WO2001098354A3 - Recepteurs - Google Patents

Recepteurs Download PDF

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Publication number
WO2001098354A3
WO2001098354A3 PCT/US2001/019942 US0119942W WO0198354A3 WO 2001098354 A3 WO2001098354 A3 WO 2001098354A3 US 0119942 W US0119942 W US 0119942W WO 0198354 A3 WO0198354 A3 WO 0198354A3
Authority
WO
WIPO (PCT)
Prior art keywords
reptr
human receptors
provides
polynucleotides
agonists
Prior art date
Application number
PCT/US2001/019942
Other languages
English (en)
Other versions
WO2001098354A2 (fr
Inventor
Jennifer A Griffin
Original Assignee
Incyte Genomics Inc
Jennifer A Griffin
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Application filed by Incyte Genomics Inc, Jennifer A Griffin filed Critical Incyte Genomics Inc
Priority to AU2001272974A priority Critical patent/AU2001272974A1/en
Priority to CA002414015A priority patent/CA2414015A1/fr
Priority to EP01952189A priority patent/EP1294764A2/fr
Priority to JP2002504309A priority patent/JP2004516812A/ja
Priority to US10/311,623 priority patent/US20040023244A1/en
Publication of WO2001098354A2 publication Critical patent/WO2001098354A2/fr
Publication of WO2001098354A3 publication Critical patent/WO2001098354A3/fr

Links

Classifications

    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07K—PEPTIDES
    • C07K14/00—Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof
    • C07K14/435—Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof from animals; from humans
    • C07K14/705—Receptors; Cell surface antigens; Cell surface determinants
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P1/00—Drugs for disorders of the alimentary tract or the digestive system
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P15/00—Drugs for genital or sexual disorders; Contraceptives
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P25/00—Drugs for disorders of the nervous system
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P29/00—Non-central analgesic, antipyretic or antiinflammatory agents, e.g. antirheumatic agents; Non-steroidal antiinflammatory drugs [NSAID]
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P35/00—Antineoplastic agents
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P37/00—Drugs for immunological or allergic disorders
    • A61P37/02—Immunomodulators
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P43/00—Drugs for specific purposes, not provided for in groups A61P1/00-A61P41/00
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P5/00—Drugs for disorders of the endocrine system
    • A—HUMAN NECESSITIES
    • A01—AGRICULTURE; FORESTRY; ANIMAL HUSBANDRY; HUNTING; TRAPPING; FISHING
    • A01K—ANIMAL HUSBANDRY; CARE OF BIRDS, FISHES, INSECTS; FISHING; REARING OR BREEDING ANIMALS, NOT OTHERWISE PROVIDED FOR; NEW BREEDS OF ANIMALS
    • A01K2217/00—Genetically modified animals
    • A01K2217/05—Animals comprising random inserted nucleic acids (transgenic)
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K38/00—Medicinal preparations containing peptides

Abstract

L'invention concerne des récepteurs humains (REPTR) et des polynucléotides qui identifient et codent les récepteurs REPTR. Elle concerne aussi des vecteurs d'expression, des cellules hôtes, des anticorps, des agonistes et des antagonistes. Elle concerne enfin des méthodes de diagnostic, de traitement ou de prévention de troubles associés à l'expression aberrante des récepteurs REPTR.
PCT/US2001/019942 2000-06-21 2001-06-21 Recepteurs WO2001098354A2 (fr)

Priority Applications (5)

Application Number Priority Date Filing Date Title
AU2001272974A AU2001272974A1 (en) 2000-06-21 2001-06-21 Human receptors
CA002414015A CA2414015A1 (fr) 2000-06-21 2001-06-21 Recepteurs
EP01952189A EP1294764A2 (fr) 2000-06-21 2001-06-21 Recepteurs humaines
JP2002504309A JP2004516812A (ja) 2000-06-21 2001-06-21 受容体
US10/311,623 US20040023244A1 (en) 2001-06-21 2001-06-21 Receptors

Applications Claiming Priority (6)

Application Number Priority Date Filing Date Title
US21402700P 2000-06-21 2000-06-21
US60/214,027 2000-06-21
US22804500P 2000-08-25 2000-08-25
US60/228,045 2000-08-25
US25510400P 2000-12-12 2000-12-12
US60/255,104 2000-12-12

Publications (2)

Publication Number Publication Date
WO2001098354A2 WO2001098354A2 (fr) 2001-12-27
WO2001098354A3 true WO2001098354A3 (fr) 2002-10-17

Family

ID=27395939

Family Applications (1)

Application Number Title Priority Date Filing Date
PCT/US2001/019942 WO2001098354A2 (fr) 2000-06-21 2001-06-21 Recepteurs

Country Status (4)

Country Link
JP (1) JP2004516812A (fr)
AU (1) AU2001272974A1 (fr)
CA (1) CA2414015A1 (fr)
WO (1) WO2001098354A2 (fr)

Cited By (1)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
US9228013B2 (en) 2005-10-31 2016-01-05 OncoMed Pharmaceuticals Methods of using the FRI domain of human frizzled receptor for inhibiting Wnt signaling in a tumor or tumor cell

Families Citing this family (15)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
US20030204052A1 (en) * 2000-10-04 2003-10-30 Herrmann John L. Novel proteins and nucleic acids encoding same and antibodies directed against these proteins
US6984522B2 (en) 2000-08-03 2006-01-10 Regents Of The University Of Michigan Isolation and use of solid tumor stem cells
AU2001293870A1 (en) * 2000-10-16 2002-04-29 Bayer Aktiengesellschaft Regulation of human netrin binding membrane receptor unc5h-1
WO2002046402A2 (fr) * 2000-12-05 2002-06-13 Bayer Aktiengesellschaft Regulation de la proteine humaine de type 'patched'
AU2002237225A1 (en) * 2000-12-05 2002-06-18 Bayer Aktiengesellschaft Regulation of human patched-like protein
EP1558737A4 (fr) * 2002-10-18 2008-06-11 Lg Life Sciences Ltd Familles de genes associes a des cancers
JP4675671B2 (ja) * 2005-05-11 2011-04-27 学校法人北里研究所 核酸増幅反応の新規短時間検出方法
JP5368798B2 (ja) 2005-10-31 2013-12-18 オンコメッド ファーマシューティカルズ インコーポレイテッド 癌を診断し処置するための組成物および方法
CA2662041A1 (fr) 2006-09-08 2008-03-13 Genentech, Inc. Antagonistes de wnt et leur utilisation pour le diagnostic et le traitement de troubles a mediation wnt
US8551789B2 (en) 2010-04-01 2013-10-08 OncoMed Pharmaceuticals Frizzled-binding agents and their use in screening for WNT inhibitors
SG190568A1 (en) 2008-09-26 2013-06-28 Oncomed Pharm Inc Frizzled-binding agents and uses thereof
TWI535445B (zh) 2010-01-12 2016-06-01 安可美德藥物股份有限公司 Ｗｎｔ拮抗劑及治療和篩選方法
EP2911691B1 (fr) 2012-10-23 2018-10-10 OncoMed Pharmaceuticals, Inc. Méthodes de traitement de tumeurs neuro-endocrines à l'aide d'agents liants de parcours wnt
JP2016510411A (ja) 2013-02-04 2016-04-07 オンコメッド ファーマシューティカルズ インコーポレイテッド Ｗｎｔ経路インヒビターによる処置の方法およびモニタリング
US9168300B2 (en) 2013-03-14 2015-10-27 Oncomed Pharmaceuticals, Inc. MET-binding agents and uses thereof

Citations (2)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
WO1998037085A1 (fr) * 1997-02-19 1998-08-27 The Regents Of The University Of California Recepteurs de netrine
WO2001057190A2 (fr) * 2000-02-03 2001-08-09 Hyseq, Inc. Acides nucleiques et polypeptides

Patent Citations (2)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
WO1998037085A1 (fr) * 1997-02-19 1998-08-27 The Regents Of The University Of California Recepteurs de netrine
WO2001057190A2 (fr) * 2000-02-03 2001-08-09 Hyseq, Inc. Acides nucleiques et polypeptides

Non-Patent Citations (2)

* Cited by examiner, † Cited by third party
Title
DATABASE EMBL 16 June 2001 (2001-06-16), STRAUSBERG, R.: "Homo sapiens, Similar to transmembrane receptor Unc5H1, clone IMAGE:4126760, mRNA, partial cds.", XP002197545 *
DATABASE EMBL 24 October 1999 (1999-10-24), BIRREN, B. ET AL.: "Homo sapiens clone RP11-1G22, WORKING DRAFT SEQUENCE, 8 unordered pieces.", XP002197544 *

Cited By (1)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
US9228013B2 (en) 2005-10-31 2016-01-05 OncoMed Pharmaceuticals Methods of using the FRI domain of human frizzled receptor for inhibiting Wnt signaling in a tumor or tumor cell

Also Published As

Publication number Publication date
CA2414015A1 (fr) 2001-12-27
AU2001272974A1 (en) 2002-01-02
JP2004516812A (ja) 2004-06-10
WO2001098354A2 (fr) 2001-12-27

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