)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
US4835690A (en) * 1985-11-19 1989-05-30 Picker International, Inc. Integrated expert system for medical imaging scan, set-up, and scheduling

Non-Patent Citations (3)

* Cited by examiner, † Cited by third party
Title
BAUERNSCHMITT ET AL.: 'Simulation of Baroreflex control in a pulsatile mathematical model of the human arterial circulation' COMPUTERS IN CARDIOLOGY September 1999, pages 229 - 232, XP010367087 *
CEVENINI ET AL.: 'A neural network improves the classification of high-risk intensive care patients' 18TH INT. IEEE CONF. ENGINEERING IN MEDICINE & BIOLOGY SOC. vol. 5, October 1996, pages 2207 - 2208, XP010261814 *
URSINO ET AL.: 'A mathematical study of some biomechanical factors affecting the oscillometric blood pressure measurement' IEEE TRANS. BIOMEDICAL ENGINEERING vol. 43, no. 8, August 1996, pages 761 - 778, XP002908451 *

Cited By (6)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
DE102005022360A1 (de) * 2005-02-21 2006-08-31 Universität Duisburg-Essen Vorrichtung und Verfahren zur Bestimmung von Gewebe des menschlichen oder tierischen Körpers
CN110235206A (zh) * 2017-04-07 2019-09-13 北京悦琦创通科技有限公司 推理机训练方法和装置、升级方法和装置及存储介质
CN110235206B (zh) * 2017-04-07 2023-05-09 北京悦琦创通科技有限公司 推理机训练方法和装置、升级方法和装置及存储介质
CN112955974A (zh) * 2018-10-26 2021-06-11 皇家飞利浦有限公司 处置反应指数的确定
CN111192653A (zh) * 2020-01-20 2020-05-22 张学堂 一种家庭化幽门螺杆菌决策自引系统
CN113066083A (zh) * 2021-04-25 2021-07-02 青岛海信医疗设备股份有限公司 流体的多普勒参数确定方法和电子设备

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Publication number Publication date
AU1531302A (en) 2002-04-08
WO2002026111A3 (fr) 2002-07-04

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