WO2001093844A3 - Compositions comprising a serotonin transporter inhibitor and a 5-ht1d antagonist - Google Patents

Compositions comprising a serotonin transporter inhibitor and a 5-ht1d antagonist Download PDF

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Publication number
WO2001093844A3
WO2001093844A3 PCT/US2001/010824 US0110824W WO0193844A3 WO 2001093844 A3 WO2001093844 A3 WO 2001093844A3 US 0110824 W US0110824 W US 0110824W WO 0193844 A3 WO0193844 A3 WO 0193844A3
Authority
WO
WIPO (PCT)
Prior art keywords
compositions
serotonin transporter
transporter inhibitor
ht1d antagonist
ht1d
Prior art date
Application number
PCT/US2001/010824
Other languages
French (fr)
Other versions
WO2001093844A2 (en
Inventor
Stephen Nicholas Mitchell
Ian Alexander Pullar
Original Assignee
Lilly Co Eli
Stephen Nicholas Mitchell
Ian Alexander Pullar
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Application filed by Lilly Co Eli, Stephen Nicholas Mitchell, Ian Alexander Pullar filed Critical Lilly Co Eli
Priority to AU2001262928A priority Critical patent/AU2001262928A1/en
Priority to US10/276,107 priority patent/US20030212109A1/en
Priority to EP01937165A priority patent/EP1299120A2/en
Publication of WO2001093844A2 publication Critical patent/WO2001093844A2/en
Publication of WO2001093844A3 publication Critical patent/WO2001093844A3/en

Links

Classifications

    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K31/00—Medicinal preparations containing organic active ingredients
    • A61K31/33—Heterocyclic compounds
    • A61K31/395—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins
    • A61K31/435—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins having six-membered rings with one nitrogen as the only ring hetero atom
    • A61K31/44—Non condensed pyridines; Hydrogenated derivatives thereof
    • A61K31/445—Non condensed piperidines, e.g. piperocaine
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K31/00—Medicinal preparations containing organic active ingredients
    • A61K31/33—Heterocyclic compounds
    • A61K31/395—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins
    • A61K31/495—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins having six-membered rings with two or more nitrogen atoms as the only ring heteroatoms, e.g. piperazine or tetrazines
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P25/00—Drugs for disorders of the nervous system
    • A61P25/24—Antidepressants
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P25/00—Drugs for disorders of the nervous system
    • A61P25/28—Drugs for disorders of the nervous system for treating neurodegenerative disorders of the central nervous system, e.g. nootropic agents, cognition enhancers, drugs for treating Alzheimer's disease or other forms of dementia
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P25/00—Drugs for disorders of the nervous system
    • A61P25/30—Drugs for disorders of the nervous system for treating abuse or dependence

Landscapes

  • Health & Medical Sciences (AREA)
  • Veterinary Medicine (AREA)
  • Chemical & Material Sciences (AREA)
  • Medicinal Chemistry (AREA)
  • Pharmacology & Pharmacy (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • Animal Behavior & Ethology (AREA)
  • General Health & Medical Sciences (AREA)
  • Public Health (AREA)
  • Engineering & Computer Science (AREA)
  • Neurosurgery (AREA)
  • Neurology (AREA)
  • Biomedical Technology (AREA)
  • Bioinformatics & Cheminformatics (AREA)
  • Psychiatry (AREA)
  • Chemical Kinetics & Catalysis (AREA)
  • General Chemical & Material Sciences (AREA)
  • Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
  • Organic Chemistry (AREA)
  • Epidemiology (AREA)
  • Addiction (AREA)
  • Pain & Pain Management (AREA)
  • Hospice & Palliative Care (AREA)
  • Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
  • Medicines That Contain Protein Lipid Enzymes And Other Medicines (AREA)

Abstract

A pharmaceutical composition comprising a serotonin transport inhibitor and a 5-HT1D antagonist, together with a pharmaceutically acceptable diluent or carrier.
PCT/US2001/010824 2000-06-02 2001-05-21 Compositions comprising a serotonin transporter inhibitor and a 5-ht1d antagonist WO2001093844A2 (en)

Priority Applications (3)

Application Number Priority Date Filing Date Title
AU2001262928A AU2001262928A1 (en) 2000-06-02 2001-05-21 Pharmaceutical compositions and their use
US10/276,107 US20030212109A1 (en) 2000-06-02 2001-05-21 Pharmaceutical compositions and their use
EP01937165A EP1299120A2 (en) 2000-06-02 2001-05-21 Compositions comprising a serotonin transporter inhibitor and a 5-ht1d antagonist

Applications Claiming Priority (2)

Application Number Priority Date Filing Date Title
GB0013503.8 2000-06-02
GB0013503A GB2362826A (en) 2000-06-02 2000-06-02 A pharmaceutical composition comprising a serotonin transport inhibitor and a serotonin recptor antagonist

Publications (2)

Publication Number Publication Date
WO2001093844A2 WO2001093844A2 (en) 2001-12-13
WO2001093844A3 true WO2001093844A3 (en) 2002-04-04

Family

ID=9892909

Family Applications (1)

Application Number Title Priority Date Filing Date
PCT/US2001/010824 WO2001093844A2 (en) 2000-06-02 2001-05-21 Compositions comprising a serotonin transporter inhibitor and a 5-ht1d antagonist

Country Status (4)

Country Link
EP (1) EP1299120A2 (en)
AU (1) AU2001262928A1 (en)
GB (1) GB2362826A (en)
WO (1) WO2001093844A2 (en)

Families Citing this family (5)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
US6602911B2 (en) 2001-11-05 2003-08-05 Cypress Bioscience, Inc. Methods of treating fibromyalgia
US7517899B2 (en) 2004-03-30 2009-04-14 Wyeth Phenylaminopropanol derivatives and methods of their use
US7414052B2 (en) 2004-03-30 2008-08-19 Wyeth Phenylaminopropanol derivatives and methods of their use
AU2005319367B2 (en) 2004-12-20 2012-05-24 Collegium Pharmaceutical, Inc. Pharmaceutical compositions for sleep disorders
US7994220B2 (en) 2005-09-28 2011-08-09 Cypress Bioscience, Inc. Milnacipran for the long-term treatment of fibromyalgia syndrome

Citations (3)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
EP0533267A1 (en) * 1991-09-18 1993-03-24 Glaxo Group Limited Benzanilide derivatives as 5-HT1D antagonists
EP0701819A2 (en) * 1994-09-14 1996-03-20 Pfizer Inc. Novel compositions containing sertraline and a 5-HT1D receptor agonist or antagonist
EP0780388A1 (en) * 1995-12-19 1997-06-25 Lilly Industries Limited 5HT1Dalpha and 5HT2A ligands

Family Cites Families (3)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
CA2134038C (en) * 1994-06-16 1997-06-03 David Taiwai Wong Potentiation of drug response
PA8469101A1 (en) * 1998-04-09 2000-09-29 Pfizer Prod Inc AZABICICLIC LEAGUES OF RECEIVERS 5HT1
WO1999059593A1 (en) * 1998-05-21 1999-11-25 Eli Lilly And Company Combination therapy for treatment of depression

Patent Citations (3)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
EP0533267A1 (en) * 1991-09-18 1993-03-24 Glaxo Group Limited Benzanilide derivatives as 5-HT1D antagonists
EP0701819A2 (en) * 1994-09-14 1996-03-20 Pfizer Inc. Novel compositions containing sertraline and a 5-HT1D receptor agonist or antagonist
EP0780388A1 (en) * 1995-12-19 1997-06-25 Lilly Industries Limited 5HT1Dalpha and 5HT2A ligands

Also Published As

Publication number Publication date
WO2001093844A2 (en) 2001-12-13
GB2362826A (en) 2001-12-05
AU2001262928A1 (en) 2001-12-17
EP1299120A2 (en) 2003-04-09
GB0013503D0 (en) 2000-07-26

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