WO2002014876A3 - Testeinheit und verfahren zur herstellung stabiler formulierungen - Google Patents

Testeinheit und verfahren zur herstellung stabiler formulierungen Download PDF

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Publication number
WO2002014876A3
WO2002014876A3 PCT/EP2001/009470 EP0109470W WO0214876A3 WO 2002014876 A3 WO2002014876 A3 WO 2002014876A3 EP 0109470 W EP0109470 W EP 0109470W WO 0214876 A3 WO0214876 A3 WO 0214876A3
Authority
WO
WIPO (PCT)
Prior art keywords
test unit
formulations
array
production
stable formulations
Prior art date
Application number
PCT/EP2001/009470
Other languages
English (en)
French (fr)
Other versions
WO2002014876A2 (de
Inventor
Robert Heger
Wolfgang Schrof
Michael Seufert
Simon Nord
Harald Koehle
Original Assignee
Basf Ag
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Application filed by Basf Ag filed Critical Basf Ag
Priority to JP2002519954A priority Critical patent/JP2004506902A/ja
Priority to EP01958079A priority patent/EP1311861A2/de
Priority to AU2001279820A priority patent/AU2001279820A1/en
Publication of WO2002014876A2 publication Critical patent/WO2002014876A2/de
Publication of WO2002014876A3 publication Critical patent/WO2002014876A3/de

Links

Classifications

    • G—PHYSICS
    • G01—MEASURING; TESTING
    • G01N—INVESTIGATING OR ANALYSING MATERIALS BY DETERMINING THEIR CHEMICAL OR PHYSICAL PROPERTIES
    • G01N35/00—Automatic analysis not limited to methods or materials provided for in any single one of groups G01N1/00 - G01N33/00; Handling materials therefor
    • G01N35/10—Devices for transferring samples or any liquids to, in, or from, the analysis apparatus, e.g. suction devices, injection devices
    • B—PERFORMING OPERATIONS; TRANSPORTING
    • B01—PHYSICAL OR CHEMICAL PROCESSES OR APPARATUS IN GENERAL
    • B01J—CHEMICAL OR PHYSICAL PROCESSES, e.g. CATALYSIS OR COLLOID CHEMISTRY; THEIR RELEVANT APPARATUS
    • B01J19/00—Chemical, physical or physico-chemical processes in general; Their relevant apparatus
    • B01J19/0046—Sequential or parallel reactions, e.g. for the synthesis of polypeptides or polynucleotides; Apparatus and devices for combinatorial chemistry or for making molecular arrays
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K9/00—Medicinal preparations characterised by special physical form
    • A61K9/10—Dispersions; Emulsions
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K9/00—Medicinal preparations characterised by special physical form
    • A61K9/10—Dispersions; Emulsions
    • A61K9/107—Emulsions ; Emulsion preconcentrates; Micelles
    • B—PERFORMING OPERATIONS; TRANSPORTING
    • B01—PHYSICAL OR CHEMICAL PROCESSES OR APPARATUS IN GENERAL
    • B01J—CHEMICAL OR PHYSICAL PROCESSES, e.g. CATALYSIS OR COLLOID CHEMISTRY; THEIR RELEVANT APPARATUS
    • B01J2219/00—Chemical, physical or physico-chemical processes in general; Their relevant apparatus
    • B01J2219/00274—Sequential or parallel reactions; Apparatus and devices for combinatorial chemistry or for making arrays; Chemical library technology
    • B01J2219/00277—Apparatus
    • B01J2219/00279—Features relating to reactor vessels
    • B01J2219/00306—Reactor vessels in a multiple arrangement
    • B01J2219/00313—Reactor vessels in a multiple arrangement the reactor vessels being formed by arrays of wells in blocks
    • B01J2219/00315—Microtiter plates
    • B—PERFORMING OPERATIONS; TRANSPORTING
    • B01—PHYSICAL OR CHEMICAL PROCESSES OR APPARATUS IN GENERAL
    • B01J—CHEMICAL OR PHYSICAL PROCESSES, e.g. CATALYSIS OR COLLOID CHEMISTRY; THEIR RELEVANT APPARATUS
    • B01J2219/00—Chemical, physical or physico-chemical processes in general; Their relevant apparatus
    • B01J2219/00274—Sequential or parallel reactions; Apparatus and devices for combinatorial chemistry or for making arrays; Chemical library technology
    • B01J2219/00277—Apparatus
    • B01J2219/00351—Means for dispensing and evacuation of reagents
    • B01J2219/00364—Pipettes
    • B—PERFORMING OPERATIONS; TRANSPORTING
    • B01—PHYSICAL OR CHEMICAL PROCESSES OR APPARATUS IN GENERAL
    • B01J—CHEMICAL OR PHYSICAL PROCESSES, e.g. CATALYSIS OR COLLOID CHEMISTRY; THEIR RELEVANT APPARATUS
    • B01J2219/00—Chemical, physical or physico-chemical processes in general; Their relevant apparatus
    • B01J2219/00274—Sequential or parallel reactions; Apparatus and devices for combinatorial chemistry or for making arrays; Chemical library technology
    • B01J2219/00277—Apparatus
    • B01J2219/00351—Means for dispensing and evacuation of reagents
    • B01J2219/00373—Hollow needles
    • B—PERFORMING OPERATIONS; TRANSPORTING
    • B01—PHYSICAL OR CHEMICAL PROCESSES OR APPARATUS IN GENERAL
    • B01J—CHEMICAL OR PHYSICAL PROCESSES, e.g. CATALYSIS OR COLLOID CHEMISTRY; THEIR RELEVANT APPARATUS
    • B01J2219/00—Chemical, physical or physico-chemical processes in general; Their relevant apparatus
    • B01J2219/00274—Sequential or parallel reactions; Apparatus and devices for combinatorial chemistry or for making arrays; Chemical library technology
    • B01J2219/00277—Apparatus
    • B01J2219/00479—Means for mixing reactants or products in the reaction vessels
    • B—PERFORMING OPERATIONS; TRANSPORTING
    • B01—PHYSICAL OR CHEMICAL PROCESSES OR APPARATUS IN GENERAL
    • B01J—CHEMICAL OR PHYSICAL PROCESSES, e.g. CATALYSIS OR COLLOID CHEMISTRY; THEIR RELEVANT APPARATUS
    • B01J2219/00—Chemical, physical or physico-chemical processes in general; Their relevant apparatus
    • B01J2219/00274—Sequential or parallel reactions; Apparatus and devices for combinatorial chemistry or for making arrays; Chemical library technology
    • B01J2219/00583—Features relative to the processes being carried out
    • B01J2219/00585—Parallel processes
    • B—PERFORMING OPERATIONS; TRANSPORTING
    • B01—PHYSICAL OR CHEMICAL PROCESSES OR APPARATUS IN GENERAL
    • B01J—CHEMICAL OR PHYSICAL PROCESSES, e.g. CATALYSIS OR COLLOID CHEMISTRY; THEIR RELEVANT APPARATUS
    • B01J2219/00—Chemical, physical or physico-chemical processes in general; Their relevant apparatus
    • B01J2219/00274—Sequential or parallel reactions; Apparatus and devices for combinatorial chemistry or for making arrays; Chemical library technology
    • B01J2219/00583—Features relative to the processes being carried out
    • B01J2219/00603—Making arrays on substantially continuous surfaces
    • B01J2219/00659—Two-dimensional arrays
    • B—PERFORMING OPERATIONS; TRANSPORTING
    • B01—PHYSICAL OR CHEMICAL PROCESSES OR APPARATUS IN GENERAL
    • B01J—CHEMICAL OR PHYSICAL PROCESSES, e.g. CATALYSIS OR COLLOID CHEMISTRY; THEIR RELEVANT APPARATUS
    • B01J2219/00—Chemical, physical or physico-chemical processes in general; Their relevant apparatus
    • B01J2219/00274—Sequential or parallel reactions; Apparatus and devices for combinatorial chemistry or for making arrays; Chemical library technology
    • B01J2219/0068—Means for controlling the apparatus of the process
    • B01J2219/00686—Automatic
    • B01J2219/00691—Automatic using robots
    • B—PERFORMING OPERATIONS; TRANSPORTING
    • B01—PHYSICAL OR CHEMICAL PROCESSES OR APPARATUS IN GENERAL
    • B01J—CHEMICAL OR PHYSICAL PROCESSES, e.g. CATALYSIS OR COLLOID CHEMISTRY; THEIR RELEVANT APPARATUS
    • B01J2219/00—Chemical, physical or physico-chemical processes in general; Their relevant apparatus
    • B01J2219/00274—Sequential or parallel reactions; Apparatus and devices for combinatorial chemistry or for making arrays; Chemical library technology
    • B01J2219/0068—Means for controlling the apparatus of the process
    • B01J2219/00702—Processes involving means for analysing and characterising the products
    • B01J2219/00704—Processes involving means for analysing and characterising the products integrated with the reactor apparatus
    • B—PERFORMING OPERATIONS; TRANSPORTING
    • B01—PHYSICAL OR CHEMICAL PROCESSES OR APPARATUS IN GENERAL
    • B01J—CHEMICAL OR PHYSICAL PROCESSES, e.g. CATALYSIS OR COLLOID CHEMISTRY; THEIR RELEVANT APPARATUS
    • B01J2219/00—Chemical, physical or physico-chemical processes in general; Their relevant apparatus
    • B01J2219/00274—Sequential or parallel reactions; Apparatus and devices for combinatorial chemistry or for making arrays; Chemical library technology
    • B01J2219/0068—Means for controlling the apparatus of the process
    • B01J2219/00702—Processes involving means for analysing and characterising the products
    • B01J2219/00707—Processes involving means for analysing and characterising the products separated from the reactor apparatus
    • B—PERFORMING OPERATIONS; TRANSPORTING
    • B01—PHYSICAL OR CHEMICAL PROCESSES OR APPARATUS IN GENERAL
    • B01J—CHEMICAL OR PHYSICAL PROCESSES, e.g. CATALYSIS OR COLLOID CHEMISTRY; THEIR RELEVANT APPARATUS
    • B01J2219/00—Chemical, physical or physico-chemical processes in general; Their relevant apparatus
    • B01J2219/00274—Sequential or parallel reactions; Apparatus and devices for combinatorial chemistry or for making arrays; Chemical library technology
    • B01J2219/00718—Type of compounds synthesised
    • B01J2219/0072—Organic compounds
    • C—CHEMISTRY; METALLURGY
    • C40—COMBINATORIAL TECHNOLOGY
    • C40B—COMBINATORIAL CHEMISTRY; LIBRARIES, e.g. CHEMICAL LIBRARIES
    • C40B40/00—Libraries per se, e.g. arrays, mixtures
    • G—PHYSICS
    • G01—MEASURING; TESTING
    • G01N—INVESTIGATING OR ANALYSING MATERIALS BY DETERMINING THEIR CHEMICAL OR PHYSICAL PROPERTIES
    • G01N13/00—Investigating surface or boundary effects, e.g. wetting power; Investigating diffusion effects; Analysing materials by determining surface, boundary, or diffusion effects
    • G01N2013/006—Dissolution of tablets or the like
    • G—PHYSICS
    • G01—MEASURING; TESTING
    • G01N—INVESTIGATING OR ANALYSING MATERIALS BY DETERMINING THEIR CHEMICAL OR PHYSICAL PROPERTIES
    • G01N35/00—Automatic analysis not limited to methods or materials provided for in any single one of groups G01N1/00 - G01N33/00; Handling materials therefor
    • G01N2035/00178—Special arrangements of analysers
    • G01N2035/00188—Special arrangements of analysers the analyte being in the solid state
    • G01N2035/00198—Dissolution analysers
    • G—PHYSICS
    • G01—MEASURING; TESTING
    • G01N—INVESTIGATING OR ANALYSING MATERIALS BY DETERMINING THEIR CHEMICAL OR PHYSICAL PROPERTIES
    • G01N35/00—Automatic analysis not limited to methods or materials provided for in any single one of groups G01N1/00 - G01N33/00; Handling materials therefor
    • G01N35/10—Devices for transferring samples or any liquids to, in, or from, the analysis apparatus, e.g. suction devices, injection devices
    • G01N2035/1027—General features of the devices
    • G01N2035/1032—Dilution or aliquotting

Landscapes

  • Chemical & Material Sciences (AREA)
  • Organic Chemistry (AREA)
  • Immunology (AREA)
  • Pathology (AREA)
  • Analytical Chemistry (AREA)
  • Biochemistry (AREA)
  • General Health & Medical Sciences (AREA)
  • General Physics & Mathematics (AREA)
  • Physics & Mathematics (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • Health & Medical Sciences (AREA)
  • Chemical Kinetics & Catalysis (AREA)
  • Medicinal Preparation (AREA)
  • Measuring Or Testing Involving Enzymes Or Micro-Organisms (AREA)
  • Automatic Analysis And Handling Materials Therefor (AREA)
  • Feeding, Discharge, Calcimining, Fusing, And Gas-Generation Devices (AREA)

Abstract

Die Erfindung betrifft eine Testeinheit zur Auffindung und/oder Identifizierung von stabilen Formulierungen, die die folgenden Komponenten enthalten mindestens einen in einem Dipsergiermedium schwerlöslichen oder unlöslichen Wirkstoff, mindestens ein Formulierhilfsmittel, ein Dispergiermedium, und gegebenenfalls mindestens ein Lösungsmittel, wobei die Testeinheit einen Roboter zur Ansteurerung eine Matrix von Positionen auf einem Substrat aufweist, der mindestens einen Roboterarm aufweist, dadurch gekennzeichnet, dass in den Roboterarm eine Mischkammer integriert ist. Des weiteren betrifft die Erfindung Verfahren zur Herstellung eines Arrays enthaltend n Formulierungen, wobei sich jede der n Formulierungen in einer bekannten Position von M Positionen auf einem Substrat befindet, wobei n und m jeweils eine natürliche Zahl grösser oder gleich 2 sind un m grösser oder gleich m ist sowie eine Array enthaltend n Formulierung und die Verwendung des Arrays Identifizierung und/oder Auffindung stabiler Fromulierung sowie der Testeinheit zur Herstellung des Arrays.
PCT/EP2001/009470 2000-08-17 2001-08-16 Testeinheit und verfahren zur herstellung stabiler formulierungen WO2002014876A2 (de)

Priority Applications (3)

Application Number Priority Date Filing Date Title
JP2002519954A JP2004506902A (ja) 2000-08-17 2001-08-16 安定配合物製造用試験単位装置及び製造方法
EP01958079A EP1311861A2 (de) 2000-08-17 2001-08-16 Testeinheit und verfahren zur herstellung stabiler formulierungen
AU2001279820A AU2001279820A1 (en) 2000-08-17 2001-08-16 Test unit and method for the production of stable formulations

Applications Claiming Priority (2)

Application Number Priority Date Filing Date Title
US64009100A 2000-08-17 2000-08-17
US09/640,091 2000-08-17

Publications (2)

Publication Number Publication Date
WO2002014876A2 WO2002014876A2 (de) 2002-02-21
WO2002014876A3 true WO2002014876A3 (de) 2003-01-30

Family

ID=24566800

Family Applications (1)

Application Number Title Priority Date Filing Date
PCT/EP2001/009470 WO2002014876A2 (de) 2000-08-17 2001-08-16 Testeinheit und verfahren zur herstellung stabiler formulierungen

Country Status (4)

Country Link
EP (1) EP1311861A2 (de)
JP (1) JP2004506902A (de)
AU (1) AU2001279820A1 (de)
WO (1) WO2002014876A2 (de)

Families Citing this family (2)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
FR2832630B1 (fr) * 2001-11-28 2005-01-14 Oreal Composition cosmetique et/ou dermatologique contenant au moins un actif hydrophile sensible a l'oxydation stabilise par au moins un copolymere de n-vinylimidazole
ES2254885T3 (es) 2002-06-20 2006-06-16 L'oreal Utilizacion cosmetica y/o dermatologica de una composicion que contiene al menos un agente hidrofilo sensible a la oxidacion por al menos un copolimero de anhidrido maleico.

Citations (10)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
US4199013A (en) * 1977-04-01 1980-04-22 Packard Instrument Company, Inc. Liquid sample aspirating and/or dispensing system
US5147412A (en) * 1989-05-20 1992-09-15 Bayer Aktiengesellschaft Production of dispersions of spherical particles by crystallization of emulsions
EP0668111A2 (de) * 1994-02-18 1995-08-23 Nordson Corporation Zweikomponenten Abgabesystem
WO1998032002A1 (en) * 1997-01-22 1998-07-23 Biacore Ab Pipette and carrier assembly for a sensor
WO1999004247A1 (en) * 1997-07-14 1999-01-28 Symyx Technologies Systems and methods for employing optical probes to characterize material properties
DE19805719A1 (de) * 1998-02-12 1999-08-19 Basf Ag Verfahren zur kombinatorischen Herstellung und Testung von Heterogenkatalysatoren
WO1999051206A1 (en) * 1998-04-03 1999-10-14 Valentis, Inc. Cationic lipid formulation delivering nucleic acid to peritoneal tumors
US5979794A (en) * 1997-05-13 1999-11-09 Ingersoll-Rand Company Two-part stream dispensing for high viscosity materials
WO2000059627A1 (en) * 1999-04-05 2000-10-12 Millennium Pharmaceuticals, Inc. Formulation arrays and use thereof
WO2002006353A1 (de) * 2000-07-18 2002-01-24 Basf Aktiengesellschaft Arrays von n wässrigen polymerdispersionen und m formulierungen wäsriger polymerdispersionen

Patent Citations (10)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
US4199013A (en) * 1977-04-01 1980-04-22 Packard Instrument Company, Inc. Liquid sample aspirating and/or dispensing system
US5147412A (en) * 1989-05-20 1992-09-15 Bayer Aktiengesellschaft Production of dispersions of spherical particles by crystallization of emulsions
EP0668111A2 (de) * 1994-02-18 1995-08-23 Nordson Corporation Zweikomponenten Abgabesystem
WO1998032002A1 (en) * 1997-01-22 1998-07-23 Biacore Ab Pipette and carrier assembly for a sensor
US5979794A (en) * 1997-05-13 1999-11-09 Ingersoll-Rand Company Two-part stream dispensing for high viscosity materials
WO1999004247A1 (en) * 1997-07-14 1999-01-28 Symyx Technologies Systems and methods for employing optical probes to characterize material properties
DE19805719A1 (de) * 1998-02-12 1999-08-19 Basf Ag Verfahren zur kombinatorischen Herstellung und Testung von Heterogenkatalysatoren
WO1999051206A1 (en) * 1998-04-03 1999-10-14 Valentis, Inc. Cationic lipid formulation delivering nucleic acid to peritoneal tumors
WO2000059627A1 (en) * 1999-04-05 2000-10-12 Millennium Pharmaceuticals, Inc. Formulation arrays and use thereof
WO2002006353A1 (de) * 2000-07-18 2002-01-24 Basf Aktiengesellschaft Arrays von n wässrigen polymerdispersionen und m formulierungen wäsriger polymerdispersionen

Also Published As

Publication number Publication date
AU2001279820A1 (en) 2002-02-25
EP1311861A2 (de) 2003-05-21
WO2002014876A2 (de) 2002-02-21
JP2004506902A (ja) 2004-03-04

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