WO2002014324A3 - Diazepinones as antiviral agents - Google Patents

Diazepinones as antiviral agents Download PDF

Info

Publication number
WO2002014324A3
WO2002014324A3 PCT/US2001/024731 US0124731W WO0214324A3 WO 2002014324 A3 WO2002014324 A3 WO 2002014324A3 US 0124731 W US0124731 W US 0124731W WO 0214324 A3 WO0214324 A3 WO 0214324A3
Authority
WO
WIPO (PCT)
Prior art keywords
diazepinones
antiviral agents
useful
novel
compounds
Prior art date
Application number
PCT/US2001/024731
Other languages
French (fr)
Other versions
WO2002014324A2 (en
Inventor
Hidetsura Cho
Rocco Dean Gogliotti
Harriet Wall Hamilton
Alexei Krasutsky
Takashi Nakamura
Hiroki Tade
Peter Craig Weber
Original Assignee
Warner Lambert Co
Japan Tobacco Inc
Hidetsura Cho
Rocco Dean Gogliotti
Harriet Wall Hamilton
Alexei Krasutsky
Takashi Nakamura
Hiroki Tade
Peter Craig Weber
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Application filed by Warner Lambert Co, Japan Tobacco Inc, Hidetsura Cho, Rocco Dean Gogliotti, Harriet Wall Hamilton, Alexei Krasutsky, Takashi Nakamura, Hiroki Tade, Peter Craig Weber filed Critical Warner Lambert Co
Priority to AU2001281142A priority Critical patent/AU2001281142A1/en
Priority to US10/344,924 priority patent/US20040116410A1/en
Publication of WO2002014324A2 publication Critical patent/WO2002014324A2/en
Publication of WO2002014324A3 publication Critical patent/WO2002014324A3/en
Priority to US11/165,139 priority patent/US20050250765A1/en

Links

Classifications

    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D491/00—Heterocyclic compounds containing in the condensed ring system both one or more rings having oxygen atoms as the only ring hetero atoms and one or more rings having nitrogen atoms as the only ring hetero atoms, not provided for by groups C07D451/00 - C07D459/00, C07D463/00, C07D477/00 or C07D489/00
    • C07D491/02—Heterocyclic compounds containing in the condensed ring system both one or more rings having oxygen atoms as the only ring hetero atoms and one or more rings having nitrogen atoms as the only ring hetero atoms, not provided for by groups C07D451/00 - C07D459/00, C07D463/00, C07D477/00 or C07D489/00 in which the condensed system contains two hetero rings
    • C07D491/04—Ortho-condensed systems
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D495/00—Heterocyclic compounds containing in the condensed system at least one hetero ring having sulfur atoms as the only ring hetero atoms
    • C07D495/02—Heterocyclic compounds containing in the condensed system at least one hetero ring having sulfur atoms as the only ring hetero atoms in which the condensed system contains two hetero rings
    • C07D495/04—Ortho-condensed systems

Landscapes

  • Chemical & Material Sciences (AREA)
  • Organic Chemistry (AREA)
  • Nitrogen And Oxygen Or Sulfur-Condensed Heterocyclic Ring Systems (AREA)
  • Heterocyclic Carbon Compounds Containing A Hetero Ring Having Oxygen Or Sulfur (AREA)
  • Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)

Abstract

The invention is novel compounds of formula (I) which exhibit an improved therapeutic index and improved metabolic stability which are useful in the treatment and/or prevention of herpes viral infections. Novel intermediates useful in the synthesis of the final compounds are also part of the invention.
PCT/US2001/024731 2000-08-16 2001-08-07 Diazepinones as antiviral agents WO2002014324A2 (en)

Priority Applications (3)

Application Number Priority Date Filing Date Title
AU2001281142A AU2001281142A1 (en) 2000-08-16 2001-08-07 Diazepinones as antiviral agents
US10/344,924 US20040116410A1 (en) 2001-08-07 2001-08-07 Diazepinones as antiviral agents
US11/165,139 US20050250765A1 (en) 2000-08-16 2005-06-22 Diazepinones as antiviral agents

Applications Claiming Priority (2)

Application Number Priority Date Filing Date Title
US22582000P 2000-08-16 2000-08-16
US60/225,820 2000-08-16

Related Child Applications (1)

Application Number Title Priority Date Filing Date
US11/165,139 Continuation US20050250765A1 (en) 2000-08-16 2005-06-22 Diazepinones as antiviral agents

Publications (2)

Publication Number Publication Date
WO2002014324A2 WO2002014324A2 (en) 2002-02-21
WO2002014324A3 true WO2002014324A3 (en) 2002-05-02

Family

ID=22846381

Family Applications (1)

Application Number Title Priority Date Filing Date
PCT/US2001/024731 WO2002014324A2 (en) 2000-08-16 2001-08-07 Diazepinones as antiviral agents

Country Status (2)

Country Link
AU (1) AU2001281142A1 (en)
WO (1) WO2002014324A2 (en)

Families Citing this family (2)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
CN112250687A (en) * 2020-09-25 2021-01-22 江苏师范大学 Preparation method of benzofuran fused hepta-diazepine ketone compound
JP2022061021A (en) * 2020-10-05 2022-04-15 日本たばこ産業株式会社 Tetrahydrobenzofurodiazepinone compound and pharmaceutical use thereof

Citations (3)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
WO1994017075A1 (en) * 1993-01-20 1994-08-04 A. Menarini Industrie Farmaceutiche Riunite S.R.L. Diazepin derivatives and antiviral compositions
WO1995024408A1 (en) * 1994-03-07 1995-09-14 Warner-Lambert Company Benzothiophene, benzofuran and indolethiazepinones, oxazepinones and diazepinones as inhibitors of cell adhesion and as inhibitors of hiv
WO1996029077A1 (en) * 1995-03-22 1996-09-26 Warner-Lambert Company Use of thiazepine, oxazepine and diazepine coumpounds for inhibiting hiv, herpesvirus and suppressing the immune system

Patent Citations (4)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
WO1994017075A1 (en) * 1993-01-20 1994-08-04 A. Menarini Industrie Farmaceutiche Riunite S.R.L. Diazepin derivatives and antiviral compositions
WO1995024408A1 (en) * 1994-03-07 1995-09-14 Warner-Lambert Company Benzothiophene, benzofuran and indolethiazepinones, oxazepinones and diazepinones as inhibitors of cell adhesion and as inhibitors of hiv
US5489586A (en) * 1994-03-07 1996-02-06 Warner-Lambert Company Method for treating inflammatory disease in humans
WO1996029077A1 (en) * 1995-03-22 1996-09-26 Warner-Lambert Company Use of thiazepine, oxazepine and diazepine coumpounds for inhibiting hiv, herpesvirus and suppressing the immune system

Also Published As

Publication number Publication date
WO2002014324A2 (en) 2002-02-21
AU2001281142A1 (en) 2002-02-25

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