WO2002022569A8 - Method for producing chiral compounds - Google Patents

Method for producing chiral compounds

Info

Publication number
WO2002022569A8
WO2002022569A8 PCT/EP2001/010626 EP0110626W WO0222569A8 WO 2002022569 A8 WO2002022569 A8 WO 2002022569A8 EP 0110626 W EP0110626 W EP 0110626W WO 0222569 A8 WO0222569 A8 WO 0222569A8
Authority
WO
WIPO (PCT)
Prior art keywords
chiral compounds
producing chiral
producing
antalgic
compound
Prior art date
Application number
PCT/EP2001/010626
Other languages
German (de)
French (fr)
Other versions
WO2002022569A1 (en
Inventor
Matthias Gerlach
Claudia Puetz
D Enders
Gero Gaube
Original Assignee
Gruenenthal Gmbh
Matthias Gerlach
Claudia Puetz
D Enders
Gero Gaube
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Priority to DK01980386T priority Critical patent/DK1317427T3/en
Priority to KR10-2003-7003777A priority patent/KR20030039371A/en
Priority to AU2002212241A priority patent/AU2002212241A1/en
Priority to JP2002526822A priority patent/JP2004509102A/en
Priority to CA002422024A priority patent/CA2422024A1/en
Priority to SI200130306T priority patent/SI1317427T1/en
Priority to IL15491501A priority patent/IL154915A0/en
Priority to MXPA03002253A priority patent/MXPA03002253A/en
Priority to BR0113944-4A priority patent/BR0113944A/en
Priority to HU0302903A priority patent/HUP0302903A3/en
Application filed by Gruenenthal Gmbh, Matthias Gerlach, Claudia Puetz, D Enders, Gero Gaube filed Critical Gruenenthal Gmbh
Priority to NZ524973A priority patent/NZ524973A/en
Priority to AT01980386T priority patent/ATE284867T1/en
Priority to DE50104847T priority patent/DE50104847D1/en
Priority to SK279-2003A priority patent/SK2792003A3/en
Priority to PL01363012A priority patent/PL363012A1/en
Priority to EP01980386A priority patent/EP1317427B1/en
Publication of WO2002022569A1 publication Critical patent/WO2002022569A1/en
Publication of WO2002022569A8 publication Critical patent/WO2002022569A8/en
Priority to NO20031137A priority patent/NO20031137L/en
Priority to US10/387,870 priority patent/US20030236429A1/en
Priority to HK03105139.8A priority patent/HK1052923B/en

Links

Classifications

    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07C—ACYCLIC OR CARBOCYCLIC COMPOUNDS
    • C07C319/00—Preparation of thiols, sulfides, hydropolysulfides or polysulfides
    • C07C319/14—Preparation of thiols, sulfides, hydropolysulfides or polysulfides of sulfides
    • C07C319/18—Preparation of thiols, sulfides, hydropolysulfides or polysulfides of sulfides by addition of thiols to unsaturated compounds
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07C—ACYCLIC OR CARBOCYCLIC COMPOUNDS
    • C07C323/00—Thiols, sulfides, hydropolysulfides or polysulfides substituted by halogen, oxygen or nitrogen atoms, or by sulfur atoms not being part of thio groups
    • C07C323/50—Thiols, sulfides, hydropolysulfides or polysulfides substituted by halogen, oxygen or nitrogen atoms, or by sulfur atoms not being part of thio groups containing thio groups and carboxyl groups bound to the same carbon skeleton
    • C07C323/51—Thiols, sulfides, hydropolysulfides or polysulfides substituted by halogen, oxygen or nitrogen atoms, or by sulfur atoms not being part of thio groups containing thio groups and carboxyl groups bound to the same carbon skeleton having the sulfur atoms of the thio groups bound to acyclic carbon atoms of the carbon skeleton
    • C07C323/57—Thiols, sulfides, hydropolysulfides or polysulfides substituted by halogen, oxygen or nitrogen atoms, or by sulfur atoms not being part of thio groups containing thio groups and carboxyl groups bound to the same carbon skeleton having the sulfur atoms of the thio groups bound to acyclic carbon atoms of the carbon skeleton the carbon skeleton being further substituted by nitrogen atoms, not being part of nitro or nitroso groups
    • C07C323/58—Thiols, sulfides, hydropolysulfides or polysulfides substituted by halogen, oxygen or nitrogen atoms, or by sulfur atoms not being part of thio groups containing thio groups and carboxyl groups bound to the same carbon skeleton having the sulfur atoms of the thio groups bound to acyclic carbon atoms of the carbon skeleton the carbon skeleton being further substituted by nitrogen atoms, not being part of nitro or nitroso groups with amino groups bound to the carbon skeleton
    • C07C323/59—Thiols, sulfides, hydropolysulfides or polysulfides substituted by halogen, oxygen or nitrogen atoms, or by sulfur atoms not being part of thio groups containing thio groups and carboxyl groups bound to the same carbon skeleton having the sulfur atoms of the thio groups bound to acyclic carbon atoms of the carbon skeleton the carbon skeleton being further substituted by nitrogen atoms, not being part of nitro or nitroso groups with amino groups bound to the carbon skeleton with acylated amino groups bound to the carbon skeleton
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P25/00—Drugs for disorders of the nervous system
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P25/00—Drugs for disorders of the nervous system
    • A61P25/04—Centrally acting analgesics, e.g. opioids
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07C—ACYCLIC OR CARBOCYCLIC COMPOUNDS
    • C07C319/00—Preparation of thiols, sulfides, hydropolysulfides or polysulfides
    • C07C319/14—Preparation of thiols, sulfides, hydropolysulfides or polysulfides of sulfides
    • C07C319/16—Preparation of thiols, sulfides, hydropolysulfides or polysulfides of sulfides by addition of hydrogen sulfide or its salts to unsaturated compounds
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07B—GENERAL METHODS OF ORGANIC CHEMISTRY; APPARATUS THEREFOR
    • C07B2200/00—Indexing scheme relating to specific properties of organic compounds
    • C07B2200/07—Optical isomers

Abstract

The invention relates to a method for producing chiral compounds according to the condition of a 1.4 Michael reaction in addition to a compound of general formula (31) and the use thereof as an antalgic.
PCT/EP2001/010626 2000-09-14 2001-09-14 Method for producing chiral compounds WO2002022569A1 (en)

Priority Applications (19)

Application Number Priority Date Filing Date Title
NZ524973A NZ524973A (en) 2000-09-14 2001-09-14 Process for the production of chiral compounds
KR10-2003-7003777A KR20030039371A (en) 2000-09-14 2001-09-14 Method for producing chiral compounds
JP2002526822A JP2004509102A (en) 2000-09-14 2001-09-14 Method for producing chiral compound
CA002422024A CA2422024A1 (en) 2000-09-14 2001-09-14 Process for the production of chiral compounds
SI200130306T SI1317427T1 (en) 2000-09-14 2001-09-14 Method for producing chiral compounds
IL15491501A IL154915A0 (en) 2000-09-14 2001-09-14 Method for producing chiral compounds
MXPA03002253A MXPA03002253A (en) 2000-09-14 2001-09-14 Method for producing chiral compounds.
AT01980386T ATE284867T1 (en) 2000-09-14 2001-09-14 METHOD FOR PRODUCING CHIRAL COMPOUNDS
HU0302903A HUP0302903A3 (en) 2000-09-14 2001-09-14 Method for producing chiral compounds
DK01980386T DK1317427T3 (en) 2000-09-14 2001-09-14 Process for the preparation of chiral compounds
AU2002212241A AU2002212241A1 (en) 2000-09-14 2001-09-14 Method for producing chiral compounds
BR0113944-4A BR0113944A (en) 2000-09-14 2001-09-14 Process for the production of chiral compounds
DE50104847T DE50104847D1 (en) 2000-09-14 2001-09-14 PROCESS FOR PREPARING CHIRAL COMPOUNDS
SK279-2003A SK2792003A3 (en) 2000-09-14 2001-09-14 Method for producing chiral compounds
PL01363012A PL363012A1 (en) 2000-09-14 2001-09-14 Method for producing chiral compounds
EP01980386A EP1317427B1 (en) 2000-09-14 2001-09-14 Method for producing chiral compounds
NO20031137A NO20031137L (en) 2000-09-14 2003-03-12 The present invention relates to a process for the preparation of chiral compounds under the conditions of a 1,4-Michael addition.
US10/387,870 US20030236429A1 (en) 2000-09-14 2003-03-14 Process for the production of chiral compounds
HK03105139.8A HK1052923B (en) 2000-09-14 2003-07-16 Method for producing chiral compounds

Applications Claiming Priority (2)

Application Number Priority Date Filing Date Title
DE10045832.7 2000-09-14
DE10045832A DE10045832A1 (en) 2000-09-14 2000-09-14 Process for the preparation of chiral compounds

Related Child Applications (1)

Application Number Title Priority Date Filing Date
US10/387,870 Continuation US20030236429A1 (en) 2000-09-14 2003-03-14 Process for the production of chiral compounds

Publications (2)

Publication Number Publication Date
WO2002022569A1 WO2002022569A1 (en) 2002-03-21
WO2002022569A8 true WO2002022569A8 (en) 2002-06-13

Family

ID=7656434

Family Applications (1)

Application Number Title Priority Date Filing Date
PCT/EP2001/010626 WO2002022569A1 (en) 2000-09-14 2001-09-14 Method for producing chiral compounds

Country Status (25)

Country Link
US (1) US20030236429A1 (en)
EP (1) EP1317427B1 (en)
JP (1) JP2004509102A (en)
KR (1) KR20030039371A (en)
CN (1) CN1474808A (en)
AT (1) ATE284867T1 (en)
AU (1) AU2002212241A1 (en)
BR (1) BR0113944A (en)
CA (1) CA2422024A1 (en)
CZ (1) CZ2003733A3 (en)
DE (2) DE10045832A1 (en)
EC (1) ECSP034515A (en)
ES (1) ES2234908T3 (en)
HK (1) HK1052923B (en)
HU (1) HUP0302903A3 (en)
IL (1) IL154915A0 (en)
MX (1) MXPA03002253A (en)
NO (1) NO20031137L (en)
NZ (1) NZ524973A (en)
PL (1) PL363012A1 (en)
PT (1) PT1317427E (en)
RU (1) RU2003109607A (en)
SK (1) SK2792003A3 (en)
WO (1) WO2002022569A1 (en)
ZA (1) ZA200302824B (en)

Families Citing this family (4)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
CN101643383B (en) * 2008-12-19 2012-05-23 烟台金正精细化工有限公司 Preparation method of 1,1-diphenylethane insulating oil
JP2012136466A (en) * 2010-12-27 2012-07-19 Sumitomo Chemical Co Ltd Process for producing 2-oxo-4-methylthiobutanoic acid or its salt
CN105294519B (en) * 2015-11-20 2017-03-29 哈尔滨工业大学（威海） A kind of synthetic method of the moCys fragments of marine natural productss apratoxin E
CN111423332B (en) * 2020-05-25 2023-02-10 上海科技大学 Method for splitting chiral compound

Family Cites Families (1)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
GB2217706A (en) * 1988-07-07 1989-11-01 W A Gibbons alpha -Amino-alkanoic acid derivatives and process for their preparation with anti-inflammatory, analgesic, sedative, hypnotic, anxiolytic, spasmolytic, anaesthetic, muscle relaxant and cardiovascular activity

Also Published As

Publication number Publication date
SK2792003A3 (en) 2003-10-07
NO20031137D0 (en) 2003-03-12
ECSP034515A (en) 2003-04-25
JP2004509102A (en) 2004-03-25
RU2003109607A (en) 2004-10-20
CA2422024A1 (en) 2003-03-12
DE10045832A1 (en) 2002-05-29
EP1317427B1 (en) 2004-12-15
HK1052923A1 (en) 2003-10-03
ZA200302824B (en) 2004-05-11
CN1474808A (en) 2004-02-11
NO20031137L (en) 2003-05-05
HUP0302903A3 (en) 2007-05-02
DE50104847D1 (en) 2005-01-20
EP1317427A1 (en) 2003-06-11
AU2002212241A1 (en) 2002-03-26
BR0113944A (en) 2004-06-22
HUP0302903A2 (en) 2003-12-29
WO2002022569A1 (en) 2002-03-21
US20030236429A1 (en) 2003-12-25
NZ524973A (en) 2005-08-26
HK1052923B (en) 2005-06-30
PT1317427E (en) 2005-04-29
MXPA03002253A (en) 2003-06-24
KR20030039371A (en) 2003-05-17
PL363012A1 (en) 2004-11-15
ES2234908T3 (en) 2005-07-01
IL154915A0 (en) 2003-10-31
CZ2003733A3 (en) 2003-09-17
ATE284867T1 (en) 2005-01-15

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