WO2002016555A3 - Htert-immortalised cell lines, their preparation and use - Google Patents
Htert-immortalised cell lines, their preparation and use Download PDFInfo
- Publication number
- WO2002016555A3 WO2002016555A3 PCT/GB2001/003726 GB0103726W WO0216555A3 WO 2002016555 A3 WO2002016555 A3 WO 2002016555A3 GB 0103726 W GB0103726 W GB 0103726W WO 0216555 A3 WO0216555 A3 WO 0216555A3
- Authority
- WO
- WIPO (PCT)
- Prior art keywords
- cell lines
- htert
- cells
- transfected
- immortalised
- Prior art date
Links
Classifications
-
- G—PHYSICS
- G01—MEASURING; TESTING
- G01N—INVESTIGATING OR ANALYSING MATERIALS BY DETERMINING THEIR CHEMICAL OR PHYSICAL PROPERTIES
- G01N33/00—Investigating or analysing materials by specific methods not covered by groups G01N1/00 - G01N31/00
- G01N33/48—Biological material, e.g. blood, urine; Haemocytometers
- G01N33/50—Chemical analysis of biological material, e.g. blood, urine; Testing involving biospecific ligand binding methods; Immunological testing
- G01N33/5005—Chemical analysis of biological material, e.g. blood, urine; Testing involving biospecific ligand binding methods; Immunological testing involving human or animal cells
- G01N33/5008—Chemical analysis of biological material, e.g. blood, urine; Testing involving biospecific ligand binding methods; Immunological testing involving human or animal cells for testing or evaluating the effect of chemical or biological compounds, e.g. drugs, cosmetics
- G01N33/5044—Chemical analysis of biological material, e.g. blood, urine; Testing involving biospecific ligand binding methods; Immunological testing involving human or animal cells for testing or evaluating the effect of chemical or biological compounds, e.g. drugs, cosmetics involving specific cell types
-
- C—CHEMISTRY; METALLURGY
- C12—BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
- C12N—MICROORGANISMS OR ENZYMES; COMPOSITIONS THEREOF; PROPAGATING, PRESERVING, OR MAINTAINING MICROORGANISMS; MUTATION OR GENETIC ENGINEERING; CULTURE MEDIA
- C12N5/00—Undifferentiated human, animal or plant cells, e.g. cell lines; Tissues; Cultivation or maintenance thereof; Culture media therefor
- C12N5/06—Animal cells or tissues; Human cells or tissues
- C12N5/0602—Vertebrate cells
- C12N5/0652—Cells of skeletal and connective tissues; Mesenchyme
- C12N5/0656—Adult fibroblasts
-
- G—PHYSICS
- G01—MEASURING; TESTING
- G01N—INVESTIGATING OR ANALYSING MATERIALS BY DETERMINING THEIR CHEMICAL OR PHYSICAL PROPERTIES
- G01N33/00—Investigating or analysing materials by specific methods not covered by groups G01N1/00 - G01N31/00
- G01N33/48—Biological material, e.g. blood, urine; Haemocytometers
- G01N33/50—Chemical analysis of biological material, e.g. blood, urine; Testing involving biospecific ligand binding methods; Immunological testing
- G01N33/5005—Chemical analysis of biological material, e.g. blood, urine; Testing involving biospecific ligand binding methods; Immunological testing involving human or animal cells
- G01N33/5008—Chemical analysis of biological material, e.g. blood, urine; Testing involving biospecific ligand binding methods; Immunological testing involving human or animal cells for testing or evaluating the effect of chemical or biological compounds, e.g. drugs, cosmetics
-
- G—PHYSICS
- G01—MEASURING; TESTING
- G01N—INVESTIGATING OR ANALYSING MATERIALS BY DETERMINING THEIR CHEMICAL OR PHYSICAL PROPERTIES
- G01N33/00—Investigating or analysing materials by specific methods not covered by groups G01N1/00 - G01N31/00
- G01N33/48—Biological material, e.g. blood, urine; Haemocytometers
- G01N33/50—Chemical analysis of biological material, e.g. blood, urine; Testing involving biospecific ligand binding methods; Immunological testing
- G01N33/5005—Chemical analysis of biological material, e.g. blood, urine; Testing involving biospecific ligand binding methods; Immunological testing involving human or animal cells
- G01N33/5008—Chemical analysis of biological material, e.g. blood, urine; Testing involving biospecific ligand binding methods; Immunological testing involving human or animal cells for testing or evaluating the effect of chemical or biological compounds, e.g. drugs, cosmetics
- G01N33/502—Chemical analysis of biological material, e.g. blood, urine; Testing involving biospecific ligand binding methods; Immunological testing involving human or animal cells for testing or evaluating the effect of chemical or biological compounds, e.g. drugs, cosmetics for testing non-proliferative effects
-
- G—PHYSICS
- G01—MEASURING; TESTING
- G01N—INVESTIGATING OR ANALYSING MATERIALS BY DETERMINING THEIR CHEMICAL OR PHYSICAL PROPERTIES
- G01N33/00—Investigating or analysing materials by specific methods not covered by groups G01N1/00 - G01N31/00
- G01N33/48—Biological material, e.g. blood, urine; Haemocytometers
- G01N33/50—Chemical analysis of biological material, e.g. blood, urine; Testing involving biospecific ligand binding methods; Immunological testing
- G01N33/5005—Chemical analysis of biological material, e.g. blood, urine; Testing involving biospecific ligand binding methods; Immunological testing involving human or animal cells
- G01N33/5091—Chemical analysis of biological material, e.g. blood, urine; Testing involving biospecific ligand binding methods; Immunological testing involving human or animal cells for testing the pathological state of an organism
-
- G—PHYSICS
- G01—MEASURING; TESTING
- G01N—INVESTIGATING OR ANALYSING MATERIALS BY DETERMINING THEIR CHEMICAL OR PHYSICAL PROPERTIES
- G01N33/00—Investigating or analysing materials by specific methods not covered by groups G01N1/00 - G01N31/00
- G01N33/48—Biological material, e.g. blood, urine; Haemocytometers
- G01N33/50—Chemical analysis of biological material, e.g. blood, urine; Testing involving biospecific ligand binding methods; Immunological testing
- G01N33/53—Immunoassay; Biospecific binding assay; Materials therefor
- G01N33/569—Immunoassay; Biospecific binding assay; Materials therefor for microorganisms, e.g. protozoa, bacteria, viruses
- G01N33/56983—Viruses
-
- C—CHEMISTRY; METALLURGY
- C12—BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
- C12N—MICROORGANISMS OR ENZYMES; COMPOSITIONS THEREOF; PROPAGATING, PRESERVING, OR MAINTAINING MICROORGANISMS; MUTATION OR GENETIC ENGINEERING; CULTURE MEDIA
- C12N2503/00—Use of cells in diagnostics
-
- C—CHEMISTRY; METALLURGY
- C12—BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
- C12N—MICROORGANISMS OR ENZYMES; COMPOSITIONS THEREOF; PROPAGATING, PRESERVING, OR MAINTAINING MICROORGANISMS; MUTATION OR GENETIC ENGINEERING; CULTURE MEDIA
- C12N2510/00—Genetically modified cells
- C12N2510/02—Cells for production
-
- C—CHEMISTRY; METALLURGY
- C12—BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
- C12N—MICROORGANISMS OR ENZYMES; COMPOSITIONS THEREOF; PROPAGATING, PRESERVING, OR MAINTAINING MICROORGANISMS; MUTATION OR GENETIC ENGINEERING; CULTURE MEDIA
- C12N2510/00—Genetically modified cells
- C12N2510/04—Immortalised cells
-
- G—PHYSICS
- G01—MEASURING; TESTING
- G01N—INVESTIGATING OR ANALYSING MATERIALS BY DETERMINING THEIR CHEMICAL OR PHYSICAL PROPERTIES
- G01N2333/00—Assays involving biological materials from specific organisms or of a specific nature
- G01N2333/005—Assays involving biological materials from specific organisms or of a specific nature from viruses
- G01N2333/01—DNA viruses
- G01N2333/03—Herpetoviridae, e.g. pseudorabies virus
- G01N2333/04—Varicella-zoster virus
- G01N2333/045—Cytomegalovirus
Landscapes
- Health & Medical Sciences (AREA)
- Life Sciences & Earth Sciences (AREA)
- Engineering & Computer Science (AREA)
- Biomedical Technology (AREA)
- Immunology (AREA)
- Chemical & Material Sciences (AREA)
- Hematology (AREA)
- Molecular Biology (AREA)
- Urology & Nephrology (AREA)
- Biotechnology (AREA)
- Cell Biology (AREA)
- Biochemistry (AREA)
- General Health & Medical Sciences (AREA)
- Microbiology (AREA)
- Medicinal Chemistry (AREA)
- Food Science & Technology (AREA)
- Tropical Medicine & Parasitology (AREA)
- Physics & Mathematics (AREA)
- Analytical Chemistry (AREA)
- Bioinformatics & Cheminformatics (AREA)
- General Physics & Mathematics (AREA)
- Pathology (AREA)
- Toxicology (AREA)
- Wood Science & Technology (AREA)
- Virology (AREA)
- Genetics & Genomics (AREA)
- Zoology (AREA)
- Organic Chemistry (AREA)
- Rheumatology (AREA)
- Physiology (AREA)
- General Engineering & Computer Science (AREA)
- Micro-Organisms Or Cultivation Processes Thereof (AREA)
- Medicines Containing Antibodies Or Antigens For Use As Internal Diagnostic Agents (AREA)
Abstract
Priority Applications (1)
Application Number | Priority Date | Filing Date | Title |
---|---|---|---|
AU2001282290A AU2001282290A1 (en) | 2000-08-17 | 2001-08-17 | Htert-immortalised cell lines, their preparation and use |
Applications Claiming Priority (4)
Application Number | Priority Date | Filing Date | Title |
---|---|---|---|
US22573400P | 2000-08-17 | 2000-08-17 | |
US60/225,734 | 2000-08-17 | ||
GB0020246.5 | 2000-08-17 | ||
GB0020246A GB0020246D0 (en) | 2000-08-17 | 2000-08-17 | Cell lines |
Publications (2)
Publication Number | Publication Date |
---|---|
WO2002016555A2 WO2002016555A2 (en) | 2002-02-28 |
WO2002016555A3 true WO2002016555A3 (en) | 2002-10-17 |
Family
ID=26244847
Family Applications (1)
Application Number | Title | Priority Date | Filing Date |
---|---|---|---|
PCT/GB2001/003726 WO2002016555A2 (en) | 2000-08-17 | 2001-08-17 | Htert-immortalised cell lines, their preparation and use |
Country Status (2)
Country | Link |
---|---|
AU (1) | AU2001282290A1 (en) |
WO (1) | WO2002016555A2 (en) |
Families Citing this family (4)
Publication number | Priority date | Publication date | Assignee | Title |
---|---|---|---|---|
GB0321978D0 (en) * | 2003-09-19 | 2003-10-22 | Integrin Advanced Biosystems L | New method of producing cell cultures |
US9453209B2 (en) | 2012-12-27 | 2016-09-27 | Sierra Sciences, Llc | Enhancing health in mammals using telomerase reverse transcriptase gene therapy |
PT3405212T (en) | 2016-01-19 | 2020-08-25 | Pfizer | Cancer vaccines |
US20220387516A1 (en) * | 2019-11-02 | 2022-12-08 | Figene, Llc | Fibroblast-derived universal immunological composition |
Citations (2)
Publication number | Priority date | Publication date | Assignee | Title |
---|---|---|---|---|
WO1998037181A2 (en) * | 1997-02-20 | 1998-08-27 | Whitehead Institute For Biomedical Research | Telomerase catalytic subunit gene and encoded protein |
WO2001036651A1 (en) * | 1999-11-19 | 2001-05-25 | Cantab Pharmaceuticals Research Limited | Preparation of human or animal herpesviruses |
-
2001
- 2001-08-17 AU AU2001282290A patent/AU2001282290A1/en not_active Abandoned
- 2001-08-17 WO PCT/GB2001/003726 patent/WO2002016555A2/en active Application Filing
Patent Citations (2)
Publication number | Priority date | Publication date | Assignee | Title |
---|---|---|---|---|
WO1998037181A2 (en) * | 1997-02-20 | 1998-08-27 | Whitehead Institute For Biomedical Research | Telomerase catalytic subunit gene and encoded protein |
WO2001036651A1 (en) * | 1999-11-19 | 2001-05-25 | Cantab Pharmaceuticals Research Limited | Preparation of human or animal herpesviruses |
Non-Patent Citations (13)
Title |
---|
BODNAR ANDREA G ET AL: "Extension of life-span by introduction of telomerase into normal human cells", SCIENCE, AMERICAN ASSOCIATION FOR THE ADVANCEMENT OF SCIENCE,, US, vol. 279, no. 5349, 16 January 1998 (1998-01-16), pages 349 - 352, XP002157587, ISSN: 0036-8075 * |
BRESNAHAN WADE A ET AL: "Replication of wild-type and mutant human cytomegalovirus in life-extended human diploid fibroblasts", JOURNAL OF VIROLOGY, THE AMERICAN SOCIETY FOR MICROBIOLOGY, US, vol. 74, no. 22, November 2000 (2000-11-01), pages 10816 - 10818, XP002163581, ISSN: 0022-538X * |
FRANCO S ET AL: "Clonal variation in phenotype and life span of human embryonic fibroblasts (MRC-5) transduced with the catalytic component of telomerase (hTERT).", EXPERIMENTAL CELL RESEARCH, vol. 268, no. 1, 1 August 2001 (2001-08-01), pages 14 - 25, XP002188247, ISSN: 0014-4827 * |
FRANCO SONIA ET AL: "Expression of telomerase after retroviral transduction increases lifespan of primary human fibroblasts.", PEDIATRIC RESEARCH, vol. 45, no. 4 PART 2, April 1999 (1999-04-01), Annual Meeting of the American Pediatric Society and the Society for Pediatric Research;San Francisco, California, USA; May 1-4, 1999, pages 146A, XP001027601, ISSN: 0031-3998 * |
JIANG XU-RONG ET AL: "Telomerase expression in human somatic cells does not induce changes associated with a transformed phenotype", NATURE GENETICS, NATURE AMERICA, NEW YORK, US, vol. 21, no. 1, January 1999 (1999-01-01), pages 111 - 114, XP002144961, ISSN: 1061-4036 * |
MACKENZIE KAREN L ET AL: "Mass cultured fibroblasts overexpressing hTERT from a retroviral vector enter crisis following an extended period of proliferation.", PROCEEDINGS OF THE AMERICAN ASSOCIATION FOR CANCER RESEARCH ANNUAL, no. 41, March 2000 (2000-03-01), 91st Annual Meeting of the American Association for Cancer Research.;San Francisco, California, USA; April 01-05, 2000, March, 2000, pages 226, XP001026310, ISSN: 0197-016X * |
MACKENZIE KAREN L ET AL: "Mass cultured human fibroblasts overexpressing hTERT encounter a growth crisis following an extended period of proliferation.", EXPERIMENTAL CELL RESEARCH, vol. 259, no. 2, 15 September 2000 (2000-09-15), pages 336 - 350, XP002188248, ISSN: 0014-4827 * |
MCSHARRY B P ET AL: "Human telomerase reverse transcriptase-immortalized MRC-5 and HCA2 human fibroblasts are fully permissive for human cytomegalovirus.", JOURNAL OF GENERAL VIROLOGY, vol. 82, no. 4, April 2001 (2001-04-01), pages 855 - 863, XP001027071, ISSN: 0022-1317 * |
NAKAYAMA JUN-ICHI ET AL: "Telomerase activation by hTRT in human normal fibroblasts and hepatocellular carcinomas.", NATURE GENETICS, vol. 18, no. 1, January 1998 (1998-01-01), pages 65 - 68, XP001027528, ISSN: 1061-4036 * |
OH SANGTAEK ET AL: "Identification of Mad as a repressor of the human telomerase (hTERT) gene.", ONCOGENE, vol. 19, no. 11, 9 March 2000 (2000-03-09), pages 1485 - 1490, XP001027580, ISSN: 0950-9232 * |
TAHARA HIDETOSHI ET AL: "Possible role of loss of p16 in the immortalization of human cells with telomerase catalytic subunit of telomerase (hTERT).", PROCEEDINGS OF THE AMERICAN ASSOCIATION FOR CANCER RESEARCH ANNUAL, no. 41, March 2000 (2000-03-01), 91st Annual Meeting of the American Association for Cancer Research.;San Francisco, California, USA; April 01-05, 2000, March, 2000, pages 225, XP001026311, ISSN: 0197-016X * |
WEN JIANPING ET AL: "Reconstitution of wild-type or mutant telomerase activity in telomerase-negative immortal human cells.", HUMAN MOLECULAR GENETICS, vol. 7, no. 7, July 1998 (1998-07-01), pages 1137 - 1141, XP001027557, ISSN: 0964-6906 * |
WYLLIE F S ET AL: "Telomerase prevents the accelerated cell ageing of Werner syndrome fibroblasts.", NATURE GENETICS, (2000 JAN) 24 (1) 16-7., XP002188246 * |
Also Published As
Publication number | Publication date |
---|---|
WO2002016555A2 (en) | 2002-02-28 |
AU2001282290A1 (en) | 2002-03-04 |
Similar Documents
Publication | Publication Date | Title |
---|---|---|
Chi et al. | DNA vaccine encoding Middle East respiratory syndrome coronavirus S1 protein induces protective immune responses in mice | |
Rodrigues et al. | Viral vaccines and their manufacturing cell substrates: New trends and designs in modern vaccinology | |
ES2536745T3 (en) | Methods of production of influenza vaccine compositions | |
ES2009350A6 (en) | Expression and purification of an HTLV-III gag/env gene protein | |
ES2716010T3 (en) | Methods and compositions for cytomegalovirus IL-10 protein | |
WO2006031264A3 (en) | Siv and hiv vaccination using rhcmv- and hcmv-based vaccine vectors | |
ATE527281T1 (en) | VACCINES AGAINST AIDS COMPRISING CMV/R NUCLEIC ACID CONSTRUCTS | |
BR9814606A (en) | Vaccine formulation and methods of treating an individual infected with an hpv virus and preventing papillomavirus infection | |
WO2002022080A3 (en) | Enhanced first generation adenovirus vaccines expressing codon optimized hiv1-gag, pol, nef and modifications | |
WO2006004661A1 (en) | Recombinant human cytomegalovirus and vaccines comprising heterologous antigens | |
WO2000053729A3 (en) | Viral particles which are released after the infection with the human cytomegalovirus and the use of said particles as a vaccine | |
HUP0202826A2 (en) | Novel composition | |
Sharpe et al. | Single oral immunization with replication deficient recombinant adenovirus elicits long-lived transgene-specific cellular and humoral immune responses | |
Perez et al. | A single dose of an MVA vaccine expressing a prefusion-stabilized SARS-CoV-2 spike protein neutralizes variants of concern and protects mice from a lethal SARS-CoV-2 infection | |
ES8706208A1 (en) | Expression of immunologically reactive viral proteins. | |
Wang et al. | Vaccination with a single consensus envelope protein ectodomain sequence administered in a heterologous regimen induces tetravalent immune responses and protection against dengue viruses in mice | |
Zhao et al. | Co-immunization with CHIKV VLP and DNA vaccines induces a promising humoral response in mice | |
HUP0105392A2 (en) | Enhanced vaccines | |
WO2002004007A3 (en) | Stable (fixed) forms of viral capsid proteins, fusion proteins and uses thereof | |
WO2002016555A3 (en) | Htert-immortalised cell lines, their preparation and use | |
WO2003040305A3 (en) | Porcine adenovirus e1 and e4 regions | |
WO1999053047A3 (en) | Porcine adenovirus type 3 genome | |
Khattar et al. | Enhanced immune responses to HIV-1 envelope elicited by a vaccine regimen consisting of priming with Newcastle disease virus expressing HIV gp160 and boosting with gp120 and SOSIP gp140 proteins | |
Robertson | An overview of host cell selection. | |
Homan et al. | Further studies of naturally occurring latent bovine herpesvirus infection. |
Legal Events
Date | Code | Title | Description |
---|---|---|---|
AK | Designated states |
Kind code of ref document: A2 Designated state(s): AE AG AL AM AT AU AZ BA BB BG BR BY BZ CA CH CN CO CR CU CZ DE DK DM DZ EC EE ES FI GB GD GE GH GM HR HU ID IL IN IS JP KE KG KP KR KZ LC LK LR LS LT LU LV MA MD MG MK MN MW MX MZ NO NZ PH PL PT RO RU SD SE SG SI SK SL TJ TM TR TT TZ UA UG US UZ VN YU ZA ZW |
|
AL | Designated countries for regional patents |
Kind code of ref document: A2 Designated state(s): GH GM KE LS MW MZ SD SL SZ TZ UG ZW AM AZ BY KG KZ MD RU TJ TM AT BE CH CY DE DK ES FI FR GB GR IE IT LU MC NL PT SE TR BF BJ CF CG CI CM GA GN GQ GW ML MR NE SN TD TG |
|
121 | Ep: the epo has been informed by wipo that ep was designated in this application | ||
DFPE | Request for preliminary examination filed prior to expiration of 19th month from priority date (pct application filed before 20040101) | ||
AK | Designated states |
Kind code of ref document: A3 Designated state(s): AE AG AL AM AT AU AZ BA BB BG BR BY BZ CA CH CN CO CR CU CZ DE DK DM DZ EC EE ES FI GB GD GE GH GM HR HU ID IL IN IS JP KE KG KP KR KZ LC LK LR LS LT LU LV MA MD MG MK MN MW MX MZ NO NZ PH PL PT RO RU SD SE SG SI SK SL TJ TM TR TT TZ UA UG US UZ VN YU ZA ZW |
|
AL | Designated countries for regional patents |
Kind code of ref document: A3 Designated state(s): GH GM KE LS MW MZ SD SL SZ TZ UG ZW AM AZ BY KG KZ MD RU TJ TM AT BE CH CY DE DK ES FI FR GB GR IE IT LU MC NL PT SE TR BF BJ CF CG CI CM GA GN GQ GW ML MR NE SN TD TG |
|
REG | Reference to national code |
Ref country code: DE Ref legal event code: 8642 |
|
122 | Ep: pct application non-entry in european phase | ||
NENP | Non-entry into the national phase |
Ref country code: JP |