WO2002020609A3 - Interleukin-11 for the treatment of stroke and neuropathies - Google Patents

Interleukin-11 for the treatment of stroke and neuropathies Download PDF

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Publication number
WO2002020609A3
WO2002020609A3 PCT/EP2001/009923 EP0109923W WO0220609A3 WO 2002020609 A3 WO2002020609 A3 WO 2002020609A3 EP 0109923 W EP0109923 W EP 0109923W WO 0220609 A3 WO0220609 A3 WO 0220609A3
Authority
WO
WIPO (PCT)
Prior art keywords
neuropathies
interleukin
stroke
treatment
polypeptides
Prior art date
Application number
PCT/EP2001/009923
Other languages
French (fr)
Other versions
WO2002020609A2 (en
Inventor
Stewart Alan Bates
Israel Simon Gloger
Simon Read
Original Assignee
Smithkline Beecham Plc
Stewart Alan Bates
Israel Simon Gloger
Simon Read
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Application filed by Smithkline Beecham Plc, Stewart Alan Bates, Israel Simon Gloger, Simon Read filed Critical Smithkline Beecham Plc
Priority to AU1046702A priority Critical patent/AU1046702A/en
Publication of WO2002020609A2 publication Critical patent/WO2002020609A2/en
Publication of WO2002020609A3 publication Critical patent/WO2002020609A3/en

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Classifications

    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07K—PEPTIDES
    • C07K14/00—Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof
    • C07K14/435—Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof from animals; from humans
    • C07K14/52—Cytokines; Lymphokines; Interferons
    • C07K14/54—Interleukins [IL]
    • C07K14/5431—IL-11
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P25/00—Drugs for disorders of the nervous system
    • A61P25/02—Drugs for disorders of the nervous system for peripheral neuropathies
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P9/00—Drugs for disorders of the cardiovascular system
    • A61P9/10—Drugs for disorders of the cardiovascular system for treating ischaemic or atherosclerotic diseases, e.g. antianginal drugs, coronary vasodilators, drugs for myocardial infarction, retinopathy, cerebrovascula insufficiency, renal arteriosclerosis
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K38/00—Medicinal preparations containing peptides

Landscapes

  • Health & Medical Sciences (AREA)
  • Chemical & Material Sciences (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • Organic Chemistry (AREA)
  • Engineering & Computer Science (AREA)
  • Bioinformatics & Cheminformatics (AREA)
  • General Health & Medical Sciences (AREA)
  • Medicinal Chemistry (AREA)
  • Chemical Kinetics & Catalysis (AREA)
  • Animal Behavior & Ethology (AREA)
  • General Chemical & Material Sciences (AREA)
  • Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
  • Veterinary Medicine (AREA)
  • Pharmacology & Pharmacy (AREA)
  • Public Health (AREA)
  • Toxicology (AREA)
  • Genetics & Genomics (AREA)
  • Vascular Medicine (AREA)
  • Cardiology (AREA)
  • Heart & Thoracic Surgery (AREA)
  • Zoology (AREA)
  • Gastroenterology & Hepatology (AREA)
  • Biochemistry (AREA)
  • Biophysics (AREA)
  • Urology & Nephrology (AREA)
  • Molecular Biology (AREA)
  • Proteomics, Peptides & Aminoacids (AREA)
  • Biomedical Technology (AREA)
  • Neurology (AREA)
  • Neurosurgery (AREA)
  • Medicines That Contain Protein Lipid Enzymes And Other Medicines (AREA)
  • Peptides Or Proteins (AREA)

Abstract

New uses for interleukin 11 polypeptides and polynucleotides encoding IL-11 polypeptides are disclosed. Such uses include their use in the therapy of strokes and neuropathies and in identifying agonist compounds which are potentially useful in therapy.
PCT/EP2001/009923 2000-09-04 2001-08-27 Interleukin-11 for the treatment of stroke and neuropathies WO2002020609A2 (en)

Priority Applications (1)

Application Number Priority Date Filing Date Title
AU1046702A AU1046702A (en) 2000-09-04 2001-08-27 New use

Applications Claiming Priority (2)

Application Number Priority Date Filing Date Title
GB0021668.9 2000-09-04
GBGB0021668.9A GB0021668D0 (en) 2000-09-04 2000-09-04 New use

Publications (2)

Publication Number Publication Date
WO2002020609A2 WO2002020609A2 (en) 2002-03-14
WO2002020609A3 true WO2002020609A3 (en) 2002-07-04

Family

ID=9898797

Family Applications (1)

Application Number Title Priority Date Filing Date
PCT/EP2001/009923 WO2002020609A2 (en) 2000-09-04 2001-08-27 Interleukin-11 for the treatment of stroke and neuropathies

Country Status (3)

Country Link
AU (1) AU1046702A (en)
GB (1) GB0021668D0 (en)
WO (1) WO2002020609A2 (en)

Families Citing this family (4)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
GB201522186D0 (en) 2015-12-16 2016-01-27 Singapore Health Services Pte Ltd And Nat University Of Singapore The Treatment of fibrosis
GB201621439D0 (en) 2016-12-16 2017-02-01 Singapore Health Services Pte Ltd And Nat Univ Of Singapore IL-11Ra Antibodies
TW201829460A (en) 2016-12-16 2018-08-16 新加坡商新加坡保健服務私人有限公司 Il-11 antibodies
TW202043276A (en) 2019-01-21 2020-12-01 新加坡商新加坡保健服務私人有限公司 Treatment of hepatotoxicity

Citations (3)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
JPH08176008A (en) * 1994-12-27 1996-07-09 Toray Ind Inc Neurotrophic agent
WO1997001353A1 (en) * 1995-06-27 1997-01-16 Genetics Institute, Inc. Use of il-11 to treat inflammation
WO2001012236A2 (en) * 1999-08-18 2001-02-22 The General Hospital Corporation Methods, compositions and kits for promoting recovery from damage to the central nervous system

Patent Citations (3)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
JPH08176008A (en) * 1994-12-27 1996-07-09 Toray Ind Inc Neurotrophic agent
WO1997001353A1 (en) * 1995-06-27 1997-01-16 Genetics Institute, Inc. Use of il-11 to treat inflammation
WO2001012236A2 (en) * 1999-08-18 2001-02-22 The General Hospital Corporation Methods, compositions and kits for promoting recovery from damage to the central nervous system

Non-Patent Citations (2)

* Cited by examiner, † Cited by third party
Title
PATENT ABSTRACTS OF JAPAN vol. 1996, no. 11 29 November 1996 (1996-11-29) *
THIER MICHAEL ET AL: "Trophic effects of cardiotrophin-1 and interleukin-11 on rat dorsal root ganglion neurons in vitro.", MOLECULAR BRAIN RESEARCH, vol. 64, no. 1, 22 January 1999 (1999-01-22), pages 80 - 84, XP001057071, ISSN: 0169-328X *

Also Published As

Publication number Publication date
WO2002020609A2 (en) 2002-03-14
GB0021668D0 (en) 2000-10-18
AU1046702A (en) 2002-03-22

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