WO2002007754A3 - New use - Google Patents

New use Download PDF

Info

Publication number
WO2002007754A3
WO2002007754A3 PCT/GB2001/003341 GB0103341W WO0207754A3 WO 2002007754 A3 WO2002007754 A3 WO 2002007754A3 GB 0103341 W GB0103341 W GB 0103341W WO 0207754 A3 WO0207754 A3 WO 0207754A3
Authority
WO
WIPO (PCT)
Prior art keywords
new use
ucp3
polynucleotides
obesity
polypeptides
Prior art date
Application number
PCT/GB2001/003341
Other languages
French (fr)
Other versions
WO2002007754A2 (en
Inventor
John Clapham
Original Assignee
Smithkline Beecham Plc
John Clapham
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Application filed by Smithkline Beecham Plc, John Clapham filed Critical Smithkline Beecham Plc
Priority to AU2002224528A priority Critical patent/AU2002224528A1/en
Publication of WO2002007754A2 publication Critical patent/WO2002007754A2/en
Publication of WO2002007754A3 publication Critical patent/WO2002007754A3/en

Links

Classifications

    • C—CHEMISTRY; METALLURGY
    • C12—BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
    • C12N—MICROORGANISMS OR ENZYMES; COMPOSITIONS THEREOF; PROPAGATING, PRESERVING, OR MAINTAINING MICROORGANISMS; MUTATION OR GENETIC ENGINEERING; CULTURE MEDIA
    • C12N15/00—Mutation or genetic engineering; DNA or RNA concerning genetic engineering, vectors, e.g. plasmids, or their isolation, preparation or purification; Use of hosts therefor
    • C12N15/09—Recombinant DNA-technology
    • C12N15/63—Introduction of foreign genetic material using vectors; Vectors; Use of hosts therefor; Regulation of expression
    • C12N15/79—Vectors or expression systems specially adapted for eukaryotic hosts
    • C12N15/85—Vectors or expression systems specially adapted for eukaryotic hosts for animal cells
    • C12N15/8509—Vectors or expression systems specially adapted for eukaryotic hosts for animal cells for producing genetically modified animals, e.g. transgenic
    • A—HUMAN NECESSITIES
    • A01—AGRICULTURE; FORESTRY; ANIMAL HUSBANDRY; HUNTING; TRAPPING; FISHING
    • A01K—ANIMAL HUSBANDRY; CARE OF BIRDS, FISHES, INSECTS; FISHING; REARING OR BREEDING ANIMALS, NOT OTHERWISE PROVIDED FOR; NEW BREEDS OF ANIMALS
    • A01K67/00—Rearing or breeding animals, not otherwise provided for; New breeds of animals
    • A01K67/027—New breeds of vertebrates
    • A01K67/0275—Genetically modified vertebrates, e.g. transgenic
    • A—HUMAN NECESSITIES
    • A01—AGRICULTURE; FORESTRY; ANIMAL HUSBANDRY; HUNTING; TRAPPING; FISHING
    • A01K—ANIMAL HUSBANDRY; CARE OF BIRDS, FISHES, INSECTS; FISHING; REARING OR BREEDING ANIMALS, NOT OTHERWISE PROVIDED FOR; NEW BREEDS OF ANIMALS
    • A01K67/00—Rearing or breeding animals, not otherwise provided for; New breeds of animals
    • A01K67/027—New breeds of vertebrates
    • A01K67/0275—Genetically modified vertebrates, e.g. transgenic
    • A01K67/0278—Humanized animals, e.g. knockin
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P3/00—Drugs for disorders of the metabolism
    • A61P3/04—Anorexiants; Antiobesity agents
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P3/00—Drugs for disorders of the metabolism
    • A61P3/08—Drugs for disorders of the metabolism for glucose homeostasis
    • A61P3/10—Drugs for disorders of the metabolism for glucose homeostasis for hyperglycaemia, e.g. antidiabetics
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07K—PEPTIDES
    • C07K14/00—Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof
    • C07K14/435—Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof from animals; from humans
    • C07K14/46—Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof from animals; from humans from vertebrates
    • C07K14/47—Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof from animals; from humans from vertebrates from mammals
    • A—HUMAN NECESSITIES
    • A01—AGRICULTURE; FORESTRY; ANIMAL HUSBANDRY; HUNTING; TRAPPING; FISHING
    • A01K—ANIMAL HUSBANDRY; CARE OF BIRDS, FISHES, INSECTS; FISHING; REARING OR BREEDING ANIMALS, NOT OTHERWISE PROVIDED FOR; NEW BREEDS OF ANIMALS
    • A01K2207/00—Modified animals
    • A01K2207/15—Humanized animals
    • A—HUMAN NECESSITIES
    • A01—AGRICULTURE; FORESTRY; ANIMAL HUSBANDRY; HUNTING; TRAPPING; FISHING
    • A01K—ANIMAL HUSBANDRY; CARE OF BIRDS, FISHES, INSECTS; FISHING; REARING OR BREEDING ANIMALS, NOT OTHERWISE PROVIDED FOR; NEW BREEDS OF ANIMALS
    • A01K2217/00—Genetically modified animals
    • A—HUMAN NECESSITIES
    • A01—AGRICULTURE; FORESTRY; ANIMAL HUSBANDRY; HUNTING; TRAPPING; FISHING
    • A01K—ANIMAL HUSBANDRY; CARE OF BIRDS, FISHES, INSECTS; FISHING; REARING OR BREEDING ANIMALS, NOT OTHERWISE PROVIDED FOR; NEW BREEDS OF ANIMALS
    • A01K2217/00—Genetically modified animals
    • A01K2217/05—Animals comprising random inserted nucleic acids (transgenic)
    • A—HUMAN NECESSITIES
    • A01—AGRICULTURE; FORESTRY; ANIMAL HUSBANDRY; HUNTING; TRAPPING; FISHING
    • A01K—ANIMAL HUSBANDRY; CARE OF BIRDS, FISHES, INSECTS; FISHING; REARING OR BREEDING ANIMALS, NOT OTHERWISE PROVIDED FOR; NEW BREEDS OF ANIMALS
    • A01K2227/00—Animals characterised by species
    • A01K2227/10—Mammal
    • A01K2227/105—Murine
    • A—HUMAN NECESSITIES
    • A01—AGRICULTURE; FORESTRY; ANIMAL HUSBANDRY; HUNTING; TRAPPING; FISHING
    • A01K—ANIMAL HUSBANDRY; CARE OF BIRDS, FISHES, INSECTS; FISHING; REARING OR BREEDING ANIMALS, NOT OTHERWISE PROVIDED FOR; NEW BREEDS OF ANIMALS
    • A01K2267/00—Animals characterised by purpose
    • A01K2267/03—Animal model, e.g. for test or diseases
    • A—HUMAN NECESSITIES
    • A01—AGRICULTURE; FORESTRY; ANIMAL HUSBANDRY; HUNTING; TRAPPING; FISHING
    • A01K—ANIMAL HUSBANDRY; CARE OF BIRDS, FISHES, INSECTS; FISHING; REARING OR BREEDING ANIMALS, NOT OTHERWISE PROVIDED FOR; NEW BREEDS OF ANIMALS
    • A01K2267/00—Animals characterised by purpose
    • A01K2267/03—Animal model, e.g. for test or diseases
    • A01K2267/035—Animal model for multifactorial diseases
    • A01K2267/0362—Animal model for lipid/glucose metabolism, e.g. obesity, type-2 diabetes
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K38/00—Medicinal preparations containing peptides
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K48/00—Medicinal preparations containing genetic material which is inserted into cells of the living body to treat genetic diseases; Gene therapy

Abstract

The use of UCP3 polypeptides and polynucleotides in the design of protocols for the treatment of obesity, diabetes or body weight disorder, among others.
PCT/GB2001/003341 2000-07-25 2001-07-25 New use WO2002007754A2 (en)

Priority Applications (1)

Application Number Priority Date Filing Date Title
AU2002224528A AU2002224528A1 (en) 2000-07-25 2001-07-25 New use

Applications Claiming Priority (2)

Application Number Priority Date Filing Date Title
GB0018248.5 2000-07-25
GBGB0018248.5A GB0018248D0 (en) 2000-07-25 2000-07-25 New use

Publications (2)

Publication Number Publication Date
WO2002007754A2 WO2002007754A2 (en) 2002-01-31
WO2002007754A3 true WO2002007754A3 (en) 2003-06-05

Family

ID=9896319

Family Applications (1)

Application Number Title Priority Date Filing Date
PCT/GB2001/003341 WO2002007754A2 (en) 2000-07-25 2001-07-25 New use

Country Status (3)

Country Link
AU (1) AU2002224528A1 (en)
GB (1) GB0018248D0 (en)
WO (1) WO2002007754A2 (en)

Families Citing this family (2)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
FR2866233B1 (en) 2004-02-18 2008-02-08 Vincience DERMATOLOGICAL AND / OR COSMETIC COMPOSITION CONTAINING POLYPEPTIDES
FR2879924B1 (en) * 2004-12-23 2007-06-15 Soc Extraction Principes Actif SLIMMING COSMETIC COMPOSITION

Citations (4)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
WO1995006411A1 (en) * 1993-08-30 1995-03-09 Lipocyte, Inc. Method and composition for weight reduction
WO1998039432A1 (en) * 1997-03-05 1998-09-11 Smithkline Beecham Plc Polynucleotides and polypeptides belonging to the uncoupling proteins family
WO1998045438A1 (en) * 1997-04-09 1998-10-15 Beth Israel Deaconess Medical Center Ucp3: an uncoupling protein homologue
WO2000002577A1 (en) * 1998-07-09 2000-01-20 Smithkline Beecham Plc Therapeutic use of uncoupling protein hhfcw60

Patent Citations (4)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
WO1995006411A1 (en) * 1993-08-30 1995-03-09 Lipocyte, Inc. Method and composition for weight reduction
WO1998039432A1 (en) * 1997-03-05 1998-09-11 Smithkline Beecham Plc Polynucleotides and polypeptides belonging to the uncoupling proteins family
WO1998045438A1 (en) * 1997-04-09 1998-10-15 Beth Israel Deaconess Medical Center Ucp3: an uncoupling protein homologue
WO2000002577A1 (en) * 1998-07-09 2000-01-20 Smithkline Beecham Plc Therapeutic use of uncoupling protein hhfcw60

Non-Patent Citations (2)

* Cited by examiner, † Cited by third party
Title
BOSS O ET AL: "UNCOUPLING PROTEIN-3: A NEW MEMBER OF THE MITOCHONDRIAL CARRIER FAMILY WITH TISSUE-SPECIFIC EXPRESSION", FEBS LETTERS, ELSEVIER SCIENCE PUBLISHERS, AMSTERDAM, NL, vol. 408, no. 1, 1997, pages 39 - 42, XP002067895, ISSN: 0014-5793 *
CLAPHAM J C ET AL: "Mice overexpressing human uncoupling protein-3 in skeletal muscle are hyperphagic and lean.", NATURE, (2000 JUL 27) 406 (6794) 415-8., XP002216373 *

Also Published As

Publication number Publication date
AU2002224528A1 (en) 2002-02-05
GB0018248D0 (en) 2000-09-13
WO2002007754A2 (en) 2002-01-31

Similar Documents

Publication Publication Date Title
HK1061679A1 (en) Phenylsulfonyl-1,3-dihydro-2h-indole-2-ibe derivatives, their preparation and their therapeutic use.
ZA200201806B (en) Substituted 2-thio-3,5-dicyano-4-aryl-6-aminopyridines and the use thereof.
WO2002038052A3 (en) Steerable loop structure
HK1068335A1 (en) Novel arylsusfonamide compounds for the treatment of obesity, type ii diabetes and cns-disorders
IL202332A0 (en) Liv-1 related protein, polynucleotides encoding the same and use thereof for treatment of cancer
AU2002307722A1 (en) Niobium powder, niobium sintered body and capacitor using the sintered body
IL158195A0 (en) Thiohydantoins and use thereof for treating diabetes
ZA200407868B (en) 17alpha-Alkyl-17beta-oxy-estratrienes, uses thereof and pharmaceutical preparations.
AU4072799A (en) 2,3,5-substituted biphenyls useful in the treatment of insulin resistance and hyperglycemia
AU2001264042A1 (en) 1,4-diazabicyclo(3.2.2)nonane-phenylisoxazole derivatives, preparation and therapeutic use thereof
AU2001235595A1 (en) 4-heteroaryl-1,4-diazabicyclo(3.2.2)nonane, preparation and therapeutic use thereof
IL158397A0 (en) Polypeptides, their preparation and their use
IS6874A (en) 3,7-diazabicyclo [3.3.0] octane and its use in the treatment of arrhythmias
IL160229A0 (en) Polynucleotides, polypeptides encoded thereby and their use
ZA200400313B (en) Use of BIBN4096 in combination with other antimigraine drugs for the treatment of migraine.
AU1851002A (en) Powder for capacitor, sintered body thereof and capacitor using the sintered body
AU3593599A (en) Drugs for reducing vaginal acidity and treatment of vaginitis, and the use thereof
TWI320413B (en) 1,4-diazabicyclo [ 3.2.2 ] nonanecarboxamide derivatives, preparation thereof and therapeutic use thereof
WO2002007754A3 (en) New use
AU2001238585A1 (en) Human polynucleotides, polypeptides, and antibodies
MXPA03000508A (en) REGULATORS OF PPARdgr;(bgr;) AND THEIR USE IN THE TREATMENT OF OBESITY AND INSULIN RESISTANCE.
MXPA03008393A (en) Bicyclic guanidine derivatives and therapeutic uses thereof.
EP1433187A4 (en) Tantalum sintered body and capacitor using the sintered body
AU2401601A (en) Check valve, and syringe using the same
MXPA03006162A (en) Mikanolide derivatives, their preparation and therapeutic uses.

Legal Events

Date Code Title Description
AK Designated states

Kind code of ref document: A2

Designated state(s): AE AG AL AM AT AU AZ BA BB BG BR BY BZ CA CH CN CO CR CU CZ DE DK DM DZ EC EE ES FI GB GD GE GH GM HR HU ID IL IN IS JP KE KG KP KR KZ LC LK LR LS LT LU LV MA MD MG MK MN MW MX MZ NO NZ PL PT RO RU SD SE SG SI SK SL TJ TM TR TT TZ UA UG US UZ VN YU ZA ZW

AL Designated countries for regional patents

Kind code of ref document: A2

Designated state(s): GH GM KE LS MW MZ SD SL SZ TZ UG ZW AM AZ BY KG KZ MD RU TJ TM AT BE CH CY DE DK ES FI FR GB GR IE IT LU MC NL PT SE TR BF BJ CF CG CI CM GA GN GQ GW ML MR NE SN TD TG

121 Ep: the epo has been informed by wipo that ep was designated in this application
REG Reference to national code

Ref country code: DE

Ref legal event code: 8642

122 Ep: pct application non-entry in european phase
NENP Non-entry into the national phase

Ref country code: JP