WO2002004068A1 - Treatment of obesity by bilateral vagus nerve stimulation - Google Patents
Treatment of obesity by bilateral vagus nerve stimulation Download PDFInfo
- Publication number
- WO2002004068A1 WO2002004068A1 PCT/US2000/040301 US0040301W WO0204068A1 WO 2002004068 A1 WO2002004068 A1 WO 2002004068A1 US 0040301 W US0040301 W US 0040301W WO 0204068 A1 WO0204068 A1 WO 0204068A1
- Authority
- WO
- WIPO (PCT)
- Prior art keywords
- stimulating
- vagi
- electrical signal
- patient
- pulses
- Prior art date
Links
Classifications
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61N—ELECTROTHERAPY; MAGNETOTHERAPY; RADIATION THERAPY; ULTRASOUND THERAPY
- A61N1/00—Electrotherapy; Circuits therefor
- A61N1/18—Applying electric currents by contact electrodes
- A61N1/32—Applying electric currents by contact electrodes alternating or intermittent currents
- A61N1/36—Applying electric currents by contact electrodes alternating or intermittent currents for stimulation
- A61N1/36007—Applying electric currents by contact electrodes alternating or intermittent currents for stimulation of urogenital or gastrointestinal organs, e.g. for incontinence control
Definitions
- Morbid obesity is defined as having a body mass index of more than forty, or, as is more commonly understood, being more than one hundred pounds overweight for a person of average height. This data is alarming for numerous reasons, not the least of which is it indicates an obesity epidemic. Many health experts believe that obesity is the first or second leading cause of preventable deaths in the United States, with cigarette smoking either just lagging or leading. A recent study from the Kaiser HMO system has demonstrated that morbid obesity drastically increases health care costs (Journal of the American Medical Association (JAMA)). It is the consequences of being overweight that are most alarming.
- JAMA American Medical Association
- an implantable neurostimulator included a signal generator or electronics package adapted to generate an electrical output signal in the form of a sequence of pulses, with parameter values programmable by the attending physician within predetermined ranges for treating the disorder, and a lead/ electrode system for applying the programmed output signal to the patient's vagus nerve. Calibration of the overall treatment system for a particular patient was to be performed by telemetry by means of an external programmer to and from the implant.
- the stimulating electrode (nerve electrode, e.g., a cuff) would be implanted about the vagus nerve or a branch thereof in the esophageal region slightly above the stomach, and the vagal stimulation applied to produce or induce satiety.
- the patient would experience a satisfied feeling of fullness at a level of consumption sufficient to maintain physiologic needs but supportive of weight reduction.
- the dietary pattern included twice- a-day feedings of approximately 400 grams of solid food with one scoop of soft meat product added to make the food more edible.
- a threshold referred to herein as the retching threshold was documented while the animal was under anesthesia, based on the threshold value of the stimulus output current of the device at which the animal exhibited a retching or emetic response. The amount of current was adjusted to determine this threshold.
- Other parameters were left fixed at a frequency of 30 Hertz (Hz), apulse width of 500 milliseconds (ms), and an on/off cycle of one minute on and 1.8 minutes off.
Landscapes
- Health & Medical Sciences (AREA)
- Gastroenterology & Hepatology (AREA)
- Engineering & Computer Science (AREA)
- Biomedical Technology (AREA)
- Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
- Radiology & Medical Imaging (AREA)
- Life Sciences & Earth Sciences (AREA)
- Animal Behavior & Ethology (AREA)
- General Health & Medical Sciences (AREA)
- Public Health (AREA)
- Veterinary Medicine (AREA)
- Electrotherapy Devices (AREA)
Abstract
Description
Claims
Priority Applications (5)
Application Number | Priority Date | Filing Date | Title |
---|---|---|---|
AU68028/00A AU782785B2 (en) | 2000-07-06 | 2000-07-06 | Treatment of obesity by bilateral vagus nerve stimulation |
CA2401098A CA2401098C (en) | 2000-07-06 | 2000-07-06 | Treatment of obesity by bilateral vagus nerve stimulation |
EP00955908A EP1296743A1 (en) | 2000-07-06 | 2000-07-06 | Treatment of obesity by bilateral vagus nerve stimulation |
JP2002508519A JP2004502506A (en) | 2000-07-06 | 2000-07-06 | Treatment of obesity by stimulating both vagus nerves |
PCT/US2000/040301 WO2002004068A1 (en) | 2000-07-06 | 2000-07-06 | Treatment of obesity by bilateral vagus nerve stimulation |
Applications Claiming Priority (1)
Application Number | Priority Date | Filing Date | Title |
---|---|---|---|
PCT/US2000/040301 WO2002004068A1 (en) | 2000-07-06 | 2000-07-06 | Treatment of obesity by bilateral vagus nerve stimulation |
Publications (1)
Publication Number | Publication Date |
---|---|
WO2002004068A1 true WO2002004068A1 (en) | 2002-01-17 |
Family
ID=21742130
Family Applications (1)
Application Number | Title | Priority Date | Filing Date |
---|---|---|---|
PCT/US2000/040301 WO2002004068A1 (en) | 2000-07-06 | 2000-07-06 | Treatment of obesity by bilateral vagus nerve stimulation |
Country Status (5)
Country | Link |
---|---|
EP (1) | EP1296743A1 (en) |
JP (1) | JP2004502506A (en) |
AU (1) | AU782785B2 (en) |
CA (1) | CA2401098C (en) |
WO (1) | WO2002004068A1 (en) |
Cited By (20)
Publication number | Priority date | Publication date | Assignee | Title |
---|---|---|---|---|
US6754536B2 (en) | 2001-01-31 | 2004-06-22 | Medtronic, Inc | Implantable medical device affixed internally within the gastrointestinal tract |
US7167751B1 (en) | 2001-03-01 | 2007-01-23 | Advanced Bionics Corporation | Method of using a fully implantable miniature neurostimulator for vagus nerve stimulation |
US7236822B2 (en) | 2002-03-22 | 2007-06-26 | Leptos Biomedical, Inc. | Wireless electric modulation of sympathetic nervous system |
US7239912B2 (en) | 2002-03-22 | 2007-07-03 | Leptos Biomedical, Inc. | Electric modulation of sympathetic nervous system |
US7551964B2 (en) | 2002-03-22 | 2009-06-23 | Leptos Biomedical, Inc. | Splanchnic nerve stimulation for treatment of obesity |
US7623924B2 (en) | 2004-08-31 | 2009-11-24 | Leptos Biomedical, Inc. | Devices and methods for gynecologic hormone modulation in mammals |
US7689276B2 (en) | 2002-09-13 | 2010-03-30 | Leptos Biomedical, Inc. | Dynamic nerve stimulation for treatment of disorders |
US7689277B2 (en) | 2002-03-22 | 2010-03-30 | Leptos Biomedical, Inc. | Neural stimulation for treatment of metabolic syndrome and type 2 diabetes |
US7725176B2 (en) | 2003-07-10 | 2010-05-25 | Schuler Eleanor L | Method and system for regulation of endocrine and exocrine glands by means of neuro-electrical coded signals |
US7908000B2 (en) | 2004-02-20 | 2011-03-15 | Brainsgate Ltd. | Transmucosal electrical stimulation |
US7937145B2 (en) | 2002-03-22 | 2011-05-03 | Advanced Neuromodulation Systems, Inc. | Dynamic nerve stimulation employing frequency modulation |
US8064994B2 (en) | 2003-01-14 | 2011-11-22 | The United States Of America As Represented By The Department Of Veterans Affairs | Cervical vagal stimulation induced weight loss |
US8295926B2 (en) | 2006-06-02 | 2012-10-23 | Advanced Neuromodulation Systems, Inc. | Dynamic nerve stimulation in combination with other eating disorder treatment modalities |
US8958881B2 (en) | 2005-08-19 | 2015-02-17 | Brainsgate Ltd. | Neuroprotective electrical stimulation |
US9233245B2 (en) | 2004-02-20 | 2016-01-12 | Brainsgate Ltd. | SPG stimulation |
US9254388B2 (en) | 2003-07-10 | 2016-02-09 | Codes Of Life, Llc | Method and system for regulation of endocrine and exocrine glands by means of neuro-electrical coded signals |
US9616234B2 (en) | 2002-05-03 | 2017-04-11 | Trustees Of Boston University | System and method for neuro-stimulation |
US9675796B2 (en) | 2013-11-10 | 2017-06-13 | Brainsgate Ltd. | Implant and delivery system for neural stimulator |
US10271907B2 (en) | 2015-05-13 | 2019-04-30 | Brainsgate Ltd. | Implant and delivery system for neural stimulator |
US11154238B2 (en) | 2015-08-07 | 2021-10-26 | Electroceuticals, Llc | Systems, methods and apparatuses for providing bioelectronic neurocode-based therapies to mammals |
Families Citing this family (3)
Publication number | Priority date | Publication date | Assignee | Title |
---|---|---|---|---|
US6609025B2 (en) * | 2001-01-02 | 2003-08-19 | Cyberonics, Inc. | Treatment of obesity by bilateral sub-diaphragmatic nerve stimulation |
US7702386B2 (en) | 2002-03-22 | 2010-04-20 | Leptos Biomedical, Inc. | Nerve stimulation for treatment of obesity, metabolic syndrome, and Type 2 diabetes |
US8321030B2 (en) | 2009-04-20 | 2012-11-27 | Advanced Neuromodulation Systems, Inc. | Esophageal activity modulated obesity therapy |
Citations (4)
Publication number | Priority date | Publication date | Assignee | Title |
---|---|---|---|---|
US5035437A (en) | 1989-11-13 | 1991-07-30 | Outboard Marine Corporation | Outboard motor carrier |
US5263480A (en) | 1991-02-01 | 1993-11-23 | Cyberonics, Inc. | Treatment of eating disorders by nerve stimulation |
US5330507A (en) * | 1992-04-24 | 1994-07-19 | Medtronic, Inc. | Implantable electrical vagal stimulation for prevention or interruption of life threatening arrhythmias |
US5540730A (en) * | 1995-06-06 | 1996-07-30 | Cyberonics, Inc. | Treatment of motility disorders by nerve stimulation |
Family Cites Families (1)
Publication number | Priority date | Publication date | Assignee | Title |
---|---|---|---|---|
US5188104A (en) * | 1991-02-01 | 1993-02-23 | Cyberonics, Inc. | Treatment of eating disorders by nerve stimulation |
-
2000
- 2000-07-06 AU AU68028/00A patent/AU782785B2/en not_active Ceased
- 2000-07-06 JP JP2002508519A patent/JP2004502506A/en active Pending
- 2000-07-06 WO PCT/US2000/040301 patent/WO2002004068A1/en not_active Application Discontinuation
- 2000-07-06 CA CA2401098A patent/CA2401098C/en not_active Expired - Lifetime
- 2000-07-06 EP EP00955908A patent/EP1296743A1/en not_active Withdrawn
Patent Citations (4)
Publication number | Priority date | Publication date | Assignee | Title |
---|---|---|---|---|
US5035437A (en) | 1989-11-13 | 1991-07-30 | Outboard Marine Corporation | Outboard motor carrier |
US5263480A (en) | 1991-02-01 | 1993-11-23 | Cyberonics, Inc. | Treatment of eating disorders by nerve stimulation |
US5330507A (en) * | 1992-04-24 | 1994-07-19 | Medtronic, Inc. | Implantable electrical vagal stimulation for prevention or interruption of life threatening arrhythmias |
US5540730A (en) * | 1995-06-06 | 1996-07-30 | Cyberonics, Inc. | Treatment of motility disorders by nerve stimulation |
Cited By (26)
Publication number | Priority date | Publication date | Assignee | Title |
---|---|---|---|---|
US6754536B2 (en) | 2001-01-31 | 2004-06-22 | Medtronic, Inc | Implantable medical device affixed internally within the gastrointestinal tract |
US7167751B1 (en) | 2001-03-01 | 2007-01-23 | Advanced Bionics Corporation | Method of using a fully implantable miniature neurostimulator for vagus nerve stimulation |
US7937145B2 (en) | 2002-03-22 | 2011-05-03 | Advanced Neuromodulation Systems, Inc. | Dynamic nerve stimulation employing frequency modulation |
US7236822B2 (en) | 2002-03-22 | 2007-06-26 | Leptos Biomedical, Inc. | Wireless electric modulation of sympathetic nervous system |
US7239912B2 (en) | 2002-03-22 | 2007-07-03 | Leptos Biomedical, Inc. | Electric modulation of sympathetic nervous system |
US7551964B2 (en) | 2002-03-22 | 2009-06-23 | Leptos Biomedical, Inc. | Splanchnic nerve stimulation for treatment of obesity |
US7689277B2 (en) | 2002-03-22 | 2010-03-30 | Leptos Biomedical, Inc. | Neural stimulation for treatment of metabolic syndrome and type 2 diabetes |
US8838231B2 (en) | 2002-03-22 | 2014-09-16 | Advanced Neuromodulation Systems, Inc. | Neural Stimulation for treatment of metabolic syndrome and type 2 diabetes |
US9616234B2 (en) | 2002-05-03 | 2017-04-11 | Trustees Of Boston University | System and method for neuro-stimulation |
US7689276B2 (en) | 2002-09-13 | 2010-03-30 | Leptos Biomedical, Inc. | Dynamic nerve stimulation for treatment of disorders |
US8064994B2 (en) | 2003-01-14 | 2011-11-22 | The United States Of America As Represented By The Department Of Veterans Affairs | Cervical vagal stimulation induced weight loss |
US8818502B2 (en) | 2003-07-10 | 2014-08-26 | Codes Of Life, Llc | Method and system for regulation of endocrine and exocrine glands by means of neuro-electrical coded signals |
US7725176B2 (en) | 2003-07-10 | 2010-05-25 | Schuler Eleanor L | Method and system for regulation of endocrine and exocrine glands by means of neuro-electrical coded signals |
US9254388B2 (en) | 2003-07-10 | 2016-02-09 | Codes Of Life, Llc | Method and system for regulation of endocrine and exocrine glands by means of neuro-electrical coded signals |
US9233245B2 (en) | 2004-02-20 | 2016-01-12 | Brainsgate Ltd. | SPG stimulation |
US7908000B2 (en) | 2004-02-20 | 2011-03-15 | Brainsgate Ltd. | Transmucosal electrical stimulation |
US8010189B2 (en) | 2004-02-20 | 2011-08-30 | Brainsgate Ltd. | SPG stimulation for treating complications of subarachnoid hemorrhage |
US8954149B2 (en) | 2004-02-20 | 2015-02-10 | Brainsgate Ltd. | External stimulation of the SPG |
US7623924B2 (en) | 2004-08-31 | 2009-11-24 | Leptos Biomedical, Inc. | Devices and methods for gynecologic hormone modulation in mammals |
US8958881B2 (en) | 2005-08-19 | 2015-02-17 | Brainsgate Ltd. | Neuroprotective electrical stimulation |
US8295926B2 (en) | 2006-06-02 | 2012-10-23 | Advanced Neuromodulation Systems, Inc. | Dynamic nerve stimulation in combination with other eating disorder treatment modalities |
US9675796B2 (en) | 2013-11-10 | 2017-06-13 | Brainsgate Ltd. | Implant and delivery system for neural stimulator |
US10512771B2 (en) | 2013-11-10 | 2019-12-24 | Brainsgate Ltd. | Implant and delivery system for neural stimulator |
US10271907B2 (en) | 2015-05-13 | 2019-04-30 | Brainsgate Ltd. | Implant and delivery system for neural stimulator |
US11154238B2 (en) | 2015-08-07 | 2021-10-26 | Electroceuticals, Llc | Systems, methods and apparatuses for providing bioelectronic neurocode-based therapies to mammals |
US11950923B2 (en) | 2015-08-07 | 2024-04-09 | Electroceuticals, Llc | Systems, methods and apparatuses for providing bioelectronic neurocode-based therapies to mammals |
Also Published As
Publication number | Publication date |
---|---|
JP2004502506A (en) | 2004-01-29 |
AU782785B2 (en) | 2005-08-25 |
EP1296743A1 (en) | 2003-04-02 |
CA2401098A1 (en) | 2002-01-17 |
CA2401098C (en) | 2012-03-13 |
AU6802800A (en) | 2002-01-21 |
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