WO2002002741A3 - Methods for genetic interpretation and prediction of phenotype - Google Patents

Methods for genetic interpretation and prediction of phenotype Download PDF

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Publication number
WO2002002741A3
WO2002002741A3 PCT/US2001/020931 US0120931W WO0202741A3 WO 2002002741 A3 WO2002002741 A3 WO 2002002741A3 US 0120931 W US0120931 W US 0120931W WO 0202741 A3 WO0202741 A3 WO 0202741A3
Authority
WO
WIPO (PCT)
Prior art keywords
methods
phenotype
present
biological response
response profiles
Prior art date
Application number
PCT/US2001/020931
Other languages
French (fr)
Other versions
WO2002002741A2 (en
Inventor
Roland Stoughton
Matthew J Marton
Original Assignee
Rosetta Inpharmatics Inc
Roland Stoughton
Matthew J Marton
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Application filed by Rosetta Inpharmatics Inc, Roland Stoughton, Matthew J Marton filed Critical Rosetta Inpharmatics Inc
Priority to AU2001271721A priority Critical patent/AU2001271721A1/en
Priority to US10/332,352 priority patent/US20040091933A1/en
Publication of WO2002002741A2 publication Critical patent/WO2002002741A2/en
Publication of WO2002002741A3 publication Critical patent/WO2002002741A3/en

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Classifications

    • C—CHEMISTRY; METALLURGY
    • C12—BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
    • C12N—MICROORGANISMS OR ENZYMES; COMPOSITIONS THEREOF; PROPAGATING, PRESERVING, OR MAINTAINING MICROORGANISMS; MUTATION OR GENETIC ENGINEERING; CULTURE MEDIA
    • C12N15/00—Mutation or genetic engineering; DNA or RNA concerning genetic engineering, vectors, e.g. plasmids, or their isolation, preparation or purification; Use of hosts therefor
    • C12N15/09—Recombinant DNA-technology
    • C12N15/10—Processes for the isolation, preparation or purification of DNA or RNA
    • C12N15/1034—Isolating an individual clone by screening libraries
    • C12N15/1079—Screening libraries by altering the phenotype or phenotypic trait of the host
    • G—PHYSICS
    • G16—INFORMATION AND COMMUNICATION TECHNOLOGY [ICT] SPECIALLY ADAPTED FOR SPECIFIC APPLICATION FIELDS
    • G16B—BIOINFORMATICS, i.e. INFORMATION AND COMMUNICATION TECHNOLOGY [ICT] SPECIALLY ADAPTED FOR GENETIC OR PROTEIN-RELATED DATA PROCESSING IN COMPUTATIONAL MOLECULAR BIOLOGY
    • G16B20/00—ICT specially adapted for functional genomics or proteomics, e.g. genotype-phenotype associations
    • C—CHEMISTRY; METALLURGY
    • C12—BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
    • C12Q—MEASURING OR TESTING PROCESSES INVOLVING ENZYMES, NUCLEIC ACIDS OR MICROORGANISMS; COMPOSITIONS OR TEST PAPERS THEREFOR; PROCESSES OF PREPARING SUCH COMPOSITIONS; CONDITION-RESPONSIVE CONTROL IN MICROBIOLOGICAL OR ENZYMOLOGICAL PROCESSES
    • C12Q2600/00—Oligonucleotides characterized by their use
    • C12Q2600/158—Expression markers

Abstract

The present invention relates to methods for determining the genetic causes of certain phenotypes. The present invention further relates to methods for predicting the phenotype of a organism from its genotype. In particular, the methods of the invention relate to the use of compendia of biological response profiles of cells having known genetic mutations for comparisons with the biological response profiles of cells having unknown phenotypes and genotypes. The methods of the present invention are particularly useful for monitoring the success of genetic engineering and cross-breeding of crops and livestock. The present invention further relates to a computer system for comparing biological response profiles to a compendium of biological response profiles and to kits for relating the phenotype of a cell type to its genotype or for predicting the phenotype of a cell type.
PCT/US2001/020931 2000-07-05 2001-07-02 Methods for genetic interpretation and prediction of phenotype WO2002002741A2 (en)

Priority Applications (2)

Application Number Priority Date Filing Date Title
AU2001271721A AU2001271721A1 (en) 2000-07-05 2001-07-02 Methods for genetic interpretation and prediction of phenotype
US10/332,352 US20040091933A1 (en) 2001-07-02 2001-07-02 Methods for genetic interpretation and prediction of phenotype

Applications Claiming Priority (2)

Application Number Priority Date Filing Date Title
US21593500P 2000-07-05 2000-07-05
US60/215,935 2000-07-05

Publications (2)

Publication Number Publication Date
WO2002002741A2 WO2002002741A2 (en) 2002-01-10
WO2002002741A3 true WO2002002741A3 (en) 2002-04-04

Family

ID=22804996

Family Applications (1)

Application Number Title Priority Date Filing Date
PCT/US2001/020931 WO2002002741A2 (en) 2000-07-05 2001-07-02 Methods for genetic interpretation and prediction of phenotype

Country Status (2)

Country Link
AU (1) AU2001271721A1 (en)
WO (1) WO2002002741A2 (en)

Families Citing this family (1)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
WO2004065573A2 (en) * 2003-01-15 2004-08-05 Wyeth Novel high throughput method of generating and purifying labeled crna targets for gene expression analysis

Citations (2)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
US5300425A (en) * 1987-10-13 1994-04-05 Terrapin Technologies, Inc. Method to produce immunodiagnostic reagents
US5769074A (en) * 1994-10-13 1998-06-23 Horus Therapeutics, Inc. Computer assisted methods for diagnosing diseases

Patent Citations (3)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
US5300425A (en) * 1987-10-13 1994-04-05 Terrapin Technologies, Inc. Method to produce immunodiagnostic reagents
US5541070A (en) * 1987-10-13 1996-07-30 Kauvar; Lawrence M. Method to identify and characterize candidate drugs
US5769074A (en) * 1994-10-13 1998-06-23 Horus Therapeutics, Inc. Computer assisted methods for diagnosing diseases

Non-Patent Citations (2)

* Cited by examiner, † Cited by third party
Title
LIN ET AL.: "Antiproliferative effects of oxygenated sterols: Positive correlation with binding affinities for the antiestrogen-binding sites", BIOCHIMICA ET BIOPHYSICA ACTA, vol. 1082, 1991, pages 177 - 184, XP002905497 *
OKADA ET AL.: "Synergistic activation of PtdIns 3-kinase by tyrosine-phosphorylated peptide and beta gamma-subunits of GTP-binding proteins", BIOCHEMICAL JOURNAL, vol. 317, 1996, pages 475 - 480, XP002905495 *

Also Published As

Publication number Publication date
WO2002002741A2 (en) 2002-01-10
AU2001271721A1 (en) 2002-01-14

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