WO2002024152A3 - Oil in glycerin emulsion - Google Patents

Oil in glycerin emulsion Download PDF

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Publication number
WO2002024152A3
WO2002024152A3 PCT/IL2001/000826 IL0100826W WO0224152A3 WO 2002024152 A3 WO2002024152 A3 WO 2002024152A3 IL 0100826 W IL0100826 W IL 0100826W WO 0224152 A3 WO0224152 A3 WO 0224152A3
Authority
WO
WIPO (PCT)
Prior art keywords
oil
glycerin
bioactive compound
glycerin emulsion
emulsion
Prior art date
Application number
PCT/IL2001/000826
Other languages
French (fr)
Other versions
WO2002024152A2 (en
Inventor
Doron L Friedman
Original Assignee
J P M E D Ltd
Doron L Friedman
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Application filed by J P M E D Ltd, Doron L Friedman filed Critical J P M E D Ltd
Priority to EP01965547A priority Critical patent/EP1320353A2/en
Priority to AU2001286179A priority patent/AU2001286179A1/en
Publication of WO2002024152A2 publication Critical patent/WO2002024152A2/en
Publication of WO2002024152A3 publication Critical patent/WO2002024152A3/en

Links

Classifications

    • B—PERFORMING OPERATIONS; TRANSPORTING
    • B82—NANOTECHNOLOGY
    • B82Y—SPECIFIC USES OR APPLICATIONS OF NANOSTRUCTURES; MEASUREMENT OR ANALYSIS OF NANOSTRUCTURES; MANUFACTURE OR TREATMENT OF NANOSTRUCTURES
    • B82Y5/00—Nanobiotechnology or nanomedicine, e.g. protein engineering or drug delivery
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K47/00—Medicinal preparations characterised by the non-active ingredients used, e.g. carriers or inert additives; Targeting or modifying agents chemically bound to the active ingredient
    • A61K47/06—Organic compounds, e.g. natural or synthetic hydrocarbons, polyolefins, mineral oil, petrolatum or ozokerite
    • A61K47/08—Organic compounds, e.g. natural or synthetic hydrocarbons, polyolefins, mineral oil, petrolatum or ozokerite containing oxygen, e.g. ethers, acetals, ketones, quinones, aldehydes, peroxides
    • A61K47/10—Alcohols; Phenols; Salts thereof, e.g. glycerol; Polyethylene glycols [PEG]; Poloxamers; PEG/POE alkyl ethers
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K47/00—Medicinal preparations characterised by the non-active ingredients used, e.g. carriers or inert additives; Targeting or modifying agents chemically bound to the active ingredient
    • A61K47/44—Oils, fats or waxes according to two or more groups of A61K47/02-A61K47/42; Natural or modified natural oils, fats or waxes, e.g. castor oil, polyethoxylated castor oil, montan wax, lignite, shellac, rosin, beeswax or lanolin
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K8/00—Cosmetics or similar toiletry preparations
    • A61K8/02—Cosmetics or similar toiletry preparations characterised by special physical form
    • A61K8/04—Dispersions; Emulsions
    • A61K8/06—Emulsions
    • A61K8/062—Oil-in-water emulsions
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K8/00—Cosmetics or similar toiletry preparations
    • A61K8/18—Cosmetics or similar toiletry preparations characterised by the composition
    • A61K8/30—Cosmetics or similar toiletry preparations characterised by the composition containing organic compounds
    • A61K8/33—Cosmetics or similar toiletry preparations characterised by the composition containing organic compounds containing oxygen
    • A61K8/34—Alcohols
    • A61K8/345—Alcohols containing more than one hydroxy group
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K8/00—Cosmetics or similar toiletry preparations
    • A61K8/18—Cosmetics or similar toiletry preparations characterised by the composition
    • A61K8/30—Cosmetics or similar toiletry preparations characterised by the composition containing organic compounds
    • A61K8/33—Cosmetics or similar toiletry preparations characterised by the composition containing organic compounds containing oxygen
    • A61K8/35—Ketones, e.g. benzophenone
    • A61K8/355—Quinones
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K8/00—Cosmetics or similar toiletry preparations
    • A61K8/18—Cosmetics or similar toiletry preparations characterised by the composition
    • A61K8/30—Cosmetics or similar toiletry preparations characterised by the composition containing organic compounds
    • A61K8/60—Sugars; Derivatives thereof
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K8/00—Cosmetics or similar toiletry preparations
    • A61K8/18—Cosmetics or similar toiletry preparations characterised by the composition
    • A61K8/30—Cosmetics or similar toiletry preparations characterised by the composition containing organic compounds
    • A61K8/64—Proteins; Peptides; Derivatives or degradation products thereof
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K8/00—Cosmetics or similar toiletry preparations
    • A61K8/18—Cosmetics or similar toiletry preparations characterised by the composition
    • A61K8/30—Cosmetics or similar toiletry preparations characterised by the composition containing organic compounds
    • A61K8/67—Vitamins
    • A61K8/678—Tocopherol, i.e. vitamin E
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K8/00—Cosmetics or similar toiletry preparations
    • A61K8/18—Cosmetics or similar toiletry preparations characterised by the composition
    • A61K8/30—Cosmetics or similar toiletry preparations characterised by the composition containing organic compounds
    • A61K8/68—Sphingolipids, e.g. ceramides, cerebrosides, gangliosides
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K8/00—Cosmetics or similar toiletry preparations
    • A61K8/18—Cosmetics or similar toiletry preparations characterised by the composition
    • A61K8/92—Oils, fats or waxes; Derivatives thereof, e.g. hydrogenation products thereof
    • A61K8/922—Oils, fats or waxes; Derivatives thereof, e.g. hydrogenation products thereof of vegetable origin
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K8/00—Cosmetics or similar toiletry preparations
    • A61K8/18—Cosmetics or similar toiletry preparations characterised by the composition
    • A61K8/96—Cosmetics or similar toiletry preparations characterised by the composition containing materials, or derivatives thereof of undetermined constitution
    • A61K8/97—Cosmetics or similar toiletry preparations characterised by the composition containing materials, or derivatives thereof of undetermined constitution from algae, fungi, lichens or plants; from derivatives thereof
    • A61K8/9771—Ginkgophyta, e.g. Ginkgoaceae [Ginkgo family]
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K8/00—Cosmetics or similar toiletry preparations
    • A61K8/18—Cosmetics or similar toiletry preparations characterised by the composition
    • A61K8/96—Cosmetics or similar toiletry preparations characterised by the composition containing materials, or derivatives thereof of undetermined constitution
    • A61K8/97—Cosmetics or similar toiletry preparations characterised by the composition containing materials, or derivatives thereof of undetermined constitution from algae, fungi, lichens or plants; from derivatives thereof
    • A61K8/9783—Angiosperms [Magnoliophyta]
    • A61K8/9789—Magnoliopsida [dicotyledons]
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K9/00—Medicinal preparations characterised by special physical form
    • A61K9/0012—Galenical forms characterised by the site of application
    • A61K9/0014—Skin, i.e. galenical aspects of topical compositions
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K9/00—Medicinal preparations characterised by special physical form
    • A61K9/10—Dispersions; Emulsions
    • A61K9/107—Emulsions ; Emulsion preconcentrates; Micelles
    • A61K9/1075—Microemulsions or submicron emulsions; Preconcentrates or solids thereof; Micelles, e.g. made of phospholipids or block copolymers
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61Q—SPECIFIC USE OF COSMETICS OR SIMILAR TOILETRY PREPARATIONS
    • A61Q19/00—Preparations for care of the skin
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K2800/00—Properties of cosmetic compositions or active ingredients thereof or formulation aids used therein and process related aspects
    • A61K2800/20—Chemical, physico-chemical or functional or structural properties of the composition as a whole
    • A61K2800/21—Emulsions characterized by droplet sizes below 1 micron

Landscapes

  • Health & Medical Sciences (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • General Health & Medical Sciences (AREA)
  • Public Health (AREA)
  • Animal Behavior & Ethology (AREA)
  • Veterinary Medicine (AREA)
  • Chemical & Material Sciences (AREA)
  • Epidemiology (AREA)
  • Birds (AREA)
  • Engineering & Computer Science (AREA)
  • Biotechnology (AREA)
  • Medicinal Chemistry (AREA)
  • Pharmacology & Pharmacy (AREA)
  • Biophysics (AREA)
  • Oil, Petroleum & Natural Gas (AREA)
  • Mycology (AREA)
  • Microbiology (AREA)
  • Molecular Biology (AREA)
  • Botany (AREA)
  • Nanotechnology (AREA)
  • Dermatology (AREA)
  • Bioinformatics & Cheminformatics (AREA)
  • General Engineering & Computer Science (AREA)
  • Medical Informatics (AREA)
  • Crystallography & Structural Chemistry (AREA)
  • Emergency Medicine (AREA)
  • Dispersion Chemistry (AREA)
  • Natural Medicines & Medicinal Plants (AREA)
  • General Chemical & Material Sciences (AREA)
  • Chemical Kinetics & Catalysis (AREA)
  • Medicinal Preparation (AREA)
  • Cosmetics (AREA)

Abstract

The invention provides a cosmetic or pharmaceutical composition in the form in oil-in-glycerin emulsion with mean droplet size below one micron, comprising a continuous glycerin phase at least one vegetable oil comprising an internal phase at least one emulsifying stabilizer and at least one bioactive compound comprising at least one hydrophobic moiety within its structure, wherein said composition facilitates stratum corneum penetration and dermal penetration of said bioactive compound.
PCT/IL2001/000826 2000-09-21 2001-09-02 Oil in glycerin emulsion WO2002024152A2 (en)

Priority Applications (2)

Application Number Priority Date Filing Date Title
EP01965547A EP1320353A2 (en) 2000-09-21 2001-09-02 Oil in glycerin emulsion
AU2001286179A AU2001286179A1 (en) 2000-09-21 2001-09-02 Oil in glycerin emulsion

Applications Claiming Priority (2)

Application Number Priority Date Filing Date Title
IL138,616 2000-09-21
IL13861600A IL138616A0 (en) 2000-09-21 2000-09-21 Oil in glycerin emulsion

Related Child Applications (1)

Application Number Title Priority Date Filing Date
US10/394,111 Continuation-In-Part US7393548B2 (en) 1999-03-22 2003-03-21 Nano oil in glycerin emulsion

Publications (2)

Publication Number Publication Date
WO2002024152A2 WO2002024152A2 (en) 2002-03-28
WO2002024152A3 true WO2002024152A3 (en) 2002-07-25

Family

ID=11074664

Family Applications (1)

Application Number Title Priority Date Filing Date
PCT/IL2001/000826 WO2002024152A2 (en) 2000-09-21 2001-09-02 Oil in glycerin emulsion

Country Status (4)

Country Link
EP (1) EP1320353A2 (en)
AU (1) AU2001286179A1 (en)
IL (1) IL138616A0 (en)
WO (1) WO2002024152A2 (en)

Families Citing this family (18)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
US7393548B2 (en) 1999-03-22 2008-07-01 J.P. M.E.D. Ltd. Nano oil in glycerin emulsion
EP1562543A1 (en) * 2002-11-21 2005-08-17 J.P.M.E.D. Ltd. Compositions for treating infected skin and mucous membrane comprising an anti-microbial agent and an essential oil
US8758743B2 (en) 2003-01-17 2014-06-24 Taiyo Kagaku Co., Ltd. Compositions containing coenzyme Q10
DE10301505A1 (en) * 2003-01-17 2004-07-29 Cognis Deutschland Gmbh & Co. Kg Liquid crystalline aqueous surfactant gel for use in cosmetics and skin moisture regulation contains a carbohydrate ester and an amphiphilic structure-former
CN100453115C (en) * 2003-05-26 2009-01-21 上海医药工业研究院 Self-emulsifying agglomerant of oral polypeptide medicine
WO2005034913A1 (en) 2003-10-10 2005-04-21 Eisai Co., Ltd. Novel liquid preparation composition
IL159729A0 (en) * 2004-01-06 2004-06-20 Doron I Friedman Non-aqueous composition for oral delivery of insoluble bioactive agents
CN101212950B (en) * 2005-05-02 2013-09-18 Isp投资有限公司 Lamellar oil-in-glycol gel compositions and the process of preparation
EP2016833A1 (en) * 2007-07-17 2009-01-21 Cognis IP Management GmbH Emulsion
FR2933871B1 (en) * 2008-07-18 2012-12-14 Yvery FORMULATION FOR IMPROVING THE BIOAVAILABILITY OF A HYDROPHOBIC MOLECULE
JP2012510466A (en) * 2008-12-01 2012-05-10 ライラ ファーマシューティカルズ ピーブイティ．エルティディ． Topical formulations for the treatment of inflammation, skin and mucosal abnormalities and other skin and mucosal diseases
US8557264B2 (en) * 2009-12-10 2013-10-15 3rd Rock Sunblock, Inc. Glycerine based jelly compositions
WO2011095970A1 (en) * 2010-02-07 2011-08-11 J.P.M.E.D. Ltd. Hair follicle targeting compositions
JP5936234B2 (en) * 2010-04-09 2016-06-22 ディーエスエム アイピー アセッツ ビー．ブイ． Heat-stable oil-in-water emulsion containing oil containing polyunsaturated fatty acid
BRPI1003486B1 (en) * 2010-05-25 2017-03-28 Isp Do Brasil Ltda skin barrier repair comedic composition, uses of cosmetic composition, cosmetic product and method for preparation of lipid barrier in orthorhombic
RU2460511C1 (en) * 2011-05-23 2012-09-10 Вагинак Львович Ханикян Composition for making cosmetic and therapeutic emulsions and method for making it
CN103861090B (en) * 2012-12-18 2017-06-13 美迪思生物科技(北京)有限公司 Hydrophobic sol, Preparation Method And The Use containing albumen or polypeptide
GB2518845A (en) * 2013-10-01 2015-04-08 Cosmetic Warriors Ltd Composition

Citations (6)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
EP0361928A2 (en) * 1988-09-29 1990-04-04 Shiseido Company Limited Emulsified composition
US5350773A (en) * 1992-01-14 1994-09-27 Basf Aktiengesellschaft Stable, liquid products containing fat-soluble substances
JPH09111237A (en) * 1995-10-20 1997-04-28 T Hasegawa Co Ltd Antioxidant for docosahexaenoic acid compound
US6004566A (en) * 1992-03-26 1999-12-21 Pharmos Corp. Topical and transdermal delivery system utilizing submicron oil spheres
US6066328A (en) * 1994-10-07 2000-05-23 L'oreal Cosmetic or dermatological composition comprising an oil-in-water emulsion comprising oily globules with a lamellar liquid crystal coating
WO2000056346A1 (en) * 1999-03-22 2000-09-28 J.P.M.E.D. Ltd. Stable oil-in-glycerin emulsion

Patent Citations (6)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
EP0361928A2 (en) * 1988-09-29 1990-04-04 Shiseido Company Limited Emulsified composition
US5350773A (en) * 1992-01-14 1994-09-27 Basf Aktiengesellschaft Stable, liquid products containing fat-soluble substances
US6004566A (en) * 1992-03-26 1999-12-21 Pharmos Corp. Topical and transdermal delivery system utilizing submicron oil spheres
US6066328A (en) * 1994-10-07 2000-05-23 L'oreal Cosmetic or dermatological composition comprising an oil-in-water emulsion comprising oily globules with a lamellar liquid crystal coating
JPH09111237A (en) * 1995-10-20 1997-04-28 T Hasegawa Co Ltd Antioxidant for docosahexaenoic acid compound
WO2000056346A1 (en) * 1999-03-22 2000-09-28 J.P.M.E.D. Ltd. Stable oil-in-glycerin emulsion

Non-Patent Citations (1)

* Cited by examiner, † Cited by third party
Title
DATABASE WPI Week 199727, Derwent World Patents Index; AN 1997-295229, XP002199808, "Antioxidant for docosa:hexenoic acids preventing changes over time due to e.g. light-contains tocopherol, l-ascorbic acid fatty acid ester and tea extract" *

Also Published As

Publication number Publication date
WO2002024152A2 (en) 2002-03-28
AU2001286179A1 (en) 2002-04-02
IL138616A0 (en) 2001-10-31
EP1320353A2 (en) 2003-06-25

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