WO2001098340A3 - Regulation of human mast cell protease 6-like enzyme - Google Patents

Regulation of human mast cell protease 6-like enzyme Download PDF

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Publication number
WO2001098340A3
WO2001098340A3 PCT/EP2001/007002 EP0107002W WO0198340A3 WO 2001098340 A3 WO2001098340 A3 WO 2001098340A3 EP 0107002 W EP0107002 W EP 0107002W WO 0198340 A3 WO0198340 A3 WO 0198340A3
Authority
WO
WIPO (PCT)
Prior art keywords
mast cell
human mast
cell protease
enzyme
regulation
Prior art date
Application number
PCT/EP2001/007002
Other languages
French (fr)
Other versions
WO2001098340A2 (en
Inventor
Yonghong Xiao
Original Assignee
Bayer Ag
Yonghong Xiao
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Application filed by Bayer Ag, Yonghong Xiao filed Critical Bayer Ag
Priority to EP01951617A priority Critical patent/EP1297157A2/en
Priority to AU2001272497A priority patent/AU2001272497A1/en
Publication of WO2001098340A2 publication Critical patent/WO2001098340A2/en
Publication of WO2001098340A3 publication Critical patent/WO2001098340A3/en

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Classifications

    • C—CHEMISTRY; METALLURGY
    • C12—BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
    • C12N—MICROORGANISMS OR ENZYMES; COMPOSITIONS THEREOF; PROPAGATING, PRESERVING, OR MAINTAINING MICROORGANISMS; MUTATION OR GENETIC ENGINEERING; CULTURE MEDIA
    • C12N9/00—Enzymes; Proenzymes; Compositions thereof; Processes for preparing, activating, inhibiting, separating or purifying enzymes
    • C12N9/14—Hydrolases (3)
    • C12N9/48—Hydrolases (3) acting on peptide bonds (3.4)
    • C12N9/50—Proteinases, e.g. Endopeptidases (3.4.21-3.4.25)
    • C12N9/64—Proteinases, e.g. Endopeptidases (3.4.21-3.4.25) derived from animal tissue
    • C12N9/6421—Proteinases, e.g. Endopeptidases (3.4.21-3.4.25) derived from animal tissue from mammals
    • C12N9/6424—Serine endopeptidases (3.4.21)
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K38/00—Medicinal preparations containing peptides
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07K—PEPTIDES
    • C07K2319/00—Fusion polypeptide

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  • Health & Medical Sciences (AREA)
  • Engineering & Computer Science (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • Chemical & Material Sciences (AREA)
  • Biomedical Technology (AREA)
  • Organic Chemistry (AREA)
  • Zoology (AREA)
  • Bioinformatics & Cheminformatics (AREA)
  • Wood Science & Technology (AREA)
  • Genetics & Genomics (AREA)
  • Microbiology (AREA)
  • Biotechnology (AREA)
  • Molecular Biology (AREA)
  • Biochemistry (AREA)
  • General Engineering & Computer Science (AREA)
  • General Health & Medical Sciences (AREA)
  • Medicinal Chemistry (AREA)
  • Enzymes And Modification Thereof (AREA)
  • Micro-Organisms Or Cultivation Processes Thereof (AREA)
  • Medicines That Contain Protein Lipid Enzymes And Other Medicines (AREA)
  • Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)

Abstract

Reagents which regulate human mast cell protease 6-like enzyme activity and reagents which bind to human mast cell protease 6-like enzyme gene products can be used to regulate human mast cell protease 6-like enzyme activity. Such regulation is particularly useful for treating metastasis of malignant cells, tumor angiogenesis, inflammation including asthma, atherosclerosis, neurodegenerative diseases, and pathogenic infections.
PCT/EP2001/007002 2000-06-23 2001-06-21 Regulation of human mast cell protease 6-like enzyme WO2001098340A2 (en)

Priority Applications (2)

Application Number Priority Date Filing Date Title
EP01951617A EP1297157A2 (en) 2000-06-23 2001-06-21 Regulation of human mast cell protease 6-like enzyme
AU2001272497A AU2001272497A1 (en) 2000-06-23 2001-06-21 Regulation of human mast cell protease 6-like enzyme

Applications Claiming Priority (2)

Application Number Priority Date Filing Date Title
US21358900P 2000-06-23 2000-06-23
US60/213,589 2000-06-23

Publications (2)

Publication Number Publication Date
WO2001098340A2 WO2001098340A2 (en) 2001-12-27
WO2001098340A3 true WO2001098340A3 (en) 2002-06-06

Family

ID=22795691

Family Applications (1)

Application Number Title Priority Date Filing Date
PCT/EP2001/007002 WO2001098340A2 (en) 2000-06-23 2001-06-21 Regulation of human mast cell protease 6-like enzyme

Country Status (3)

Country Link
EP (1) EP1297157A2 (en)
AU (1) AU2001272497A1 (en)
WO (1) WO2001098340A2 (en)

Families Citing this family (5)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
AU2003250830A1 (en) * 2002-06-12 2003-12-31 Bayer Healthcare Ag Regulation of human subtilase-like serine protease
JP5189082B2 (en) 2006-05-25 2013-04-24 バイエル・ファルマ・アクチェンゲゼルシャフト Dimeric molecular complex
AU2008299376B2 (en) 2007-09-12 2013-02-28 Glaxosmithkline Biologicals S.A. GAS57 mutant antigens and GAS57 antibodies
BRPI0821240B8 (en) 2007-12-21 2022-10-04 Novartis Ag mutant forms of streptolysin o
AU2010204139A1 (en) 2009-01-12 2011-08-11 Novartis Ag Cna_B domain antigens in vaccines against gram positive bacteria

Citations (3)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
WO1998033812A1 (en) * 1997-02-05 1998-08-06 Brigham And Women's Hospital, Inc. Mast cell protease peptide inhibitors
WO1999060139A1 (en) * 1998-05-15 1999-11-25 Promega Corporation ENZYMATICALLY-ACTIVE RECOMBINANT HUMAN β-TRYPTASE AND METHOD OF MAKING SAME
WO2001070978A2 (en) * 2000-03-20 2001-09-27 Curagen Corporation Polypeptides and nucleic acids encoding same

Patent Citations (3)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
WO1998033812A1 (en) * 1997-02-05 1998-08-06 Brigham And Women's Hospital, Inc. Mast cell protease peptide inhibitors
WO1999060139A1 (en) * 1998-05-15 1999-11-25 Promega Corporation ENZYMATICALLY-ACTIVE RECOMBINANT HUMAN β-TRYPTASE AND METHOD OF MAKING SAME
WO2001070978A2 (en) * 2000-03-20 2001-09-27 Curagen Corporation Polypeptides and nucleic acids encoding same

Non-Patent Citations (6)

* Cited by examiner, † Cited by third party
Title
BURGESS L E: "Mast cell tryptase as a target for drug design", DRUG NEWS AND PERSPECTIVES, vol. 13, no. 3, 2000, pages 147 - 157, XP000986039, ISSN: 0214-0934 *
DATABASE EM_HUM EMBL; 23 September 1998 (1998-09-23), LLOYD C: "Human DNA sequence from clone LA16-303A1 on chromosome 16", XP002194597 *
HUANG C ET AL.: "Regulation and function of mast cell proteases in inflammation", JOURNAL OF CLINICAL IMMUNOLOGY, vol. 18, no. 3, May 1998 (1998-05-01), pages 169 - 183, XP000990876, ISSN: 0271-9142 *
PALLAORO M ET AL.: "Characterization of genes encoding known and novel human mast cell tryptases on chromosome 16p13.3", JOURNAL OF BIOLOGICAL CHEMISTRY, vol. 274, no. 6, 5 February 1999 (1999-02-05), pages 3355 - 3362, XP002177260, ISSN: 0021-9258 *
REYNOLDS D S ET AL.: "Cloning of the cDNA and gene of mouse mast cell protease-6. Transcription by progenitor mast cells of the connective tissue subclass", JOURNAL OF BIOLOGICAL CHEMISTRY, vol. 266, no. 6, 25 February 1991 (1991-02-25), pages 3847 - 3853, XP002934402, ISSN: 0021-9258 *
WALLS A F ET AL.: "Production and characterization of monoclonal antibodies specific for human mast cell tryptase", CLINICAL AND EXPERIMENTAL ALLERGY, vol. 20, no. 5, 1 September 1990 (1990-09-01), pages 581 - 589, XP000647681, ISSN: 0954-7894 *

Also Published As

Publication number Publication date
EP1297157A2 (en) 2003-04-02
AU2001272497A1 (en) 2002-01-02
WO2001098340A2 (en) 2001-12-27

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