WO2002000005A8 - Libraries displaying human antibody fragments with hybrid complementarity determining regions - Google Patents

Libraries displaying human antibody fragments with hybrid complementarity determining regions

Info

Publication number
WO2002000005A8
WO2002000005A8 PCT/US2001/019502 US0119502W WO0200005A8 WO 2002000005 A8 WO2002000005 A8 WO 2002000005A8 US 0119502 W US0119502 W US 0119502W WO 0200005 A8 WO0200005 A8 WO 0200005A8
Authority
WO
WIPO (PCT)
Prior art keywords
determining regions
hybrid
antibody fragments
human antibody
complementarity determining
Prior art date
Application number
PCT/US2001/019502
Other languages
French (fr)
Other versions
WO2002000005A1 (en
Inventor
Russell Rother
William L Fodor
Stephen P Squinto
Original Assignee
Alexion Pharma Inc
Russell Rother
William L Fodor
Stephen P Squinto
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Application filed by Alexion Pharma Inc, Russell Rother, William L Fodor, Stephen P Squinto filed Critical Alexion Pharma Inc
Priority to AU2001268545A priority Critical patent/AU2001268545A1/en
Publication of WO2002000005A1 publication Critical patent/WO2002000005A1/en
Publication of WO2002000005A8 publication Critical patent/WO2002000005A8/en

Links

Classifications

    • G—PHYSICS
    • G01—MEASURING; TESTING
    • G01N—INVESTIGATING OR ANALYSING MATERIALS BY DETERMINING THEIR CHEMICAL OR PHYSICAL PROPERTIES
    • G01N33/00—Investigating or analysing materials by specific methods not covered by groups G01N1/00 - G01N31/00
    • G01N33/48—Biological material, e.g. blood, urine; Haemocytometers
    • G01N33/50—Chemical analysis of biological material, e.g. blood, urine; Testing involving biospecific ligand binding methods; Immunological testing
    • G01N33/68—Chemical analysis of biological material, e.g. blood, urine; Testing involving biospecific ligand binding methods; Immunological testing involving proteins, peptides or amino acids
    • G01N33/6854—Immunoglobulins
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07K—PEPTIDES
    • C07K16/00—Immunoglobulins [IGs], e.g. monoclonal or polyclonal antibodies
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07K—PEPTIDES
    • C07K2317/00—Immunoglobulins specific features
    • C07K2317/20—Immunoglobulins specific features characterized by taxonomic origin
    • C07K2317/24—Immunoglobulins specific features characterized by taxonomic origin containing regions, domains or residues from different species, e.g. chimeric, humanized or veneered
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07K—PEPTIDES
    • C07K2317/00—Immunoglobulins specific features
    • C07K2317/50—Immunoglobulins specific features characterized by immunoglobulin fragments
    • C07K2317/56—Immunoglobulins specific features characterized by immunoglobulin fragments variable (Fv) region, i.e. VH and/or VL
    • C07K2317/565—Complementarity determining region [CDR]

Landscapes

  • Health & Medical Sciences (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • Chemical & Material Sciences (AREA)
  • Immunology (AREA)
  • Molecular Biology (AREA)
  • Engineering & Computer Science (AREA)
  • General Health & Medical Sciences (AREA)
  • Medicinal Chemistry (AREA)
  • Hematology (AREA)
  • Organic Chemistry (AREA)
  • Proteomics, Peptides & Aminoacids (AREA)
  • Urology & Nephrology (AREA)
  • Biomedical Technology (AREA)
  • Biochemistry (AREA)
  • Physics & Mathematics (AREA)
  • Cell Biology (AREA)
  • Analytical Chemistry (AREA)
  • Food Science & Technology (AREA)
  • Biotechnology (AREA)
  • General Physics & Mathematics (AREA)
  • Pathology (AREA)
  • Biophysics (AREA)
  • Genetics & Genomics (AREA)
  • Microbiology (AREA)
  • Peptides Or Proteins (AREA)

Abstract

Libraries displaying human antibodies (i.e., whole antibody-like molecules and antigen binding fragments thereof) having nonhuman complementary determining regions are provided. Methods of obtaining human antibodies that recognize self antigens and using such libraries are described.
PCT/US2001/019502 2000-06-21 2001-06-18 Libraries displaying human antibody fragments with hybrid complementarity determining regions WO2002000005A1 (en)

Priority Applications (1)

Application Number Priority Date Filing Date Title
AU2001268545A AU2001268545A1 (en) 2000-06-21 2001-06-18 Libraries displaying human antibody fragments with hybrid complementarity determining regions

Applications Claiming Priority (2)

Application Number Priority Date Filing Date Title
US21319600P 2000-06-21 2000-06-21
US60/213,196 2000-06-21

Publications (2)

Publication Number Publication Date
WO2002000005A1 WO2002000005A1 (en) 2002-01-03
WO2002000005A8 true WO2002000005A8 (en) 2002-03-07

Family

ID=22794104

Family Applications (1)

Application Number Title Priority Date Filing Date
PCT/US2001/019502 WO2002000005A1 (en) 2000-06-21 2001-06-18 Libraries displaying human antibody fragments with hybrid complementarity determining regions

Country Status (2)

Country Link
AU (1) AU2001268545A1 (en)
WO (1) WO2002000005A1 (en)

Families Citing this family (4)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
CA2553692C (en) * 2004-01-20 2014-10-07 Kalobios, Inc. Antibody specificity transfer using minimal essential binding determinants
DK2343380T3 (en) 2004-11-16 2019-09-09 Humanigen Inc IMMUNOGLOBULIN VARIABLE REGION CARTRIDGE REPLACEMENT
JO2787B1 (en) 2005-04-27 2014-03-15 امجين إنك, Substituted Amid derivatives & methods of use
WO2015133882A1 (en) * 2014-03-07 2015-09-11 사회복지법인 삼성생명공익재단 Scfv antibody library, method for preparing same, and scfv antibody screening method using same

Family Cites Families (3)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
US5565332A (en) * 1991-09-23 1996-10-15 Medical Research Council Production of chimeric antibodies - a combinatorial approach
WO1998042752A1 (en) * 1997-03-21 1998-10-01 Brigham And Women's Hospital Inc. Immunotherapeutic ctla-4 binding peptides
US6160099A (en) * 1998-11-24 2000-12-12 Jonak; Zdenka Ludmila Anti-human αv β3 and αv β5 antibodies

Also Published As

Publication number Publication date
WO2002000005A1 (en) 2002-01-03
AU2001268545A1 (en) 2002-01-08

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