WO2002020830A3 - Test systems based on transmembrane receptors from helminths and the use thereof for identifying and characterizing compounds - Google Patents

Test systems based on transmembrane receptors from helminths and the use thereof for identifying and characterizing compounds Download PDF

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Publication number
WO2002020830A3
WO2002020830A3 PCT/EP2001/009771 EP0109771W WO0220830A3 WO 2002020830 A3 WO2002020830 A3 WO 2002020830A3 EP 0109771 W EP0109771 W EP 0109771W WO 0220830 A3 WO0220830 A3 WO 0220830A3
Authority
WO
WIPO (PCT)
Prior art keywords
helminths
identifying
test systems
transmembrane receptors
systems based
Prior art date
Application number
PCT/EP2001/009771
Other languages
German (de)
French (fr)
Other versions
WO2002020830A2 (en
Inventor
Samson-Himmelstjerna Georg Von
Achim Harder
Frank Wunderlich
Hans-Peter Schmitt-Wrede
Beate Saeger
Original Assignee
Bayer Ag
Samson-Himmelstjerna Georg Von
Achim Harder
Frank Wunderlich
Hans-Peter Schmitt-Wrede
Beate Saeger
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Priority claimed from DE10053785A external-priority patent/DE10053785A1/en
Application filed by Bayer Ag, Samson-Himmelstjerna Georg Von, Achim Harder, Frank Wunderlich, Hans-Peter Schmitt-Wrede, Beate Saeger filed Critical Bayer Ag
Priority to AU2001293789A priority Critical patent/AU2001293789A1/en
Priority to US10/363,946 priority patent/US20050037436A1/en
Priority to CA002421248A priority patent/CA2421248A1/en
Priority to EP01974211A priority patent/EP1317562A2/en
Priority to JP2002525836A priority patent/JP2004508052A/en
Priority to NZ524533A priority patent/NZ524533A/en
Publication of WO2002020830A2 publication Critical patent/WO2002020830A2/en
Publication of WO2002020830A3 publication Critical patent/WO2002020830A3/en

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Classifications

    • G—PHYSICS
    • G01—MEASURING; TESTING
    • G01N—INVESTIGATING OR ANALYSING MATERIALS BY DETERMINING THEIR CHEMICAL OR PHYSICAL PROPERTIES
    • G01N33/00—Investigating or analysing materials by specific methods not covered by groups G01N1/00 - G01N31/00
    • G01N33/48—Biological material, e.g. blood, urine; Haemocytometers
    • G01N33/50—Chemical analysis of biological material, e.g. blood, urine; Testing involving biospecific ligand binding methods; Immunological testing
    • G01N33/5005—Chemical analysis of biological material, e.g. blood, urine; Testing involving biospecific ligand binding methods; Immunological testing involving human or animal cells
    • G01N33/5008—Chemical analysis of biological material, e.g. blood, urine; Testing involving biospecific ligand binding methods; Immunological testing involving human or animal cells for testing or evaluating the effect of chemical or biological compounds, e.g. drugs, cosmetics
    • G01N33/502—Chemical analysis of biological material, e.g. blood, urine; Testing involving biospecific ligand binding methods; Immunological testing involving human or animal cells for testing or evaluating the effect of chemical or biological compounds, e.g. drugs, cosmetics for testing non-proliferative effects
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P33/00—Antiparasitic agents
    • A61P33/10—Anthelmintics
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07K—PEPTIDES
    • C07K14/00—Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof
    • C07K14/435—Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof from animals; from humans
    • C07K14/43504—Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof from animals; from humans from invertebrates
    • C07K14/43536—Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof from animals; from humans from invertebrates from worms
    • C07K14/4354—Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof from animals; from humans from invertebrates from worms from nematodes
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07K—PEPTIDES
    • C07K14/00—Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof
    • C07K14/435—Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof from animals; from humans
    • C07K14/705—Receptors; Cell surface antigens; Cell surface determinants
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07K—PEPTIDES
    • C07K14/00—Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof
    • C07K14/435—Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof from animals; from humans
    • C07K14/705—Receptors; Cell surface antigens; Cell surface determinants
    • C07K14/72—Receptors; Cell surface antigens; Cell surface determinants for hormones
    • C07K14/723—G protein coupled receptor, e.g. TSHR-thyrotropin-receptor, LH/hCG receptor, FSH receptor
    • C—CHEMISTRY; METALLURGY
    • C12—BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
    • C12Q—MEASURING OR TESTING PROCESSES INVOLVING ENZYMES, NUCLEIC ACIDS OR MICROORGANISMS; COMPOSITIONS OR TEST PAPERS THEREFOR; PROCESSES OF PREPARING SUCH COMPOSITIONS; CONDITION-RESPONSIVE CONTROL IN MICROBIOLOGICAL OR ENZYMOLOGICAL PROCESSES
    • C12Q1/00—Measuring or testing processes involving enzymes, nucleic acids or microorganisms; Compositions therefor; Processes of preparing such compositions
    • C12Q1/68—Measuring or testing processes involving enzymes, nucleic acids or microorganisms; Compositions therefor; Processes of preparing such compositions involving nucleic acids
    • C12Q1/6876—Nucleic acid products used in the analysis of nucleic acids, e.g. primers or probes
    • C12Q1/6888—Nucleic acid products used in the analysis of nucleic acids, e.g. primers or probes for detection or identification of organisms
    • G—PHYSICS
    • G01—MEASURING; TESTING
    • G01N—INVESTIGATING OR ANALYSING MATERIALS BY DETERMINING THEIR CHEMICAL OR PHYSICAL PROPERTIES
    • G01N33/00—Investigating or analysing materials by specific methods not covered by groups G01N1/00 - G01N31/00
    • G01N33/48—Biological material, e.g. blood, urine; Haemocytometers
    • G01N33/50—Chemical analysis of biological material, e.g. blood, urine; Testing involving biospecific ligand binding methods; Immunological testing
    • G01N33/5005—Chemical analysis of biological material, e.g. blood, urine; Testing involving biospecific ligand binding methods; Immunological testing involving human or animal cells
    • G01N33/5008—Chemical analysis of biological material, e.g. blood, urine; Testing involving biospecific ligand binding methods; Immunological testing involving human or animal cells for testing or evaluating the effect of chemical or biological compounds, e.g. drugs, cosmetics
    • G—PHYSICS
    • G01—MEASURING; TESTING
    • G01N—INVESTIGATING OR ANALYSING MATERIALS BY DETERMINING THEIR CHEMICAL OR PHYSICAL PROPERTIES
    • G01N33/00—Investigating or analysing materials by specific methods not covered by groups G01N1/00 - G01N31/00
    • G01N33/48—Biological material, e.g. blood, urine; Haemocytometers
    • G01N33/50—Chemical analysis of biological material, e.g. blood, urine; Testing involving biospecific ligand binding methods; Immunological testing
    • G01N33/5005—Chemical analysis of biological material, e.g. blood, urine; Testing involving biospecific ligand binding methods; Immunological testing involving human or animal cells
    • G01N33/5008—Chemical analysis of biological material, e.g. blood, urine; Testing involving biospecific ligand binding methods; Immunological testing involving human or animal cells for testing or evaluating the effect of chemical or biological compounds, e.g. drugs, cosmetics
    • G01N33/5014—Chemical analysis of biological material, e.g. blood, urine; Testing involving biospecific ligand binding methods; Immunological testing involving human or animal cells for testing or evaluating the effect of chemical or biological compounds, e.g. drugs, cosmetics for testing toxicity
    • G—PHYSICS
    • G01—MEASURING; TESTING
    • G01N—INVESTIGATING OR ANALYSING MATERIALS BY DETERMINING THEIR CHEMICAL OR PHYSICAL PROPERTIES
    • G01N33/00—Investigating or analysing materials by specific methods not covered by groups G01N1/00 - G01N31/00
    • G01N33/48—Biological material, e.g. blood, urine; Haemocytometers
    • G01N33/50—Chemical analysis of biological material, e.g. blood, urine; Testing involving biospecific ligand binding methods; Immunological testing
    • G01N33/5005—Chemical analysis of biological material, e.g. blood, urine; Testing involving biospecific ligand binding methods; Immunological testing involving human or animal cells
    • G01N33/5008—Chemical analysis of biological material, e.g. blood, urine; Testing involving biospecific ligand binding methods; Immunological testing involving human or animal cells for testing or evaluating the effect of chemical or biological compounds, e.g. drugs, cosmetics
    • G01N33/5082—Supracellular entities, e.g. tissue, organisms
    • G01N33/5085—Supracellular entities, e.g. tissue, organisms of invertebrates
    • G—PHYSICS
    • G01—MEASURING; TESTING
    • G01N—INVESTIGATING OR ANALYSING MATERIALS BY DETERMINING THEIR CHEMICAL OR PHYSICAL PROPERTIES
    • G01N33/00—Investigating or analysing materials by specific methods not covered by groups G01N1/00 - G01N31/00
    • G01N33/48—Biological material, e.g. blood, urine; Haemocytometers
    • G01N33/50—Chemical analysis of biological material, e.g. blood, urine; Testing involving biospecific ligand binding methods; Immunological testing
    • G01N33/53—Immunoassay; Biospecific binding assay; Materials therefor
    • G01N33/5308—Immunoassay; Biospecific binding assay; Materials therefor for analytes not provided for elsewhere, e.g. nucleic acids, uric acid, worms, mites
    • G—PHYSICS
    • G01—MEASURING; TESTING
    • G01N—INVESTIGATING OR ANALYSING MATERIALS BY DETERMINING THEIR CHEMICAL OR PHYSICAL PROPERTIES
    • G01N33/00—Investigating or analysing materials by specific methods not covered by groups G01N1/00 - G01N31/00
    • G01N33/48—Biological material, e.g. blood, urine; Haemocytometers
    • G01N33/50—Chemical analysis of biological material, e.g. blood, urine; Testing involving biospecific ligand binding methods; Immunological testing
    • G01N33/68—Chemical analysis of biological material, e.g. blood, urine; Testing involving biospecific ligand binding methods; Immunological testing involving proteins, peptides or amino acids
    • G01N33/6872—Intracellular protein regulatory factors and their receptors, e.g. including ion channels
    • G—PHYSICS
    • G01—MEASURING; TESTING
    • G01N—INVESTIGATING OR ANALYSING MATERIALS BY DETERMINING THEIR CHEMICAL OR PHYSICAL PROPERTIES
    • G01N2333/00—Assays involving biological materials from specific organisms or of a specific nature
    • G01N2333/435—Assays involving biological materials from specific organisms or of a specific nature from animals; from humans
    • G01N2333/43504—Assays involving biological materials from specific organisms or of a specific nature from animals; from humans from invertebrates
    • G01N2333/43526—Assays involving biological materials from specific organisms or of a specific nature from animals; from humans from invertebrates from worms
    • G01N2333/4353—Assays involving biological materials from specific organisms or of a specific nature from animals; from humans from invertebrates from worms from nematodes
    • G—PHYSICS
    • G01—MEASURING; TESTING
    • G01N—INVESTIGATING OR ANALYSING MATERIALS BY DETERMINING THEIR CHEMICAL OR PHYSICAL PROPERTIES
    • G01N2333/00—Assays involving biological materials from specific organisms or of a specific nature
    • G01N2333/435—Assays involving biological materials from specific organisms or of a specific nature from animals; from humans
    • G01N2333/46—Assays involving biological materials from specific organisms or of a specific nature from animals; from humans from vertebrates
    • G01N2333/47—Assays involving proteins of known structure or function as defined in the subgroups
    • G01N2333/4701—Details
    • G01N2333/4719—G-proteins
    • G—PHYSICS
    • G01—MEASURING; TESTING
    • G01N—INVESTIGATING OR ANALYSING MATERIALS BY DETERMINING THEIR CHEMICAL OR PHYSICAL PROPERTIES
    • G01N2333/00—Assays involving biological materials from specific organisms or of a specific nature
    • G01N2333/435—Assays involving biological materials from specific organisms or of a specific nature from animals; from humans
    • G01N2333/705—Assays involving receptors, cell surface antigens or cell surface determinants

Abstract

The invention relates to test systems that are based on transmembrane receptors from helminths and arthropods and to their use for identifying and characterizing substances that are effective against helminths, arthropods or that have an effect on the calcium metabolism of organisms and/or cells. The invention further relates to the use of a specific ligand in said test system and to the use thereof as an anthelminthic or arthropodan active substance.
PCT/EP2001/009771 2000-09-07 2001-08-24 Test systems based on transmembrane receptors from helminths and the use thereof for identifying and characterizing compounds WO2002020830A2 (en)

Priority Applications (6)

Application Number Priority Date Filing Date Title
AU2001293789A AU2001293789A1 (en) 2000-09-07 2001-08-24 Test systems based on transmembrane receptors from helminths and the use thereof for identifying and characterizing compounds
US10/363,946 US20050037436A1 (en) 2000-09-07 2001-08-24 Test systems and the use thereof for identifying and characterizing compounds
CA002421248A CA2421248A1 (en) 2000-09-07 2001-08-24 Test systems based on transmembrane receptors from helminths and the use thereof for identifying and characterizing compounds
EP01974211A EP1317562A2 (en) 2000-09-07 2001-08-24 Test systems based on transmembrane receptors from helminths and the use thereof for identifying and characterizing compounds
JP2002525836A JP2004508052A (en) 2000-09-07 2001-08-24 Test system for identifying and characterizing compounds and uses thereof
NZ524533A NZ524533A (en) 2000-09-07 2001-08-24 Test systems and the use thereof for identifying and characterizing compounds

Applications Claiming Priority (4)

Application Number Priority Date Filing Date Title
DE10044098.3 2000-09-07
DE10044098 2000-09-07
DE10053785A DE10053785A1 (en) 2000-09-07 2000-10-30 Test systems and their use to identify and characterize compounds
DE10053785.5 2000-10-30

Publications (2)

Publication Number Publication Date
WO2002020830A2 WO2002020830A2 (en) 2002-03-14
WO2002020830A3 true WO2002020830A3 (en) 2002-07-25

Family

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Family Applications (1)

Application Number Title Priority Date Filing Date
PCT/EP2001/009771 WO2002020830A2 (en) 2000-09-07 2001-08-24 Test systems based on transmembrane receptors from helminths and the use thereof for identifying and characterizing compounds

Country Status (7)

Country Link
EP (1) EP1317562A2 (en)
JP (1) JP2004508052A (en)
CN (1) CN1543508A (en)
AU (1) AU2001293789A1 (en)
CA (1) CA2421248A1 (en)
NZ (1) NZ524533A (en)
WO (1) WO2002020830A2 (en)

Families Citing this family (5)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
US7498408B2 (en) 2002-09-23 2009-03-03 E. I. Du Pont De Nemours And Company Ryanodine receptor polypeptides
CN102839193A (en) * 2012-08-22 2012-12-26 海狸（广州）生物科技有限公司 Detection method for compound specificity through G protein-coupled receptor (GPCR)
EP3411477A4 (en) * 2016-02-06 2019-07-10 Novozymes A/S Polypeptides having protease activity and polynucleotides encoding same
CN111903618B (en) * 2020-08-11 2023-04-25 福建省农业科学院水稻研究所 Artificial cultivation method of rice lice thysanoptera (Anagrus nilaparvatae)
CN112715487B (en) * 2020-12-23 2022-08-05 广西壮族自治区林业科学研究院 Breeding method of erythema plexum schottii

Citations (2)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
US4925664A (en) * 1986-10-20 1990-05-15 University Of Utah Spider toxins and methods for their use as blockers of calcium channels and amino acid receptor function
DE19704024A1 (en) * 1996-10-10 1998-04-16 Bayer Ag Proteins, DNA sequences coding for them, on the other hand specific antibodies and their use to find nematicidal active substances

Patent Citations (2)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
US4925664A (en) * 1986-10-20 1990-05-15 University Of Utah Spider toxins and methods for their use as blockers of calcium channels and amino acid receptor function
DE19704024A1 (en) * 1996-10-10 1998-04-16 Bayer Ag Proteins, DNA sequences coding for them, on the other hand specific antibodies and their use to find nematicidal active substances

Non-Patent Citations (2)

* Cited by examiner, † Cited by third party
Title
MARTIN R J ET AL: "ANTHELMINTICS AND ION-CHANNELS: AFTER A PUNCTURE, USE A PATCH", INTERNATIONAL JOURNAL OF PARASITOLOGY, PERGAMON PRESS, GB, vol. 28, no. 6, June 1998 (1998-06-01), pages 849 - 862, XP000951698, ISSN: 0020-7519 *
SAEGER BEATE ET AL: "Latrophilin-like receptor from the parasitic nematode Haemonchus contortus as target for the anthelmintic depsipeptide PF1022A.", FASEB JOURNAL, vol. 15, no. 7, May 2001 (2001-05-01), pages 1332 - 1334, XP001069101, ISSN: 0892-6638 *

Also Published As

Publication number Publication date
CA2421248A1 (en) 2002-03-14
AU2001293789A1 (en) 2002-03-22
JP2004508052A (en) 2004-03-18
EP1317562A2 (en) 2003-06-11
NZ524533A (en) 2005-04-29
WO2002020830A2 (en) 2002-03-14
CN1543508A (en) 2004-11-03

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