WO2001092565A3 - Diagnosis of diseases associated dna transcription by means of assessing the methylation status of genes associated with dna transcription - Google Patents

Diagnosis of diseases associated dna transcription by means of assessing the methylation status of genes associated with dna transcription Download PDF

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Publication number
WO2001092565A3
WO2001092565A3 PCT/EP2001/003973 EP0103973W WO0192565A3 WO 2001092565 A3 WO2001092565 A3 WO 2001092565A3 EP 0103973 W EP0103973 W EP 0103973W WO 0192565 A3 WO0192565 A3 WO 0192565A3
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WIPO (PCT)
Prior art keywords
dna transcription
genes associated
assessing
diagnosis
methylation status
Prior art date
Application number
PCT/EP2001/003973
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French (fr)
Other versions
WO2001092565A2 (en
WO2001092565A8 (en
Inventor
Alexander Olek
Christian Piepenbrock
Kurt Berlin
Original Assignee
Epigenomics Ag
Alexander Olek
Christian Piepenbrock
Kurt Berlin
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Priority claimed from DE10019058A external-priority patent/DE10019058A1/en
Priority claimed from DE10032529A external-priority patent/DE10032529A1/en
Application filed by Epigenomics Ag, Alexander Olek, Christian Piepenbrock, Kurt Berlin filed Critical Epigenomics Ag
Priority to EP01969303A priority Critical patent/EP1268861A2/en
Priority to AU2001289600A priority patent/AU2001289600A1/en
Publication of WO2001092565A2 publication Critical patent/WO2001092565A2/en
Publication of WO2001092565A8 publication Critical patent/WO2001092565A8/en
Publication of WO2001092565A3 publication Critical patent/WO2001092565A3/en

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    • C12Q1/00—Measuring or testing processes involving enzymes, nucleic acids or microorganisms; Compositions therefor; Processes of preparing such compositions
    • C12Q1/68—Measuring or testing processes involving enzymes, nucleic acids or microorganisms; Compositions therefor; Processes of preparing such compositions involving nucleic acids
    • C12Q1/6876—Nucleic acid products used in the analysis of nucleic acids, e.g. primers or probes
    • C12Q1/6883—Nucleic acid products used in the analysis of nucleic acids, e.g. primers or probes for diseases caused by alterations of genetic material
    • C12Q1/6886—Nucleic acid products used in the analysis of nucleic acids, e.g. primers or probes for diseases caused by alterations of genetic material for cancer
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    • C12Q2600/00—Oligonucleotides characterized by their use
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    • C12Q2600/00—Oligonucleotides characterized by their use
    • C12Q2600/156—Polymorphic or mutational markers

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Abstract

The present invention relates to the chemically modified genomic sequences of genes associated with DNA transcription, to oligonucleotides and/or PNA-oligomers for detecting the cytosine methylation state of genes associated with DNA transcription which are directed against the sequence, as well as to a method for ascertaining genetic and/or epigenetic parameters of genes associated with DNA transcription.
PCT/EP2001/003973 2000-04-06 2001-04-06 Diagnosis of diseases associated dna transcription by means of assessing the methylation status of genes associated with dna transcription WO2001092565A2 (en)

Priority Applications (2)

Application Number Priority Date Filing Date Title
EP01969303A EP1268861A2 (en) 2000-04-06 2001-04-06 Diagnosis of diseases associated with dna transcription
AU2001289600A AU2001289600A1 (en) 2000-04-06 2001-04-06 Diagnosis of diseases associated dna transcription by means of assessing the methylation status of genes associated with dna transcription

Applications Claiming Priority (8)

Application Number Priority Date Filing Date Title
DE10019058.8 2000-04-06
DE10019058A DE10019058A1 (en) 2000-04-06 2000-04-06 Designing primers and probes for analyzing diseases associated with cytosine methylation state e.g. arthritis, cancer, aging, arteriosclerosis comprising fragments of chemically modified genes associated with cell cycle
DE10019173 2000-04-07
DE10019173.8 2000-04-07
DE10032529.7 2000-06-30
DE10032529A DE10032529A1 (en) 2000-06-30 2000-06-30 Diagnosis of major genetic parameters within the Major Histocompatibility Complex (MHC)
DE10043826 2000-09-01
DE10043826.1 2000-09-01

Publications (3)

Publication Number Publication Date
WO2001092565A2 WO2001092565A2 (en) 2001-12-06
WO2001092565A8 WO2001092565A8 (en) 2002-05-30
WO2001092565A3 true WO2001092565A3 (en) 2002-09-06

Family

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Family Applications (8)

Application Number Title Priority Date Filing Date
PCT/EP2001/003972 WO2001081622A2 (en) 2000-04-06 2001-04-06 Diagnosis of diseases associated with dna repair
PCT/EP2001/003968 WO2001077375A2 (en) 2000-04-06 2001-04-06 Diagnosis of diseases associated with gene regulation
PCT/EP2001/004015 WO2001077378A2 (en) 2000-04-06 2001-04-06 Diagnosis of diseases associated with dna adducts
PCT/EP2001/003973 WO2001092565A2 (en) 2000-04-06 2001-04-06 Diagnosis of diseases associated dna transcription by means of assessing the methylation status of genes associated with dna transcription
PCT/EP2001/003971 WO2001077377A2 (en) 2000-04-06 2001-04-06 Diagnosis of diseases associated with dna replication by assessing dna methylation
PCT/EP2001/003970 WO2001077376A2 (en) 2000-04-06 2001-04-06 Diagnosis of diseases associated with metastasis
PCT/EP2001/003969 WO2001077164A2 (en) 2000-04-06 2001-04-06 Diagnosis of diseases associated with apoptosis by means of assessing the methylation status of genes associated with apoptosis
PCT/EP2001/004016 WO2001076451A2 (en) 2000-04-06 2001-04-06 Diagnosis of diseases associated with metabolism

Family Applications Before (3)

Application Number Title Priority Date Filing Date
PCT/EP2001/003972 WO2001081622A2 (en) 2000-04-06 2001-04-06 Diagnosis of diseases associated with dna repair
PCT/EP2001/003968 WO2001077375A2 (en) 2000-04-06 2001-04-06 Diagnosis of diseases associated with gene regulation
PCT/EP2001/004015 WO2001077378A2 (en) 2000-04-06 2001-04-06 Diagnosis of diseases associated with dna adducts

Family Applications After (4)

Application Number Title Priority Date Filing Date
PCT/EP2001/003971 WO2001077377A2 (en) 2000-04-06 2001-04-06 Diagnosis of diseases associated with dna replication by assessing dna methylation
PCT/EP2001/003970 WO2001077376A2 (en) 2000-04-06 2001-04-06 Diagnosis of diseases associated with metastasis
PCT/EP2001/003969 WO2001077164A2 (en) 2000-04-06 2001-04-06 Diagnosis of diseases associated with apoptosis by means of assessing the methylation status of genes associated with apoptosis
PCT/EP2001/004016 WO2001076451A2 (en) 2000-04-06 2001-04-06 Diagnosis of diseases associated with metabolism

Country Status (7)

Country Link
US (7) US20040067491A1 (en)
EP (9) EP1370685A2 (en)
JP (3) JP2003534780A (en)
AT (1) ATE353975T1 (en)
AU (9) AU2001289600A1 (en)
DE (1) DE60126593T2 (en)
WO (8) WO2001081622A2 (en)

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