WO2002024633A1 - Phenylpropionic acid derivatives - Google Patents
Phenylpropionic acid derivatives Download PDFInfo
- Publication number
- WO2002024633A1 WO2002024633A1 PCT/JP2001/008151 JP0108151W WO0224633A1 WO 2002024633 A1 WO2002024633 A1 WO 2002024633A1 JP 0108151 W JP0108151 W JP 0108151W WO 0224633 A1 WO0224633 A1 WO 0224633A1
- Authority
- WO
- WIPO (PCT)
- Prior art keywords
- acid derivatives
- phenylpropionic acid
- halogeno
- alkoxy
- alkyl
- Prior art date
Links
Classifications
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D213/00—Heterocyclic compounds containing six-membered rings, not condensed with other rings, with one nitrogen atom as the only ring hetero atom and three or more double bonds between ring members or between ring members and non-ring members
- C07D213/02—Heterocyclic compounds containing six-membered rings, not condensed with other rings, with one nitrogen atom as the only ring hetero atom and three or more double bonds between ring members or between ring members and non-ring members having three double bonds between ring members or between ring members and non-ring members
- C07D213/04—Heterocyclic compounds containing six-membered rings, not condensed with other rings, with one nitrogen atom as the only ring hetero atom and three or more double bonds between ring members or between ring members and non-ring members having three double bonds between ring members or between ring members and non-ring members having no bond between the ring nitrogen atom and a non-ring member or having only hydrogen or carbon atoms directly attached to the ring nitrogen atom
- C07D213/24—Heterocyclic compounds containing six-membered rings, not condensed with other rings, with one nitrogen atom as the only ring hetero atom and three or more double bonds between ring members or between ring members and non-ring members having three double bonds between ring members or between ring members and non-ring members having no bond between the ring nitrogen atom and a non-ring member or having only hydrogen or carbon atoms directly attached to the ring nitrogen atom with substituted hydrocarbon radicals attached to ring carbon atoms
- C07D213/44—Radicals substituted by doubly-bound oxygen, sulfur, or nitrogen atoms, or by two such atoms singly-bound to the same carbon atom
- C07D213/53—Nitrogen atoms
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K31/00—Medicinal preparations containing organic active ingredients
- A61K31/185—Acids; Anhydrides, halides or salts thereof, e.g. sulfur acids, imidic, hydrazonic or hydroximic acids
- A61K31/19—Carboxylic acids, e.g. valproic acid
- A61K31/192—Carboxylic acids, e.g. valproic acid having aromatic groups, e.g. sulindac, 2-aryl-propionic acids, ethacrynic acid
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K31/00—Medicinal preparations containing organic active ingredients
- A61K31/33—Heterocyclic compounds
- A61K31/395—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins
- A61K31/435—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins having six-membered rings with one nitrogen as the only ring hetero atom
- A61K31/44—Non condensed pyridines; Hydrogenated derivatives thereof
- A61K31/4418—Non condensed pyridines; Hydrogenated derivatives thereof having a carbocyclic group directly attached to the heterocyclic ring, e.g. cyproheptadine
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P3/00—Drugs for disorders of the metabolism
- A61P3/08—Drugs for disorders of the metabolism for glucose homeostasis
- A61P3/10—Drugs for disorders of the metabolism for glucose homeostasis for hyperglycaemia, e.g. antidiabetics
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P43/00—Drugs for specific purposes, not provided for in groups A61P1/00-A61P41/00
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P5/00—Drugs for disorders of the endocrine system
- A61P5/48—Drugs for disorders of the endocrine system of the pancreatic hormones
- A61P5/50—Drugs for disorders of the endocrine system of the pancreatic hormones for increasing or potentiating the activity of insulin
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07C—ACYCLIC OR CARBOCYCLIC COMPOUNDS
- C07C251/00—Compounds containing nitrogen atoms doubly-bound to a carbon skeleton
- C07C251/32—Oximes
- C07C251/50—Oximes having oxygen atoms of oxyimino groups bound to carbon atoms of substituted hydrocarbon radicals
- C07C251/54—Oximes having oxygen atoms of oxyimino groups bound to carbon atoms of substituted hydrocarbon radicals of hydrocarbon radicals substituted by singly-bound oxygen atoms
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D213/00—Heterocyclic compounds containing six-membered rings, not condensed with other rings, with one nitrogen atom as the only ring hetero atom and three or more double bonds between ring members or between ring members and non-ring members
- C07D213/02—Heterocyclic compounds containing six-membered rings, not condensed with other rings, with one nitrogen atom as the only ring hetero atom and three or more double bonds between ring members or between ring members and non-ring members having three double bonds between ring members or between ring members and non-ring members
- C07D213/04—Heterocyclic compounds containing six-membered rings, not condensed with other rings, with one nitrogen atom as the only ring hetero atom and three or more double bonds between ring members or between ring members and non-ring members having three double bonds between ring members or between ring members and non-ring members having no bond between the ring nitrogen atom and a non-ring member or having only hydrogen or carbon atoms directly attached to the ring nitrogen atom
- C07D213/60—Heterocyclic compounds containing six-membered rings, not condensed with other rings, with one nitrogen atom as the only ring hetero atom and three or more double bonds between ring members or between ring members and non-ring members having three double bonds between ring members or between ring members and non-ring members having no bond between the ring nitrogen atom and a non-ring member or having only hydrogen or carbon atoms directly attached to the ring nitrogen atom with hetero atoms or with carbon atoms having three bonds to hetero atoms with at the most one bond to halogen, e.g. ester or nitrile radicals, directly attached to ring carbon atoms
- C07D213/61—Halogen atoms or nitro radicals
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D213/00—Heterocyclic compounds containing six-membered rings, not condensed with other rings, with one nitrogen atom as the only ring hetero atom and three or more double bonds between ring members or between ring members and non-ring members
- C07D213/02—Heterocyclic compounds containing six-membered rings, not condensed with other rings, with one nitrogen atom as the only ring hetero atom and three or more double bonds between ring members or between ring members and non-ring members having three double bonds between ring members or between ring members and non-ring members
- C07D213/04—Heterocyclic compounds containing six-membered rings, not condensed with other rings, with one nitrogen atom as the only ring hetero atom and three or more double bonds between ring members or between ring members and non-ring members having three double bonds between ring members or between ring members and non-ring members having no bond between the ring nitrogen atom and a non-ring member or having only hydrogen or carbon atoms directly attached to the ring nitrogen atom
- C07D213/60—Heterocyclic compounds containing six-membered rings, not condensed with other rings, with one nitrogen atom as the only ring hetero atom and three or more double bonds between ring members or between ring members and non-ring members having three double bonds between ring members or between ring members and non-ring members having no bond between the ring nitrogen atom and a non-ring member or having only hydrogen or carbon atoms directly attached to the ring nitrogen atom with hetero atoms or with carbon atoms having three bonds to hetero atoms with at the most one bond to halogen, e.g. ester or nitrile radicals, directly attached to ring carbon atoms
- C07D213/62—Oxygen or sulfur atoms
- C07D213/63—One oxygen atom
- C07D213/65—One oxygen atom attached in position 3 or 5
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07B—GENERAL METHODS OF ORGANIC CHEMISTRY; APPARATUS THEREFOR
- C07B2200/00—Indexing scheme relating to specific properties of organic compounds
- C07B2200/07—Optical isomers
Landscapes
- Health & Medical Sciences (AREA)
- Chemical & Material Sciences (AREA)
- Organic Chemistry (AREA)
- Life Sciences & Earth Sciences (AREA)
- Diabetes (AREA)
- Pharmacology & Pharmacy (AREA)
- Animal Behavior & Ethology (AREA)
- General Health & Medical Sciences (AREA)
- Public Health (AREA)
- Veterinary Medicine (AREA)
- Medicinal Chemistry (AREA)
- Engineering & Computer Science (AREA)
- Bioinformatics & Cheminformatics (AREA)
- Chemical Kinetics & Catalysis (AREA)
- General Chemical & Material Sciences (AREA)
- Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
- Epidemiology (AREA)
- Endocrinology (AREA)
- Emergency Medicine (AREA)
- Hematology (AREA)
- Obesity (AREA)
- Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
- Acyclic And Carbocyclic Compounds In Medicinal Compositions (AREA)
Abstract
Phenylpropionic acid derivatives of the general formula (I) or their pharmacologically acceptable salts or esters, which are highly active and extremely safe and can ameliorate hyperlipemia, hyperglycemia and so on: (I) wherein X is CH or N; R1 is H, C¿1-6? alkyl, C1-6 alkoxy, or halogeno; and R?2¿ is C¿1-6? alkyl, C1-6 alkoxy, or halogeno.
Priority Applications (1)
Application Number | Priority Date | Filing Date | Title |
---|---|---|---|
AU2001288067A AU2001288067A1 (en) | 2000-09-21 | 2001-09-19 | Phenylpropionic acid derivatives |
Applications Claiming Priority (2)
Application Number | Priority Date | Filing Date | Title |
---|---|---|---|
JP2000-286495 | 2000-09-21 | ||
JP2000286495 | 2000-09-21 |
Publications (1)
Publication Number | Publication Date |
---|---|
WO2002024633A1 true WO2002024633A1 (en) | 2002-03-28 |
Family
ID=18770409
Family Applications (1)
Application Number | Title | Priority Date | Filing Date |
---|---|---|---|
PCT/JP2001/008151 WO2002024633A1 (en) | 2000-09-21 | 2001-09-19 | Phenylpropionic acid derivatives |
Country Status (2)
Country | Link |
---|---|
AU (1) | AU2001288067A1 (en) |
WO (1) | WO2002024633A1 (en) |
Cited By (4)
Publication number | Priority date | Publication date | Assignee | Title |
---|---|---|---|---|
WO2005030193A1 (en) * | 2003-09-25 | 2005-04-07 | Wyeth | 4-(phenyl-ethylideneaminoxy-propoxy) -phenyl-acetic acid derivatives and related compounds as pai-1 inhibitors for the treatment of impairment of the fibrinolytic system and of thrombosis |
EP1602642A1 (en) * | 2003-03-13 | 2005-12-07 | Ono Pharmaceutical Co., Ltd. | Imino ether derivative compounds and drugs containing the compounds as the active ingredient |
US10023528B2 (en) | 2011-04-13 | 2018-07-17 | Bayer Pharma Aktiengesellschaft | Branched 3-phenylpropionic acid derivatives and their use |
US11344519B2 (en) | 2018-07-24 | 2022-05-31 | Bayer Pharma Aktiengesellschaft | Orally administrable modified-release pharmaceutical dosage form |
Citations (3)
Publication number | Priority date | Publication date | Assignee | Title |
---|---|---|---|---|
WO1997008126A1 (en) * | 1995-08-28 | 1997-03-06 | American Home Products Corporation | Phenoxy acetic acids as aldose reductase inhibitors and antihyperglycemic agents |
EP0916651A1 (en) * | 1996-04-04 | 1999-05-19 | Sankyo Company, Limited | Phenylalkylcarboxylic acid derivatives |
JPH11193272A (en) * | 1997-10-01 | 1999-07-21 | Sankyo Co Ltd | Medicine containing phenylalkylcarboxylic acid derivative |
-
2001
- 2001-09-19 WO PCT/JP2001/008151 patent/WO2002024633A1/en active Application Filing
- 2001-09-19 AU AU2001288067A patent/AU2001288067A1/en not_active Abandoned
Patent Citations (3)
Publication number | Priority date | Publication date | Assignee | Title |
---|---|---|---|---|
WO1997008126A1 (en) * | 1995-08-28 | 1997-03-06 | American Home Products Corporation | Phenoxy acetic acids as aldose reductase inhibitors and antihyperglycemic agents |
EP0916651A1 (en) * | 1996-04-04 | 1999-05-19 | Sankyo Company, Limited | Phenylalkylcarboxylic acid derivatives |
JPH11193272A (en) * | 1997-10-01 | 1999-07-21 | Sankyo Co Ltd | Medicine containing phenylalkylcarboxylic acid derivative |
Cited By (8)
Publication number | Priority date | Publication date | Assignee | Title |
---|---|---|---|---|
EP1602642A1 (en) * | 2003-03-13 | 2005-12-07 | Ono Pharmaceutical Co., Ltd. | Imino ether derivative compounds and drugs containing the compounds as the active ingredient |
EP1602642A4 (en) * | 2003-03-13 | 2006-11-08 | Ono Pharmaceutical Co | Imino ether derivative compounds and drugs containing the compounds as the active ingredient |
WO2005030193A1 (en) * | 2003-09-25 | 2005-04-07 | Wyeth | 4-(phenyl-ethylideneaminoxy-propoxy) -phenyl-acetic acid derivatives and related compounds as pai-1 inhibitors for the treatment of impairment of the fibrinolytic system and of thrombosis |
JP2007506773A (en) * | 2003-09-25 | 2007-03-22 | ワイス | 4- (Phenyl-ethylideneaminoxy-propoxy) -phenyl-acetic acid derivatives and related compounds as PAI-1 inhibitors for the treatment of fibrinolytic disorders and thrombosis |
US10023528B2 (en) | 2011-04-13 | 2018-07-17 | Bayer Pharma Aktiengesellschaft | Branched 3-phenylpropionic acid derivatives and their use |
US10259776B2 (en) | 2011-04-13 | 2019-04-16 | Bayer Intellectual Property Gmbh | Branched 3-phenylpropionic acid derivatives and their use |
US11377417B2 (en) | 2011-04-13 | 2022-07-05 | Bayer Intellectual Property Gmbh | Branched 3-phenylpropionic acid derivatives and their use |
US11344519B2 (en) | 2018-07-24 | 2022-05-31 | Bayer Pharma Aktiengesellschaft | Orally administrable modified-release pharmaceutical dosage form |
Also Published As
Publication number | Publication date |
---|---|
AU2001288067A1 (en) | 2002-04-02 |
Similar Documents
Publication | Publication Date | Title |
---|---|---|
WO1996016046A3 (en) | Novel benzyl pyrimidines | |
CA2317462A1 (en) | 4-(2-keto-1-benzimidazolinyl)piperidine compounds as orl1-receptor agonists | |
WO2002101007A3 (en) | Antipathogenic benzamide compounds | |
CA2408602A1 (en) | Phenylglycine derivatives | |
EP1813270A4 (en) | Hsp90 family protein inhibitors | |
WO2002044153A8 (en) | 4-6-diphenyl pyridine derivatives as antiinflammatory agents | |
WO1999000373A8 (en) | Benzimidazole derivatives | |
AU2854399A (en) | NF-kappa inhibitors containing as the active ingredient phenylmethyl benzoquinone | |
EP0640586A4 (en) | Stilbene derivative and stilbene analog derivative, and use thereof. | |
CA2226894A1 (en) | 2-(4-substituted)-benzylamino-2-methyl-propanamide derivatives | |
WO2002024633A1 (en) | Phenylpropionic acid derivatives | |
DE50101861D1 (en) | TOCOTRIENOLCHINONE CYCLIZING PRODUCTS WITH ANTIHYPERCHOLESTERINE EFFECT | |
ES2093091T3 (en) | DERIVED FROM GLUTATION. | |
WO2003031414A1 (en) | Novel heterocyclic compound and anti-inflammatory agent | |
HK1049335A1 (en) | Hydrates and crystals of a neuraminic acid compound. | |
EP1437339A4 (en) | Substituted benzoic acid derivatives exhibiting nf-kappa b inhibiting activity | |
WO2004099130A3 (en) | 1,2-diarylimidazoles useful as inhibitors of cox | |
WO2001019811A3 (en) | N-arymethylthioanilide compounds useful for the inhibition of the replication of hiv | |
HRP20010885B1 (en) | Ethanesulfonyl-piperidine derivatives | |
EP0773214A4 (en) | Trifluoromethylquinolinecarboxylic acid derivative | |
EP1130018A4 (en) | Drug dependence remedies | |
EP1264829A4 (en) | Oxygen-containing heterocyclic compounds | |
WO2002010167A1 (en) | Dementia remedies containing 2-aryl-8-oxodihydropurine derivatives as the active ingredient | |
AU1651201A (en) | Amidinophenylpyruvic acid derivative | |
AU622590B2 (en) | Lowering of blood uric acid levels |
Legal Events
Date | Code | Title | Description |
---|---|---|---|
AK | Designated states |
Kind code of ref document: A1 Designated state(s): AU BR CA CN CO CZ HU ID IL IN KR MX NO NZ PL RU SG SK US ZA |
|
AL | Designated countries for regional patents |
Kind code of ref document: A1 Designated state(s): AT BE CH CY DE DK ES FI FR GB GR IE IT LU MC NL PT SE TR |
|
121 | Ep: the epo has been informed by wipo that ep was designated in this application | ||
122 | Ep: pct application non-entry in european phase |