WO2001094306A3 - (bis)sulfonamide derivatives - Google Patents

(bis)sulfonamide derivatives Download PDF

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Publication number
WO2001094306A3
WO2001094306A3 PCT/US2001/010829 US0110829W WO0194306A3 WO 2001094306 A3 WO2001094306 A3 WO 2001094306A3 US 0110829 W US0110829 W US 0110829W WO 0194306 A3 WO0194306 A3 WO 0194306A3
Authority
WO
WIPO (PCT)
Prior art keywords
alkyl
represent hydrogen
independently represent
derivatives
bis
Prior art date
Application number
PCT/US2001/010829
Other languages
French (fr)
Other versions
WO2001094306A2 (en
Inventor
James Allen Knobelsdorf
Hamideh Zarrinmayeh
Original Assignee
Lilly Co Eli
James Allen Knobelsdorf
Hamideh Zarrinmayeh
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Application filed by Lilly Co Eli, James Allen Knobelsdorf, Hamideh Zarrinmayeh filed Critical Lilly Co Eli
Priority to EP01937169A priority Critical patent/EP1292571A2/en
Priority to AU2001262932A priority patent/AU2001262932A1/en
Priority to US10/275,335 priority patent/US20040054009A1/en
Publication of WO2001094306A2 publication Critical patent/WO2001094306A2/en
Publication of WO2001094306A3 publication Critical patent/WO2001094306A3/en

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Classifications

    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07C—ACYCLIC OR CARBOCYCLIC COMPOUNDS
    • C07C311/00—Amides of sulfonic acids, i.e. compounds having singly-bound oxygen atoms of sulfo groups replaced by nitrogen atoms, not being part of nitro or nitroso groups
    • C07C311/01—Sulfonamides having sulfur atoms of sulfonamide groups bound to acyclic carbon atoms
    • C07C311/02—Sulfonamides having sulfur atoms of sulfonamide groups bound to acyclic carbon atoms of an acyclic saturated carbon skeleton
    • C07C311/03—Sulfonamides having sulfur atoms of sulfonamide groups bound to acyclic carbon atoms of an acyclic saturated carbon skeleton having the nitrogen atoms of the sulfonamide groups bound to hydrogen atoms or to acyclic carbon atoms
    • C07C311/05—Sulfonamides having sulfur atoms of sulfonamide groups bound to acyclic carbon atoms of an acyclic saturated carbon skeleton having the nitrogen atoms of the sulfonamide groups bound to hydrogen atoms or to acyclic carbon atoms to acyclic carbon atoms of hydrocarbon radicals substituted by nitrogen atoms, not being part of nitro or nitroso groups
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P25/00—Drugs for disorders of the nervous system
    • A61P25/18—Antipsychotics, i.e. neuroleptics; Drugs for mania or schizophrenia
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P25/00—Drugs for disorders of the nervous system
    • A61P25/28—Drugs for disorders of the nervous system for treating neurodegenerative disorders of the central nervous system, e.g. nootropic agents, cognition enhancers, drugs for treating Alzheimer's disease or other forms of dementia

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  • Health & Medical Sciences (AREA)
  • Organic Chemistry (AREA)
  • Chemical & Material Sciences (AREA)
  • Engineering & Computer Science (AREA)
  • Bioinformatics & Cheminformatics (AREA)
  • Neurosurgery (AREA)
  • Biomedical Technology (AREA)
  • Neurology (AREA)
  • Chemical Kinetics & Catalysis (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • Veterinary Medicine (AREA)
  • General Chemical & Material Sciences (AREA)
  • Medicinal Chemistry (AREA)
  • Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
  • Pharmacology & Pharmacy (AREA)
  • Psychiatry (AREA)
  • Animal Behavior & Ethology (AREA)
  • General Health & Medical Sciences (AREA)
  • Public Health (AREA)
  • Hospice & Palliative Care (AREA)
  • Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
  • Organic Low-Molecular-Weight Compounds And Preparation Thereof (AREA)

Abstract

The present invention provides bissulphonamide derivatives of formula (I), in which R1 represents C¿1-6?-alkyl, C2-6-alkenyl, or NR?7R8,R2 and R3¿ each independently represent hydrogen, C¿1-4?.alkyl, F, aryl, or C1-6.alkylaryl; R?4 and R5¿ each represent hydrogen; R6 represents C¿1-6?-alkyl; n is an integer from 7 to 14; and R?7 and R8¿ each independently represent hydrogen or C¿1-4?-alkyl; or a pharmaceutically acceptable salt thereof. Bissulphonamide derivatives of formula (I), in which R?1¿ represents C¿1-6?-alkyl, C2-6-alkenyl, or NR?7R8, R2, R2, R4, and R5¿ each represent hydrogen; R6 represents C¿1-6?-alkyl; n is an integer from 6 to 14; and R?7 and R8¿ each independently represent hydrogen or C¿1-4?-alkyl; or a pharmaceutically acceptable salt thereof; are useful for potentiating glutamate receptor function in a mammal and, therefore, useful for treating a wide variety of conditions, such as psychiatric and neurological disorders.
PCT/US2001/010829 2000-06-06 2001-05-23 (bis)sulfonamide derivatives WO2001094306A2 (en)

Priority Applications (3)

Application Number Priority Date Filing Date Title
EP01937169A EP1292571A2 (en) 2000-06-06 2001-05-23 (bis)sulfonamide derivatives
AU2001262932A AU2001262932A1 (en) 2000-06-06 2001-05-23 (bis)sulfonamide derivatives
US10/275,335 US20040054009A1 (en) 2001-05-23 2001-05-23 (BIS)sulfonamide derivatives

Applications Claiming Priority (2)

Application Number Priority Date Filing Date Title
US20967500P 2000-06-06 2000-06-06
US60/209,675 2000-06-06

Publications (2)

Publication Number Publication Date
WO2001094306A2 WO2001094306A2 (en) 2001-12-13
WO2001094306A3 true WO2001094306A3 (en) 2002-05-23

Family

ID=22779775

Family Applications (1)

Application Number Title Priority Date Filing Date
PCT/US2001/010829 WO2001094306A2 (en) 2000-06-06 2001-05-23 (bis)sulfonamide derivatives

Country Status (3)

Country Link
EP (1) EP1292571A2 (en)
AU (1) AU2001262932A1 (en)
WO (1) WO2001094306A2 (en)

Families Citing this family (1)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
CA2915405A1 (en) 2013-06-13 2014-12-18 Veroscience Llc Compositions and methods for treating metabolic disorders

Citations (1)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
WO1998033496A1 (en) * 1997-02-04 1998-08-06 Eli Lilly And Company Sulphonamide derivatives

Patent Citations (1)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
WO1998033496A1 (en) * 1997-02-04 1998-08-06 Eli Lilly And Company Sulphonamide derivatives

Non-Patent Citations (4)

* Cited by examiner, † Cited by third party
Title
A. VANDI, ET AL.: "Some amonolysis and deamonation reactions of dialkylsulphanyl chlorides and sulphamide with polyamines", JOURNAL OF ORGANIC CHEMISTRY, vol. 26, no. 9, 12 September 1961 (1961-09-12), American Chemical Society, Washington, DC, US, pages 3478 - 3480, XP002187582, ISSN: 0022-3263 *
G. WEISS, ET AL.: "Herstellung und Reaktionen von N-Monoalkylamidosulfonylchloriden", LIEBIGS ANNALEN DER CHEMIE, vol. 729, December 1969 (1969-12-01), Verlag Chemie, Weinheim, DE, pages 40 - 51, XP002187581, ISSN: 0170-2041 *
H.A. OFFE: "Über die Electrolyse von Aminosäure-Derivaten", ZEITSCHRIFT FUER NATURFORSCHUNG., vol. 2b, 1947, Dietrich'sche Verlagsbuchhandlung, Wiesbaden, DE, pages 182 - 184, XP001052935 *
M. COHEN: "New epoxide resins by reaction of epichlorohydrin with sulphonamides", INDUSTRIAL AND ENGINEERING CHEMISTRY., vol. 47, no. 10, October 1955 (1955-10-01), American Chemical Society, Washington, DC, US, pages 2095 - 2101, XP001042164 *

Also Published As

Publication number Publication date
WO2001094306A2 (en) 2001-12-13
EP1292571A2 (en) 2003-03-19
AU2001262932A1 (en) 2001-12-17

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