WO2002000891A3 - Human napsin-like aspartyl protease - Google Patents

Human napsin-like aspartyl protease Download PDF

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Publication number
WO2002000891A3
WO2002000891A3 PCT/EP2001/007000 EP0107000W WO0200891A3 WO 2002000891 A3 WO2002000891 A3 WO 2002000891A3 EP 0107000 W EP0107000 W EP 0107000W WO 0200891 A3 WO0200891 A3 WO 0200891A3
Authority
WO
WIPO (PCT)
Prior art keywords
aspartyl protease
human napsin
napsin
human
reagents
Prior art date
Application number
PCT/EP2001/007000
Other languages
French (fr)
Other versions
WO2002000891A2 (en
Inventor
Shyam Ramakrishnan
Original Assignee
Bayer Ag
Shyam Ramakrishnan
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Application filed by Bayer Ag, Shyam Ramakrishnan filed Critical Bayer Ag
Priority to AU2001267548A priority Critical patent/AU2001267548A1/en
Publication of WO2002000891A2 publication Critical patent/WO2002000891A2/en
Publication of WO2002000891A3 publication Critical patent/WO2002000891A3/en

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Classifications

    • C—CHEMISTRY; METALLURGY
    • C12—BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
    • C12N—MICROORGANISMS OR ENZYMES; COMPOSITIONS THEREOF; PROPAGATING, PRESERVING, OR MAINTAINING MICROORGANISMS; MUTATION OR GENETIC ENGINEERING; CULTURE MEDIA
    • C12N9/00—Enzymes; Proenzymes; Compositions thereof; Processes for preparing, activating, inhibiting, separating or purifying enzymes
    • C12N9/14—Hydrolases (3)
    • C12N9/48—Hydrolases (3) acting on peptide bonds (3.4)
    • C12N9/50—Proteinases, e.g. Endopeptidases (3.4.21-3.4.25)
    • C12N9/64—Proteinases, e.g. Endopeptidases (3.4.21-3.4.25) derived from animal tissue
    • C12N9/6421—Proteinases, e.g. Endopeptidases (3.4.21-3.4.25) derived from animal tissue from mammals
    • C12N9/6478—Aspartic endopeptidases (3.4.23)
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K38/00—Medicinal preparations containing peptides
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07K—PEPTIDES
    • C07K2319/00—Fusion polypeptide

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  • Health & Medical Sciences (AREA)
  • Engineering & Computer Science (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • Chemical & Material Sciences (AREA)
  • Biomedical Technology (AREA)
  • Organic Chemistry (AREA)
  • Zoology (AREA)
  • Bioinformatics & Cheminformatics (AREA)
  • Wood Science & Technology (AREA)
  • Genetics & Genomics (AREA)
  • Microbiology (AREA)
  • Biotechnology (AREA)
  • Molecular Biology (AREA)
  • Biochemistry (AREA)
  • General Engineering & Computer Science (AREA)
  • General Health & Medical Sciences (AREA)
  • Medicinal Chemistry (AREA)
  • Preparation Of Compounds By Using Micro-Organisms (AREA)
  • Micro-Organisms Or Cultivation Processes Thereof (AREA)
  • Enzymes And Modification Thereof (AREA)

Abstract

Reagents which regulate human napsin-like aspartyl protease activity and reagents which bind to human napsin-like aspartyl protease gene products can be used to treat cancer and osteoporosis.
PCT/EP2001/007000 2000-06-26 2001-06-21 Human napsin-like aspartyl protease WO2002000891A2 (en)

Priority Applications (1)

Application Number Priority Date Filing Date Title
AU2001267548A AU2001267548A1 (en) 2000-06-26 2001-06-21 Regulation of human napsin-like aspartyl protease

Applications Claiming Priority (2)

Application Number Priority Date Filing Date Title
US21401000P 2000-06-26 2000-06-26
US60/214,010 2000-06-26

Publications (2)

Publication Number Publication Date
WO2002000891A2 WO2002000891A2 (en) 2002-01-03
WO2002000891A3 true WO2002000891A3 (en) 2002-04-11

Family

ID=22797423

Family Applications (1)

Application Number Title Priority Date Filing Date
PCT/EP2001/007000 WO2002000891A2 (en) 2000-06-26 2001-06-21 Human napsin-like aspartyl protease

Country Status (2)

Country Link
AU (1) AU2001267548A1 (en)
WO (1) WO2002000891A2 (en)

Families Citing this family (1)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
ITMI20081135A1 (en) 2008-06-24 2009-12-25 Trapani Paolo Di LIGHTING DEVICE

Citations (2)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
WO1998022597A2 (en) * 1996-11-20 1998-05-28 Oklahoma Medical Research Foundation Cloning and characterization of napsin, an aspartic protease
WO2000004137A1 (en) * 1998-07-16 2000-01-27 Incyte Pharmaceuticals, Inc. Human aspartic proteases

Patent Citations (2)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
WO1998022597A2 (en) * 1996-11-20 1998-05-28 Oklahoma Medical Research Foundation Cloning and characterization of napsin, an aspartic protease
WO2000004137A1 (en) * 1998-07-16 2000-01-27 Incyte Pharmaceuticals, Inc. Human aspartic proteases

Non-Patent Citations (1)

* Cited by examiner, † Cited by third party
Title
DATABASE EMBL EBI; 6 January 2000 (2000-01-06), NATIONAL CANCER INSTITUTE, CANCER GENOME ANATOMY PROJECT (CGAP): "Homo sapiens cDNA clone similar to napsin 1 precursor", XP002188681 *

Also Published As

Publication number Publication date
WO2002000891A2 (en) 2002-01-03
AU2001267548A1 (en) 2002-01-08

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