WO2002002744A3 - Dna encoding a human melanin concentrating hormone receptor (mch1) and uses thereof - Google Patents

Dna encoding a human melanin concentrating hormone receptor (mch1) and uses thereof Download PDF

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Publication number
WO2002002744A3
WO2002002744A3 PCT/US2001/021350 US0121350W WO0202744A3 WO 2002002744 A3 WO2002002744 A3 WO 2002002744A3 US 0121350 W US0121350 W US 0121350W WO 0202744 A3 WO0202744 A3 WO 0202744A3
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WIPO (PCT)
Prior art keywords
subject
human mch1
mch1
nucleic acid
human
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PCT/US2001/021350
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French (fr)
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WO2002002744A2 (en
Inventor
John A Salon
Thomas M Laz
Raisa Nagorny
Amy E Wilson
Carlos Forray
Thomas P Blackburn
Beth Borowsky
Kristine Ogazalek
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Synaptic Pharma Corp
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Publication date
Application filed by Synaptic Pharma Corp filed Critical Synaptic Pharma Corp
Priority to JP2002507986A priority Critical patent/JP2004502423A/en
Priority to AU73207/01A priority patent/AU7320701A/en
Priority to CA002384358A priority patent/CA2384358A1/en
Priority to EP01952456A priority patent/EP1246847A2/en
Publication of WO2002002744A2 publication Critical patent/WO2002002744A2/en
Publication of WO2002002744A3 publication Critical patent/WO2002002744A3/en

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    • C07K—PEPTIDES
    • C07K14/00—Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof
    • C07K14/435—Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof from animals; from humans
    • C07K14/705—Receptors; Cell surface antigens; Cell surface determinants
    • C07K14/72—Receptors; Cell surface antigens; Cell surface determinants for hormones
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    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P11/00—Drugs for disorders of the respiratory system
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
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    • A—HUMAN NECESSITIES
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    • A61P25/02—Drugs for disorders of the nervous system for peripheral neuropathies
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P25/00—Drugs for disorders of the nervous system
    • A61P25/04—Centrally acting analgesics, e.g. opioids
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P25/00—Drugs for disorders of the nervous system
    • A61P25/14—Drugs for disorders of the nervous system for treating abnormal movements, e.g. chorea, dyskinesia
    • A—HUMAN NECESSITIES
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    • A61P3/08—Drugs for disorders of the metabolism for glucose homeostasis
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    • A61P9/00—Drugs for disorders of the cardiovascular system
    • A61P9/12—Antihypertensives

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Abstract

This invention provides an isolated nucleic acid encoding a human MCH1 receptor, a purified human MCH1 receptor, vectors comprising isolated nucleic acid encoding a human MCH1 receptor, cells comprising such vectors, antibodies directed to a human MCH1 receptor, nucleic acid probes useful for detecting nucleic acid encoding human MCH1 receptors, antisense oligonucleotides complementary to unique sequence of nucleic acid encoding human MCH1 receptors, transgenic, nonhuman animals which express DNA encoding a normal or mutant human MCH1 receptor, methods of isolating a human MCH1 receptor, methods of treating an abnormality that is linked to the activity of a human MCH1 receptor, as well as methods of determining binding of compounds to mammalian MCH1 receptors. This invention provides a method of modifying the feeding behavior of a subject which comprises administering to the subject an amount of an MCH1 antagonist effective to decrease the body mass of the subject and/or decrease the consumption of food by the subject. This invention further provides a method of treating a subject suffering from depression and/or anxiety which comprises administering to the subject an amount of an MCH1 antagonist effective to treat the subject's depression and/or anxiety.
PCT/US2001/021350 2000-07-05 2001-07-05 Dna encoding a human melanin concentrating hormone receptor (mch1) and uses thereof WO2002002744A2 (en)

Priority Applications (4)

Application Number Priority Date Filing Date Title
JP2002507986A JP2004502423A (en) 2000-07-05 2001-07-05 DNA encoding human melanin-concentrating hormone receptor (MCH1) and use thereof
AU73207/01A AU7320701A (en) 2000-07-05 2001-07-05 DNA encoding a human melanin concentrating hormone receptor (MCH1) and uses thereof
CA002384358A CA2384358A1 (en) 2000-07-05 2001-07-05 Dna encoding a human melanin concentrating hormone receptor (mch1) and uses thereof
EP01952456A EP1246847A2 (en) 2000-07-05 2001-07-05 Dna encoding a human melanin concentrating hormone receptor (mch1) and uses thereof

Applications Claiming Priority (2)

Application Number Priority Date Filing Date Title
US61063500A 2000-07-05 2000-07-05
US09/610,635 2000-07-05

Publications (2)

Publication Number Publication Date
WO2002002744A2 WO2002002744A2 (en) 2002-01-10
WO2002002744A3 true WO2002002744A3 (en) 2002-08-08

Family

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Family Applications (1)

Application Number Title Priority Date Filing Date
PCT/US2001/021350 WO2002002744A2 (en) 2000-07-05 2001-07-05 Dna encoding a human melanin concentrating hormone receptor (mch1) and uses thereof

Country Status (5)

Country Link
EP (1) EP1246847A2 (en)
JP (1) JP2004502423A (en)
AU (1) AU7320701A (en)
CA (1) CA2384358A1 (en)
WO (1) WO2002002744A2 (en)

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US6221613B1 (en) 1998-12-31 2001-04-24 Synaptic Pharmaceutical Corporation DNA encoding a human melanin concentrating hormone receptor (MCH1) and uses thereof
CA2414198A1 (en) 2000-07-06 2002-01-17 Neurogen Corporation Melanin concentrating hormone receptor ligands
US7078484B2 (en) 2001-04-19 2006-07-18 Neurogen Corporation Melanin concentrating hormone receptors
US7078187B2 (en) 2001-04-19 2006-07-18 Neurogen Corporation Melanin concentrating hormone receptors
AU2002305323A1 (en) 2001-05-04 2002-11-18 Tularik Inc. Fused heterocyclic compounds
US6809104B2 (en) 2001-05-04 2004-10-26 Tularik Inc. Fused heterocyclic compounds
MXPA03010612A (en) 2001-05-22 2004-04-02 Neurogen Corp Melanin concentrating hormone receptor ligands: substituted 1-benzyl-4-aryl piperazine analogues.
US6727264B1 (en) 2001-07-05 2004-04-27 Synaptic Pharmaceutical Corporation Substituted anilinic piperidines as MCH selective antagonists
CN1671386A (en) * 2001-07-05 2005-09-21 H·隆德贝克有限公司 Substituted anilinic piperidines as MCH selective antagonists
US7199135B2 (en) 2001-07-05 2007-04-03 H. Lundbeck A/S Substituted alkyl amido piperidines
US7105544B2 (en) * 2001-07-05 2006-09-12 Synaptic Pharmaceutical Corporation Substituted alkyl amido piperidines
JP2005532991A (en) 2002-01-10 2005-11-04 ニューロジェン・コーポレーション Melanin-concentrating hormone receptor ligand: substituted 2- (4-benzyl-piperazin-1-ylmethyl)-and 2- (4-benzyl-diazepan-1-ylmethyl) -1H-benzimidazole analogs
JP2005526709A (en) 2002-01-10 2005-09-08 ニューロジェン・コーポレーション Melanin-concentrating hormone receptor ligand: substituted benzimidazole analogs
UA77814C2 (en) 2002-07-03 2007-01-15 Lundbeck & Co As H Spirocyclic piperidines as antagonists of mch1 and use thereof
UA77536C2 (en) * 2002-07-03 2006-12-15 Lundbeck & Co As H Secondary aminoaniline piperidines as mch1 antagonists and their use
DE60329513D1 (en) 2002-07-30 2009-11-12 Banyu Pharma Co Ltd ANTAGONIST OF MELANINE CONCENTRATING HORMONE RECEPTOR, CONTAINING A BENZIMIDAZOLE DERIVATIVE AS AN ACTIVE SUBSTANCE
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RU2009108280A (en) 2006-08-08 2010-09-20 Санофи-Авентис (Fr) Arylamino-arylalkyl-substituted imidazolidine-2,4-dione, methods for their preparation containing these compounds and their use
EP2025674A1 (en) 2007-08-15 2009-02-18 sanofi-aventis Substituted tetra hydro naphthalines, method for their manufacture and their use as drugs
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AU7320701A (en) 2002-01-14
WO2002002744A2 (en) 2002-01-10
CA2384358A1 (en) 2002-01-10
EP1246847A2 (en) 2002-10-09
JP2004502423A (en) 2004-01-29

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