WO2002024698A1 - Xanthine phosphodiesterase v inhibitors - Google Patents
Xanthine phosphodiesterase v inhibitors Download PDFInfo
- Publication number
- WO2002024698A1 WO2002024698A1 PCT/US2001/028983 US0128983W WO0224698A1 WO 2002024698 A1 WO2002024698 A1 WO 2002024698A1 US 0128983 W US0128983 W US 0128983W WO 0224698 A1 WO0224698 A1 WO 0224698A1
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- Prior art keywords
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- substituents
- compound
- alkyl
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- LRFVTYWOQMYALW-UHFFFAOYSA-N 9H-xanthine Chemical compound O=C1NC(=O)NC2=C1NC=N2 LRFVTYWOQMYALW-UHFFFAOYSA-N 0.000 title abstract description 35
- 239000002590 phosphodiesterase V inhibitor Substances 0.000 title abstract description 27
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- 150000001875 compounds Chemical class 0.000 claims abstract description 189
- 125000001424 substituent group Chemical group 0.000 claims abstract description 124
- 208000037265 diseases, disorders, signs and symptoms Diseases 0.000 claims abstract description 40
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Classifications
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- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D473/00—Heterocyclic compounds containing purine ring systems
- C07D473/02—Heterocyclic compounds containing purine ring systems with oxygen, sulphur, or nitrogen atoms directly attached in positions 2 and 6
- C07D473/04—Heterocyclic compounds containing purine ring systems with oxygen, sulphur, or nitrogen atoms directly attached in positions 2 and 6 two oxygen atoms
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- A61P3/08—Drugs for disorders of the metabolism for glucose homeostasis
- A61P3/10—Drugs for disorders of the metabolism for glucose homeostasis for hyperglycaemia, e.g. antidiabetics
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- A61P9/00—Drugs for disorders of the cardiovascular system
- A61P9/12—Antihypertensives
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D473/00—Heterocyclic compounds containing purine ring systems
- C07D473/02—Heterocyclic compounds containing purine ring systems with oxygen, sulphur, or nitrogen atoms directly attached in positions 2 and 6
- C07D473/04—Heterocyclic compounds containing purine ring systems with oxygen, sulphur, or nitrogen atoms directly attached in positions 2 and 6 two oxygen atoms
- C07D473/06—Heterocyclic compounds containing purine ring systems with oxygen, sulphur, or nitrogen atoms directly attached in positions 2 and 6 two oxygen atoms with radicals containing only hydrogen and carbon atoms, attached in position 1 or 3
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D473/00—Heterocyclic compounds containing purine ring systems
- C07D473/02—Heterocyclic compounds containing purine ring systems with oxygen, sulphur, or nitrogen atoms directly attached in positions 2 and 6
- C07D473/04—Heterocyclic compounds containing purine ring systems with oxygen, sulphur, or nitrogen atoms directly attached in positions 2 and 6 two oxygen atoms
- C07D473/06—Heterocyclic compounds containing purine ring systems with oxygen, sulphur, or nitrogen atoms directly attached in positions 2 and 6 two oxygen atoms with radicals containing only hydrogen and carbon atoms, attached in position 1 or 3
- C07D473/08—Heterocyclic compounds containing purine ring systems with oxygen, sulphur, or nitrogen atoms directly attached in positions 2 and 6 two oxygen atoms with radicals containing only hydrogen and carbon atoms, attached in position 1 or 3 with methyl radicals in positions 1 and 3, e.g. theophylline
Definitions
- the invention relates to polycyclic nucleotide xanthine phosphodiesterase V inhibitors.
- Phosphodiesterase V inhibitor compounds are described by Kenneth J. Murray in Phosphodiesterase V A Inhibitors, DN & P 6(3). pp. 150-
- MIMAX a polycyclic xanthine PDE V inhibitor substituted at its 8-position with a -NHCH 3 group.
- WO 93/23401 which is hereby incorporated herein by reference in its entirety, discloses xanthine PDE V inhibitors that are substituted at the 8-
- WO 92/05176 which is hereby incorporated herein by reference in its entirety, discloses 8-acylaminoxanthine PDE V inhibitors that are substituted at the 8-position with -NHCOC 6 H 5 COOH.
- WO 92/05175 which is hereby incorporated herein by reference in its entirety, discloses 8-aminoxanthine PDE V inhibitors that are substituted at the 8-position with -NH 2 or -NHR, where R is an alkyl, arylalkyl or unsaturated heterocyclic (e.g., heteroaryl) group.
- PDE V inhibitors have been found useful for specific indications.
- the use of PDE V inhibitors for treating impotence has met with commercial success with the introduction of sildenafil citrate,
- Erectile dysfunction is a treatable and highly recognized health concern, affecting more than 30 million men in the United States, including one in four over age 65. Erectile dysfunction occurs when a man consistently is unable to sustain an erection sufficient for conducting sexual intercourse. In the past, psychological reasons were the most common explanation for erectile dysfunction or it was considered a natural part of aging. However, researchers today acknowledge that more than 70 percent of instances of erectile dysfunction are due to physical or medical problems. There are several factors that may contribute to erectile dysfunction, including:
- U.S. 5,939,419 and U.S 5,393,755 disclose polycyclic guanine PDE V derivatives that are useful for the treatment of cardiovascular and pulmonary disorders.
- certain xanthine/guanine PDE V inhibitors have been found to be useful for treating cardiovascular and pulmonary disorders, while some others have been found useful for treating impotence.
- certain xanthine PDE V inhibitors can be substituted at the 8-position by a variety of groups, including nitro and unsubstituted or substituted amino groups.
- the substituted amino groups include saturated heterocycles, where the nitrogen atom and its substituents together form an unsaturated heterocyclic group (e.g., -NR x R y can form a heterocycle).
- PDE V inhibitor that is effective for treating a variety of physiological symptoms and diseases in which PDE V plays a role. It is also an object of the invention to provide a polycyclic xanthine PDE V inhibitor that is especially effective for treating erectile dysfunction with minimal side effects.
- alkyl refers to “alkyl” as well as the “alkyl” portions of "hydroxyalkyl,” “haloalkyl,” “alkoxy,” etc.
- chemically-compatible means that a substituent or variable in a structure, process or the like is selected to be capable of resulting in a stable compound.
- substituted or the phrase "with . . . one or more substituents,” as used herein, means the replacement of one or more atoms or radicals, usually hydrogen atoms, in a given structure with a chemically- compatible atom(s) or radical(s) selected from a specified group. In the situations where more than one atom or radical may be replaced with substituents selected from the same specified group, the substituents may be, unless otherwise specified, either the same or different at every position.
- Radicals of specified groups such as alkyl, cycloalkyl, alkenyl, cycloalkenyl, alkynyl, arylalkyl, alkylaryl, heterocycloalkyl, aryl and heteroaryl groups, independently of or together with one another, may be substituents for any substituted group, unless otherwise known, stated or shown to be to the contrary.
- substituents for alkyl, cycloalkyl, alkenyl, cycloalkenyl, alkynyl, arylalkyl, alkylaryl, aryl, heteroaryl and heterocycloalkyl groups include, but are not limited to, the following moieties: alkyl, cycloalkyl, alkenyl, cycloalkenyl, alkynyl, arylalkyl, alkylaryl, aryl, heteroaryl, heterocycloalkyl, hydroxyalkyl, arylalkyl, aminoalkyl, haloalkyl, thioalkyl, alkylthioalkyl, carboxyalkyl, imidazolylalkyl, indolylalkyl, mono-, di- and trihaloalkyl, mono-, di- and trihaloalkoxy, amino, alkylamino, dialkylamino, alkoxy, hydroxy, halo (e.g.,
- R 50 , R 51 and R 52 may be independently selected from the following: a hydrogen atom and a branched or straight-chain, Ci- ⁇ alkyl, C 3 -6 cycloalkyl, C . 6 heterocycloalkyl, heteroaryl and aryl group, with or without substituents. When permissible, R 50 and R 51 can be joined together to form a carbocyclic or heterocyclic ring system. R 50 , R 51 and R 52 may also include:
- R 40 and R 41 are, independently of one another, each a hydrogen atom or a branched or straight-chain, optionally substituted, alkyl, cycloalkyl, heterocycloalkyl, halo, aryl, imidazolylalkyl, indolylalkyl, heteroaryl, arylalkyl, arylalkoxy, heteroarylalkyl, heteroarylalkoxy, aminoalkyl, haloalkyl, mono-, di- or trihaloalkyl, mono-, di- or trihaloalkoxy, nitro, cyano, alkoxy, hydroxy, amino, phosphino, phosphate, alkylamino, dialkylamino, formyl, alkylthio, trialkylsilyl, alkylsulfonyl, arylsulfonyl, alkylsulfinyl, aminoalkyl, alkylaminoalkyl, dialkylaminoalky
- R 42 is a hydrogen atom or a branched or straight-chain, optionally substituted, alkyl, alkenyl, arylalkyl or acyl group;
- R 43 is a hydrogen atom or a branched or straight-chain, optionally substituted, alkyl or aryl group; wherein, the optional substituents are defined the same as above for the one or more substituents.
- aryl and heteroaryl groups include, but are not limited to, any of the moieties recited above in the definition for R 40 and R 41 .
- heteroatom means a nitrogen, sulfur, or oxygen atom. Multiple heteroatoms in the same group may be the same or different.
- hydrocarbon as used herein, means a compound or radical consisting of only carbon and hydrogen atoms, including aliphatic, aromatic, normal, saturated and unsaturated hydrocarbons.
- alkyl means an unsubstituted or substituted, straight or branched, hydrocarbon chain (i.e., comprising carbon and hydrogen atoms bonded together), having, preferably, from one to twenty-four carbon atoms, more preferably, from one to twelve carbon atoms, and most preferably, from one to eight carbon atoms.
- cycloalkyl or "cycloalkane,” as used herein, means an unsubstituted or substituted, saturated, stable non-aromatic carbocyclic ring, having, preferably, from three to fifteen carbon atoms, more preferably, from three to eight carbon atoms.
- the carbon ring radical is saturated and may be fused, for example, benzofused, with one to three cycloalkyl, aromatic, heterocyclic or heteroaromatic rings.
- the cycloalkyl may be attached at any endocyclic carbon atom that results in a stable structure.
- Preferred carbocycles have from five to six carbons. Examples of carbocycle radicals include cyclopropyl, cyclobutyl, cyclopentyl, cyclohexyl, cycloheptyl and the like.
- alkenyl means an unsubstituted or substituted, unsaturated, straight or branched, hydrocarbon chain having at least one double bond present and, preferably, from two to fifteen carbon atoms, more preferably, from two to twelve carbon atoms.
- cycloalkenyl means an unsubstituted or substituted, unsaturated carbocyclic ring having at least one double bond present and, preferably, from three to fifteen carbon atoms, more preferably, from five to eight carbon atoms.
- a cycloalkenyl goup is an unsaturated carbocyclic group.
- Examples of cycloalkenyl groups include cyclopentenyl and cyclohexenyl.
- alkynyl means an unsubstituted or substituted, unsaturated, straight or branched, hydrocarbon chain having at least one triple bond present and, preferably, from two to twelve carbon atoms, more preferably, two to ten carbon atoms.
- bicycloalkyl represents a saturated linearly fused or bridged carbocyclic ring having, preferably, from 5 to 12 carbon atoms.
- aryl means a substituted or unsubstituted, aromatic, mono- or bicyclic carbocyclic ring system having from one to two aromatic rings.
- the aryl moiety will generally have from 6 to 14 carbon atoms with all available substitutable carbon atoms of the aryl moiety being intended as possible points of attachment.
- Representative examples include phenyl, tolyl, xylyl, cumenyl, naphthyl, tetrahydronaphthyl, indanyl, indenyl and the like.
- the carbocyclic moiety can be substituted with from one to five, preferably, one to three moieties, such as mono- through pentahalo, alkyl, trifluoromethyl, phenyl, hydroxy, alkoxy, phenoxy, amino, monoalkylamino, dialkylamino and the like.
- heteroaryl means a mono- or bicyclic ring system containing one or two aromatic rings and at least one nitrogen, oxygen or sulfur atom in an aromatic ring.
- Heteroaryl groups can be unsubstituted or substituted with a plurality of substituents, preferably, one to five substituents, more preferably, one, two or three substituents (e.g., mono- through pentahalo, alkyl, trifluoromethyl, phenyl, hydroxy, alkoxy, phenoxy, amino, monoalkylamino, dialkylamino and the like).
- a heteroaryl group represents a cyclic group of five or six atoms, or a bicyclic group of nine or ten atoms, at least one of which is carbon, and having at least one oxygen, sulfur or nitrogen atom interrupting a
- heteroaryl (heteroaromatic) groups are pyridinyl, pyrimidinyl, pyrazinyl, pyridazinyl, furanyl, benzofuranyl, thienyl, benzothienyl, thiazolyl, thiadiazolyl, imidazolyl, pyrazolyl, triazolyl, isothiazolyl, benzothiazolyl, benzoxazolyl, oxazolyl, pyrrolyl, isoxazolyl, 1 ,3,5-triazinyl and indolyl groups.
- arylalkyl means an alkyl moiety substituted with an optionally substituted, aryl or heteroaryl group.
- Representative arylalkyl groups include a benzyl group and fused bicyclic systems which contain one aryl group.
- alkylaryl means an aryl or heteroaryl moiety substituted with an optionally substituted, alkyl group.
- Representative alkylaryl groups include o-, m- and p-linked tolyl and xylyl groups.
- heterocycloalkyl means an unsubstituted or substituted, saturated cyclic ring system having from three to fifteen members, preferably, from three to eight members, and comprising carbon atoms and at least one heteroatom as part of the ring.
- heterocyclic ring or “heterocycle,” as used herein, means an unsubstituted or substituted, saturated, unsaturated or aromatic ring, comprised of carbon atoms and one or more heteroatoms in the ring.
- Heterocyclic rings may be monocyclic or polycyclic. Monocyclic rings preferably contain from three to eight atoms, most preferably, five to seven atoms.
- Polycyclic ring systems consisting of two rings preferably contain from six to sixteen atoms, most preferably, ten to twelve atoms.
- Polycyclic ring systems consisting of three rings contain, preferably, from thirteen to seventeen atoms, most preferably, fourteen to fifteen atoms.
- Each heterocyclic ring has at least one hetero atom. Unless otherwise stated, the heteroatoms may be independently selected from the following: nitrogen, sulfur and oxygen atoms.
- Carbocyclic ring or “carbocycle,” as used herein, means an unsubstituted or substituted, saturated, unsaturated or aromatic (e.g., aryl), hydrocarbon ring, unless otherwise specifically identified.
- Carbocycles may be monocyclic or polycyclic. Monocyclic rings preferably contain from three to eight atoms, most preferably, five to seven atoms. Polycyclic rings having two rings preferably contain from six to sixteen atoms, most preferably, ten to twelve atoms, and those having three rings preferably contain from thirteen to seventeen atoms, most preferably, fourteen to fifteen atoms.
- alkoxy means an oxygen atom bonded to a hydrocarbon chain, such as an alkyl or alkenyl group (e.g., -O-alkyl or -O- alkenyl).
- Representative alkoxy groups include methoxy, ethoxy, and isopropoxy groups.
- hydroxyalkyl means a substituted hydrocarbon chain, preferably, an alkyl group, having at least one hydroxy substituent (I.e., -OH). Additional substituents to the alkyl group may also be present.
- Representative hydroxyalkyl groups include hydroxy methyl, hydroxyethyl and hydroxypropyl groups.
- carboxyalkyl means a substituted hydrocarbon chain, preferably, a substituted alkyl group, which has a carboxyl substituent (e.g., -COOH) and may also have additional substituents (such as one of the representative substituents identified above for the term “substituted”).
- Representative carboxyalkyl groups include carboxymethyl (- CH 2 C0 2 H) and carboxyethyl (-CH 2 CH 2 CO 2 H) groups, and derivatives thereof, such as the corresponding esters.
- aminoalkyl means an alkyl group substituted with an amine moiety (e.g., -alkylNH2), such as aminomethyl.
- alkylamino means an amino moiety having from one or two alkyl substituents (e.g., -NH-alkyl), such as dimethylamino.
- alkenylamino means an amino moiety having from one or two alkenyl substituents, where the nitrogen atom of the amino group is not attached to the alkene-forming carbon atom (e.g., -NH-
- CH 2 -alkenyl such as dibutenylamino
- arylamino means an amine moiety substituted with an aryl group (i.e., -NH-aryl).
- aroyl means the radical R-CO-; where R is an aromatic group. Representative aroyls are benzoyl and naphthoyl.
- aryloxy means an oxygen atom having an aryl substituent (e.g., -O-aryl).
- esters means compounds containing a substituted carboxylic acid (e.g., -COO-aryl).
- Representative acyl groups include acetyl, propionyl, butanoyl and benzoyl groups.
- halo means a chloro, bromo, fluoro or iodo atom radical. Chlorides, bromides and fluorides are preferred halides.
- lower hydrocarbon e.g., “lower alkyl”
- lower alkyl means a hydrocarbon chain comprised of from, unless otherwise stated, one to eight carbon atoms, preferably, one to six carbon atoms, and most preferably, one to four carbon atoms.
- polyhalo represents substitution of at least two halo atoms to a group modified by the term “polyhalo.”
- aminosulfonyl represents a group having the formula: -SO 2 NR 79 R 89 , where R 79 and R 89 are, independently of one another, each a hydrogen atom or a lower alkyl (e.g., from 1 to 6 carbon atoms) or aryl group.
- sulfonyl represents a group having the formula: -S(O) 2 -.
- prodrug represents a compound that is a drug precursor, which following administration to a patient, releases a drug in Vo via some kind of chemical and/or physiological process (e.g., a prodrug on being brought to a physiological pH and/or through an enzyme action is converted to a desired drug form).
- compound of the formula (1.1 ) or (11.1) represents a compound having a chemical structure encompassed by the formula (1.1 ) or (11.1 ), and includes any and all enantiomers, stereoisomers, rotomers, tautomers and prodrugs of the compound.
- Compounds of the formula (1.1 ) or (11.1 ) also include their corresponding pharmaceutically- acceptable salts, solvates, esters and derivatives.
- pharmaceutically-acceptable excipients includes any physiologically inert, pharmacologically inactive material known to one skilled in the art, which is compatible with the physical and chemical characteristics of the particular active ingredient selected for use.
- Pharmaceutically-acceptable excipients include polymers, resins, plasticizers, fillers, binders, lubricants, glidants, disintegrates, solvents, co-solvents, buffer systems, surfactants, preservatives, sweetening agents, flavoring agents, pharmaceutical grade dyes or pigments, and viscosity agents.
- composition means a combination of at least one inventive compound (e.g., PDE V inhibitor) and at least one pharmaceutically-acceptable excipient.
- inventive compound e.g., PDE V inhibitor
- pharmaceutically-acceptable excipient e.g., PDE V inhibitor
- pharmaceutically-acceptable salt means a cationic salt formed at an acidic (e.g., carboxyl) group or an anionic salt formed at a basic (e.g., amino) group of the compound.
- acidic e.g., carboxyl
- anionic salt formed at a basic (e.g., amino) group of the compound.
- salts are known in the art, for example, those that are described in WO 87/05297 (1987), which is hereby incorporated in its entirety by reference herein.
- Preferred cationic salts include the alkali-metal salts (e.g., sodium and potassium) and alkaline earth metal salts (e.g., magnesium and calcium).
- Preferred anionic salts include the halide (e.g., chloride), acetate and phosphate salts.
- effective amount means an amount of a compound or composition which is sufficient to significantly and positively modify the symptoms and/or conditions to be treated (e.g., provide a positive clinical response).
- safe and effective amount means that an "effective amount” must also be safe, that is, an amount that is sufficient to provoke a positive response, yet is small enough to avoid serious side effects (at a reasonable benefit/risk ratio), within the scope of sound medical judgment.
- an active ingredient for use in a pharmaceutical composition will vary with the particular condition being treated, the severity of the condition, the duration of the treatment, the nature of concurrent therapy, the particular active ingredient being employed, the particular pharmaceutically-acceptable excipients utilized and like factors within the knowledge and expertise of the attending physician.
- administering [to a patient a safe and effective amount of the inventive compound] refers to any mode of introducing any form (e.g., solid, liquid or gas) of the inventive compounds in vivo to a patient (e.g., human or mammal).
- introduction of the inventive compound to a patient may be accomplished via oral ingestion (e.g., tablets, capsules, gels, solutions, etc.), adsorption, absorption (e.g., transmucosal sublingual or buccal administration), transdermal applications (e.g., topical applications via patches, lotions, etc.), suppositories, etc.
- oral dosage form means any pharmaceutical composition intended to be systemically administered to an individual by delivering the composition to the gastrointestinal tract of an individual, via the mouth of the individual.
- the delivered form can be a tablet (coated or non-coated), solution, suspension or capsule (coated or non-coated).
- injection means any pharmaceutical composition intended to be systemically administered to a human or other mammal, via delivery of a solution or emulsion containing the active ingredient, by puncturing the skin of said individual, in order to deliver the solution or emulsion to the circulatory system of the individual either by intravenous, intramuscular, intraperitoneal or subcutaneous injection.
- injection means any pharmaceutical composition intended to be systemically administered to a human or other mammal, via delivery of a solution or emulsion containing the active ingredient, by puncturing the skin of said individual, in order to deliver the solution or emulsion to the circulatory system of the individual either by intravenous, intramuscular, intraperitoneal or subcutaneous injection.
- the invention comprises a compound having the formula (I):
- R 1 and R 2 are, independently of one another, each a CM S alkyl group, branched or straight chain, with or without one or more substituents, such as a hydroxy or alkoxy substituent group, a C 2 . 15 alkenyl group, branched or straight chain, with or without one or more substituents, a C 2 - 15 alkynyl group, branched or straight chain, with or without one or more substituents, a C3-15 cycloalkyl group, with or without one or more substituents, an arylalkyl group, with or without one or more substituents, an aryl group, with or without one or more substituents, a heteroaryl group, with or without one or more substituents, -OR 5 , -COOR 5 , -C(O)R 5 or -C(O)N(R 5 ) 2 , where R 5 is a hydrogen atom or a hydrocarbon radical, with or without one or more substituents, such
- R 3 is an aryl group, with or without one or more substituents, such as a hydroxy or alkoxy substituent group, a heteroaryl group, with or without one or more substituents, or a heterocyclic group having from 1 to 3 heteroatoms fused to a 5- or 6-membered aryl ring, with or without one or more substituents, with the proviso that R 3 is not an aryl group substituted at its para position with a -Y-aryl group, where Y is a carbon-carbon single bond, -CO-, -O-, -S-, -N(R 21 )-, -CON(R 22 )-, -N(R 22 )CO-, -OCH2-, -CH 2 O-, -SCH 2 -, -CH 2 S-, -NHC(R 23 )(R 24 )-, -NR 23 SO 2 -, -SO 2 NR 23 -, -C(R 23 )
- R 21 is a hydrogen atom or a -CO(C ⁇ - 4 alkyl), C ⁇ - 6 alkyl, allyl, C 3 - 6 cycloalkyl, phenyl or benzyl group;
- R 22 is a hydrogen atom or a Ci- 6 alkyl group
- R 23 is a hydrogen atom or a C ⁇ _ 5 alkyl, aryl or -CH 2 -aryl group
- R 24 is a hydrogen atom or a C ⁇ - 4 alkyl group
- R 25 is a hydrogen atom or a C ⁇ . 8 alkyl, C ⁇ . 8 perfluoroalkyl, C 3 - 6 cycloalkyl, phenyl or benzyl group;
- R 26 is a hydrogen atom or a C ⁇ - 6 alkyl, C 3 . 6 cycloalkyl, phenyl or benzyl group;
- R 27 is -NR 23 R 24 , -OR 24 , -NHCONH 2 , -NHCSNH 2)
- R 28 and R 29 are, independently of one another, each a C-i- 4 alkyl group or, taken together, a -(CH2 group, where q is 2 or 3; Wherein, R 21 through R 29 are with or without one or more substituents; and
- R 4 is a C 3 . 15 cycloalkyl group, with or without substituents, such as a hydroxy substituent group, a C 3 - 15 cycloalkenyl group, with or without one or more substituents, or a heterocycloalkyl group of 3 to 15 members, with or without one or more substituents; wherein, the optional one or more substituents for all the groups are chemically-compatible and are, independently of one another, each defined the same as recited above in the definition section.
- the invention comprises at least one compound of the formula (I), which includes any and all enantiomers, stereoisomers, rotomers, tautomers and prodrugs of the at least one inventive compound.
- Compounds of the formula (I) also include their corresponding salts, solvates (e.g., hydrates), esters, and the like.
- the invention further comprises pharmaceutically- acceptable compositions prepared from an inventive compound or a mixture of inventive compounds, or a salt, solvate or ester thereof.
- the compounds of formula (I) can be useful for treating a variety of diseases, symptoms and physiological disorders, such as sexual dysfunction, especially impotence (e.g., erectile dysfunction).
- inventive compounds having the formula (I) are substituted at the 8-position on the chemical structure with an amino group that itself is substituted with one of the following groups: an unsaturated or saturated carbocyclic group and a saturated heterocyclic group.
- inventive substituted xanthines exhibited unexpectedly enhanced properties with respect to enzyme activity and enzyme selectivity. It is believed that the substitution at the 8-position of the subject PDE V inhibitor compounds with these specific groups, helped produce unexpectedly highly potent and selective xanthines, which exhibited increased isozyme selectivity when compared to conventional xanthines.
- Pharmaceutical compositions comprising the inventive compounds possess unexpectedly superior therapeutic properties.
- the 8-position on the chemical structure is substituted with a -NHR 4 group, where R 4 represents a carbocyclic or heterocyclic system defined as follows: a C 3 . 15 cycloalkyl group, a C3-1 5 cycloalkenyl group or a heterocycloalkyl group of 3 to 15 members. All of the cyclic systems are optionally substituted.
- Preferred substituents on the cyclic systems include a C 3 - 6 cycloalkyl group, a C ⁇ - 6 alkoxy C 1 - 6 alkyl group, a C1-6 alkyl group, an amino C1- 6 alkyl group, a C- ⁇ - 6 dialkylamino C ⁇ _ 6 alkyl group, a C 3 . 6 dicycloalkylamino C 1 .
- R 6 is a hydrogen atom or an optionally substituted, C- ⁇ - 6 alkyl, C 3 . 6 cycloalkyl, C 3 - 6 heterocycloalkyl, aryl or heteroaryl group;
- R 7 is a hydrogen atom or an optionally substituted, C- ⁇ - 6 alkyl, C 3 - 6 cycloalkyl, C 3 - 6 heterocycloalkyl, aryl or heteroaryl group; or R 6 and R 7 , when applicable, may be joined together to form a heterocyclic ring system; and
- R 8 is a hydrogen atom or an optionally substituted, C- ⁇ - 6 alkyl, C 3 - 6 cycloalkyl, C 3 . 6 heterocycloalkyl, aryl or heteroaryl group.
- R 4 may also be substituted with -ZR 70 Z'-, where R 70 , together with Z and Z', form a spiro-fused 5- to 7-membered ring or a linearly fused 4- to 7-membered ring system, and Z and Z', independently of one another, are each an oxygen, sulfur or nitrogen atom.
- R 4 may be substituted by the following structure having the formula (VIII):
- substituents are defined above for the groups.
- Other substituents may also be used, such as ketones, oximes, cyclic systems, including lineraly fused and bridged, mono-, bi- and tricyclic rings, spiro-cyclic systems, including ketals and thioketals directly attached to R 4 , halogens and sulfonamides.
- ketones, oximes, cyclic systems, including lineraly fused and bridged, mono-, bi- and tricyclic rings, spiro-cyclic systems, including ketals and thioketals directly attached to R 4 , halogens and sulfonamides One skilled in the art can determine other possible substituents depending on the conditions employed and the desired properties.
- a preferred structure of the invention is represented by formula (II):
- R 1 , R 2 and R 3 are defined the same as above for the compound of formula (I);
- R 9 is one of the following atoms or groups: (a) a hydrogen atom; (b) an oximino group;
- R 10 and R 11 are substituents on the same or different carbon atoms of the ring and, independently of one another, are each defined the same as above for R 9 and, additionally, may each be one of the following groups: (a) a hydroxy group;
- R 14 is a hydrogen atom or an optionally substituted, alkyl or aryl group; or R 10 and R 11 , taken together with each other and, optionally, with one or more carbon and/or hetero atoms of the ring, form an optionally substituted, spiro-fused, linearly fused, bi- or tri-cyclic ring system of from 8 to 12 members, including from 0 to 4 hetero atoms, where, all of the above R 10 , R 11 and R 14 groups are optionally substituted; m and n are, independently of one another, each from 1 to 3; and
- X is a chemcially-compatible group, which is -C(R 10 R 11 )-, -S(0) y , -O-, -N(R 60 )-, where:
- R 10 and R 11 are, independently of one another, each defined the same as previously; y is from 0 to 2;
- R 60 is a hydrogen atom or a C-
- R 61 is a hydrogen atom or a C ⁇ - 8 alkyl, C ⁇ - 8 alkynyl, C 1 - 8 alkenyl, C 3 -s cycloalkyl, aryl, heteroaryl or C . 8 heterocyclic group, with or without substituents;
- R 62 is a hydrogen atom or a C ⁇ - 8 alkyl, C ⁇ . 8 alkynyl, C ⁇ - 8 alkenyl, C 3 - 8 cycloalkyl, aryl, heteroaryl or C .
- R 61 and R 62 are (the same or different) alkyl groups, they can, if desired, be joined together to form a carbocyclic or heterocyclic ring system; wherein, the optional substituents and the one or more substituents are defined the same as for the one or more substituents of formula (I) above.
- the different carbon atoms to which R 10 and R 11 may be connected can be adjacent or non-adjacent.
- R 9 , R 10 and R 11 are all hydrogen atoms.
- one of R 10 or R 11 is, advantageously, a hydroxy group.
- R 1 is, preferably, an alkyl group or an arylalkyl group, particularly, a benzyl group. More preferably, R 1 is a lower alkyl group of from 1 to 4 carbon atoms, and most preferably, a methyl or ethyl group.
- R 2 in the compounds of formulas (I) and (II), is, preferably, an alkyl group, particularly, an alkyl group substituted with a hydroxy group. More preferably, R 2 is a lower alkyl group of from 1 to 3 carbon atoms or a hydroxyalkyl group, and most preferably, R 2 is a methyl, ethyl, iso-butyl or hydroxyethyl group.
- R 3 is, preferably, an aryl group, particularly, an aryl group substituted with a hydroxy-, alkoxy- or amino-sulfonyl group, which may be, advantageously, substituted with 1 or 2 halogen atoms.
- R 3 is a heteroaryl group in the compounds of formulas (I) and (II), it is generally preferable to utilize heteroaryl groups other than furan.
- R 3 is a methoxyaryl group substituted on its aryl ring with at least one halogen atom, for example, a substitution with 1 or 2 halogen atoms, such as chlorine or bromine.
- R 3 can be 4- hydroxyphenyl, 3-chloro-4-hydroxyphenyl, 3-bromo-4-hydroxyphenyl, 4- methoxyphenyl, 3-ch!oro-4-methoxyphenyl, 3-bromo-4-methoxyphenyl, 4- aminosulfonylphenyl group, 3-chloro-4-aminosulfonylphenyl group or 3- bromo-4-aminosulfonyl-phenyl.
- R 4 in the compound of formula (I), is, preferably, a cycloalkyl or heterocycloalkyl group, particularly, a cycloalkyl group substituted with a hydroxy group. More preferably, R 4 is a cyclohexyl, hydroxycyclopentyl or tetrahydropyranyl group. Most preferably, R 4 is a hydroxycyclopentyl group. For instance, R 4 can be a 2(R)-hydroxy-1 (R)-cycIopentyl group. All of the preferred embodiments may be unsubstituted or substituted.
- the compounds of formulas (I) and (II) are useful for treating urogenital diseases, such as male (e.g., impotence / erectile dysfunction) and female sexual dysfunction.
- urogenital diseases such as male (e.g., impotence / erectile dysfunction) and female sexual dysfunction.
- the following compounds listed in Tables I and II are illustrative of the invention:
- the compounds of the invention are useful for inhibiting PDE V enzymes. Their enzyme activities and enzyme selectivities can be evaluated in a number of ways. In particular, enzyme activity can be measured by the PDE V IC 50 value, which is the concentration (in nM) of the compound required to provide 50% inhibition of PDE V. The lower the value of IC50, the more active is the compound. Measurements on the compounds in Tables I and II gave the following data (all numbers are modified by the word "about”):
- PDE VI / PDE V a ratio of PDE VI ICso / PDE V IC 50 (identified as "PDE VI / PDE V"), which is an indicator of enzyme selectivity - the higher the ratio, the more selective is the compound to inhibiting PDE V enzyme relative to PDE VI enzyme.
- 177, 185 and 199 had a PDE VI / PDE V ratio within the range of from > 25 to 50; J. compound nos. 103, 110, 111 , 117, 159, 166, 182 and 187 had a PDE VI / PDE V ratio within the range of from > 50 to 75; K. compound nos. 105, 106, 147 and 171 had a PDE VI / PDE V ratio within the range of from > 75 to 100; L compound nos. 112, 113, 123, 124, 126, 169, 172 and 184 had a PDE VI / PDE V ratio within the range of from > 100 to 140; and M. compound nos. 107, 114-16, 118-22, 128, 160-61, 176, 178-81,
- Preferred compounds of the invention include those found in classes E and/or M: compound nos. 60-65, 67, 103-07, 114-24, 128, 142, 160-61 , 168- 70, 176-78, 179, 186, 188, 191 , 197 and 198. More preferred compounds of the invention are compound nos. 107, 114, 116, 118, 119, 122, 160, 178 and 186 of Table II.
- Another preferred compound of the invention would have the following chemical structure:
- the invention includes a method for producing a compound having the formula (I), comprising:
- R 1 is a hydrogen atom or a C 1 . 15 alkyl group, branched or straight chain, with or without one or more substituents, a C2-15 alkenyl group, branched or straight chain, with or without one or more substituents, a C 2 - 15 alkynyl group, branched or straight chain, with or without one or more substituents, a C 3 - 15 cycloalkyl group, with or without one or more substituents, an arylalkyl group, with or without one or more substituents, an aryl group, with or without one or more substituents, a heteroaryl group, with or without one or more substituents, -OR 5 , -COOR 5 , -C(O)R 5 or -C(O)N(R 5 ) 2 , where R 5 is a hydrogen atom or a hydrocarbon radical, branched or straight-chain, with or without one or more substituents
- L is R 2 or a protected form of R 2 ;
- Ph is a phenyl group
- X is a halogen atom (e.g., a chlorine or bromine atom) and R 3 is an aryl group, with or without one or more substituents, a heteroaryl group, with or without one or more substituents, or a heterocyclic group having 1 to 3 heteroatoms fused to a 5 or 6 membered aryl ring, with or without one or more substituents, with the proviso that R 3 is not an aryl group substituted at its para position with a -Y-aryl group, where Y is a carbon-carbon single bond, -CO-, -O-, -S-, -N(R 21 )-, -CON(R 22 )-, -N(R 22 )CO-, -OCH 2 -, -CH 2 O-, -SCH2-, -CH 2 S-, -NHC(R 23 )(R 24 )-, -NR 23 S0 2 -, -S0 2 NR 23
- R 21 is a hydrogen atom or a -CO(C ⁇ _ 4 alkyl), C ⁇ . 6 alkyl, allyl, C 3 - 6 cycloalkyl, phenyl or benzyl group;
- R 22 is a hydrogen atom or a C1-6 alkyl group
- R 23 is a hydrogen atom or a C1- 5 alkyl, aryl or -CH 2 -aryl group
- R 24 is a hydrogen atom or a C ⁇ - 4 alkyl group
- R 25 is a hydrogen atom or a C 1 . 8 alkyl, C ⁇ - 8 perfluoroalkyl; C3-6 cycloalkyl, phenyl or benzyl group;
- R 26 is a hydrogen atom or a C 1 - 6 alkyl, C 3 . 6 cycloalkyl, phenyl or benzyl group;
- R 27 is -NR 23 R 24 , -OR 24 , -NHCONH 2> -NHCSNH 2 ,
- R 28 and R 29 are, independently of one another, each a C1- alkyl group, or R 28 and R 29 , taken together with each other, are a -(CH2)g group, where q is 2 or 3; wherein, R 21 through R 29 are optionally substituted with any of the groups defined above for the one or more substituents; and
- Hal is a halogen atom
- R 2 is defined the same as R 1 above, with the proviso that at least one of R 1 and R 2 is not a hydrogen atom; wherein, the one or more substituents are defined the same as for the one or more substituents of formula (I) above.
- compositions of the present invention may be administered to humans or other mammals by a variety of routes, including oral dosage forms and injections (intravenous, intramuscular, intraperitoneal, subcutaneous, and the like).
- oral dosage forms and injections intravenous, intramuscular, intraperitoneal, subcutaneous, and the like.
- Numerous other dosage forms containing the compounds of the present invention can be readily formulated by one skilled in the art, utilizing the suitable pharmaceutical excipients as defined below.
- oral dosage forms are generally most preferred.
- the rate of systemic delivery can be satisfactorily controlled by one skilled in the art, by manipulating any one or more of the following: (a) the active ingredient proper; (b) the pharmaceutically-acceptable excipient(s), so long as the variants do not interfere in the activity of the particular active ingredient selected;
- compositions include flavoring agents, pharmaceutical-grade dyes or pigments, solvents, co-solvents, buffer systems, surfactants, preservatives, sweetener agents, viscosity agents, fillers, lubricants, glidants, disintegrants, binders and resins.
- compositions of the invention generally contain from about 0 to 2 % of flavoring agents.
- compositions of the invention generally contain from about 0 to 2 % of dyes and/or pigments.
- compositions of the invention generally contain from about 0.1 to 99.9 % of solvent(s).
- a preferred solvent is water.
- Preferred co-solvents include ethanol, glycerin, propylene glycol, polyethylene glycol, and the like.
- the pharmaceutical compositions of the invention may include from about 0 to 50 % of co-solvents.
- Preferred buffer systems include acetic, boric, carbonic, phosphoric, succinic, malaic, tartaric, citric, acetic, benzoic, lactic, glyceric, gluconic, glutaric and glutamic acids and their sodium, potassium and ammonium salts.
- Particularly preferred buffers are phosphoric, tartaric, citric and acetic acids and salts thereof.
- the pharmaceutical compositions of the invention generally contain from about 0 to 5 % of a buffer.
- Preferred surfactants include polyoxyethylene sorbitan fatty acid esters, polyoxyethylene monoalkyl ethers, sucrose monoesters and lanolin esters and ethers, alkyl sulfate salts and sodium, potassium and ammonium salts of fatty acids.
- the pharmaceutical compositions of the invention generally contain from about 0 to 2 % of surfactants.
- Preferred preservatives include phenol, alkyl esters of parahydroxybenzoic acid, o-phenylphenol benzoic acid and salts thereof, boric acid and salts thereof, sorbic acid and salts thereof, chlorobutanol, benzyl alcohol, thimerosal, phenylmercuric acetate and nitrate, nitromersol, benzalkonium chloride, cetylpyridinium chloride, methyl paraben and propyl paraben.
- Particularly preferred preservatives are the salts of benzoic acid, cetylpyridinium chloride, methyl paraben and propyl paraben.
- the pharmaceutical compositions of the invention generally include from about 0 to 2 % of preservatives.
- Preferred sweeteners include sucrose, glucose, saccharin, sorbitol, mannitol and aspartame. Particularly preferred sweeteners are sucrose and saccharin.
- Pharmaceutical compositions of the invention generally include from about 0 to 5 % of sweeteners.
- Preferred viscosity agents include methylcellulose, sodium carboxymethylcellulose, hydroxypropyl-methylcellulose, hydroxypropylcellulose, sodium alginate, carbomer, povidone, acacia, guar gum, xanthan gum and tragacanth. Particularly preferred viscosity agents are methylcellulose, carbomer, xanthan gum, guar gum, povidone, sodium carboxymethylcellulose, and magnesium aluminum silicate.
- Pharmaceutical compositions of the invention generally include from about 0 to 5 % of viscosity agents.
- Preferred fillers include lactose, mannitol, sorbitol, tribasic calcium phosphate, diabasic calcium phosphate, compressible sugar, starch, calcium sulfate, dextro and microcrystalline cellulose.
- Pharmaceutical compositions of the invention generally contain from about 0 to 75 % of fillers.
- Preferred lubricants/glidants include magnesium stearate, stearic acid and talc.
- Pharmaceutical compositions of the invention generally include from about 0 to 7 %, preferably, about 1 to 5 % of lubricants/glidants.
- Preferred disintegrants include starch, sodium starch glycolate, crospovidone and croscarmelose sodium and microcrystalline cellulose.
- compositions of the invention generally include from about 0 to 20 %, preferably, about 4 to 15 % of disintegrants.
- Preferred binders include acacia, tragacanth, hydroxypropylcellulose, pregelatinized starch, gelatin, povidone, hydroxypropylcellulose, hydroxypropylmethylcellulose, methylcellulose, sugar solutions, such as sucrose and sorbitol, and ethylcellulose.
- Pharmaceutical compositions of the invention generally include from about 0 to 12 %, preferably, about 1 to10 % of binders. Additional agents known to a skilled formulator may be combined with the compounds of the invention to create a single dosage form. Alternatively, additional agents may be separately administered to a mammal as part of a multiple dosage form.
- pharmaceutically acceptable carriers can be either solid or liquid.
- Solid form preparations include powders, tablets, dispersible granules, capsules, cachets and suppositories.
- the powders and tablets may be comprised of from about 5 to 95 weight percent of active ingredient.
- Suitable solid carriers are known in the art, for example, magnesium carbonate, magnesium stearate, talc, sugar and lactose. Tablets, powders, cachets and capsules can be used as solid dosage forms suitable for oral administration. Examples of pharmaceutically-acceptable carriers and methods of manufacture for various compositions may be found in Remington's
- Liquid form preparations include solutions, suspensions and emulsions. Common liquid form preparations include water and water-propylene glycol solutions for parenteral injection or addition of sweeteners and opacifiers for oral solutions, suspensions and emulsions. Liquid form preparations may also include solutions for intranasal administration.
- Aerosol preparations suitable for inhalation include solutions and solids in powder form, which may be combined with a pharmaceutically acceptable carrier, such as an inert compressed gas (e.g., nitrogen).
- a pharmaceutically acceptable carrier such as an inert compressed gas (e.g., nitrogen).
- solid form preparations that may be converted, shortly before use, to liquid form preparations for either oral or parenteral administration.
- liquid forms include solutions, suspensions and emulsions.
- the compounds of the invention may also be delivered transdermally.
- the transdermal compositions can take the form of creams, lotions, aerosols and emulsions and may be included in a transdermal patch of a matrix or reservoir type as is conventional in the art for this purpose.
- the preferred mode of administering the compounds of the invention is oral.
- the pharmaceutical preparation is in a unit dosage form. In such a form, the preparation is subdivided into suitable sized unit doses containing appropriate quantities of the active component, for example, an effective amount to achieve the desired purpose.
- the quantity of active ingredient (compound) in a unit dose of preparation may be varied or adjusted from about 0.01 to 4,000 mg, preferably, from about 0.02 to 1 ,000 mg, more preferably, from about 0.3 to 500 mg, and most preferably, from about 0.04 to 250 mg, according to the particular application.
- a typical recommended daily dosage regimen for oral administration can range from about 0.02 to 2,000 mg/day, in two to four divided doses.
- the total daily dosage may be divided and administered in portions during the day as required.
- pharmaceutical compositions of the invention will be administered from about 1 to 5 times per day, or alternatively, as a continuous infusion. Such administration can be used as a chronic or acute therapy.
- the amount of active ingredient that may be combined with carrier materials to produce a single dosage form will vary depending upon the host treated and the particular mode of administration.
- a typical preparation will contain from about 5 to 95 % of active compound (w/w).
- such preparations will contain from about 20 to 80 wt. % of active compound.
- the pharmaceutically-acceptable carriers employed in conjunction with the compounds of the present invention are used at a concentration sufficient to provide a practical size to dosage relationship.
- the pharmaceutically- acceptable carriers in total, may comprise from about 0.1 to 99.9 % by weight of the pharmaceutical compositions of the invention, preferably, from about 20 to 80 % by weight.
- a maintenance dose of a compound, composition or combination of the invention may be administered, if necessary. Subsequently, the dosage or frequency of administration, or both, may be reduced, as a function of the symptoms, to a level at which the improved condition is retained. When the symptoms have been alleviated to the desired level, treatment should cease. Patients may, however, require intermittent treatment on a long-term basis upon any recurrence of disease symptoms.
- Specific dosage and treatment regimens for any particular patient may be varied and will depend upon a variety of factors, including the activity of the specific compound employed, the age, body weight, general health status, sex and diet of the patient, the time of administration, the rate of excretion, the specific drug combination, the severity and course of the symptoms being treated, the patient's disposition to the condition being treated and the judgment of the treating physician. Determination of the proper dosage regimen for a particular situation is within the skill of the art.
- the amount and frequency of the administration of compounds of the invention or their pharmaceutically acceptable salts may be regulated according to the judgment of the attending clinician, based on the factors recited above. As a skilled artisan will appreciate, lower or higher doses than those recited above may be required.
- a proper dosage level is based on the weight of the patient.
- dosage levels of between about 0.01 and 100 mg/kg of body weight per day, preferably, between about 0.5 and 75 mg/kg of body weight per day, and more preferably, between about 1 and 50 mg/kg of body weight per day, of the inventive compounds, compositions and salts thereof described herein, are therapeutically useful for the treatment of a variety of biological disorders, particularly, male and female sexual dysfunction. Between two patients of differing weights, a higher dosage will be used for the heavier patient, all other things being equal.
- the inventive compounds are understood to provide efficacious treatment of (male) erectile dysfunction, including a reasonable time of onset upon administration, and a reasonable duration after administration.
- a dosage of the inventive compound may be taken about an hour before a sex act is to be undertaken. Particular dosages will work within about thirty minutes of their administration.
- Ideal dosages will affect a patient within about fifteen minutes of their administration. While food, diet, pre-existing conditions, alcohol and other systemic conditions could lengthen the time delay for an inventive drug to work after its administration, it is understood that optimum dosages in combination with sexual stimulation will result in an efficacious drug treatment within and for a reasonable amount of time.
- inventive compounds can exist in unsolvated as well as solvated forms, including hydrated forms.
- solvated forms with pharmaceutically- acceptable solvents, such as water, ethanol and the like, are equivalent to the unsolvated forms for purposes of this invention.
- the inventive compounds may form pharmaceutically-acceptable salts with organic and inorganic acids.
- suitable acids for salt formation are hydrochloric, sulfuric, phosphoric, acetic, citric, malonic, salicylic, malic, fumaric, succinic, ascorbic, maleic, methanesulfonic and other mineral and carboxylic acids well known to those skilled in the art.
- the salts are prepared by contacting the free base forms with a sufficient amount of the desired acid to produce a salt in a conventional manner.
- the free base forms may be regenerated by treating the salt with a suitable dilute aqueous base solution, such as dilute aqueous sodium hydroxide, potassium carbonate, ammonia or sodium bicarbonate.
- the free base forms may differ somewhat from their respective salt forms in certain physical properties, such as solubility in polar solvents, but the salts are otherwise equivalent to their respective free base forms for purposes of the invention.
- the invention comprises a compound having the formula (I) or (II), a method for making an inventive compound, a method for making a pharmaceutical composition from at least one inventive compound and at least one pharmaceutically-acceptable carrier, and a method of using one or more inventive compounds to treat a variety of disorders, symptoms and diseases.
- inventive compounds and their pharmaceutically-acceptable salt and neutral compositions may be formulated together with a pharmaceutically- acceptable carrier.
- the resulting composition may be administered in vivo to mammals, such as men or women, to treat a variety of disorders, symptoms and diseases.
- the inventive compounds and compositions may be used to treat diseases of the urogenital system, specifically, male erectile dysfunction (e.g., impotence) and female sexual dysfunction.
- Male erectile dysfunction may be defined as an inability of the male to sufficiently obtain and/or sustain an erection to have intercourse with his mate.
- inventive PDE V inhibitors of formulas (I) and (II) are beneficial therapeutic agents because they elevate cGMP levels in the human body. This action facilitates corpus cavernosum smooth muscle relaxation, which provides an increased flow of blood therein and results in an erection. This makes the inventive compounds especially useful for treating impotence and other types of diseases that are affected by cGMP levels.
- another aspect of the invention is a method for treating erectile dysfunction in a mammal in need of such treatment, comprising administering to the mammal at least one compound having the formula (I) or (II) or a pharmaceutical composition thereof in an amount effective to ameliorate and/or reduce one or more of the symptoms associated with erectile dysfunction sufficiently enough so that the mammal can complete intercourse with another mammal.
- Viagra ® today is the most commonly prescribed medication to treat physiologically-caused erectile dysfunction ("ED"). Certain patients, however, can experience undesirable side effects while taking Viagra ® . For instance, the use of Viagra ® is contraindicated to patients who are using organic nitrates, either regularly or
- Combining Viagra ® with nitrates can cause a hypotensive episode or suddenly reduce blood pressure to dangerous levels, which may cause a heart attack.
- An advantage of the inventive compounds is that they can be particularly selective for the PDE V isoenzyme in comparison to other types of PDE isoenzymes, such as the PDE VI isoenzyme. It is believed that this increased selectivity will ameliorate side effects associated with the use of
- a representative inventive compound did not adversely react with nitrate medication in a rat. It is believed the same lack of adverse interaction will apply to all inventive compounds in all mammals, including humans.
- An adverse reaction with nitrate medication may be dangerous and fatal.
- Adverse reactions include any reaction that could jeopardize or otherwise diminish the body's physiological functions. More specifically, in the case of combination therapy for a patient, comprising administering to the patient a nitrate donating agent combined with a PDE V inhibitor agent, an adverse nitrate reaction would be one in which the patient's blood pressure drops significantly more than with either agent administered alone.
- This feature opens up a method of erectile dysfunction treatment to many patients who suffer from both an erectile dysfunction and a cardiovascular or other disease(s) that is treated with a nitrate donating medicament.
- Patients suffering from two or more different ailments that require dual (or multiple) treatments may have been born with one or both ailments, or later developed one or both ailments due to genetics or some other type of injury or disease, such as nerve damage, spinal cord injury, diabetes, and the like.
- the patient suffering from both erectile dysfunction and a need for a nitrate donating medicament can be treated for both conditions sequentially, concurrently and/or simultaneously.
- the combination therapy can be taken separately in any form, preferably in oral or patch doses, or can be formulated together for a single, combined dosage.
- the compounds of the present invention may be employed alone or in combination with other agents, particularly, other types of PDE inhibitors
- cGMP PDE V inhibitors prostanoids, ⁇ -adrenergic receptor, dopamine receptor agonists, melanocortin receptor agonists, endothelin receptor antagonists, endothelin converting enzyme inhibitors, angiotensin II receptor antagonists, angiotensin converting enzyme inhibitors, neutral metalloendopeptidase inhibitors, renin inhibitors, serotonin 5-HT 2c receptor agonists, nociceptin receptor agonists, rho kinase inhibitors, potassium channel modulators and inhibitors of multidrug resistance protein 5.
- cGMP PDE V inhibitors prostanoids, ⁇ -adrenergic receptor, dopamine receptor agonists, melanocortin receptor agonists, endothelin receptor antagonists, endothelin converting enzyme inhibitors, angiotensin II receptor antagonists, angiotensin converting enzyme inhibitors, neutral metalloendopeptidase inhibitors, renin inhibitors,
- therapeutic agents that may be used in combination with compounds of the invention are the following: PDE V inhibitors, such as
- sildenafil citrate (Viagra ® , Pfizer, Connecticut, United States), VardenafilTM
- prostanoids such as prostaglandin E-i; ⁇ -adrenergic agonists,
- inventive compounds may be used in an application of monotherapy to treat erectile dysfunction, they also may be used in combination therapy, in which the inventive compounds are combined with one or more other pharmaceutical compounds that are useful for treating erectile dysfunction and/or other types of disorders, symptoms and diseases.
- the inventive compounds are useful for treating urological disorders, in particular, female and male sexual dysfunctions. Other physiological disorders, symptoms and diseases can also benefit from cGMP-PDE V inhibition. More specifically, the inventive compounds, salts and derivatives thereof may be used to treat cardiovascular and cerebrovascular diseases, angina pectoris, hypertension, restenosis post angioplasty, endarterectomy, stent introduction, peripheral vascular diseases, cerebral stroke, respiratory tract disorders, such as reversible airway obstruction, chronic asthma and bronchitis, allergic disorders associated with atopy, such as urticaria, eczema, and rinitis, pulmonary hypertension, ischemic heart diseases, impaired glucose tolerance, diabetes and related complications, insulin resistance syndrome, hyperglycemia, polycystic ovarian syndrome, glomerular diseases, renal insufficiency, nephritis, tubular interstitial disease, autoimmune diseases, glaucoma, intestinal mot
- kits comprising separate containers in a single package, wherein the inventive pharmaceutical compounds, compositions and/or salts thereof are used in combination with pharmaceutically-acceptable carriers to treat disorders, symptoms and diseases where cGMP-PDE V inhibition plays a role.
- inventive compounds may be used in an application of monotherapy to treat erectile dysfunction, they also may be used in combination therapy, in which the inventive compounds are combined with one or more other pharmaceutical compounds that are useful for treating erectile dysfunction and/or other types of disorders, symptoms and diseases.
- the inventive compounds are useful for treating urological disorders, in particular, female and male sexual dysfunctions. Other physiological disorders, symptoms and diseases can also benefit from cGMP-PDE V inhibition. More specifically, the inventive compounds, salts and derivatives thereof may be used to treat cardiovascular and cerebrovascular diseases, angina pectoris, hypertension, restenosis post angioplasty, endarterectomy, stent introduction, peripheral vascular diseases, cerebral stroke, respiratory tract disorders, such as reversible airway obstruction, chronic asthma and bronchitis, allergic disorders associated with atopy, such as urticaria, eczema, and rinitis, pulmonary hypertension, ischemic heart diseases, impaired glucose tolerance, diabetes and related complications, insulin resistance syndrome, hyperglycemia, polycystic ovarian syndrome, glomerular diseases, renal insufficiency, nephritis, tubular interstitial disease, autoimmune diseases, glaucoma, intestinal mot
- kits comprising separate containers in a single package, wherein the inventive pharmaceutical compounds, compositions and/or salts thereof are used in combination with pharmaceutically-acceptable carriers to treat disorders, symptoms and diseases where cGMP-PDE V inhibition plays a role.
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Abstract
Description
Claims
Priority Applications (19)
Application Number | Priority Date | Filing Date | Title |
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BR0113953-3A BR0113953A (en) | 2000-09-19 | 2001-09-17 | Xanthine phosphodiesterase inhibitors v |
DK01971092T DK1319003T3 (en) | 2000-09-19 | 2001-09-17 | Xanthine Phosphodiesterase V Inhibitors |
IL15483901A IL154839A0 (en) | 2000-09-19 | 2001-09-17 | Xanthine phosphodiesterase v inhibitors |
KR1020037003898A KR100610417B1 (en) | 2000-09-19 | 2001-09-17 | Xanthine phosphodiesterase V inhibitors |
AU9102201A AU9102201A (en) | 2000-09-19 | 2001-09-17 | Xanthine phosphodiesterase v inhibitors |
AU2001291022A AU2001291022B2 (en) | 2000-09-19 | 2001-09-17 | Xanthine phosphodiesterase v inhibitors |
AT01971092T ATE433451T1 (en) | 2000-09-19 | 2001-09-17 | XANTHINE PHOSPHODIESTERAS V INHIBITORS |
JP2002529108A JP4015547B2 (en) | 2000-09-19 | 2001-09-17 | Xanthine phosphodiesterase V inhibitor |
CA002421910A CA2421910C (en) | 2000-09-19 | 2001-09-17 | Xanthine phosphodiesterase v inhibitors |
PL361729A PL205188B1 (en) | 2000-09-19 | 2001-09-17 | Xanthine phosphodiesterase v inhibitors |
HU0303016A HUP0303016A3 (en) | 2000-09-19 | 2001-09-17 | Xanthine phosphodiesterase v inhibitors, process for their preparation and pharmaceutical compositions containing them and their use |
SI200130934T SI1319003T1 (en) | 2000-09-19 | 2001-09-17 | Xanthine phosphodiesterase v inhibitors |
SK319-2003A SK3192003A3 (en) | 2000-09-19 | 2001-09-17 | Xanthine phosphodiesterase V inhibitors, process for their preparation, pharmaceutical composition comprising same and their use |
MXPA03002361A MXPA03002361A (en) | 2000-09-19 | 2001-09-17 | Xanthine phosphodiesterase v inhibitors. |
NZ524433A NZ524433A (en) | 2000-09-19 | 2001-09-17 | Xanthine phosphodiesterase V inhibitors |
DE60138955T DE60138955D1 (en) | 2000-09-19 | 2001-09-17 | Xanthin-phosphodiesteras-v-inhibitoren |
EP01971092A EP1319003B1 (en) | 2000-09-19 | 2001-09-17 | Xanthine phosphodiesterase v inhibitors |
NO20031238A NO328753B1 (en) | 2000-09-19 | 2003-03-18 | Xanthine phosphodiesterase V inhibitors |
HK03104628.9A HK1056550A1 (en) | 2000-09-19 | 2003-06-27 | Xanthine phosphodiesterase v inhibitors |
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US23356700P | 2000-09-19 | 2000-09-19 | |
US60/233,567 | 2000-09-19 |
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EP (1) | EP1319003B1 (en) |
JP (2) | JP4015547B2 (en) |
KR (1) | KR100610417B1 (en) |
CN (1) | CN1252071C (en) |
AR (1) | AR035199A1 (en) |
AT (1) | ATE433451T1 (en) |
AU (2) | AU9102201A (en) |
BR (1) | BR0113953A (en) |
CA (1) | CA2421910C (en) |
CY (1) | CY1109329T1 (en) |
DE (1) | DE60138955D1 (en) |
DK (1) | DK1319003T3 (en) |
EC (1) | ECSP034519A (en) |
ES (1) | ES2326956T3 (en) |
HK (1) | HK1056550A1 (en) |
HU (1) | HUP0303016A3 (en) |
IL (1) | IL154839A0 (en) |
MX (1) | MXPA03002361A (en) |
NO (1) | NO328753B1 (en) |
NZ (1) | NZ524433A (en) |
PE (1) | PE20020469A1 (en) |
PL (1) | PL205188B1 (en) |
PT (1) | PT1319003E (en) |
RU (1) | RU2302420C9 (en) |
SI (1) | SI1319003T1 (en) |
SK (1) | SK3192003A3 (en) |
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