WO2002024215A3 - Method for using activated protein c for the treatment of coagulation-associated disorders - Google Patents

Method for using activated protein c for the treatment of coagulation-associated disorders Download PDF

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Publication number
WO2002024215A3
WO2002024215A3 PCT/US2001/026028 US0126028W WO0224215A3 WO 2002024215 A3 WO2002024215 A3 WO 2002024215A3 US 0126028 W US0126028 W US 0126028W WO 0224215 A3 WO0224215 A3 WO 0224215A3
Authority
WO
WIPO (PCT)
Prior art keywords
activated protein
coagulation
treatment
associated disorders
remains
Prior art date
Application number
PCT/US2001/026028
Other languages
French (fr)
Other versions
WO2002024215A2 (en
Inventor
Sau-Chi Betty Yan
Original Assignee
Lilly Co Eli
Sau-Chi Betty Yan
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Application filed by Lilly Co Eli, Sau-Chi Betty Yan filed Critical Lilly Co Eli
Priority to AU2001290553A priority Critical patent/AU2001290553A1/en
Publication of WO2002024215A2 publication Critical patent/WO2002024215A2/en
Publication of WO2002024215A3 publication Critical patent/WO2002024215A3/en

Links

Classifications

    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K38/00—Medicinal preparations containing peptides
    • A61K38/16—Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof
    • A61K38/43—Enzymes; Proenzymes; Derivatives thereof
    • A61K38/46—Hydrolases (3)
    • A61K38/48—Hydrolases (3) acting on peptide bonds (3.4)
    • A61K38/482—Serine endopeptidases (3.4.21)
    • A61K38/4866—Protein C (3.4.21.69)
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P7/00—Drugs for disorders of the blood or the extracellular fluid

Landscapes

  • Health & Medical Sciences (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • Animal Behavior & Ethology (AREA)
  • Veterinary Medicine (AREA)
  • Chemical & Material Sciences (AREA)
  • Engineering & Computer Science (AREA)
  • Bioinformatics & Cheminformatics (AREA)
  • Public Health (AREA)
  • Medicinal Chemistry (AREA)
  • Pharmacology & Pharmacy (AREA)
  • General Health & Medical Sciences (AREA)
  • Epidemiology (AREA)
  • Proteomics, Peptides & Aminoacids (AREA)
  • Immunology (AREA)
  • Gastroenterology & Hepatology (AREA)
  • Diabetes (AREA)
  • Hematology (AREA)
  • Chemical Kinetics & Catalysis (AREA)
  • General Chemical & Material Sciences (AREA)
  • Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
  • Organic Chemistry (AREA)
  • Medicines That Contain Protein Lipid Enzymes And Other Medicines (AREA)

Abstract

A method of reducing the duration a human patient with a hypercoagulable state or protein C deficiency remains in a hospital, an intensive care unit, and/or remains on mechanical ventilation, which comprises administering to said patient activated Protein C (aPC).
PCT/US2001/026028 2000-09-18 2001-09-17 Method for using activated protein c for the treatment of coagulation-associated disorders WO2002024215A2 (en)

Priority Applications (1)

Application Number Priority Date Filing Date Title
AU2001290553A AU2001290553A1 (en) 2000-09-18 2001-09-17 Method for using activated protein c for the treatment of coagulation-associated disorders

Applications Claiming Priority (2)

Application Number Priority Date Filing Date Title
US23363600P 2000-09-18 2000-09-18
US60/233,636 2000-09-18

Publications (2)

Publication Number Publication Date
WO2002024215A2 WO2002024215A2 (en) 2002-03-28
WO2002024215A3 true WO2002024215A3 (en) 2003-05-22

Family

ID=22878074

Family Applications (1)

Application Number Title Priority Date Filing Date
PCT/US2001/026028 WO2002024215A2 (en) 2000-09-18 2001-09-17 Method for using activated protein c for the treatment of coagulation-associated disorders

Country Status (2)

Country Link
AU (1) AU2001290553A1 (en)
WO (1) WO2002024215A2 (en)

Citations (4)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
US6008199A (en) * 1997-10-20 1999-12-28 Eli Lilly And Company Methods for treating hypercoagulable states or acquired protein C deficiency
WO2000030677A1 (en) * 1998-11-20 2000-06-02 Eli Lilly And Company Method of treating viral hemorrhagic fever
WO2000030676A1 (en) * 1998-11-23 2000-06-02 Eli Lilly And Company Method of treating sickle cell disease and thalassemia
WO2001089558A2 (en) * 2000-05-24 2001-11-29 Eli Lilly And Company Formulations and use of activated protein c and protein c zymogen for treating hypercoagulable states

Patent Citations (4)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
US6008199A (en) * 1997-10-20 1999-12-28 Eli Lilly And Company Methods for treating hypercoagulable states or acquired protein C deficiency
WO2000030677A1 (en) * 1998-11-20 2000-06-02 Eli Lilly And Company Method of treating viral hemorrhagic fever
WO2000030676A1 (en) * 1998-11-23 2000-06-02 Eli Lilly And Company Method of treating sickle cell disease and thalassemia
WO2001089558A2 (en) * 2000-05-24 2001-11-29 Eli Lilly And Company Formulations and use of activated protein c and protein c zymogen for treating hypercoagulable states

Also Published As

Publication number Publication date
AU2001290553A1 (en) 2002-04-02
WO2002024215A2 (en) 2002-03-28

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