WO2002024734A3 - Influenza a virus haemagglutinin subtype h16 proteins and their encoding nuclei c acid - Google Patents

Influenza a virus haemagglutinin subtype h16 proteins and their encoding nuclei c acid Download PDF

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Publication number
WO2002024734A3
WO2002024734A3 PCT/IB2001/001914 IB0101914W WO0224734A3 WO 2002024734 A3 WO2002024734 A3 WO 2002024734A3 IB 0101914 W IB0101914 W IB 0101914W WO 0224734 A3 WO0224734 A3 WO 0224734A3
Authority
WO
WIPO (PCT)
Prior art keywords
influenza
proteins
acid
subtype
virus haemagglutinin
Prior art date
Application number
PCT/IB2001/001914
Other languages
French (fr)
Other versions
WO2002024734A2 (en
Inventor
Ron Fouchier
Bjorn Olsen
Albert Osterhaus
Original Assignee
Chiron Spa
Ron Fouchier
Bjorn Olsen
Albert Osterhaus
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Application filed by Chiron Spa, Ron Fouchier, Bjorn Olsen, Albert Osterhaus filed Critical Chiron Spa
Priority to EP01974591A priority Critical patent/EP1319018A2/en
Priority to CA002422564A priority patent/CA2422564A1/en
Priority to AU2001294105A priority patent/AU2001294105A1/en
Publication of WO2002024734A2 publication Critical patent/WO2002024734A2/en
Publication of WO2002024734A3 publication Critical patent/WO2002024734A3/en

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    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07K—PEPTIDES
    • C07K14/00—Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof
    • C07K14/005—Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof from viruses
    • C—CHEMISTRY; METALLURGY
    • C12—BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
    • C12N—MICROORGANISMS OR ENZYMES; COMPOSITIONS THEREOF; PROPAGATING, PRESERVING, OR MAINTAINING MICROORGANISMS; MUTATION OR GENETIC ENGINEERING; CULTURE MEDIA
    • C12N7/00—Viruses; Bacteriophages; Compositions thereof; Preparation or purification thereof
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K39/00—Medicinal preparations containing antigens or antibodies
    • A61K2039/51—Medicinal preparations containing antigens or antibodies comprising whole cells, viruses or DNA/RNA
    • A61K2039/525—Virus
    • A61K2039/5252—Virus inactivated (killed)
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K39/00—Medicinal preparations containing antigens or antibodies
    • A61K2039/51—Medicinal preparations containing antigens or antibodies comprising whole cells, viruses or DNA/RNA
    • A61K2039/53—DNA (RNA) vaccination
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K39/00—Medicinal preparations containing antigens or antibodies
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07K—PEPTIDES
    • C07K2319/00—Fusion polypeptide
    • C—CHEMISTRY; METALLURGY
    • C12—BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
    • C12N—MICROORGANISMS OR ENZYMES; COMPOSITIONS THEREOF; PROPAGATING, PRESERVING, OR MAINTAINING MICROORGANISMS; MUTATION OR GENETIC ENGINEERING; CULTURE MEDIA
    • C12N2760/00—MICROORGANISMS OR ENZYMES; COMPOSITIONS THEREOF; PROPAGATING, PRESERVING, OR MAINTAINING MICROORGANISMS; MUTATION OR GENETIC ENGINEERING; CULTURE MEDIA ssRNA viruses negative-sense
    • C12N2760/00011—Details
    • C12N2760/16011—Orthomyxoviridae
    • C12N2760/16111—Influenzavirus A, i.e. influenza A virus
    • C12N2760/16121—Viruses as such, e.g. new isolates, mutants or their genomic sequences
    • C—CHEMISTRY; METALLURGY
    • C12—BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
    • C12N—MICROORGANISMS OR ENZYMES; COMPOSITIONS THEREOF; PROPAGATING, PRESERVING, OR MAINTAINING MICROORGANISMS; MUTATION OR GENETIC ENGINEERING; CULTURE MEDIA
    • C12N2760/00—MICROORGANISMS OR ENZYMES; COMPOSITIONS THEREOF; PROPAGATING, PRESERVING, OR MAINTAINING MICROORGANISMS; MUTATION OR GENETIC ENGINEERING; CULTURE MEDIA ssRNA viruses negative-sense
    • C12N2760/00011—Details
    • C12N2760/16011—Orthomyxoviridae
    • C12N2760/16111—Influenzavirus A, i.e. influenza A virus
    • C12N2760/16122—New viral proteins or individual genes, new structural or functional aspects of known viral proteins or genes

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  • Chemical & Material Sciences (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • Health & Medical Sciences (AREA)
  • Organic Chemistry (AREA)
  • Genetics & Genomics (AREA)
  • Zoology (AREA)
  • Biochemistry (AREA)
  • General Health & Medical Sciences (AREA)
  • Engineering & Computer Science (AREA)
  • Medicinal Chemistry (AREA)
  • Wood Science & Technology (AREA)
  • Bioinformatics & Cheminformatics (AREA)
  • Virology (AREA)
  • Biophysics (AREA)
  • Immunology (AREA)
  • Proteomics, Peptides & Aminoacids (AREA)
  • Biomedical Technology (AREA)
  • Biotechnology (AREA)
  • Microbiology (AREA)
  • Molecular Biology (AREA)
  • Gastroenterology & Hepatology (AREA)
  • General Engineering & Computer Science (AREA)
  • Medicines Containing Antibodies Or Antigens For Use As Internal Diagnostic Agents (AREA)
  • Peptides Or Proteins (AREA)
  • Micro-Organisms Or Cultivation Processes Thereof (AREA)

Abstract

A sixteenth haemagglutinin subtype of influenza A virus (H16) has been isolated from gulls in Sweden and the Netherlands. The invention provides the new virus, its haemagglutinin protein and nucleic acid encoding the same. These are particularly useful for vaccination. Of the fifteen known subtypes H1 to H15, this subtype is most closely related to H13.
PCT/IB2001/001914 2000-09-19 2001-09-19 Influenza a virus haemagglutinin subtype h16 proteins and their encoding nuclei c acid WO2002024734A2 (en)

Priority Applications (3)

Application Number Priority Date Filing Date Title
EP01974591A EP1319018A2 (en) 2000-09-19 2001-09-19 Influenza a virus haemagglutinin subtype h16 proteins and their encoding nucleic acid
CA002422564A CA2422564A1 (en) 2000-09-19 2001-09-19 Influenza a virus haemagglutinin subtype h16 proteins and their encoding nucleic acid
AU2001294105A AU2001294105A1 (en) 2000-09-19 2001-09-19 Influenza a virus haemagglutinin subtype h16 proteins and their encoding nuclei c acid

Applications Claiming Priority (2)

Application Number Priority Date Filing Date Title
GB0022969.0 2000-09-19
GBGB0022969.0A GB0022969D0 (en) 2000-09-19 2000-09-19 Influenza a virus subtype H16

Publications (2)

Publication Number Publication Date
WO2002024734A2 WO2002024734A2 (en) 2002-03-28
WO2002024734A3 true WO2002024734A3 (en) 2002-08-15

Family

ID=9899734

Family Applications (1)

Application Number Title Priority Date Filing Date
PCT/IB2001/001914 WO2002024734A2 (en) 2000-09-19 2001-09-19 Influenza a virus haemagglutinin subtype h16 proteins and their encoding nuclei c acid

Country Status (5)

Country Link
EP (1) EP1319018A2 (en)
AU (1) AU2001294105A1 (en)
CA (1) CA2422564A1 (en)
GB (1) GB0022969D0 (en)
WO (1) WO2002024734A2 (en)

Families Citing this family (3)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
JP5008398B2 (en) 2003-11-04 2012-08-22 ザ アドミニストレイターズ オブ ザ テューレイン エデュケイショナル ファンド Methods of preventing virus: cell fusion by inhibiting the function of the fusion initiation region of RNA viruses with class I membrane fusion-inducing envelope proteins
CA2691358C (en) 2007-06-25 2017-08-22 The Administrators Of The Tulane Educational Fund Influenza inhibiting compositions comprising hemagglutinin 2-derived peptides and use thereof
CN103276109A (en) * 2013-05-10 2013-09-04 浙江省疾病预防控制中心 Avian influenza H7N9 virus RT-PCR (reverse transcription-polymerase chain reaction) detecting kit and detecting method

Citations (3)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
WO1993015763A1 (en) * 1992-02-18 1993-08-19 Smithkline Beecham Corporation Vaccinal polypeptides
WO1994006468A1 (en) * 1991-08-30 1994-03-31 Smithkline Beecham Corporation Recombinant influenza virus vaccine compositions
US5762939A (en) * 1993-09-13 1998-06-09 Mg-Pmc, Llc Method for producing influenza hemagglutinin multivalent vaccines using baculovirus

Patent Citations (3)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
WO1994006468A1 (en) * 1991-08-30 1994-03-31 Smithkline Beecham Corporation Recombinant influenza virus vaccine compositions
WO1993015763A1 (en) * 1992-02-18 1993-08-19 Smithkline Beecham Corporation Vaccinal polypeptides
US5762939A (en) * 1993-09-13 1998-06-09 Mg-Pmc, Llc Method for producing influenza hemagglutinin multivalent vaccines using baculovirus

Non-Patent Citations (13)

* Cited by examiner, † Cited by third party
Title
AIR G M: "SEQUENCE RELATIONSHIPS AMONG THE HEM AGGLUTININ GENES OF 12 SUBTYPES OF INFLUENZA A VIRUS", PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES, vol. 78, no. 12, 1981, 1981 (RECD. 1982), pages 7639 - 7643, XP001069135, ISSN: 0027-8424 *
CHAMBERS ET AL: "Antigenic and molecular characterization of subtype H13 hemagglutinin of influenza virus", VIROLOGY, RAVEN PRESS, NEW YORK, NY, US, vol. 172, no. 1, September 1989 (1989-09-01), pages 180 - 188, XP002105957, ISSN: 0042-6822 *
DATABASE EMBL 13 March 1992 (1992-03-13), NOBUSAWA E. ET AL.: "Influenza A gull HA gene", XP002196074 *
DATABASE EMBL 25 April 1990 (1990-04-25), CHAMBERS TM ET AL.: "Influenza A black-headed gull hemagglutinin", XP002196072 *
DATABASE EMBL 25 April 1990 (1990-04-25), CHAMBERS TM ET AL.: "Influenza A pilot whale HA cDNA", XP002196071 *
DATABASE EMBL 25 April 1990 (1990-04-25), CHAMBERS TM ET AL.: "Influenza A ring-billed gull HA", XP002196073 *
DATABASE SWISS-PROT 1 January 1990 (1990-01-01), CHAMBERS TM ET AL.: "HA precursor", XP002195962 *
DATABASE SWISS-PROT 1 January 1990 (1990-01-01), CHAMBERS TM ET AL.: "Hemaggulitin precursor (HA1 and HA2), Access. Nb P13101", XP002195960 *
DATABASE SWISS-PROT 1 January 1990 (1990-01-01), NOBUSAWA E ET AL.; CHAMBERS TM ET AL.: "HA precursor, access. Nb P13103", XP002195961 *
GUO Y J ET AL: "Characterization of the pathogenicity of members of the newly established H9N2 influenza virus lineages in Asia.", VIROLOGY, vol. 267, no. 2, 15 February 2000 (2000-02-15), pages 279 - 288, XP001063163, ISSN: 0042-6822 *
HINSHAW V S ET AL: "ANTIGENIC AND GENETIC CHARACTERIZATION OF A NOVEL HEM AGGLUTININ SUBTYPE OF INFLUENZA A VIRUSES FROM GULLS", JOURNAL OF VIROLOGY, vol. 42, no. 3, 1982, pages 865 - 872, XP001068623, ISSN: 0022-538X *
MATROSOVICH MIKHAIL ET AL: "The surface glycoproteins of H5 influenza viruses isolated from humans, chickens, and wild aquatic birds have distinguishable properties.", JOURNAL OF VIROLOGY, vol. 73, no. 2, February 1999 (1999-02-01), pages 1146 - 1155, XP002195827, ISSN: 0022-538X *
NOBUSAWA E ET AL: "COMPARISON OF COMPLETE AMINO ACID SEQUENCES AND RECEPTOR-BINDING PROPERTIES AMONG 13 SEROTYPES OF HEMAGGLUTININS OF INFLUENZA A VIRUSES", VIROLOGY, vol. 182, no. 2, 1991, pages 475 - 485, XP001063166, ISSN: 0042-6822 *

Also Published As

Publication number Publication date
CA2422564A1 (en) 2002-03-28
WO2002024734A2 (en) 2002-03-28
GB0022969D0 (en) 2000-11-01
EP1319018A2 (en) 2003-06-18
AU2001294105A1 (en) 2002-04-02

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