WO2002010334A3 - Dna element promoter of transcription activity, active in human cells and general method for adjusting the activity thereof - Google Patents

Dna element promoter of transcription activity, active in human cells and general method for adjusting the activity thereof Download PDF

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Publication number
WO2002010334A3
WO2002010334A3 PCT/FR2001/002438 FR0102438W WO0210334A3 WO 2002010334 A3 WO2002010334 A3 WO 2002010334A3 FR 0102438 W FR0102438 W FR 0102438W WO 0210334 A3 WO0210334 A3 WO 0210334A3
Authority
WO
WIPO (PCT)
Prior art keywords
activity
active
adjusting
general method
human cells
Prior art date
Application number
PCT/FR2001/002438
Other languages
French (fr)
Other versions
WO2002010334A2 (en
Inventor
Jean-Paul Issartel
Pierre Lescuyer
Original Assignee
Commissariat Energie Atomique
Centre Nat Rech Scient
Univ Joseph Fourier
Issartel Jean Paul
Pierre Lescuyer
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Application filed by Commissariat Energie Atomique, Centre Nat Rech Scient, Univ Joseph Fourier, Issartel Jean Paul, Pierre Lescuyer filed Critical Commissariat Energie Atomique
Priority to EP01960836A priority Critical patent/EP1305403A2/en
Publication of WO2002010334A2 publication Critical patent/WO2002010334A2/en
Publication of WO2002010334A3 publication Critical patent/WO2002010334A3/en

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Classifications

    • C—CHEMISTRY; METALLURGY
    • C12—BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
    • C12N—MICROORGANISMS OR ENZYMES; COMPOSITIONS THEREOF; PROPAGATING, PRESERVING, OR MAINTAINING MICROORGANISMS; MUTATION OR GENETIC ENGINEERING; CULTURE MEDIA
    • C12N9/00—Enzymes; Proenzymes; Compositions thereof; Processes for preparing, activating, inhibiting, separating or purifying enzymes
    • C12N9/10—Transferases (2.)
    • C12N9/12—Transferases (2.) transferring phosphorus containing groups, e.g. kinases (2.7)
    • C12N9/1241—Nucleotidyltransferases (2.7.7)
    • C12N9/1247—DNA-directed RNA polymerase (2.7.7.6)
    • A—HUMAN NECESSITIES
    • A01—AGRICULTURE; FORESTRY; ANIMAL HUSBANDRY; HUNTING; TRAPPING; FISHING
    • A01K—ANIMAL HUSBANDRY; CARE OF BIRDS, FISHES, INSECTS; FISHING; REARING OR BREEDING ANIMALS, NOT OTHERWISE PROVIDED FOR; NEW BREEDS OF ANIMALS
    • A01K2217/00—Genetically modified animals
    • A01K2217/05—Animals comprising random inserted nucleic acids (transgenic)

Abstract

The invention concerns an element promoter of RNA polymerase transcription activity characterised in that it comprises: i) the 241 nucleotides, extending from position 1630 to position 1870, of the sequence illustrated in figure 1 or ii) part of the sequence i) comprising at least one of the three CCAAT motifs represented in figure 1 or iii) a sequence having at least 70 % identity with the sequence i); said element further containing a NRF1 fixing site.
PCT/FR2001/002438 2000-07-28 2001-07-25 Dna element promoter of transcription activity, active in human cells and general method for adjusting the activity thereof WO2002010334A2 (en)

Priority Applications (1)

Application Number Priority Date Filing Date Title
EP01960836A EP1305403A2 (en) 2000-07-28 2001-07-25 Dna element promoter of transcription activity, active in human cells and general method for adjusting the activity thereof

Applications Claiming Priority (2)

Application Number Priority Date Filing Date Title
FR00/10007 2000-07-28
FR0010007A FR2812305B1 (en) 2000-07-28 2000-07-28 DNA MEMBER PROMOTING TRANSCRIPTION ACTIVITY, ACTIVE IN HUMAN CELLS AND GENERAL METHOD FOR ADJUSTING ACTIVITY

Publications (2)

Publication Number Publication Date
WO2002010334A2 WO2002010334A2 (en) 2002-02-07
WO2002010334A3 true WO2002010334A3 (en) 2002-04-18

Family

ID=8853087

Family Applications (1)

Application Number Title Priority Date Filing Date
PCT/FR2001/002438 WO2002010334A2 (en) 2000-07-28 2001-07-25 Dna element promoter of transcription activity, active in human cells and general method for adjusting the activity thereof

Country Status (3)

Country Link
EP (1) EP1305403A2 (en)
FR (1) FR2812305B1 (en)
WO (1) WO2002010334A2 (en)

Citations (2)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
WO1995028490A1 (en) * 1994-04-15 1995-10-26 Alliance Pharmaceutical Corp. Expression vector with non-viral promoter
WO1999038972A2 (en) * 1998-01-28 1999-08-05 Chiron Corporation Human genes and gene expression products ii

Patent Citations (2)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
WO1995028490A1 (en) * 1994-04-15 1995-10-26 Alliance Pharmaceutical Corp. Expression vector with non-viral promoter
WO1999038972A2 (en) * 1998-01-28 1999-08-05 Chiron Corporation Human genes and gene expression products ii

Non-Patent Citations (6)

* Cited by examiner, † Cited by third party
Title
ANGULO ANA ET AL: "Enhancer requirement for murine cytomegalovirus growth and genetic complementation by the human cytomegalovirus enhancer.", JOURNAL OF VIROLOGY, vol. 72, no. 11, November 1998 (1998-11-01), pages 8502 - 8509, XP002166751, ISSN: 0022-538X *
DATABASE EMBL [online] 15 June 1998 (1998-06-15), XP002166752, Database accession no. AC004923 *
DE SURY R ET AL: "Genomic structure of the human NDUFS8 gene coding for the iron-sulfur TYKY subunit of the mitochondrial NADH:ubiquinone oxidoreductase", GENE,NL,ELSEVIER BIOMEDICAL PRESS. AMSTERDAM, vol. 215, no. 1, July 1998 (1998-07-01), pages 1 - 10, XP004149223, ISSN: 0378-1119 *
GRIMES SIDNEY R JR ET AL: "Regulation of transcription of the testis-specific histone H1t gene by multiple promoter elements.", MOLECULAR BIOLOGY REPORTS, vol. 24, no. 3, 1997, pages 175 - 184, XP001001402, ISSN: 0301-4851 *
HSU L C ET AL: "Cloning of a cDNA encoding human ALDH7, a new member of the aldehyde dehydrogenase family", GENE,NL,ELSEVIER BIOMEDICAL PRESS. AMSTERDAM, vol. 151, no. 1, 30 December 1994 (1994-12-30), pages 285 - 289, XP004042653, ISSN: 0378-1119 *
VANWERT JANE M ET AL: "The TE promoter element of the histone H1t gene is essential for transcription in transgenic mouse primary spermatocytes.", BIOLOGY OF REPRODUCTION, vol. 59, no. 3, 1998, pages 704 - 710, XP002166750, ISSN: 0006-3363 *

Also Published As

Publication number Publication date
FR2812305A1 (en) 2002-02-01
FR2812305B1 (en) 2005-01-07
WO2002010334A2 (en) 2002-02-07
EP1305403A2 (en) 2003-05-02

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