WO2002002601A3 - Mutant presenilin 1 and presenilin 2 polypeptides - Google Patents

Mutant presenilin 1 and presenilin 2 polypeptides Download PDF

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Publication number
WO2002002601A3
WO2002002601A3 PCT/US2001/016508 US0116508W WO0202601A3 WO 2002002601 A3 WO2002002601 A3 WO 2002002601A3 US 0116508 W US0116508 W US 0116508W WO 0202601 A3 WO0202601 A3 WO 0202601A3
Authority
WO
WIPO (PCT)
Prior art keywords
presenilin
polypeptides
mutant
disclosed
methods
Prior art date
Application number
PCT/US2001/016508
Other languages
French (fr)
Other versions
WO2002002601A2 (en
Inventor
Donald B Carter
Alfredo G Tomasselli
Original Assignee
Upjohn Co
Donald B Carter
Alfredo G Tomasselli
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Application filed by Upjohn Co, Donald B Carter, Alfredo G Tomasselli filed Critical Upjohn Co
Priority to EP01948232A priority Critical patent/EP1294878A2/en
Priority to AU2001269705A priority patent/AU2001269705A1/en
Publication of WO2002002601A2 publication Critical patent/WO2002002601A2/en
Publication of WO2002002601A3 publication Critical patent/WO2002002601A3/en

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Classifications

    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07K—PEPTIDES
    • C07K14/00—Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof
    • C07K14/435—Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof from animals; from humans
    • C07K14/46—Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof from animals; from humans from vertebrates
    • C07K14/47—Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof from animals; from humans from vertebrates from mammals
    • C07K14/4701—Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof from animals; from humans from vertebrates from mammals not used
    • C07K14/4711—Alzheimer's disease; Amyloid plaque core protein
    • A—HUMAN NECESSITIES
    • A01—AGRICULTURE; FORESTRY; ANIMAL HUSBANDRY; HUNTING; TRAPPING; FISHING
    • A01K—ANIMAL HUSBANDRY; AVICULTURE; APICULTURE; PISCICULTURE; FISHING; REARING OR BREEDING ANIMALS, NOT OTHERWISE PROVIDED FOR; NEW BREEDS OF ANIMALS
    • A01K2217/00—Genetically modified animals
    • A01K2217/05—Animals comprising random inserted nucleic acids (transgenic)

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  • Health & Medical Sciences (AREA)
  • Chemical & Material Sciences (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • Organic Chemistry (AREA)
  • General Health & Medical Sciences (AREA)
  • Genetics & Genomics (AREA)
  • Zoology (AREA)
  • Gastroenterology & Hepatology (AREA)
  • Engineering & Computer Science (AREA)
  • Biochemistry (AREA)
  • Toxicology (AREA)
  • Neurology (AREA)
  • Biophysics (AREA)
  • Medicinal Chemistry (AREA)
  • Molecular Biology (AREA)
  • Proteomics, Peptides & Aminoacids (AREA)
  • Biomedical Technology (AREA)
  • Micro-Organisms Or Cultivation Processes Thereof (AREA)
  • Peptides Or Proteins (AREA)

Abstract

The present invention provides mutant presenilin 1 and presenilin 2 polypeptides and polynucleotides encoding the polypeptides and methods for their production by recombinant and PCR techniques are disclosed. Methods for utilizing the mutant polypeptides in screens for inhibitors of activity are also disclosed.
PCT/US2001/016508 2000-06-30 2001-06-29 Mutant presenilin 1 and presenilin 2 polypeptides WO2002002601A2 (en)

Priority Applications (2)

Application Number Priority Date Filing Date Title
EP01948232A EP1294878A2 (en) 2000-06-30 2001-06-29 Mutant presenilin 1 and presenilin 2 polypeptides
AU2001269705A AU2001269705A1 (en) 2000-06-30 2001-06-29 Mutant presenilin 1 and presenilin 2 polypeptides

Applications Claiming Priority (2)

Application Number Priority Date Filing Date Title
US21534500P 2000-06-30 2000-06-30
US60/215,345 2000-06-30

Publications (2)

Publication Number Publication Date
WO2002002601A2 WO2002002601A2 (en) 2002-01-10
WO2002002601A3 true WO2002002601A3 (en) 2002-08-29

Family

ID=22802615

Family Applications (1)

Application Number Title Priority Date Filing Date
PCT/US2001/016508 WO2002002601A2 (en) 2000-06-30 2001-06-29 Mutant presenilin 1 and presenilin 2 polypeptides

Country Status (3)

Country Link
EP (1) EP1294878A2 (en)
AU (1) AU2001269705A1 (en)
WO (1) WO2002002601A2 (en)

Citations (1)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
EP0811695A2 (en) * 1996-06-06 1997-12-10 Washington University Mutant S182(PS-1) genes

Patent Citations (1)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
EP0811695A2 (en) * 1996-06-06 1997-12-10 Washington University Mutant S182(PS-1) genes

Non-Patent Citations (2)

* Cited by examiner, † Cited by third party
Title
KIMBERLY W TAYLOR ET AL: "The transmembrane aspartates in presenilin 1 and 2 are obligatory for gamma-secretase activity and amyloid beta-protein generation", JOURNAL OF BIOLOGICAL CHEMISTRY, THE AMERICAN SOCIETY OF BIOLOGICAL CHEMISTS, INC.,, US, vol. 275, no. 5, 4 February 2000 (2000-02-04), pages 3173 - 3178, XP002173229, ISSN: 0021-9258 *
RAWLINGS N AND BARRETT A: "Family of Aspartic peptidases, and those of unknown catalytic mechanism", METHODS IN ENZYMOLOGY, vol. 248, 1995, pages 105 - 120, XP008003749 *

Also Published As

Publication number Publication date
WO2002002601A2 (en) 2002-01-10
AU2001269705A1 (en) 2002-01-14
EP1294878A2 (en) 2003-03-26

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