WO2001095874A3 - Highly efficient delivery of a large therapeutic mass aerosol - Google Patents

Highly efficient delivery of a large therapeutic mass aerosol Download PDF

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Publication number
WO2001095874A3
WO2001095874A3 PCT/US2001/018491 US0118491W WO0195874A3 WO 2001095874 A3 WO2001095874 A3 WO 2001095874A3 US 0118491 W US0118491 W US 0118491W WO 0195874 A3 WO0195874 A3 WO 0195874A3
Authority
WO
WIPO (PCT)
Prior art keywords
particles
agent
highly efficient
efficient delivery
large therapeutic
Prior art date
Application number
PCT/US2001/018491
Other languages
French (fr)
Other versions
WO2001095874A2 (en
Inventor
David A Edwards
Richard P Batycky
Lloyd Johnston
Original Assignee
Advanced Inhalation Res Inc
David A Edwards
Richard P Batycky
Lloyd Johnston
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Family has litigation
First worldwide family litigation filed litigation Critical https://patents.darts-ip.com/?family=24365965&utm_source=google_patent&utm_medium=platform_link&utm_campaign=public_patent_search&patent=WO2001095874(A3) "Global patent litigation dataset” by Darts-ip is licensed under a Creative Commons Attribution 4.0 International License.
Priority to DE60127407T priority Critical patent/DE60127407T2/en
Priority to DK01942072T priority patent/DK1296663T3/en
Priority to KR1020027016748A priority patent/KR100697479B1/en
Priority to CA002412561A priority patent/CA2412561C/en
Priority to IL15328101A priority patent/IL153281A0/en
Priority to AU2001275368A priority patent/AU2001275368B2/en
Priority to MXPA02012023A priority patent/MXPA02012023A/en
Application filed by Advanced Inhalation Res Inc, David A Edwards, Richard P Batycky, Lloyd Johnston filed Critical Advanced Inhalation Res Inc
Priority to AU7536801A priority patent/AU7536801A/en
Priority to SI200130734T priority patent/SI1296663T1/en
Priority to PL36028701A priority patent/PL360287A1/en
Priority to JP2002510053A priority patent/JP2004503482A/en
Priority to EP01942072A priority patent/EP1296663B1/en
Priority to NZ523254A priority patent/NZ523254A/en
Publication of WO2001095874A2 publication Critical patent/WO2001095874A2/en
Priority to NO20025873A priority patent/NO20025873L/en
Publication of WO2001095874A3 publication Critical patent/WO2001095874A3/en
Priority to HK03103294A priority patent/HK1051139A1/en

Links

Classifications

    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K9/00—Medicinal preparations characterised by special physical form
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K9/00—Medicinal preparations characterised by special physical form
    • A61K9/0012—Galenical forms characterised by the site of application
    • A61K9/007—Pulmonary tract; Aromatherapy
    • A61K9/0073—Sprays or powders for inhalation; Aerolised or nebulised preparations generated by other means than thermal energy
    • A61K9/0075—Sprays or powders for inhalation; Aerolised or nebulised preparations generated by other means than thermal energy for inhalation via a dry powder inhaler [DPI], e.g. comprising micronized drug mixed with lactose carrier particles
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K9/00—Medicinal preparations characterised by special physical form
    • A61K9/14—Particulate form, e.g. powders, Processes for size reducing of pure drugs or the resulting products, Pure drug nanoparticles
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K31/00—Medicinal preparations containing organic active ingredients
    • A61K31/185—Acids; Anhydrides, halides or salts thereof, e.g. sulfur acids, imidic, hydrazonic or hydroximic acids
    • A61K31/19—Carboxylic acids, e.g. valproic acid
    • A61K31/195—Carboxylic acids, e.g. valproic acid having an amino group
    • A61K31/197—Carboxylic acids, e.g. valproic acid having an amino group the amino and the carboxyl groups being attached to the same acyclic carbon chain, e.g. gamma-aminobutyric acid [GABA], beta-alanine, epsilon-aminocaproic acid, pantothenic acid
    • A61K31/198—Alpha-aminoacids, e.g. alanine, edetic acids [EDTA]
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K9/00—Medicinal preparations characterised by special physical form
    • A61K9/14—Particulate form, e.g. powders, Processes for size reducing of pure drugs or the resulting products, Pure drug nanoparticles
    • A61K9/16—Agglomerates; Granulates; Microbeadlets ; Microspheres; Pellets; Solid products obtained by spray drying, spray freeze drying, spray congealing,(multiple) emulsion solvent evaporation or extraction
    • A61K9/1605—Excipients; Inactive ingredients
    • A61K9/1617—Organic compounds, e.g. phospholipids, fats
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P11/00—Drugs for disorders of the respiratory system

Abstract

A method for delivering an agent to the pulmonary system, in a single, breath-activated step or a single breath, comprises administering from a receptacle enclosing a mass of particles, to a subject's respiratory tract, particles which have a tap density of less than 0.4 g/cm3 and deliver at least about 50 % of the mass of particles. The particles are capable of carrying agents. The agent is: 1) part of the spray-drying pre-mixture and thereby incorporated into the particles; 2) added to separately-prepared particles so that the agent is in chemical association with the particles; or 3) blended so that the agent is mixed with, and co-delivered with the particles. Respirable compositions comprising carrier particles having a tap density of less than 0.4 g/cm3 and a composition comprising an agent are also disclosed. Methods of delivering these respirable compositions are also included.
PCT/US2001/018491 2000-06-09 2001-06-08 Highly efficient delivery of a large therapeutic mass aerosol WO2001095874A2 (en)

Priority Applications (15)

Application Number Priority Date Filing Date Title
AU7536801A AU7536801A (en) 2000-06-09 2001-06-08 Highly efficient delivery of a large therapeutic mass aerosol
SI200130734T SI1296663T1 (en) 2000-06-09 2001-06-08 Highly efficient delivery of a large therapeutic mass aerosol
DK01942072T DK1296663T3 (en) 2000-06-09 2001-06-08 Very effective delivery of an aerosol with great therapeutic mass
PL36028701A PL360287A1 (en) 2000-06-09 2001-06-08 Highly efficient delivery of a large therapeutic mass aerosol
IL15328101A IL153281A0 (en) 2000-06-09 2001-06-08 Highly efficient delivery of a large therapeutic mass aerosol
AU2001275368A AU2001275368B2 (en) 2000-06-09 2001-06-08 Highly efficient delivery of a large therapeutic mass aerosol
MXPA02012023A MXPA02012023A (en) 2000-06-09 2001-06-08 Highly efficient delivery of a large therapeutic mass aerosol.
DE60127407T DE60127407T2 (en) 2000-06-09 2001-06-08 HIGH-ACTIVE ADMINISTRATION OF AEROSOL WITH HIGH THERAPEUTIC MASS
NZ523254A NZ523254A (en) 2000-06-09 2001-06-08 Method of delivering a large therapeutic mass aerosol to the pulmonary system
KR1020027016748A KR100697479B1 (en) 2000-06-09 2001-06-08 Highly efficient delivery of a large therapeutic mass aerosol
CA002412561A CA2412561C (en) 2000-06-09 2001-06-08 Highly efficient delivery of a large therapeutic mass aerosol
JP2002510053A JP2004503482A (en) 2000-06-09 2001-06-08 Highly efficient delivery of large therapeutic mass aerosols
EP01942072A EP1296663B1 (en) 2000-06-09 2001-06-08 Highly efficient delivery of a large therapeutic mass aerosol
NO20025873A NO20025873L (en) 2000-06-09 2002-12-06 Very effective delivery of a large therapeutic amount of aerosol
HK03103294A HK1051139A1 (en) 2000-06-09 2003-05-12 Highly efficient delivery of a large therapeutic mass aerosol

Applications Claiming Priority (2)

Application Number Priority Date Filing Date Title
US09/591,307 2000-06-09
US09/591,307 US6858199B1 (en) 2000-06-09 2000-06-09 High efficient delivery of a large therapeutic mass aerosol

Publications (2)

Publication Number Publication Date
WO2001095874A2 WO2001095874A2 (en) 2001-12-20
WO2001095874A3 true WO2001095874A3 (en) 2003-01-16

Family

ID=24365965

Family Applications (1)

Application Number Title Priority Date Filing Date
PCT/US2001/018491 WO2001095874A2 (en) 2000-06-09 2001-06-08 Highly efficient delivery of a large therapeutic mass aerosol

Country Status (21)

Country Link
US (6) US6858199B1 (en)
EP (2) EP1296663B1 (en)
JP (2) JP2004503482A (en)
KR (1) KR100697479B1 (en)
CN (1) CN100589796C (en)
AT (1) ATE357222T1 (en)
AU (2) AU2001275368B2 (en)
CA (1) CA2412561C (en)
DE (1) DE60127407T2 (en)
DK (1) DK1296663T3 (en)
ES (1) ES2283417T3 (en)
HK (1) HK1051139A1 (en)
IL (1) IL153281A0 (en)
MX (1) MXPA02012023A (en)
NO (1) NO20025873L (en)
NZ (1) NZ523254A (en)
PL (1) PL360287A1 (en)
PT (1) PT1296663E (en)
RU (1) RU2275900C2 (en)
SI (1) SI1296663T1 (en)
WO (1) WO2001095874A2 (en)

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US8992983B2 (en) 2010-08-30 2015-03-31 Pulmatrix, Inc. Respirably dry powder comprising calcium lactate, sodium chloride and leucine
US9061352B2 (en) 2010-08-30 2015-06-23 Pulmatrix, Inc. Dry powder formulations and methods for treating pulmonary diseases
US9421166B2 (en) 2001-12-19 2016-08-23 Novartis Ag Pulmonary delivery of aminoglycoside
US9433576B2 (en) 2010-09-29 2016-09-06 Pulmatrix, Inc. Cationic dry powders
US9554993B2 (en) 1997-09-29 2017-01-31 Novartis Ag Pulmonary delivery particles comprising an active agent

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