WO2002008446A3 - Synthesis and antiviral evaluation of nucleic acid based (nab) libraries - Google Patents

Synthesis and antiviral evaluation of nucleic acid based (nab) libraries Download PDF

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Publication number
WO2002008446A3
WO2002008446A3 PCT/IB2001/002217 IB0102217W WO0208446A3 WO 2002008446 A3 WO2002008446 A3 WO 2002008446A3 IB 0102217 W IB0102217 W IB 0102217W WO 0208446 A3 WO0208446 A3 WO 0208446A3
Authority
WO
WIPO (PCT)
Prior art keywords
synthesis
nab
libraries
nucleic acid
acid based
Prior art date
Application number
PCT/IB2001/002217
Other languages
French (fr)
Other versions
WO2002008446A9 (en
WO2002008446A2 (en
Inventor
Radhakrishnan P Iyer
Wenqiang Zhou
Yi Jin
Arlene Roland
Japhet Lyaku
Original Assignee
Origenix Technologies Inc
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Application filed by Origenix Technologies Inc filed Critical Origenix Technologies Inc
Priority to EP01984338A priority Critical patent/EP1309525A2/en
Priority to JP2002513928A priority patent/JP2004504365A/en
Priority to AU2002223939A priority patent/AU2002223939A1/en
Priority to CA002415368A priority patent/CA2415368A1/en
Publication of WO2002008446A2 publication Critical patent/WO2002008446A2/en
Publication of WO2002008446A3 publication Critical patent/WO2002008446A3/en
Publication of WO2002008446A9 publication Critical patent/WO2002008446A9/en

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Classifications

    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07H—SUGARS; DERIVATIVES THEREOF; NUCLEOSIDES; NUCLEOTIDES; NUCLEIC ACIDS
    • C07H19/00—Compounds containing a hetero ring sharing one ring hetero atom with a saccharide radical; Nucleosides; Mononucleotides; Anhydro-derivatives thereof
    • C07H19/02—Compounds containing a hetero ring sharing one ring hetero atom with a saccharide radical; Nucleosides; Mononucleotides; Anhydro-derivatives thereof sharing nitrogen
    • C07H19/04—Heterocyclic radicals containing only nitrogen atoms as ring hetero atom
    • C07H19/16—Purine radicals
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P31/00—Antiinfectives, i.e. antibiotics, antiseptics, chemotherapeutics
    • A61P31/12—Antivirals
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07H—SUGARS; DERIVATIVES THEREOF; NUCLEOSIDES; NUCLEOTIDES; NUCLEIC ACIDS
    • C07H19/00—Compounds containing a hetero ring sharing one ring hetero atom with a saccharide radical; Nucleosides; Mononucleotides; Anhydro-derivatives thereof
    • C07H19/02—Compounds containing a hetero ring sharing one ring hetero atom with a saccharide radical; Nucleosides; Mononucleotides; Anhydro-derivatives thereof sharing nitrogen
    • C07H19/04—Heterocyclic radicals containing only nitrogen atoms as ring hetero atom
    • C07H19/06—Pyrimidine radicals
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07H—SUGARS; DERIVATIVES THEREOF; NUCLEOSIDES; NUCLEOTIDES; NUCLEIC ACIDS
    • C07H21/00—Compounds containing two or more mononucleotide units having separate phosphate or polyphosphate groups linked by saccharide radicals of nucleoside groups, e.g. nucleic acids

Landscapes

  • Chemical & Material Sciences (AREA)
  • Health & Medical Sciences (AREA)
  • Organic Chemistry (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • Biochemistry (AREA)
  • Molecular Biology (AREA)
  • General Health & Medical Sciences (AREA)
  • Engineering & Computer Science (AREA)
  • Biotechnology (AREA)
  • Genetics & Genomics (AREA)
  • Oncology (AREA)
  • Pharmacology & Pharmacy (AREA)
  • Virology (AREA)
  • Chemical Kinetics & Catalysis (AREA)
  • General Chemical & Material Sciences (AREA)
  • Medicinal Chemistry (AREA)
  • Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
  • Communicable Diseases (AREA)
  • Animal Behavior & Ethology (AREA)
  • Public Health (AREA)
  • Veterinary Medicine (AREA)
  • Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
  • Saccharide Compounds (AREA)
  • Measuring Or Testing Involving Enzymes Or Micro-Organisms (AREA)
  • Agricultural Chemicals And Associated Chemicals (AREA)

Abstract

The present invention provides for compositions and methods to generate a library of small molecules that mimic the repertoire of interactions that exist amongst nucleic acids, and proteins, as well as, that which exist between proteins and nucleic acids. The designed library of nucleoside analogs are for use as competitive and non-competitive viral replication inhibitors or serve as pro-drugs of inhibitors in anti-viral drug discovery. A facile parallel solution-phase chemistry has been developed to carry out the combinatorial synthesis of nucleoside analogs as a source of pharmacore-based chemical diversity.
PCT/IB2001/002217 2000-07-13 2001-07-13 Synthesis and antiviral evaluation of nucleic acid based (nab) libraries WO2002008446A2 (en)

Priority Applications (4)

Application Number Priority Date Filing Date Title
EP01984338A EP1309525A2 (en) 2000-07-13 2001-07-13 Synthesis and antiviral evaluation of nucleic acid based (nab) libraries
JP2002513928A JP2004504365A (en) 2001-07-13 2001-07-13 Synthesis and antiviral evaluation of nucleic acid based (NAB) libraries
AU2002223939A AU2002223939A1 (en) 2000-07-13 2001-07-13 Synthesis and antiviral evaluation of nucleic acid based (NAB) libraries
CA002415368A CA2415368A1 (en) 2000-07-13 2001-07-13 Synthesis and antiviral evaluation of nucleic acid based (nab) libraries

Applications Claiming Priority (2)

Application Number Priority Date Filing Date Title
US21793100P 2000-07-13 2000-07-13
US60/217,931 2000-07-13

Publications (3)

Publication Number Publication Date
WO2002008446A2 WO2002008446A2 (en) 2002-01-31
WO2002008446A3 true WO2002008446A3 (en) 2002-08-15
WO2002008446A9 WO2002008446A9 (en) 2003-08-21

Family

ID=22813060

Family Applications (1)

Application Number Title Priority Date Filing Date
PCT/IB2001/002217 WO2002008446A2 (en) 2000-07-13 2001-07-13 Synthesis and antiviral evaluation of nucleic acid based (nab) libraries

Country Status (4)

Country Link
EP (1) EP1309525A2 (en)
AU (1) AU2002223939A1 (en)
CA (1) CA2415368A1 (en)
WO (1) WO2002008446A2 (en)

Families Citing this family (3)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
AUPS143402A0 (en) * 2002-03-28 2002-05-09 Alchemia Pty Ltd Anomeric derivatives of monosaccharides
WO2005090370A1 (en) 2004-02-05 2005-09-29 The Regents Of The University Of California Pharmacologically active agents containing esterified phosphonates and methods for use thereof
GB201609601D0 (en) * 2016-06-01 2016-07-13 Nucana Biomed Ltd Phosphoramidate compounds

Citations (3)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
WO1994022864A1 (en) * 1993-03-30 1994-10-13 Sterling Winthrop Inc. Acyclic nucleoside analogs and oligonucleotide sequences containing them
WO1999051547A2 (en) * 1998-04-07 1999-10-14 Chemicus, Inc. Solid phase synthesis of organic compounds via phosphitylating reagents
WO2001034622A1 (en) * 1999-11-08 2001-05-17 Origenix Technologies, Inc. Combinatorial library synthesis and pharmaceutically active compounds produced thereby

Patent Citations (3)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
WO1994022864A1 (en) * 1993-03-30 1994-10-13 Sterling Winthrop Inc. Acyclic nucleoside analogs and oligonucleotide sequences containing them
WO1999051547A2 (en) * 1998-04-07 1999-10-14 Chemicus, Inc. Solid phase synthesis of organic compounds via phosphitylating reagents
WO2001034622A1 (en) * 1999-11-08 2001-05-17 Origenix Technologies, Inc. Combinatorial library synthesis and pharmaceutically active compounds produced thereby

Non-Patent Citations (8)

* Cited by examiner, † Cited by third party
Title
DAVIS P W ET AL: "DRUG LEADS FROM COMBINATORIAL PHOSPHODIESTER LIBRARIES", JOURNAL OF MEDICINAL CHEMISTRY, AMERICAN CHEMICAL SOCIETY. WASHINGTON, US, vol. 38, 27 October 1995 (1995-10-27), pages 4363 - 4366, XP002919421, ISSN: 0022-2623 *
FATHI R ET AL: "SYNTHESIS AND PROPERTIES OF COMBINATORIAL LIBRARIES OF PHOSPHORAMIDATES", JOURNAL OF ORGANIC CHEMISTRY, AMERICAN CHEMICAL SOCIETY. EASTON, US, vol. 61, no. 16, 1996, pages 5600 - 5609, XP002055252, ISSN: 0022-3263 *
G.M. BLACKBURN, M.-J. GUO: "Trifluoromethylphosphinyl bis-triazolides in the synthesis of trifluoromethylphosphonate analogues of nucleotides", TETRAHEDRON LETTERS, vol. 34, 1993, pages 149 - 152, XP002201094 *
J. BURMEISTER ET AL.: "Cofactor-assisted self-cleavage in DNA libraries with a 3'-5'-phosphoramidate bond", ANGEW. CHEM. INT. ED. ENGL., vol. 36, 1997, pages 1321 - 1324, XP002201093 *
J.P.H. VERHEYDEN, J.G. MOFFATT: "Halo sugar nucleosides. II. Iodination of secondary hydroxyl groups of nucleosides with methyltriphenoxyphosphonium iodide", J. ORG. CHEM., vol. 35, 1970, pages 2868 - 2877, XP002201095 *
JIN Y ET AL: "Synthesis and antiviral evaluation of nucleic acid-based (NAB) libraries", BIOORGANIC & MEDICINAL CHEMISTRY LETTERS, OXFORD, GB, vol. 10, no. 17, September 2000 (2000-09-01), pages 1921 - 1925, XP004214138, ISSN: 0960-894X *
ZHOU W ET AL: "Combinatorial synthesis using nucleic acid-based (NAB@?) scaffold: parallel solid-phase synthesis of nucleotide libraries", TETRAHEDRON LETTERS, ELSEVIER SCIENCE PUBLISHERS, AMSTERDAM, NL, vol. 41, no. 4, January 2000 (2000-01-01), pages 441 - 445, XP004187099, ISSN: 0040-4039 *
ZHOU W ET AL: "Nucleotide libraries as a source of biologically relevant chemical diversity: solution-phase synthesis", BIOORGANIC & MEDICINAL CHEMISTRY LETTERS, OXFORD, GB, vol. 10, no. 11, June 2000 (2000-06-01), pages 1249 - 1252, XP004200567, ISSN: 0960-894X *

Also Published As

Publication number Publication date
WO2002008446A9 (en) 2003-08-21
AU2002223939A1 (en) 2002-02-05
CA2415368A1 (en) 2002-01-31
WO2002008446A2 (en) 2002-01-31
EP1309525A2 (en) 2003-05-14

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